Neurotoxicological and statistical analyses of a mixture of five organophosphorus pesticides using a ray design.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Toxicological Sciences

• Publication date

  2005-07-01

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1093/TOXSCI/KFI163PMID 15800032
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Power and Sample Size Calculations for Linear Hypotheses Associated with Mixtures of Many Components using Fixed-Ratio Ray Designs

  2006influential reference
• Pharmacokinetic and pharmacodynamic interaction for a binary mixture of chlorpyrifos and diazinon in the rat.

  2005cited by this paper
• Ds‐optimal designs for studying combinations of chemicals using multiple fixed‐ratio ray experiments

  2005cited by this paper
• Detecting interaction(s) and assessing the impact of component subsets in a chemical mixture using fixed-ratio mixture ray designs

  2004cited by this paper
• Analysis of functional effects of a mixture of five pesticides using a ray design.

  2004cited by this paper
• Interactive toxicity of the organophosphorus insecticides chlorpyrifos and methyl parathion in adult rats.

  2004cited by this paper
• Comparison of chlorpyrifos-oxon and paraoxon acetylcholinesterase inhibition dynamics: potential role of a peripheral binding site.

  2004cited by this paper
• Application of physiologically-based pharmacokinetic modeling to investigate the toxicological interaction between chlorpyrifos and parathion in the rat.

  2004cited by this paper
• Physiologically based pharmacokinetic/pharmacodynamic model for the organophosphorus pesticide diazinon.

  2004cited by this paper
• Support of science-based decisions concerning the evaluation of the toxicology of mixtures: a new beginning.

  2002cited by this paper
• Statistical analysis of interactive cytotoxicity in human epidermal keratinocytes following exposure to a mixture of four metals

  2002cited by this paper
• Generalized Linear Models

  2002cited by this paper
• A Physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model for the organophosphate insecticide chlorpyrifos in rats and humans.

  2002cited by this paper
• Using dose addition to estimate cumulative risks from exposures to multiple chemicals.

  2001cited by this paper
• In vivo interaction between chlorpyrifos and parathion in adult rats: sequence of administration can markedly influence toxic outcome.

  2001cited by this paper
• Interactions of the organophosphates paraoxon and methyl paraoxon with mouse brain acetylcholinesterase.

  2000cited by this paper
• Health risk of low-dose pesticides mixtures: a review of the 1985-1998 literature on combination toxicology and health risk assessment.

  2000cited by this paper
• Organophosphorus pesticides: do they all have the same mechanism of toxicity?

  1999cited by this paper
• Age- and gender-related differences in the time course of behavioral and biochemical effects produced by oral chlorpyrifos in rats.

  1998cited by this paper
• Hazard and risk assessment of chemical mixtures using the toxic equivalency factor approach.

  1998cited by this paper
• Characterization of Muscarinic Receptor Subtypes That Mediate Antinociception in the Rat Spinal Cord

  1997cited by this paper
• Tissue-specific effects of chlorpyrifos on carboxylesterase and cholinesterase activity in adult rats: an in vitro and in vivo comparison.

  1997cited by this paper
• The relationship of oral chlorpyrifos effects on behavior, cholinesterase inhibition, and muscarinic receptor density in rat.

  1997influential reference
• Erratum: Detection of Departures from Additivity in Mixtures of Many Chemicals with a Threshold Model

  1997cited by this paper
• Diazinon toxicokinetics, tissue distribution and anticholinesterase activity in the rat.

  1996cited by this paper
• Organophosphorus compounds preferentially affect second messenger systems coupled to M2/M4 receptors in rat frontal cortex.

  1996cited by this paper
• Utilizing Concentration-Response Data from Individual Components to Detect Statistically Significant Departures from Additivity in Chemical Mixtures

  1995cited by this paper
• An efficient experimental design for detecting departure from additivity in mixtures of many chemicals.

  1995cited by this paper
• Comparisons of the acute effects of cholinesterase inhibitors using a neurobehavioral screening battery in rats.

  1995cited by this paper
• Relating isobolograms to response surfaces.

  1995cited by this paper
• Organophosphate detoxication potential of various rat tissues via A-esterase and aliesterase activities.

  1995cited by this paper
• Role of detoxication pathways in acute toxicity levels of phosphorothionate insecticides in the rat.

  1994cited by this paper
• Generalized linear models. 2nd ed.

