A novel mechanism for the transcriptional regulation of Wnt signaling in development.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Genes & Development

• Publication date

  2011-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1101/gad.17227011PMID 21856776PMCID PMC3175715
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Lack of the ventral anterior homeodomain transcription factor VAX1 leads to induction of a second pituitary

  2011cited by this paper
• T-cell factor 4 functions as a tumor suppressor whose disruption modulates colon cell proliferation and tumorigenesis

  2011cited by this paper
• Sonic hedgehog functions through dynamic changes in temporal competence in the developing forebrain.

  2010influential reference
• The balance of TCF7L2 variants with differential activities in Wnt-signaling is regulated by lithium in a GSK3beta-independent manner.

  2010cited by this paper
• Alternative splicing of Tcf7l2 transcripts generates protein variants with differential promoter-binding and transcriptional activation properties at Wnt/β-catenin targets

  2009cited by this paper
• Apc1-Mediated Antagonism of Wnt/β-Catenin Signaling Is Required for Retino-Tectal Pathfinding in the Zebrafish

  2009influential reference
• Wnt won the war: Antagonistic role of Wnt over Shh controls dorso‐ventral patterning of the vertebrate neural tube

  2009influential reference
• Spatial and temporal regulation of Wnt/beta-catenin signaling is essential for development of the retinal pigment epithelium.

  2009influential reference
• Wnt signaling and the polarity of the primary body axis.

  2009cited by this paper
• Wnt/beta-catenin signaling: components, mechanisms, and diseases.

  2009cited by this paper
• An Integrated Software System for Analyzing Chip-chip and Chip-seq Data (supplementary Information)

  2008cited by this paper
• Canonical Wnt signaling is required for the maintenance of dorsal retinal identity

  2008cited by this paper
• An integrated system CisGenome for analyzing ChIP-chip and ChIP-seq data

  2008cited by this paper
• The Forkhead protein, FoxJ1, specifies node-like cilia in Xenopus and Zebrafish embryos

  2008influential reference
• Ocular coloboma and dorsoventral neuroretinal patterning defects in Lrp6 mutant eyes

  2008cited by this paper
• GSK‐3β and α‐catenin binding regions of β‐catenin exert opposing effects on the terminal ventral optic axonal projection

  2008influential reference
• A role for Xvax2 in controlling proliferation of Xenopus ventral eye and brain progenitors

  2008cited by this paper
• TCF4 deficiency expands ventral diencephalon signaling and increases induction of pituitary progenitors.

  2007cited by this paper
• Wnt signalling: variety at the core

  2007cited by this paper
• Diversity of LEF/TCF action in development and disease

  2006cited by this paper
• CisView: a browser and database of cis-regulatory modules predicted in the mouse genome.

  2006cited by this paper
• Chromatin immunoprecipitation and microarray-based analysis of protein location

  2006cited by this paper
• Hedgehog-regulated localization of Vax2 controls eye development.

  2006cited by this paper
• Vax genes ventralize the embryonic eye.

  2005influential reference
• Autoregulation of canonical Wnt signaling controls midbrain development.

  2004cited by this paper
• The Wnt signaling pathway in development and disease.

  2004cited by this paper
• Hedgehog signalling maintains the optic stalk-retinal interface through the regulation of Vax gene activity

  2003influential reference
• Mapping Wnt/β-catenin signaling during mouse development and in colorectal tumors

  2003cited by this paper
• The homeodomain protein Vax2 patterns the dorsoventral and nasotemporal axes of the eye.

  2002influential reference
• T‐cell factors: turn‐ons and turn‐offs

  2002influential reference
• β-catenin–sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer

  2001cited by this paper
• LEF1 turns over a new leaf

  2001cited by this paper
• Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse.

  2001influential reference
• Patterning mechanisms controlling vertebrate limb development.

  2001cited by this paper
• VISTA : visualizing global DNA sequence alignments of arbitrary length

  2000influential reference
• Repressor activity of Headless/Tcf3 is essential for vertebrate head formation

  2000cited by this paper
• Neuronal specification in the spinal cord: inductive signals and transcriptional codes

  2000cited by this paper
• Misexpression of the Emx-related homeobox genes cVax and mVax2 ventralizes the retina and perturbs the retinotectal map.

