Human relaxin-2: historical perspectives and role in cancer biology

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Amino Acids

• Publication date

  2012-08-02

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00726-012-1375-yPMID 22855207
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Atlas of Genetics and Cytogenetics in Oncology and Haematology

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• The relaxin peptide family--structure, function and clinical applications.

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• Design and recombinant expression of insulin-like peptide 5 precursors and the preparation of mature human INSL5

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• The roles of the A- and B-chains of human relaxin-2 and -3 on their biological activity.

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• The chemically synthesized human relaxin-2 analog, B-R13/17K H2, is an RXFP1 antagonist

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• Membrane receptors: structure and function of the relaxin family peptide receptors.

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• Relaxin for the treatment of patients with acute heart failure (Pre-RELAX-AHF): a multicentre, randomised, placebo-controlled, parallel-group, dose-finding phase IIb study.

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• New Roles for INSL3 in Adults

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• Orphan G protein-coupled receptors and novel neuropeptides. Introduction.

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• Relaxin-3, INSL5, and their receptors.

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• Identification of the domains in RXFP4 (GPCR142) responsible for the high affinity binding and agonistic activity of INSL5 at RXFP4 compared to RXFP3 (GPCR135).

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• Effect of helix-promoting strategies on the biological activity of novel analogues of the B-chain of INSL3

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• Synthesis, Conformation, and Activity of Human Insulin-Like Peptide 5 (INSL5)

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• Relaxin-family peptide and receptor systems in brain: insights from recent anatomical and functional studies.

  2007cited by this paper
• Relaxin Promotes Prostate Cancer Progression

  2007cited by this paper
• Relaxin-3: improved synthesis strategy and demonstration of its high-affinity interaction with the relaxin receptor LGR7 both in vitro and in vivo.

  2006cited by this paper
• The R273H p53 mutation can facilitate the androgen-independent growth of LNCaP by a mechanism that involves H2 relaxin and its cognate receptor LGR7

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• Knobil and Neill's Physiology of reproduction

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• International Union of Pharmacology LVII: Recommendations for the Nomenclature of Receptors for Relaxin Family Peptides

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• H2 relaxin overexpression increases in vivo prostate xenograft tumor growth and angiogenesis

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• Insulin-like peptide 6: characterization of secretory status and posttranslational modifications.

  2006cited by this paper
• 'Relaxin' the stiffened heart and arteries: the therapeutic potential for relaxin in the treatment of cardiovascular disease.

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• Cross-species Vascular Endothelial Growth Factor (VEGF)-blocking Antibodies Completely Inhibit the Growth of Human Tumor Xenografts and Measure the Contribution of Stromal VEGF*

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• Physiology and Molecular Biology of the Relaxin Peptide Family

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• The role of relaxin in endometrial cancer

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• Relaxin: antifibrotic properties and effects in models of disease.

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• Insulin‐Like Factor 3: Where Are We Now?

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• Central relaxin-3 administration causes hyperphagia in male Wistar rats.

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• Coevolution of the Relaxin‐Like Peptides and Their Receptors

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• Relaxin modulates cardiac fibroblast proliferation, differentiation, and collagen production and reverses cardiac fibrosis in vivo.

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• Emerging role of relaxin in renal and cardiovascular function.

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• Elevated Concentrations of Serum Relaxin are Associated with Metastatic Disease in Breast Cancer Patients

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• Paracrine regulation of mammalian oocyte maturation and male germ cell survival.

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• Synthetic human insulin 4 does not activate the G‐protein‐coupled receptors LGR7 or LGR8

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• Remembrance: The Contributions of Frederick Hisaw

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• The Contributions of Frederick Hisaw

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• Adenovirus-mediated expression of human prorelaxin promotes the invasive potential of canine mammary cancer cells.

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• Identification of Relaxin-3/INSL7 as an Endogenous Ligand for the Orphan G-protein-coupled Receptor GPCR135*

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• Nitric oxide‐mediated promotion of mammary tumour cell migration requires sequential activation of nitric oxide synthase, guanylate cyclase and mitogen‐activated protein kinase

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• The primary structure and the disulfide links of the bovine relaxin-like factor (RLF).

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• Relaxin up‐regulates inducible nitric oxide synthase expression and nitric oxide generation in rat coronary endothelial cells

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• INSL3/Leydig Insulin-like Peptide Activates the LGR8 Receptor Important in Testis Descent*

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• Activation of Orphan Receptors by the Hormone Relaxin

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• Relaxin enhances in-vitro invasiveness of breast cancer cell lines by up-regulation of matrix metalloproteases.

  2002cited by this paper
• Synthesis and conformational analysis of the insulin-like 4 gene product.

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• High serum concentrations of relaxin correlate with dissemination of breast cancer

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• The Relaxin Receptor-binding Site Geometry Suggests a Novel Gripping Mode of Interaction*

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• Identification of INSL6, a New Member of the Insulin Family That Is Expressed in the Testis of the Human and Rat1

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• Frederick L. Hisaw (1891-1972) and the Discovery of Relaxin

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• Nitric oxide promotes murine mammary tumour growth and metastasis by stimulating tumour cell migration, invasiveness and angiogenesis

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• Printed in U.S.A. Copyright © 1999 by The Endocrine Society Relaxin Up-Regulates the Nitric Oxide Biosynthetic Pathway in the Mouse Uterus: Involvement in the Inhibition of Myometrial Contractility*

  1999cited by this paper
• Relaxin promotes differentiation of human breast cancer cells MCF-7 transplanted into nude mice

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• Relationship of serum levels of endogenous relaxin to cervical size in the second trimester and to cervical ripening at term

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• Relaxin up-regulates the nitric oxide biosynthetic pathway in the mouse uterus: involvement in the inhibition of myometrial contractility.

  1999cited by this paper
• Cloning of two novel mammalian paralogs of relaxin/insulin family proteins and their expression in testis and kidney.

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• Relaxin increases the accumulation of new epithelial and stromal cells in the rat cervix during the second half of pregnancy.

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• Identification of pro-EPIL and EPIL peptides translated from insulin-like 4 (INSL4) mRNA in human placenta.

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• Relaxin induces an extracellular matrix-degrading phenotype in human lung fibroblasts in vitro and inhibits lung fibrosis in a murine model in vivo.

  1996cited by this paper
• Identification of specific relaxin-binding cells in the cervix, mammary glands, nipples, small intestine, and skin of pregnant pigs.

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• Characterization of human relaxin gene regulation in the relaxin-expressing human prostate adenocarcinoma cell line LNCaP.FGC.

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  1926cited by this paper
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  2024cites this paper
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  2024cites this paper
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