  1993cited by this paper
• Differential modulation of organophosphate-sensitive muscarinic receptors in rat brain by parathion and chlorpyrifos.

  1993cited by this paper
• Inhibition patterns of brain acetylcholinesterase and hepatic and plasma aliesterases following exposures to three phosphorothionate insecticides and their oxons in rats.

  1993cited by this paper
• 9 – Detoxication of Organophosphorus Compounds by Carboxylesterase

  1992cited by this paper
• Generalized Linear Models, 2nd Edn.

  1990cited by this paper
• Evaluation of the efficacy of two carbamates, physostigmine and pyridostigmine, when used in conjunction for protection against organophosphate exposure.

  1990cited by this paper
• Evaluation of a two-drug combination pretreatment against organophosphorus exposure.

  1990cited by this paper
• Optimal 3×3 factorial and 3-ray designs for drug interaction experiments with dichotomous responses

  1989cited by this paper
• Drinking Water and Health

  1986cited by this paper
• The expected effect of a combination of agents: the general solution.

  1985cited by this paper
• Application of response surface methods for evaluating the interactions of soman, atropine, and pralidioxime chloride.

  1985cited by this paper
• Studies on the toxicity, metabolism, and anticholinesterase properties of acephate and methamidophos.

  1985cited by this paper
• Mechanisms of toxicological interactions involving organophosphate insecticides.

  1984cited by this paper
• Role of aliesterase in organophosphate poisoning.

  1984cited by this paper
• Chemical exposures and animal activity: utility of the figure-eight maze.

  1983cited by this paper
• Chemical exposures and animal activity: utility of the figure-eight maze.

  1983cited by this paper
• Inhibition of hepatic drug-metabolizing enzymes by thiophosphate insecticides and its drug toxicological implications.

  1975cited by this paper
• Inhibition of hepatic drug-metabolizing enzymes by thiophosphate insecticides and its drug toxicological implications.

  1975cited by this paper
• A rapid, simple radiometric assay for cholinesterase, suitable for multiple determinations.

  1975cited by this paper
• Morphine‐like ligand for opiate receptors in human CSF

  1975cited by this paper
• A simplified bioassay for organophosphate detoxification and interactions.

  1974cited by this paper
• Comparative inhibition of aliesterases and cholinesterase in rats fed eighteen organophosphorus insecticides.

  1971cited by this paper
• Carboxylesterase inhibition as an indicator of malathion potentiation in mice.

  1971cited by this paper
• Malathion potentiation and inhibition of hydrolysis of various carboxylic esters by triorthotolyl phosphate (TOTP) in mice.

  1971cited by this paper
• Interaction between paraoxon and tri-o-tolyl phosphate in rats.

  1969cited by this paper
• Combined effects of pesticides.

  1969influential reference
• Effects of ethyl p-nitrophenyl thionobenzene phosphonate (EPN) on the toxicity of isopropyl methyl phosphonofluoridate (GB).

  1963cited by this paper
• Potentiation and neurotoxicity induced by certain organophosphates.

  1963cited by this paper
• Insecticide Toxicity, Effects of Parathion and Malathion Separately and Jointly upon Rat Esterases in Vivo

  1960cited by this paper
• Potentiation of Toxicity of Malathion by Triorthotolyl Phosphate.∗

  1959cited by this paper
• Marked potentiation in mammalian toxicity from simultaneous administration of two anticholinesterase compounds.

  1957cited by this paper
• Quantitative Measurement of Inhibition of the Enzymatic Detoxification of Malathion by EPN (ethyl p-nitrophenyl thionobenzenephosphonate).∗

  1957cited by this paper

• Neurobehavioral effects of low dose exposure to chemical mixtures: a review

  2025cites this paper
• Pesticide residues risk assessment and quality evaluation of four characteristic fruits in Zhejiang Province, China

  2023cites this paper
• Rapid and reliable detection and quantification of organophosphorus pesticides using SERS combined with dispersive liquid-liquid microextraction.

