Lower induction of p53 and decreased apoptosis in NQO1-null mice lead to increased sensitivity to chemical-induced skin carcinogenesis.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Cancer Research

• Publication date

  2005-03-15

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1158/0008-5472.CAN-04-3157PMID 15781611
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Tumorigenicity Studies with Diol-Epoxides of Benzo(a)pyrene Which Indicate That (±)-trans-70,8a-Dihydroxy-9a,10a-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene Is an Ultimate Carcinogen in Newborn Mice

  2006cited by this paper
• Regulation of Bax Activation and Apoptotic Response to Microtubule-damaging Agents by p53 Transcription-dependent and -independent Pathways*

  2004cited by this paper
• Mapping the role of NAD metabolism inprevention and treatment of carcinogenesis

  2004cited by this paper
• p53 hot-spot mutants are resistant to ubiquitin-independent degradation by increased binding to NAD(P)H:quinone oxidoreductase 1

  2003cited by this paper
• Interaction of Human NAD(P)H:Quinone Oxidoreductase 1 (NQO1) with the Tumor Suppressor Protein p53 in Cells and Cell-free Systems*

  2003cited by this paper
• Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1

  2002cited by this paper
• Disruption of the NAD(P)H:quinone oxidoreductase 1 (NQO1) gene in mice causes myelogenous hyperplasia.

  2002cited by this paper
• NQO1 stabilizes p53 through a distinct pathway

  2002cited by this paper
• [Tumor suppressor gene p53: mechanisms of action in cell proliferation and death].

  2001cited by this paper
• Regulation of p53 stability and p53-dependent apoptosis by NADH quinone oxidoreductase 1.

  2001cited by this paper
• NAD(P)H:quinone oxidoreductase 1 deficiency and increased susceptibility to 7,12-dimethylbenz[a]-anthracene-induced carcinogenesis in mouse skin.

  2001cited by this paper
• In Vivo Role of NAD(P)H:Quinone Oxidoreductase 1 (NQO1) in the Regulation of Intracellular Redox State and Accumulation of Abdominal Adipose Tissue*

  2001cited by this paper
• NAD(P)H:quinone oxidoreductase 1 deficiency increases susceptibility to benzo(a)pyrene-induced mouse skin carcinogenesis.

  2000cited by this paper
• Regulation of γ-glutamylcysteine synthetase subunit gene expression: Insights into transcriptional control of antioxidant defenses

  2000cited by this paper
• Mapping the role of NAD metabolism in prevention and treatment of carcinogenesis.

  1999cited by this paper
• Prevalence of the inactivating 609C-->T polymorphism in the NAD(P)H:quinone oxidoreductase (NQO1) gene in patients with primary and therapy-related myeloid leukemia.

  1999cited by this paper
• Disruption of the DT Diaphorase (NQO1) Gene in Mice Leads to Increased Menadione Toxicity*

  1998cited by this paper
• Potency equivalency factors for some polycyclic aromatic hydrocarbons and polycyclic aromatic hydrocarbon derivatives.

  1998cited by this paper
• Benzene poisoning, a risk factor for hematological malignancy, is associated with the NQO1 609C-->T mutation and rapid fractional excretion of chlorzoxazone.

  1997cited by this paper
• Oxidative stress and signal transduction.

  1997cited by this paper
• High-performance liquid chromatography analysis of oxidized and reduced pyridine dinucleotides in specific brain regions.

  1995cited by this paper
• Glutathione S-transferases, structure, regulation, and therapeutic implications.

  1993cited by this paper
• Metabolic activation of carcinogens.

  1992cited by this paper
• Comparison of ras activation during epidermal carcinogenesis in vitro and in vivo.

  1991cited by this paper
• Roles of cytochrome P-450 enzymes in chemical carcinogenesis and cancer chemotherapy.

  1988cited by this paper
• Metabolic activation of carcinogens.

  1987cited by this paper
• Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes.

  1980cited by this paper
• Tumorigenicity studies with diol-epoxides of benzo(a)pyrene which indicate that (+/-)-trans-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene is an ultimate carcinogen in newborn mice.