  1999influential reference
• A homeobox gene, vax2, controls the patterning of the eye dorsoventral axis.

  1999cited by this paper
• The homeodomain protein vax1 is required for axon guidance and major tract formation in the developing forebrain.

  1999cited by this paper
• Vax1, a novel homeobox-containing gene, directs development of the basal forebrain and visual system.

  1999cited by this paper
• Two Members of the Tcf Family Implicated in Wnt/β-Catenin Signaling during Embryogenesis in the Mouse

  1998cited by this paper
• TCF-4 binds beta-catenin and is expressed in distinct regions of the embryonic brain and limbs.

  1998cited by this paper
• Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

  1998cited by this paper
• Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma

  1997cited by this paper
• Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties

  1996cited by this paper
• Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity.

  1993cited by this paper
• Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds.

  1993cited by this paper
• The entire mesodermal mantle behaves as Spemann's organizer in dorsoanterior enhanced Xenopus laevis embryos.

  1988cited by this paper

• TCF/LEF-mediated transcriptional regulation in the canonical Wnt pathway

  2025cites this paper
• Two orthogonal differentiation gradients locally coordinate fruit morphogenesis

  2024cites this paper
• WNT/β‐catenin pathway is a key regulator of cardiac function and energetic metabolism

  2023cites this paper
• In Situ Deposition of Drug and Gene Nanoparticles on a Patterned Supramolecular Hydrogel to Construct a Directionally Osteochondral Plug

  2023cites this paper
• Defects of the spliceosomal gene SNRPB affect osteo‐ and chondro‐differentiation

  2023cites this paper
• TCF7L2 acts as a molecular switch in midbrain to control mammal vocalization through its DNA binding domain but not transcription activation domain

  2023influential citation
• Protective Prognostic Biomarkers Negatively Correlated with Macrophage M2 Infiltration in Low-Grade Glioma

  2022cites this paper
• TCF7L2 acts as a molecular switch in midbrain to control mammal vocalization through a transcriptional repression mechanism

  2022influential citation
• A classification of genes involved in normal and delayed male puberty

  2022cites this paper
• Integrated analysis of Wnt signalling system component gene expression

  2022influential citation
• Nanoparticles-in-nanofibers composites: Emphasis on some recent biomedical applications.

  2022cites this paper
• TCF7L2 silencing results in altered gene expression patterns accompanied by local genomic reorganization

  2021cites this paper
• Single-cell transcriptomics reveals opposing roles of Shp2 in Myc-driven liver tumor cells and microenvironment.

  2021influential citation
• TCF7L2 Silencing Reprograms the 4D Nucleome of Colorectal Cancer Cells

  2020cites this paper
• Hepatic FGF21 is Under the Regulation of the Canonical Wnt Signaling Pathway by Yasaman Badakhshi A thesis submitted in conformity with the requirements

  2020cites this paper
• The transcription factor TCF7L2 functions as a terminal selector in thalamic and habenular regions of the brain

  2020cites this paper
• The role of transcription factor 7‐like 2 in metabolic disorders

  2020cites this paper
• 3D Hybrid Nanofiber Aerogels Combining with Nanoparticles Made of a Biocleavable and Targeting Polycation and MiR‐26a for Bone Repair

  2020cites this paper
• Visuomotor anomalies in achiasmatic mice expressing a transfer-defective Vax1 mutant

  2020cites this paper
• TCF7L2 regulates postmitotic differentiation programmes and excitability patterns in the thalamus

  2020cites this paper
• Alternative isoforms of KDM2A and KDM2B lysine demethylases negatively regulate canonical Wnt signaling

  2020cites this paper
• Alternative UNC13D Promoter Encodes a Functional Munc13-4 Isoform Predominantly Expressed in Lymphocytes and Platelets

  2020cites this paper
• Global Analysis of Intercel lular Homeodomain Protein Transfer Graphical

  2019cites this paper
• Developmentally regulated Tcf7l2 splice variants mediate transcriptional repressor functions during eye formation

  2019cites this paper
• TCF7L2 is a terminal selector that regulates postmitotic differentiation programs and excitability patterns in the thalamus

  2019cites this paper
• Embryo polarity in moth flies and mosquitoes relies on distinct old genes with localized transcript isoforms