  2022cites this paper
• The association between organophosphate insecticides and blood pressure dysregulation: NHANES 2013–2014

  2022cites this paper
• Human health risk assessment of pesticide residues in vegetable and fruit samples in Gujarat State, India

  2022cites this paper
• Effect of intoxication by gavage with pyrethroid and neonicotinoid insecticides on the liver in adult male rats of the Wistar strain

  2022cites this paper
• Chlorphoxim induces neurotoxicity in zebrafish embryo through activation of oxidative stress

  2022cites this paper
• The integrated exposure assessment and potential risks of five organophosphorus pesticides in vegetables in Zhejiang, China (2018–2020)

  2022cites this paper
• A Bayesian Monotonic Non-parametric Dose-Response Model

  2021cites this paper
• TOXICODYNAMICS OF CHLORPYRIFOS AND «IVIN» COMBINED ACTION UNDER PROLONGED ADMISSION

  2020cites this paper
• Toxicodynamics of Chlorpyrifos and “Ivin” Combined Action under Prolonged Admission

  2020cites this paper
• Variable selection in multivariate multiple regression

  2020cites this paper
• Identification of component-based approach for prediction of joint chemical mixture toxicity risk assessment with respect to human health: A critical review.

  2020cites this paper
• Predicting the Toxicities of Ternary Mixtures of two Metals and Sodium Dodecyl Sulfate to Serratia marcescens (SerEW01) from Otamiri River Water

  2020cites this paper
• A new method for determining the benchmark dose tolerable region and endpoint probabilities for toxicology experiments

  2019cites this paper
• Pesticide interactions and risks of sperm chromosomal abnormalities.

  2019cites this paper
• Monotonic Nonparametric Dose Response Model

  2019cites this paper
• Mixture Experimental Design

  2018cites this paper
• A systems-level approach for investigating organophosphorus pesticide toxicity.

  2018cites this paper
• Metabonomic analysis of the protective effect of quercetin on the toxicity induced by mixture of organophosphate pesticides in rat urine

  2017cites this paper
• PoisNor: An R package for generation of multivariate data with Poisson and normal marginals

  2017cites this paper
• Endosulfan and Cypermethrin Pesticide Mixture Induces Synergistic or Antagonistic Effects on Developmental Exposed Rats Depending on the Analyzed Behavioral or Neurochemical End Points.

  2017cites this paper
• Metabonomic analysis of quercetin against the toxicity of chronic exposure to a mixture of four organophosphate pesticides in rat plasma

  2016cites this paper
• Neurobehavioral deficits and brain oxidative stress induced by chronic low dose exposure of persistent organic pollutants mixture in adult female rat

  2016cites this paper
• Monitoring and dietary exposure assessment of pesticide residues in cowpea (Vigna unguiculata L. Walp) in Hainan, China

  2016cites this paper
• Environmental Exposures and Sex Chromosome Abnormalities in Human Sperm

  2016cites this paper
• Variable Selection in Multivariate Multiple Regression by c ⃝

  2015cites this paper
• Chronic Exposure of Female rats to a Low Dose POPs Mixture Induced Oxidative stress in Brain cytosol and mitochondria

  2015cites this paper
• Predictability of the time-dependent toxicities of aminoglycoside antibiotic mixtures to Vibrio qinghaiensis sp.-Q67

  2015cites this paper
• Metabonomic analysis of the joint toxic action of long-term low-level exposure to a mixture of four organophosphate pesticides in rat plasma.

  2014cites this paper
• Identifying the component responsible for antagonism within ionic liquid mixtures using the up-to-down procedure integrated with a uniform design ray method.

  2014cites this paper
• Effects of Environmentally Relevant Mixtures of Persistent Organic Pollutants on the Developmental Neurobiology in Rats

  2013cites this paper
• Application of ultraperformance liquid chromatography/mass spectrometry-based metabonomic techniques to analyze the joint toxic action of long-term low-level exposure to a mixture of organophosphate pesticides on rat urine profile.

  2013cites this paper
• Impact of chemical proportions on the acute neurotoxicity of a mixture of seven carbamates in preweanling and adult rats.

  2012cites this paper
• Effects of long‐term exposure to low levels of organophosphorous pesticides and their mixture on altered antioxidative defense mechanisms and lipid peroxidation in rat liver

  2012cites this paper
• Health and Environmental Risks SCHER Scientific Committee on Emerging and Newly Identified Health Risks SCENIHR Scientific Committee on Consumer Safety SCCS Toxicity and Assessment of Chemical Mixtures

  2012cites this paper
• Metabonomics analysis of urine and plasma from rats given long-term and low-dose dimethoate by ultra-performance liquid chromatography-mass spectrometry.