  1978cited by this paper

• Unit Maxwell-Boltzmann Distribution and Its Application to Concentrations Pollutant Data

  2024cites this paper
• Review on NAD(P)H dehydrogenase quinone 1 (NQO1) pathway

  2022cites this paper
• Effect of naturally-occurring mutations on the stability and function of cancer-associated NQO1: Comparison of experiments and computation

  2022cites this paper
• The mechanism of Yinchenhao decoction in treating obstructive-jaundice-induced liver injury based on Nrf2 signaling pathway

  2022cites this paper
• Royal Jelly Protects against Epidermal Stress through Upregulation of the NQO1 Expression

  2021cites this paper
• Roles of NAD(P)H:quinone Oxidoreductase 1 in Diverse Diseases

  2021cites this paper
• Long noncoding RNA TUG1 regulates prostate cancer cell proliferation, invasion and migration via the Nrf2 signaling axis.

  2020cites this paper
• Nqo1 ablation inhibits activation of the PI3K/Akt and MAPK/ERK pathways and blocks metabolic adaptation in hepatocellular carcinoma

  2020cites this paper
• NAD(P)H Quinone Dehydrogenase 1 Ablation Inhibits Activation of the Phosphoinositide 3‐Kinase/Akt Serine/Threonine Kinase and Mitogen‐Activated Protein Kinase/Extracellular Signal‐Regulated Kinase Pathways and Blocks Metabolic Adaptation in Hepatocellular Carcinoma

  2019cites this paper
• Benefits of Caloric Restriction in Longevity and Chemical-Induced Tumorigenesis Are Transmitted Independent of NQO1

  2019cites this paper
• Dendrobium Officinale Polysaccharides Protect against MNNG-Induced PLGC in Rats via Activating the NRF2 and Antioxidant Enzymes HO-1 and NQO-1

  2019cites this paper
• Overexpression of CYB5R3 and NQO1, two NAD +‐producing enzymes, mimics aspects of caloric restriction

  2018cites this paper
• 10.11 – Quinone Reductases☆

  2018cites this paper
• Reduction of 2-methoxy-1,4-naphtoquinone by mitochondrially-localized Nqo1 yielding NAD+ supports substrate-level phosphorylation during respiratory inhibition.

  2018cites this paper
• Cutting Edge: Nqo1 Regulates Irritant Contact Hypersensitivity against Croton Oil through Maintenance of Dendritic Epidermal T Cells

  2018cites this paper
• Altered gene expression profiles in the lungs of benzo[a]pyrene-exposed mice in the presence of lipopolysaccharide-induced pulmonary inflammation

  2017cites this paper
• Chemical carcinogens and chronic inflammation

  2017cites this paper
• Phytochemicals for the Prevention of Photocarcinogenesis

  2017cites this paper
• Expression of NAD(P)H quinone dehydrogenase 1 (NQO1) is increased in the endometrium of women with endometrial cancer and women with polycystic ovary syndrome

  2017cites this paper
• New insights into regulation of p 53 protein degradation

  2017cites this paper
• Functions of NQO1 in Cellular Protection and CoQ10 Metabolism and its Potential Role as a Redox Sensitive Molecular Switch

  2017cites this paper
• Tocotrienol-rich Palm Oil Extract Induces NAD(P)H:quinone Oxidoreductase 1 (NQO1) Expression in Mice Liver

  2016cites this paper
• Association of DNA repair relevant gene polymorphisms with the risk of gastric cancer in a Han Chinese population

  2016cites this paper
• DNA damage signalling barrier, oxidative stress and treatment‐relevant DNA repair factor alterations during progression of human prostate cancer

  2016cites this paper
• NQO1 Pro187Ser Polymorphism Confers to the Susceptibility of Prostate Cancer

  2015cites this paper
• NQO1-induced activation of AMPK contributes to cancer cell death by oxygen-glucose deprivation

  2015cites this paper
• High expression of NQO1 is associated with poor prognosis in serous ovarian carcinoma

  2015cites this paper
• Retraction: NRH:Quinone Oxidoreductase 2 and NAD(P)H:Quinone Oxidoreductase 1 Protect Tumor Suppressor p53 against 20S Proteasomal Degradation Leading to Stabilization and Activation of p53.

  2015cites this paper
• Targeting Nrf2-Keap1 signaling for chemoprevention of skin carcinogenesis with bioactive phytochemicals.

  2014influential citation
• The NAD(P)H: quinine oxidoreductase 1 (NQO1) gene 609 C>T polymorphism is associated with gastric cancer risk: evidence from a case-control study and a meta-analysis.

