Transformed lymphocytes from Abelson-diseased mice express levels of a B lineage transformation-associated antigen elevated from that found on normal lymphocytes

Animals injected with Abelson murine leukemia virus (A-MuLV) rapidly develop fatal bone marrow-derived lymphosarcomas. In all such diseased animals tested, a subpopulation of bone marrow cells expressed a monoclonal antibody-defined, B lineage transformation-associated antigen (6C3 Ag) at levels increased from that detected on normal lymphocytes. Cells bearing a high level of this antigen were found to be transformed as measured by clonal growth in agar, and they expressed surface antigen markers characteristic of early pre-B cells. High-level antigen-expressing cells were found in the bone marrow, lymph nodes, and spleen, but never in the thymus of diseased animals. This distribution agrees with the published pathology of Abelson disease.

• Publication year

  1985

• Venue

  Journal of Experimental Medicine

• Publication date

  1985-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1084/JEM.162.5.1421PMID 2997360PMCID 2187927
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Transformation-associated proteins in murine B-cell lymphomas that are distinct from Abelson virus gene products.

  1984cited by this paper
• Gene product of v-fgr onc: hybrid protein containing a portion of actin and a tyrosine-specific protein kinase.

  1984cited by this paper
• Dual immunofluorescence - new frontiers in cell analysis and sorting.

  1983cited by this paper
• Surface Antigen Expression and Immunoglobulin Gene Rearrangement During Mouse pre‐B Cell Development

  1983cited by this paper
• Avian sarcoma virus UR2 encodes a transforming protein which is associated with a unique protein kinase activity

  1982cited by this paper
• One-step purification of mouse monoclonal antibodies from ascitic fluid by DEAE Affi-Gel blue chromatography.

  1982cited by this paper
• Abelson virus-infected cells can exhibit restricted in vitro growth and low oncogenic potential

  1981cited by this paper
• Localization of the Abelson murine leukemia virus protein in a detergent-insoluble subcellular matrix: architecture of the protein

  1981cited by this paper
• Cell surface appearance of unexpected host MHC determinants on thymocytes from radiation bone marrow chimeras.

  1981cited by this paper
• Four different classes of retroviruses induce phosphorylation of tyrosines present in similar cellular proteins

  1981cited by this paper
• Murine leukaemogenesis: monoclonal antibodies to T-cell determinants arrest T-lymphoma cell proliferation

  1980cited by this paper
• Characterization of protein kinase activity associated with the transforming gene product of Fujinami sarcoma virus.

  1980cited by this paper
• Abelson murine leukaemia virus protein is phosphorylated in vitro to form phosphotyrosine

  1980cited by this paper
• Structure and expression of the Abelson murine leukemia virus genome and its relationship to a normal cell gene.

  1980cited by this paper
• Characterization of Y73, an avian sarcoma virus: a unique transforming gene and its product, a phosphopolyprotein with protein kinase activity.

  1980cited by this paper
• Biochemical and immunological characterization of polyproteins coded for by the McDonough, Gardner-Arnstein, and Snyder-Theilen strains of feline sarcoma virus

  1980cited by this paper
• Abelson virus-induced lymphomagenesis in mice

  1978cited by this paper
• Protein kinase activity associated with the avian sarcoma virus src gene product.

  1978cited by this paper
• A quantitative assay for transformation of bone marrow cells by Abelson murine leukemia virus

  1976cited by this paper
• Conjugation of antibodies with fluorochromes: modifications to the standard methods.

  1976cited by this paper
• Direct transformation of 3T3 cells by Abelson murine leukaemia virus

  1975cited by this paper
• Transplantation and preliminary characterisation of lymphocyte surface markers of Abelson virus-induced lymphomas

  1975cited by this paper
• Lymphosarcoma: virus-induced thymic-independent disease in mice.

  1970cited by this paper

• c-myc by the Proto-Oncogene B Lymphocyte Commitment Program Is Driven

  2011cites this paper
• B Lymphocyte Commitment Program Is Driven by the Proto-Oncogene c-myc

  2011cites this paper
• Mouse Models of Human Blood Cancers

  2008cites this paper
• Genetic and Virological Predisposition to Pre-B Lymphomagenesis in SL/Kh

  2008cites this paper
• Bone marrow pre-B expansion by SL/Kh-Bomb1 locus: not sufficient for lymphomagenesis.

  2008cites this paper
• Bone marrow pre-B-1 (Bomb1): a quantitative trait locus inducing bone marrow pre-B-cell expansion in lymphoma-prone SL/Kh mice.

  1999cites this paper
• Genetic and epigenetic susceptibility to endogenous retrovirus-induced lymphomas in SL mice.

