A Multi-Locus Approach to Treating Fibromyalgia by Boosting Dopaminergic Activity in the Meso-Limbic System of the Brain

K. Blum,M. Oscar-Berman,R. L. Waite,E. Braverman,Florian Kreuk,Mona Li,K. Dushaj,Margaret A. Madigan,M. Hauser,T. Simpatico,D. Barh

Published 2014 in Journal of genetic syndrome & gene therapy

ABSTRACT

Fibromyalgia (FM), is associated with fatigue, chronic diffuse pain, and cognitive/mood disturbances [1,2]. FM patients have greater healthcare costs and reduced workplace productivity. Stress and the neurotransmitter dopamine may interact, and this interaction may induce FM. Interestingly, FM has been called a ‘stress-related disorder’ presenting an exacerbation of symptoms on the context of stressful events [3].Certainly, many genes are involved in FM causation and potential predisposition. However, it is important to realize that epigenetics may also be involved in the progression of this disorder. Specifically, Menzies

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