  2014cites this paper
• The NAD ( P ) H : Quinine Oxidoreductase 1 ( NQO 1 ) Gene 609 C > T Polymorphism is Associated with Gastric Cancer Risk : Evidence from a Case-control Study and a Meta-analysis

  2014cites this paper
• Efectos de la quercetina sobre las alteraciones en el comportamiento y estrés oxidativo inducidos por rayos X en ratas

  2013cites this paper
• Best Practice & Research Clinical Endocrinology & Metabolism

  2013cites this paper
• NAD(P)H: Quinone Oxidoreductase 1 and NRH:Quinone Oxidoreductase 2 Polymorphisms in Papillary Thyroid Microcarcinoma: Correlation with Phenotype

  2013cites this paper
• Elevated ornithine decarboxylase activity promotes skin tumorigenesis by stimulating the recruitment of bulge stem cells but not via toxic polyamine catabolic metabolites

  2013cites this paper
• Role of calcium sensing receptor (CaSR) in tumorigenesis.

  2013cites this paper
• The NQO1 rs1800566 polymorphism and risk of bladder cancer: evidence from 6,169 subjects.

  2012cites this paper
• Topical Application of Ochratoxin A Causes DNA Damage and Tumor Initiation in Mouse Skin

  2012cites this paper
• Stress-induced NQO1 controls stability of C/EBPα against 20S proteasomal degradation to regulate p63 expression with implications in protection against chemical-induced skin cancer

  2012cites this paper
• Meta-Analysis of the NAD(P)H: Quinine Oxidoreductase 1 Gene 609 C>T Polymorphism with Esophageal Cancer Risk

  2012cites this paper
• Null association of NQO1 609C>T and NQO2 -3423G>A polymorphisms with susceptibility and prognosis of Esophageal cancer in north Indian population and meta-analysis.

  2012cites this paper
• Induction of quinone reductase by tamoxifen or DPN protects against mammary tumorigenesis

  2012cites this paper
• Meta-analysis demonstrates that the NAD(P)H: quinone oxidoreductase 1 (NQO1) gene 609 C>T polymorphism is associated with increased gastric cancer risk in Asians.

  2012cites this paper
• Stress-induced NQO1 controls stability of C/EBPα against 20S proteasomal degradation to regulate p63 expression with implications in protection against chemical-induced skin cancer

  2012cites this paper
• CO/HO-1 Induces NQO-1 Expression via Nrf2 Activation

  2011cites this paper
• Genetic evidence for NAD(P)H:quinone oxidoreductase 1-catalyzed quinone reduction on passage through the mouse pulmonary circulation.

  2011cites this paper
• Inhibitors of NQO1: identification of compounds more potent than dicoumarol without associated off-target effects.

  2011cites this paper
• Carnosic acid induces the NAD(P)H: quinone oxidoreductase 1 expression in rat clone 9 cells through the p38/nuclear factor erythroid-2 related factor 2 pathway.

  2011cites this paper
• NAD(P)H: Quinone Oxidoreductase 1 is Induced by Progesterone in Cardiomyocytes

  2011cites this paper
• Gene Expression Signature Analysis Identifies Vorinostat as a Candidate Therapy for Gastric Cancer

  2011cites this paper
• A common carcinogen benzo[a]pyrene causes p53 overexpression in mouse cervix via DNA damage.

  2011cites this paper
• Cytochrome P450-mediated pulmonary metabolism of carcinogens: regulation and cross-talk in lung carcinogenesis.

  2011cites this paper
• Anti-inflammatory activity of xanthohumol involves heme oxygenase-1 induction via NRF2-ARE signaling in microglial BV2 cells.

  2011cites this paper
• Global Gene Expression Profiling of Endothelium Exposed to Heme Reveals an Organ-Specific Induction of Cytoprotective Enzymes in Sickle Cell Disease

  2011cites this paper
• In Silico Screening Reveals Structurally Diverse, Nanomolar Inhibitors of NQO2 That Are Functionally Active in Cells and Can Modulate NF-κB Signaling

  2011cites this paper
• Inactivation of the quinone oxidoreductases NQO1 and NQO2 strongly elevates the incidence and multiplicity of chemically induced skin tumors.

  2010cites this paper
• Nrf2-Keap1 Signaling as a Potential Target for Chemoprevention of Inflammation-Associated Carcinogenesis

  2010cites this paper
• Mitochondrial decay is involved in BaP-induced cervical damage.

  2010cites this paper
• Irradiation-induced p53 expression is attenuated in cells with NQO1 C465T polymorphism.

