On the possibility that the prereplicative increase in ornithine decarboxylase activity are related to DNA synthesis in liver

Romeo'a1 o f part o f fiae liver o f the rat is no~ fol lowed "rmmediate]y by an increase in DNA repficafion in the remnant ¢e,lts. Rather there is a prereplieafive period o f abou t 1.~ hr. It is reasonable to expect that critical changes must take place in the liver during this time in order for the nucM to enter the S period. The c r i t i c s ehange~ m a y cukrr~nate i n t h e s y n t h e s i s o f p ro teSns thai are needed for the replicative process. A2terations in tZNA and protein synthesis appear to be obligalory events o f the p~ereplicafive period after partial hepa tec tomy I1 ,2 ] . No other lNer change is known to be requisite "to DNA fornaa.ion. The dearth o f infornaation 5s not due to a failure to find alterations in regenera~ng h'ver. On the contrary, it is a reflection o f the large number o f changes tha~ have been described end of the lack of a suilable means for selecting for intensive s tudy -those changes that show promise of being related Io the later ~2¢ntheziz of DNA. T]~e availability o f two new procedures that induce hepalic DNA synthesis in unoperated rms now offers a means for at leas~ tentafiveay ass~_gning a causal re~ation~Mp be-tween a prereplicative change and ~he replicmi,on of DNA. DNA formation can be reduced in the liver of the intact animal with a honnone-contabnkng ~o]ution (TAGH solution) I3] and by shifting rats from a protein-f,ree to a pr,otein-contaiMng diet ;[.$]. A n y prexep!icative change that takes place after partial hepa tec tomy bu t fain to occur after bo'fl~, oF the o ther stimuli can be or,eluded as being essential for DNA ~ynthesis. The appearance ,of the name ,change in all thlee sys-t.ems, on the other ~hand, is consistenl wi th a relationship be tween the change and the hndnction o f DNA xep']icafion.

• Publication year

  1973

• Venue

  FEBS Letters

• Publication date

  1973-06-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/0014-5793(73)80844-0PMID 4733781
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1973cited by this paper
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  1972cited by this paper
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  1972cited by this paper
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  1972cited by this paper
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  1971cited by this paper
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  1970cited by this paper
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  1970cited by this paper
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  1970cited by this paper
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  1968cited by this paper
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  1968cited by this paper
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  1963cited by this paper

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  1988cites this paper
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  1987cites this paper
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  1986cites this paper
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  1986cites this paper
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  1984cites this paper
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  1984cites this paper
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  1984cites this paper
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  1983cites this paper
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  1983cites this paper
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  1983cites this paper
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  1982cites this paper
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  1981cites this paper
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  1981cites this paper
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  1981cites this paper
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  1980cites this paper
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  1980cites this paper
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  1980cites this paper
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  1980cites this paper
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  1979cites this paper
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  1979cites this paper
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  1979cites this paper
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  1978cites this paper
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  1978cites this paper
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  1978cites this paper
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  1978cites this paper
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  1978cites this paper
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  1978cites this paper
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  1978cites this paper
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  1978cites this paper
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  1977cites this paper
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  1977cites this paper
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  1977cites this paper
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  1977cites this paper
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  1977cites this paper
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  1977cites this paper
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  1977cites this paper
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  1977cites this paper
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  1977cites this paper
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  1976cites this paper
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  1976cites this paper
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  1976cites this paper
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  1975cites this paper
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  1975cites this paper
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  1975cites this paper
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  1975cites this paper
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  1975cites this paper
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  1974cites this paper
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  1974cites this paper
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  1974cites this paper
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  1973cites this paper