Role of stellate cells in the morphogenesis of chronic pancreatitis

This review presents an analysis of the literature on the role of pancreatic stellate cells (PSCs) in the pathogenesis of fibrosis, a predominant histological feature of chronic alcoholic pancreatitis. It is shown that ethanol and toxic products of its metabolism can affect PSCs directly and indirectly, facilitating their transformation from a quiescent to an activated state. During the pathological process, PSCs interact with parenchymal and immune cells of the pancreas through cytokines and growth factors. In activated PSCs, the proliferative and migratory activity, as well as the synthesis of extracellular matrix (ECM) proteins increases. A continuous activation of PSCs during the disease promotes the maintenance of inflammation, the deposition of excessive amounts of ECM proteins and the development of pancreatic fibrosis.

• Publication year

  2019

• Venue

  Proceedings of the National Academy of Sciences of Belarus Medical series

• Publication date

  2019-01-14

• Fields of study

  Medicine

• Identifiers
  DOI 10.29235/1814-6023-2018-15-4-455-464
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• ПАНКРЕАТИЧЕСКИЕ ЗВЕЗДЧАТЫЕ КЛЕТКИ: СТРУКТУРА И ФУНКЦИЯ. ЧАСТЬ 1. МОРФОФУНКЦИОНАЛЬНАЯ ХАРАКТЕРИСТИКА ПАНКРЕАТИЧЕСКИХ ЗВЕЗДЧАТЫХ КЛЕТОК В ФИЗИОЛОГИЧЕСКИХ УСЛОВИЯХ

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• Mathematical model of chronic pancreatitis

  2017cited by this paper
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  2017cited by this paper
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  2016cited by this paper
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  2016cited by this paper
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  2015influential reference
• Pancreatic stellate cell: physiologic role, role in fibrosis and cancer.

  2015cited by this paper
• Animal models of gastrointestinal and liver diseases. Animal models of necrotizing enterocolitis: pathophysiology, translational relevance, and challenges.

  2014cited by this paper
• Simultaneous characterization of pancreatic stellate cells and other pancreatic components within three-dimensional tissue environment during chronic pancreatitis

  2013cited by this paper
• Proteome Variations in Pancreatic Stellate Cells upon Stimulation with Proinflammatory Factors*

  2013influential reference
• Pathophysiology of chronic pancreatitis.

  2013cited by this paper
• Senescence determines the fate of activated rat pancreatic stellate cells

  2012cited by this paper
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  2012cited by this paper
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  2010cited by this paper
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  2009cited by this paper
• Mechanisms of pancreatic fibrosis and applications to the treatment of chronic pancreatitis

  2008cited by this paper
• The pancreatic stellate cell: a star on the rise in pancreatic diseases.

  2007influential reference
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  2007cited by this paper
• Pancreatic stellate cells: New target in the treatment of chronic pancreatitis

  2007cited by this paper
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  2007cited by this paper
• Activated perilobular, not periacinar, pancreatic stellate cells contribute to fibrogenesis in chronic alcoholic pancreatitis

  2007cited by this paper
• Pancreatic stellate cells and chronic alcoholic pancreatitis.

  2007cited by this paper
• Pancreas : pathological practice and research

  2007cited by this paper
• Pancreas - Pathological Practice and Research

  2007cited by this paper
• Battle‐scarred pancreas: Role of alcohol and pancreatic stellate cells in pancreatic fibrosis

  2006cited by this paper
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  2005cited by this paper
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  2004cited by this paper
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  2003cited by this paper
• Pancreatic stellate cells respond to inflammatory cytokines: potential role in chronic pancreatitis

  2002influential reference
• Ligands of Peroxisome Proliferator-activated Receptor-γ Block Activation of Pancreatic Stellate Cells*

  2002cited by this paper
• Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions.

  2001cited by this paper
• Study on Free Radicals and Pancreatic Fibrosis—Pancreatic Fibrosis Induced by Repeated Injections of Superoxide Dismutase Inhibitor

  2001cited by this paper
• Does alcohol directly stimulate pancreatic fibrogenesis? Studies with rat pancreatic stellate cells.

  2000cited by this paper
• Study on Free Radicals and Pancreatic Fibrosis : Pancreatic Fibrosis induced by Repeated Injections of Superoxide Dismutase inhibitor

  2000cited by this paper
• Angiogenesis, angiogenic growth factors, and cell adhesion molecules are upregulated in chronic pancreatic diseases: angiogenesis in chronic pancreatitis and in pancreatic cancer.

  1999cited by this paper
• Activation of pancreatic stellate cells in human and experimental pancreatic fibrosis.

  1999cited by this paper
• Identification, culture, and characterization of pancreatic stellate cells in rats and humans.

  1998cited by this paper
• Epidemiology of Chronic Pancreatitis

  1993cited by this paper

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