Psychopharmacology of theobromine in healthy volunteers

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Psychopharmacology

• Publication date

  2013-02-19

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1007/s00213-013-3021-0PMID 23420115PMCID PMC3672386
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Clarke's isolation and identification of drugs

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  2010influential reference
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  1999influential reference
• Actions of caffeine in the brain with special reference to factors that contribute to its widespread use.

  1999cited by this paper
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  1999cited by this paper
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  1996influential reference
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  1994cited by this paper
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  1982influential reference
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  1982cited by this paper
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  1981cited by this paper
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  1978influential reference
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  1973influential reference
• Comparative stimulant and diuretic actions of caffeine and theobromine in man

  1970cited by this paper
• ADENYL CYCLASE AS AN ADRENERGIC RECEPTOR *

  1967cited by this paper
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• The measurement and appraisal of adult intelligence, 4th ed.

  1958cited by this paper
• PSYCHOPHARMACOLOGY

  1957cited by this paper

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