Enhanced Steatosis and Fibrosis in Liver of Adult Offspring Exposed to Maternal High-Fat Diet.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Gene Expression

• Publication date

  2016-08-31

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.3727/105221616X692135PMID 27342733PMCID PMC5611859
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Osteopontin is a proximal effector of leptin-mediated non-alcoholic steatohepatitis (NASH) fibrosis.

  2016cited by this paper
• Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease.

  2015cited by this paper
• Mouse Models of Diet-Induced Nonalcoholic Steatohepatitis Reproduce the Heterogeneity of the Human Disease

  2015cited by this paper
• Nonalcoholic Steatohepatitis: A Search for Factual Animal Models

  2015cited by this paper
• Accumulation of duct cells with activated YAP parallels fibrosis progression in non-alcoholic fatty liver disease.

  2015cited by this paper
• Oxidative stress and altered lipid homeostasis in the programming of offspring fatty liver by maternal obesity

  2014cited by this paper
• Maternal Nutrition Induces Pervasive Gene Expression Changes but No Detectable DNA Methylation Differences in the Liver of Adult Offspring

  2014cited by this paper
• Links between hepatic fibrosis, ductular reaction, and progenitor cell expansion.

  2014cited by this paper
• Developmental origins of nonalcoholic fatty liver disease

  2014cited by this paper
• Early Life Exposure to Maternal Insulin Resistance Has Persistent Effects on Hepatic NAFLD in Juvenile Nonhuman Primates

  2014cited by this paper
• Early developmental conditioning of later health and disease: physiology or pathophysiology?

  2014cited by this paper
• Maternal obesity programs offspring nonalcoholic fatty liver disease by innate immune dysfunction in mice

  2013cited by this paper
• Maternal high-fat intake during pregnancy programs metabolic-syndrome-related phenotypes through liver mitochondrial DNA copy number and transcriptional activity of liver PPARGC1A.

  2013cited by this paper
• Pediatric non alcoholic fatty liver disease: old and new concepts on development, progression, metabolic insight and potential treatment targets

  2013cited by this paper
• The associations between maternal pre-pregnancy body mass index or gestational weight change during pregnancy and body mass index of the child at 3 years of age

  2012cited by this paper
• Prepregnancy Obesity Trends Among Low-Income Women,

  2012cited by this paper
• Hepatic progenitor cells activation, fibrosis, and adipokines production in pediatric nonalcoholic fatty liver disease

  2012cited by this paper
• Prepregnancy Obesity Trends Among Low-Income Women, United States, 1999–2008

  2012cited by this paper
• Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study.

  2011cited by this paper
• Offspring of Mothers Fed a High Fat Diet Display Hepatic Cell Cycle Inhibition and Associated Changes in Gene Expression and DNA Methylation

  2011cited by this paper
• Prospective isolation of a bipotential clonogenic liver progenitor cell in adult mice.

  2011cited by this paper
• Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis

  2011cited by this paper
• Epidemiology of Non-Alcoholic Fatty Liver Disease

  2010cited by this paper
• Maternal obesity during pregnancy and lactation programs the development of offspring non-alcoholic fatty liver disease in mice.

  2010cited by this paper
• The role of osteopontin and tumor necrosis factor alpha receptor-1 in xenobiotic-induced cholangitis and biliary fibrosis in mice

  2010cited by this paper
• Portal chronic inflammation in nonalcoholic fatty liver disease (NAFLD): A histologic marker of advanced NAFLD—Clinicopathologic correlations from the nonalcoholic steatohepatitis clinical research network

  2009cited by this paper
• Maternal high fat diet during pregnancy and lactation alters hepatic expression of insulin like growth factor-2 and key microRNAs in the adult offspring

  2009cited by this paper
• Maternal high‐fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expression

  2009cited by this paper
• The miR-15a–miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities

  2008cited by this paper
• Oxidative stress induced lipocalin 2 gene expression: addressing its expression under the harmful conditions.

  2007cited by this paper
• Histopathology of pediatric nonalcoholic fatty liver disease

  2005cited by this paper
• Nomenclature of the finer branches of the biliary tree: Canals, ductules, and ductular reactions in human livers

  2004cited by this paper
• Predicting preschooler obesity at birth: the role of maternal obesity in early pregnancy.

  2004cited by this paper
• Is weight reduction an effective therapy for nonalcoholic fatty liver? A systematic review.

  2003cited by this paper
• Peroxisome proliferator-activated receptor gamma transcriptional regulation is involved in platelet-derived growth factor-induced proliferation of human hepatic stellate cells.

  2000cited by this paper
• Ligands of peroxisome proliferator-activated receptor gamma modulate profibrogenic and proinflammatory actions in hepatic stellate cells.

  2000cited by this paper
• Fetal nutrition and cardiovascular disease in adult life.

  1993cited by this paper
• Fetal and placental size and risk of hypertension in adult life.

  1990cited by this paper
• Fetal and placental size and risk of hypertension in adult life.

  1990cited by this paper
• Nonalcoholic fatty liver disease.