  2010cites this paper
• Ubiquitin-independent p53 proteasomal degradation

  2010cites this paper
• Resveratrol: Biological and pharmaceutical properties as anticancer molecule

  2010cites this paper
• 4.11 – Quinone Reductases

  2010cites this paper
• ROLE OF TUMOR SUPPRESSOR ING4 IN HUMAN CUTANEOUS MELANOMA PATHOGENESIS AND PROGRESSION

  2010cites this paper
• NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector.

  2010cites this paper
• Evidence on the association between NQO1 Pro187Ser polymorphism and breast cancer risk in the current studies: a meta-analysis

  2010cites this paper
• Genetic polymorphism in metabolism and host defense enzymes: Implications for human health risk assessment

  2010cites this paper
• Pharmacological inhibitors of NAD(P)H quinone oxidoreductase, NQO1: structure/activity relationships and functional activity in tumour cells.

  2010cites this paper
• Preferential utilization of NADPH as the endogenous electron donor for NAD(P)H:quinone oxidoreductase 1 (NQO1) in intact pulmonary arterial endothelial cells.

  2009cites this paper
• NRH:Quinone Oxidoreductase 2-Deficient Mice Are Highly Susceptible to Radiation-Induced B-Cell Lymphomas

  2009cites this paper
• The redox-sensing quinone reductase Lot6p acts as an inducer of yeast apoptosis.

  2009cites this paper
• Functionalized 3-benzylidene-indolin-2-ones: inducers of NAD(P)H-quinone oxidoreductase 1 (NQO1) with antiproliferative activity.

  2009cites this paper
• Calcium and calcium sensing receptor modulates the expression of thymidylate synthase, NAD(P)H:quinone oxidoreductase 1 and survivin in human colon carcinoma cells: Promotion of cytotoxic response to mitomycin C and fluorouracil

  2009cites this paper
• The aryl hydrocarbon receptor nuclear translocator (Arnt) is required for tumor initiation by benzo[a]pyrene.

  2009cites this paper
• NAD(P)H:quinone oxidoreductase (NQO1) loss of function in Burkitt's lymphoma cell lines

  2008cites this paper
• NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer

  2008cites this paper
• A dicyanotriterpenoid induces cytoprotective enzymes and reduces multiplicity of skin tumors in UV-irradiated mice.

  2008cites this paper
• Disruption of NAD(P)H:quinone oxidoreductase 1 gene in mice leads to radiation-induced myeloproliferative disease.

  2008cites this paper
• NRH:quinone oxidoreductase 2 and NAD(P)H:quinone oxidoreductase 1 protect tumor suppressor p53 against 20s proteasomal degradation leading to stabilization and activation of p53.

  2007cites this paper
• Study of two tyrosine kinase inhibitors on growth and signal transduction in polycythemia vera.

  2007cites this paper
• Regulation of Urokinase Receptor Expression by p53: Novel Role in Stabilization of uPAR mRNA

  2007cites this paper
• P53 AND REACTIVE OXYGEN SPECIES: A CONVOLUTED STORY

  2007cites this paper
• Genetic deletion of NAD(P)H:quinone oxidoreductase 1 abrogates activation of nuclear factor-kappaB, IkappaBalpha kinase, c-Jun N-terminal kinase, Akt, p38, and p44/42 mitogen-activated protein kinases and potentiates apoptosis.

  2006cites this paper
• Elevation of Cellular BPDE Uptake by Human Cells: A Possible Factor Contributing to Co-Carcinogenicity by Arsenite

  2006cites this paper
• Oxidative stress in the pathogenesis of skin disease.

  2006cites this paper
• Protection against UV-light-induced skin carcinogenesis in SKH-1 high-risk mice by sulforaphane-containing broccoli sprout extracts.

  2006cites this paper
• NQO1 and NQO2 Regulation of Humoral Immunity and Autoimmunity*

  2006cites this paper
• Genetic Deletion of NAD(P)H:Quinone Oxidoreductase 1 Abrogates Activation of Nuclear Factor-κB, IκBα Kinase, c-Jun N-terminal Kinase, Akt, p38, and p44/42 Mitogen-activated Protein Kinases and Potentiates Apoptosis*

  2006cites this paper
• Ubiquitin-independent degradation: lessons from the p53 model.

  2006cites this paper
• p53 Proteasomal Degradation: Poly-Ubiquitination is Not the Whole Story

  2005cites this paper
• Extra View p 53 Proteasomal Degradation Poly-Ubiquitination is Not the Whole Story

  2005cites this paper