Hsc70 chaperone activity underlies Trio GEF function in axon growth and guidance induced by netrin-1

Jonathan DeGeer,A. Kaplan,P. Mattar,Morgane Morabito,U. Stochaj,T. Kennedy,A. Debant,M. Cayouette,A. Fournier,N. Lamarche‐Vane

Published 2015 in Journal of Cell Biology

ABSTRACT

Hsc70 chaperone activity is required for Rac1 activation by Trio and this function underlies netrin-1/DCC-dependent axon outgrowth and guidance.

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