Restricted distribution of mRNA produced from a single nucleus in hybrid myotubes

Although the proteins encoded by a single nucleus in multinucleated myotubes have a wide range of distributions within the myofiber, little is known about the distributions of their mRNAs. We have used hybrid myotubes in which one or a few nuclei are derived from myoblasts that express nonmuscle proteins to investigate this question. We find that three different mRNAs, encoding proteins that are, respectively, nuclear, cytoplasmic, and targeted to the ER, have similar distributions within myotubes. Each is confined to an area within approximately 100 microns of the nucleus that expresses it.

• Publication year

  1992

• Venue

  Journal of Cell Biology

• Publication date

  1992-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1083/JCB.119.5.1063PMID 1447288PMCID 2289719
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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