The E3 Ubiquitin Ligase c‐Cbl Inhibits Microglia‐Mediated CNS Inflammation by Regulating PI3K/Akt/NF‐κB Pathway

No abstract is available for this paper.

• Publication year

  2016

• Venue

  CNS Neuroscience & Therapeutics

• Publication date

  2016-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/cns.12557PMID 27156691PMCID PMC6492864
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Microglia-Mediated Inflammation and Neurodegenerative Disease

  2016cited by this paper
• miR-216a rescues dexamethasone suppression of osteogenesis, promotes osteoblast differentiation and enhances bone formation, by regulating c-Cbl-mediated PI3K/AKT pathway

  2015cited by this paper
• Nrf2-ARE signals mediated the anti-oxidative action of electroacupuncture in an MPTP mouse model of Parkinson's disease

  2015cited by this paper
• Systemic inflammation and microglial activation: systematic review of animal experiments

  2015cited by this paper
• The role of TLR4-mediated PTEN/PI3K/AKT/NF-κB signaling pathway in neuroinflammation in hippocampal neurons.

  2014cited by this paper
• MiR-9 promotes microglial activation by targeting MCPIP1

  2014cited by this paper
• Isobutyrylshikonin inhibits lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in BV2 microglial cells by suppressing the PI3K/Akt-mediated nuclear transcription factor-κB pathway.

  2014cited by this paper
• Protein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligases.

  2013cited by this paper
• Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation

  2013cited by this paper
• c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of the TGF-β type II receptor.

  2013cited by this paper
• Microglia and neurodegeneration: The role of systemic inflammation

  2013cited by this paper
• The Role of the E3 Ligase Cbl-B in Murine Dendritic Cells

  2013cited by this paper
• T Cell Activation Threshold Regulated by E3 Ubiquitin Ligase Cbl-b Determines Fate of Inducible Regulatory T Cells

  2013cited by this paper
• Neurodegenerative disease: Microglia in early disease stages

  2012cited by this paper
• The E3 ligase c‐Cbl regulates dendritic cell activation

  2011cited by this paper
• Macrophages: Microglial cell origins

  2010cited by this paper
• Microglia in neurodegenerative disease

  2010cited by this paper
• Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

  2010cited by this paper
• In Brief

  2010cited by this paper
• Inflammation in neurodegenerative diseases

  2010cited by this paper
• Triptolide inhibits COX‐2 expression and PGE2 release by suppressing the activity of NF‐κB and JNK in LPS‐treated microglia

  2008cited by this paper
• Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration

  2007cited by this paper
• E3 ubiquitin ligase Cblb regulates the acute inflammatory response underlying lung injury

  2007cited by this paper
• Deficiency of Cbl-b Gene Enhances Infiltration and Activation of Macrophages in Adipose Tissue and Causes Peripheral Insulin Resistance in Mice

  2007influential reference
• LY294002 inhibits interferon-gamma-stimulated inducible nitric oxide synthase expression in BV2 microglial cells.

  2004cited by this paper
• Inactivation of c-Cbl Reverses Neonatal Lethality and T Cell Developmental Arrest of SLP-76–deficient Mice

  2004cited by this paper
• Role of Microglia in Inflammation-Mediated Neurodegenerative Diseases: Mechanisms and Strategies for Therapeutic Intervention

  2003cited by this paper
• Ubiquitin ligases and the immune response.

  2003cited by this paper
• Cbl and Cbl-b in T-cell regulation.

  2002cited by this paper
• The Cbl family of ubiquitin ligases: critical negative regulators of tyrosine kinase signaling in the immune system

  2002cited by this paper
• Beyond the RING: CBL proteins as multivalent adapters

  2001cited by this paper
• The c-cbl proto-oncogene is preferentially expressed in thymus and testis tissue and encodes a nuclear protein

  1989cited by this paper
• v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas.

  1989cited by this paper

• Neuroinflammatory response after subarachnoid hemorrhage: A review of possible treatment targets.

  2025cites this paper
• Infection of 5xFAD mice with a mouse-adapted SARS-CoV-2 does not alter Alzheimer’s disease neuropathology yet induces wide-spread changes in gene expression across diverse cell types

  2025cites this paper
• In vivo and in vitro perspectives in Parkinson’s disease: Mechanisms and the role of phytomedicine

  2025cites this paper
• Integrated transcriptomic and proteomic analysis identifies FBXW7 as a key regulator of tau homeostasis in Alzheimer's disease

  2025cites this paper
• The E3 ligase c-Cbl modulates microglial phenotypes and contributes to Parkinson’s disease pathology

  2025cites this paper
• circ-0001454 alleviates asthma airway inflammation and remodeling via sponging miR-770-5p and regulating cbl-b

  2025cites this paper
• Neuroprotection of Human Umbilical Cord-Derived Mesenchymal Stem Cells (hUC-MSCs) in Alleviating Ischemic Stroke-Induced Brain Injury by Regulating Inflammation and Oxidative Stress

  2024cites this paper
• Integrated Bioinformatics Analysis for Revealing CBL is a Potential Diagnosing Biomarker and Related Immune Infiltration in Parkinson’s Disease

  2024cites this paper
• A network-based systems genetics framework identifies pathobiology and drug repurposing in Parkinson’s disease

  2024cites this paper
• The role of the ubiquitin system in the onset and reversal of neuropathic pain.