  1999cites this paper
• T and B cell development in BP-1/6C3/aminopeptidase A-deficient mice.

  1998cites this paper
• Individual LCR hypersensitive sites cooperate to generate an open chromatin domain spanning the human β‐globin locus

  1998cites this paper
• Expression of LECAM-1 and LFA-1 on pre-B lymphoma cells but not on preneoplastic pre-B cells in SL/KH mice.

  1997cites this paper
• Identification of a novel bone marrow-derived B-cell progenitor population that coexpresses B220 and Thy-1 and is highly enriched for Abelson leukemia virus targets

  1996cites this paper
• Genetic predisposition to lymphomas in mice

  1996cites this paper
• Organ distribution of aminopeptidase A and dipeptidyl peptidase IV in normal mice.

  1996cites this paper
• Regulation of B cell precursor proliferation by aminopeptidase A.

  1995cites this paper
• Abnormal bone marrow B-cell differentiation in pre-B lymphoma-prone SL/Kh mice.

  1994cites this paper
• Characterization of a 43 kD protein associated to aminopeptidase A from murine kidney.

  1994cites this paper
• Genetic predisposition to pre-B lymphomas in SL/Kh strain mice.

  1994cites this paper
• Stromal cells in long-term cultures: keys to the elucidation of hematopoietic development?

  1993cites this paper
• Pluripotent stem cells and early B lymphocyte precursors in mice.

  1992cites this paper
• In vitro and in vivo activity of murine lymphokine‐activated killer cells after cryopreservation

  1992cites this paper
• Aminopeptidase A activity of the murine B-lymphocyte differentiation antigen BP-1/6C3.

  1991cites this paper
• Bone marrow stromal cells and interleukin-7 induce coordinate expression of the BP-1/6C3 antigen and pre-B cell growth.

  1990cites this paper
• The growth factor IL-7 induces expression of a transformation-associated antigen in normal pre-B cells.

  1990cites this paper
• Molecular cloning of the murine BP-1/6C3 antigen: a member of the zinc-dependent metallopeptidase family.

  1990cites this paper
• BP-1/6C3 expression defines a differentiation stage of transformed pre-B cells and is not related to malignant potential.

  1990cites this paper
• The early B lineage antigen BP-1 and the transformation-associated antigen 6C3 are on the same molecule.

  1989cites this paper
• Identification of a novel bone marrow-derived B-cell progenitor population that coexpresses B220 and Thy-1 and is highly enriched for Abelson leukemia virus targets

  1989cites this paper
• Cultured Stromal Cell Lines from Hemopoietic Tissues

  1989cites this paper
• The stem cell antigens Sca-1 and Sca-2 subdivide thymic and peripheral T lymphocytes into unique subsets.

  1988cites this paper
• Normal thymic cortical epithelial cells developmentally regulate the expression of a B-lineage transformation-associated antigen

  1988cites this paper
• Transgenic mice and oncogenesis.

  1988cites this paper
• Murine hematopoietic cell surface antigen expression.

  1988cites this paper
• The viral and cellular forms of the Abelson (abl) oncogene.

  1988cites this paper
• Monoclonal antibodies reactive with subsets of mouse and human thymic epithelial cells.

  1988cites this paper
• Experimental models for understanding B lymphocyte formation.

  1987cites this paper
• Cloning of murine B-lymphocyte differentiation stage-specific genes.

  1987cites this paper
• Expression of the 6C3 antigen on murine hematopoietic neoplasms. Association with expression of abl, ras, fes, src, erbB, and Cas NS-1 oncogenes but not with myc

  1987cites this paper
• Early events in T-cell maturation.

  1987cites this paper
• Differentiation of B Lymphocytes

  1987cites this paper
• Bone marrow stromal cell lines with lymphopoietic activity express high levels of a pre-B neoplasia-associated molecule.

  1987cites this paper
• The expression of differentiation antigens by Rauscher virus-induced erythroid, lymphoid and myeloid cell lines.

  1987cites this paper
• Relationships between B‐lineage lymphocytes and stromal cells in long‐term bone marrow cultures

  1987cites this paper
• Murine hematopoietic cells with pre-B or pre-B/myeloid characteristics are generated by in vitro transformation with retroviruses containing fes, ras, abl, and src oncogenes

  1986cites this paper
• Expression of a monoclonal antibody-defined, B-lineage transformation antigen specifically identifies Abelson-diseased animals. Genetically determined resistance to Abelson murine leukemia virus acts before induction of gp160(6C3)

  1986cites this paper
• Isolation of a cDNA copy of an RNA species expressed in murine pre‐B cells.

  1986cites this paper
• Functions of the abl oncogene.

  1986cites this paper