  2012cites this paper
• Behavioral Changes in Adult and Young Rats as Indications of Cholinesterase Inhibition

  2012cites this paper
• Metabolomic analysis of the toxic effect of chronic low-dose exposure to acephate on rats using ultra-performance liquid chromatography/mass spectrometry.

  2012cites this paper
• Age-Related Differences in Acetylcholinesterase Inhibition Produced by Organophosphorus and N-Methyl Carbamate Pesticides

  2011cites this paper
• Predicting mixture toxicity of seven phenolic compounds with similar and dissimilar action mechanisms to Vibrio qinghaiensis sp.nov.Q67.

  2011cites this paper
• Evaluation on the toxicity of ionic liquid mixture with antagonism and synergism to Vibrio qinghaiensis sp.-Q67.

  2011cites this paper
• Additivity of Pyrethroid Actions on Sodium Influx in Cerebrocortical Neurons in Primary Culture

  2011cites this paper
• Environmental Risks ( SCHER ) Scientific Committee on Emerging and Newly Identified Health Risks ( SCENIHR ) Toxicity and Assessment of Chemical Mixtures

  2011cites this paper
• Anticholinesterase Pesticides Interactions

  2011cites this paper
• Szacowanie ryzyka dla łącznego narażenia na pozostałość pestycydów w żywności

  2011cites this paper
• Age-related differences in acute neurotoxicity produced by mevinphos, monocrotophos, dicrotophos, and phosphamidon.

  2011cites this paper
• Critical analysis of literature on low-dose synergy for use in screening chemical mixtures for risk assessment

  2011cites this paper
• The toxicity of mixtures of specific organophosphate compounds is modulated by paraoxonase 1 status.

  2010cites this paper
• Evaluation of the combined toxicity of 15 pesticides by uniform design.

  2010cites this paper
• Modeling and prediction for the acute toxicity of pesticide mixtures to the freshwater luminescent bacterium Vibrio qinghaiensis sp.-Q67.

  2010cites this paper
• Chapter 70 – Chlorpyrifos

  2010cites this paper
• Regulatory science and uncertainty in the risk assessment of pesticide residues

  2010cites this paper
• An Empirical Approach to Evaluating Sufficient Similarity: Utilization of Euclidean Distance As A Similarity Measure

  2010cites this paper
• Food Safety

  2010cites this paper
• Combined photobacterium toxicity of herbicide mixtures containing one insecticide.

  2009cites this paper
• Paraoxonase 1 (PON1) modulates the toxicity of mixed organophosphorus compounds.

  2009cites this paper
• [Risk assessment for human health associated to combined exposures and metabolic factors of individual susceptibility].

  2009cites this paper
• Development of a physiologically based pharmacokinetic and pharmacodynamic model to determine dosimetry and cholinesterase inhibition for a binary mixture of chlorpyrifos and diazinon in the rat.

  2008cites this paper
• Empirical evaluation of sufficient similarity in dose—Response for environmental risk assessment of chemical mixtures

  2008cites this paper
• Toxicological profile for diazinon

  2008cites this paper
• Prediction for the mixture toxicity of six organophosphorus pesticides to the luminescent bacterium Q67.

  2008cites this paper
• Acute and repeated effects of three organophosphorus pesticides on the acquisition and retention of an instrumental learning task in rats

  2008cites this paper
• Optimization in a multivariate generalized linear model situation

  2008cites this paper
• Toxicological profile for diazinon

  2008cites this paper
• The simultaneous analysis of mixed discrete and continuous outcomes using nonlinear threshold models

  2007cites this paper
• D-optimal designs for mixed discrete and continuous outcomes analyzed using nonlinear models

  2007influential citation
• The effects of diazinon and cypermethrin on the differentiation of neuronal and glial cell lines.

  2007cites this paper
• The simultaneous analysis of discrete and continuous outcomes in a dose-response study: using desirability functions.

  2007cites this paper
• Cumulative Effects of Organophosphorus or Carbamate Pesticides

  2006cites this paper
• Neurotoxicological interactions of a five-pesticide mixture in preweanling rats.

  2006cites this paper
• Testing for Additivity at Select Mixture Groups of Interest Based on Statistical Equivalence Testing Methods

  2006cites this paper
• 9. References

  year unknowncites this paper