  1986cited by this paper
• Fetal nutrition and cardiovascular disease in adult life Babies who

  year unknowncited by this paper

• Mitochondrial dysfunction characterises the multigenerational effects of maternal obesity on MASLD

  2025cites this paper
• High-Fat Diet in Perinatal Period Promotes Liver Steatosis and Low Desaturation Capacity of Polyunsaturated Fatty Acids in Dams: A Link with Anxiety-Like Behavior in Rats

  2025cites this paper
• Fishing for Solutions: How Pre‐Conceptional Fish Oil Supplementation in Obese Fathers Reduces Risk of Non‐Alcoholic Fatty Liver Disease in Offspring Mice

  2025cites this paper
• Reprogramming offspring liver health: maternal indole supplementation as a preventive strategy against MASLD

  2025cites this paper
• Maternal high-salt intake induces sex-specific liver injury in offspring: integrative transcriptomic and therapeutic investigation

  2025cites this paper
• C/EBPα-mediated epigenetic control of liver disorders in young children

  2024cites this paper
• Gestational and Developmental Contributors of Pediatric MASLD

  2024cites this paper
• Genetic Ablation of C/EBPα-p300 Pathway Blocks Development of Obese Pregnancy Associated Liver Disorders in Offspring

  2023cites this paper
• Maternal Weight Management to Prevent the Developmental Programming of MAFLD in Offspring of Obese Mothers

  2023cites this paper
• Maternal obesity and offspring health: Adapting metabolic changes through autophagy and mitophagy

  2023cites this paper
• MATERNAL OBESOGENIC DIET ATTENUATES MICROBIOME DEPENDENT OFFSPRING WEANING REACTION WITH WORSENING OF STEATOTIC LIVER DISEASE.

  2023cites this paper
• Maternal Exercise Protects Male Offspring from Maternal Diet Programmed Non-Alcoholic Fatty Liver Disease Progression.

  2023cites this paper
• Maternal Obesogenic Diet Regulates Offspring Bile Acid Homeostasis and Hepatic Lipid Metabolism via the Gut Microbiome in Mice.

  2022cites this paper
• Exercise performed during pregnancy positively modulates liver metabolism and promotes mitochondrial biogenesis of female offspring in a rat model of diet-induced gestational diabetes.

  2022cites this paper
• Glutathione S-transferase Mu 2 inhibits hepatic steatosis via ASK1 suppression

  2022cites this paper
• Maternal obesogenic diet enhances cholestatic liver disease in offspring

  2022cites this paper
• Maternal Choline Supplementation and High-Fat Feeding Interact to Influence DNA Methylation in Offspring in a Time-Specific Manner

  2022cites this paper
• Environmental exposure to low-dose perfluorohexanesulfonate promotes obesity and non-alcoholic fatty liver disease in mice fed a high-fat diet

  2022cites this paper
• Gut Microbiome and Organ Fibrosis

  2022cites this paper
• The postnatal window is critical for the development of sex-specific metabolic and gut microbiota outcomes in offspring

  2021cites this paper
• Hydrogen-rich water protects liver injury in nonalcoholic steatohepatitis though HO-1 enhancement via IL-10 and Sirt 1 signaling.

  2021cites this paper
• Maternal Low-Grade Chronic Inflammation and Intrauterine Programming of Health and Disease

  2021cites this paper
• MATERNAL OBESITY REVERSES THE RESISTANCE TO LPS-INDUCED ADVERSE PREGNANCY OUTCOME AND INCREASES FEMALE OFFSPRING METABOLIC ALTERATIONS IN CANNABINOID RECEPTOR 1 KNOCKOUT MICE.

  2021cites this paper
• Maternal Obesity: A Focus on Maternal Interventions to Improve Health of Offspring

  2021cites this paper
• Maternal High-Fat Feeding Affects the Liver and Thymus Metabolic Axis in the Offspring and Some Effects Are Attenuated by Maternal Diet Normalization in a Minipig Model

  2021cites this paper
• Differential effects of maternal diets on birth outcomes and metabolic parameters in rats after ethanol consumption during pregnancy

  2020cites this paper
• Maternal Diet Alters Trained Immunity in the Pathogenesis of Pediatric NAFLD

  2020cites this paper
• Developmental Programming of NAFLD by Parental Obesity

  2020cites this paper
• Molecular mechanisms governing offspring metabolic programming in rodent models of in utero stress

  2020cites this paper
• Nonalcoholic fatty liver disease: an update on the diagnosis.

  2019cites this paper
• Transgenerational impact of maternal obesogenic diet on offspring bile acid homeostasis and nonalcoholic fatty liver disease.

  2019cites this paper
• Maternal obesity in pregnancy impacts offspring cardiometabolic health: Systematic review and meta‐analysis of animal studies

  2019cites this paper
• Rôle des polyphénols de petits fruits sur les désordres métaboliques et la dysbiose associés à l'obésité

  2019cites this paper
• Programming effects of maternal and gestational obesity on offspring metabolism and metabolic inflammation

  2019cites this paper
• Prenatal exposure to diesel exhaust PM2.5 programmed non-alcoholic fatty liver disease differently in adult male offspring of mice fed normal chow and a high-fat diet.

  2019cites this paper
• Maternal obesity during lactation may protect offspring from high fat diet-induced metabolic dysfunction

  2018cites this paper
• Maternal Physical Activity and Sex Impact Markers of Hepatic Mitochondrial Health

  2018cites this paper
• Caspase Recruitment Domain Protein 6 Protects Against Hepatic Steatosis and Insulin Resistance by Suppressing Apoptosis Signal–Regulating Kinase 1

  2018cites this paper
• Developmental origins of nonalcoholic fatty liver disease as a risk factor for exaggerated metabolic and cardiovascular-renal disease.

  2018cites this paper
• Genetic and Epigenetic Associations of NAFLD: Focus on Clinical Decision Making

  2017cites this paper
• Beneficial effects of exercise on offspring obesity and insulin resistance are reduced by maternal high-fat diet

  2017cites this paper
• Maternal Exercise Improves Glucose Tolerance in Female Offspring

  2017cites this paper