  2024cites this paper
• Unraveling the AKT/ERK cascade and its role in Parkinson disease

  2024cites this paper
• Crosstalk Between miRNA and Protein Expression Profiles in Nitrate-Exposed Brain Cells

  2023cites this paper
• Lithium Chloride Exerts Anti-Inflammatory and Neuroprotective Effects by Inhibiting Microglial Activation in LPS-Induced Retinal Injury

  2023cites this paper
• Taurochenodeoxycholic acid reduces astrocytic neuroinflammation and alleviates experimental autoimmune encephalomyelitis in mice.

  2023cites this paper
• Classification and deep-learning–based prediction of Alzheimer disease subtypes by using genomic data

  2023cites this paper
• 17β-oestradiol inhibits ferroptosis in the hippocampus by upregulating DHODH and further improves memory decline after ovariectomy

  2023cites this paper
• Coupling of Alzheimer’s Disease Genetic Risk Factors with Viral Susceptibility and Inflammation

  2023cites this paper
• Quercetin improves cerebral ischemia/reperfusion injury by promoting microglia/macrophages M2 polarization via regulating PI3K/Akt/NF-κB signaling pathway.

  2023cites this paper
• The pharmacological mechanism of chaihu-jia-longgu-muli-tang for treating depression: integrated meta-analysis and network pharmacology analysis

  2023cites this paper
• 17-DMAG ameliorates neuroinflammation and BBB disruption via SOX5 mediated PI3K/Akt pathway after intracerebral hemorrhage in rats.

  2023cites this paper
• Inflammation and immune cell abnormalities in intracranial aneurysm subarachnoid hemorrhage (SAH): Relevant signaling pathways and therapeutic strategies

  2022cites this paper
• Neurotropic RNA Virus Modulation of Immune Responses within the Central Nervous System

  2022cites this paper
• Hyodeoxycholic acid inhibits lipopolysaccharide-induced microglia inflammatory responses through regulating TGR5/AKT/NF-κB signaling pathway

  2022cites this paper
• Enterovirus‐71 utilizes small extracellular vesicles to cross the blood–brain barrier for infecting the central nervous system via transcytosis

  2022cites this paper
• RNA interference-mediated silencing of DNA methyltransferase 1 attenuates neuropathic pain by accelerating microglia M2 polarization

  2022cites this paper
• Shenhuang plaster ameliorates the Inflammation of postoperative ileus through inhibiting PI3K/Akt/NF-κB pathway.

  2022cites this paper
• In Vitro Anti-Inflammatory Effects of Symplocos sumuntia Buch.-Ham. Ex D. Don Extract via Blockage of the NF-κB/JNK Signaling Pathways in LPS-Activated Microglial Cells

  2022influential citation
• Fraxetin alleviates microglia-mediated neuroinflammation after ischemic stroke

  2021cites this paper
• 5-Lipoxygenase inhibition reduces inflammation and neuronal apoptosis via AKT signaling after subarachnoid hemorrhage in rats

  2021cites this paper
• Full spectrum of clonal haematopoiesis‐driver mutations in chronic heart failure and their associations with mortality

  2021cites this paper
• Central nervous system diseases related to pathological microglial phagocytosis

  2021cites this paper
• Manuscript title: Mechanistic effects of arsenic trioxide on acute promyelocytic leukemia and other types of leukemias.

  2021cites this paper
• Beta-naphthoflavone inhibits LPS-induced inflammation in BV-2 cells via AKT/Nrf-2/HO-1-NF-κB signaling axis.

  2020cites this paper
• Mechanisms of Inhibition of Excessive Microglial Activation by Melatonin

  2020cites this paper
• The role of microglia in neuroprogressive disorders: mechanisms and possible neurotherapeutic effects of induced ketosis.

  2020cites this paper
• Silencing of Tenascin-C Inhibited Inflammation and Apoptosis Via PI3K/Akt/NF-κB Signaling Pathway in Subarachnoid Hemorrhage Cell Model.

  2019cites this paper
• Roles of JAK2 in Aging, Inflammation, Hematopoiesis and Malignant Transformation

  2019cites this paper
• PI3K/Akt/NF‐&kgr;B signaling pathway regulates behaviors in adolescent female rats following with neonatal maternal deprivation and chronic mild stress

  2019cites this paper
• E3 Ubiquitin Ligase c-cbl Inhibits Microglia Activation After Chronic Constriction Injury

  2018cites this paper
• Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNFα-mediated apoptosis

  2018influential citation
• Recent advances in the mechanisms of neuroinflammation and their roles in neurodegeneration

  2018cites this paper
• Aggf1 attenuates neuroinflammation and BBB disruption via PI3K/Akt/NF-κB pathway after subarachnoid hemorrhage in rats

  2018cites this paper
• Reduction of NF-κB (p65) in Scrapie-Infected Cultured Cells and in the Brains of Scrapie-Infected Rodents.

  2017cites this paper