Listeria cell wall fraction: a B cell mitogen.

A crude cell wall-rich fraction of Listeria monocytogenes contains a substance or substances which cause blast transformation and thymidine incorporation by mouse spleen cells. The substance, Listeria cell wall fraction (LCWF), is a B cell mitogen in the mouse. It is not endotoxin, in that it stimulates B cells in C3H/HeJ mice. It is weakly mitogenic for rat spleen cells and not at all mitogenic for human peripheral blood or tonsil lymphocytes. Thus, it is dissimilar to both endotoxin and purified protein derivative (PPD) in its spectrum of activity. A cell wall-associated mitogen may play an early role in Listeria resistance.

• Publication year

  1975

• Venue

  Journal of Immunology

• Publication date

  1975-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.114.3.1132PMID 803536
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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