Molecular analysis of the membrane insertion domain of proteinase 3, the Wegenerˈs autoantigen, in RBL cells: implication for its pathogenic activity

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Journal of Leukocyte Biology

• Publication date

  2011-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1189/jlb.1210695PMID 21821719
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Structures of human proteinase 3 and neutrophil elastase – so similar yet so different

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• The use of small molecule high‐throughput screening to identify inhibitors of the proteinase 3‐NB1 interaction

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• Membrane-bound proteinase 3 and its receptors: relevance for the pathogenesis of Wegener's Granulomatosis.

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  2008influential reference
• Proteinase 3 and CD177 are expressed on the plasma membrane of the same subset of neutrophils

  2007cited by this paper
• Computational prediction of the binding site of proteinase 3 to the plasma membrane

  2007cited by this paper
• NB1 mediates surface expression of the ANCA antigen proteinase 3 on human neutrophils.

  2007cited by this paper
• Differences in the substrate binding sites of murine and human proteinase 3 and neutrophil elastase

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• Proteinase 3, the Wegener autoantigen, is externalized during neutrophil apoptosis: evidence for a functional association with phospholipid scramblase 1 and interference with macrophage phagocytosis.

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  2004cited by this paper
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  2000influential reference
• Myeloblastin is a granulocyte colony-stimulating factor-responsive gene conferring factor-independent growth to hematopoietic cells.

  2000cited by this paper
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• Interaction of purified human proteinase 3 (PR3) with reconstituted lipid bilayers.

  1999cited by this paper
• Presence of proteinase 3 in secretory vesicles: evidence of a novel, highly mobilizable intracellular pool distinct from azurophil granules.

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• Proteinase 3, a potent secretagogue in airways, is present in cystic fibrosis sputum.

  1999cited by this paper
• Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis

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• Immunocytochemical and flow cytometric detection of proteinase 3 (myeloblastin) in normal and leukaemic myeloid cells

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• Activated neutrophils express proteinase 3 on their plasma membrane in vitro and in vivo

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  1990influential reference
• Down-regulation of a serine protease, myeloblastin, causes growth arrest and differentiation of promyelocytic leukemia cells.

  1989cited by this paper

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• Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis

  2018cites this paper
• Consequences of cathepsin C inactivation on membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis

  2018cites this paper
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  2018cites this paper
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• Granulomatosis with polyangiitis (Wegener granulomatosis): A proteinase-3 driven disease?

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• Characterization of the CD177 interaction with the ANCA antigen proteinase 3

  2017cites this paper
• Transgenic Mice Expressing Human Proteinase 3 Exhibit Sustained Neutrophil-Associated Peritonitis

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• Neutral serine proteases of neutrophils

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• Inhibitors and Antibody Fragments as Potential Anti-Inflammatory Therapeutics Targeting Neutrophil Proteinase 3 in Human Disease

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• Human neutrophils in auto-immunity.

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  2015cites this paper
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• New Selective Peptidyl Di(chlorophenyl) Phosphonate Esters for Visualizing and Blocking Neutrophil Proteinase 3 in Human Diseases*

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  2013cites this paper
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• L34. Neutrophils in ANCA-associated vasculitis: still under investigation.

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