Optical Spectroscopy of Tryptophan Metabolites in Neurodegenerative Disease

Abstract Abnormal metabolism of the essential amino acid, tryptophan, has been associated with many diseases, including cancer, but is also particularly important in the induction of neurodegenerative disease. Neuronal damage results from increased production, through the kynurenine pathway, of neurotoxic compounds, and also from imbalances in neurotransmitters, such as melatonin and serotonin. Optical spectroscopic techniques, such as native fluorescence, Raman spectroscopy, infrared spectroscopy, time-resolved spectroscopy, and fluorescent probes that make use of energy transfer, can be used to measure these compounds, to assess tryptophan to metabolite ratios and thus the degree of neuroinflammation, and to study the kinetics of aggregation of toxic proteins in the brain.

• Publication year

  2019

• Venue

  Neurophotonics and Biomedical Spectroscopy

• Publication date

  Unknown publication date

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/B978-0-323-48067-3.00007-X
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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