  2019cites this paper
• Wnt signaling in orofacial clefts: crosstalk, pathogenesis and models

  2019cites this paper
• Global Analysis of Intercellular Homeodomain Protein Transfer

  2019cites this paper
• Wnt Effector TCF4 Is Dispensable for Wnt Signaling in Human Cancer Cells

  2018influential citation
• KDM2A/B lysine demethylases and their alternative isoforms in development and disease

  2018cites this paper
• The Diabetes Gene and Wnt Pathway Effector TCF7L2 Regulates Adipocyte Development and Function

  2018cites this paper
• Alternative intronic promoters in development and disease

  2017cites this paper
• A demethylation deficient isoform of the lysine demethylase KDM2A interacts with pericentromeric heterochromatin in an HP1a-dependent manner

  2017cites this paper
• Vax1 Plays an Indirect Role in the Etiology of Murine Cleft Palate

  2017cites this paper
• Expresión de factores de transcripción tcf7l2 durante la diferenciación in vitro de células de neuroblastoma inducida por el ácido retinoico

  2017influential citation
• Vax1 plays an indirect role in the aetiology of murine cleft palate

  2017cites this paper
• A targeted approach to genome-wide studies reveals new genetic associations with central corneal thickness

  2017cites this paper
• Tcf7l2 Gene Polymorphism in T2dm with Patients in Turkish Population

  2017cites this paper
• Whole Exome Sequencing to Identify Genetic Variants Associated with Raised Atherosclerotic Lesions in Young Persons

  2017cites this paper
• Current Understanding on Role of the Wnt Signaling Pathway Effector TCF7L2 in Glucose Homeostasis.

  2016cites this paper
• Cell-free 3D scaffold with two-stage delivery of miRNA-26a to regenerate critical-sized bone defects

  2016cites this paper
• Wnt9a deficiency discloses a repressive role of Tcf7l2 on endocrine differentiation in the embryonic pancreas

  2016cites this paper
• TCF/LEF Transcription Factors: An Update from the Internet Resources

  2016cites this paper
• The Role of the C-Clamp in Wnt-Related Colorectal Cancers

  2016cites this paper
• Hedgehog inhibits β-catenin activity in synovial joint development and osteoarthritis.

  2016cites this paper
• Loss of Axin2 Causes Ocular Defects During Mouse Eye Development

  2016cites this paper
• Current Knowledge on the Role of Wnt Signaling Pathway in Glucose Homeostasis

  2016cites this paper
• Development and Maintenance of Thymic Epithelial Microenvironment

  2016cites this paper
• The Wnt Effector Transcription Factor 7-Like 2 Positively Regulates Oligodendrocyte Differentiation in a Manner Independent of Wnt/β-Catenin Signaling

  2015influential citation
• GPR124 IS A NOVEL CO-ACTIVATOR OF CANONICAL WNT SIGNALING

  2015cites this paper
• Current understanding and dispute on the function of the Wnt signaling pathway effector TCF7L2 in hepatic gluconeogenesis

  2015influential citation
• Molecular regulation of hypothalamic development and physiological functions

  2015cites this paper
• Cranial Nerve Development Requires Co-Ordinated Shh and Canonical Wnt Signaling

  2015cites this paper
• The Role of Transcription Factor 7-Like 2 in Hepatic Glucose Metabolism

  2014cites this paper
• Evolutionary Diversification of Vertebrate TCF/LEF Structure, Function, and Regulation

  2014cites this paper
• An Overview of Gene Regulation by Wnt/β‐Catenin Signaling

  2014cites this paper
• Correction: Regulation of retinal axon growth by secreted Vax1 homeodomain protein

  2014cites this paper
• Modelling of a targeted nanotherapeutic ‘stroma’ to deliver the cytokine LIF, or XAV939, a potent inhibitor of Wnt–β-catenin signalling, for use in human fetal dopaminergic grafts in Parkinson’s disease

  2014cites this paper
• Canonical WNT signaling components in vascular development and barrier formation.

  2014cites this paper
• Regulation of retinal axon growth by secreted Vax1 homeodomain protein

  2014cites this paper
• Asymmetric Differentiation of Habenular Neurons

  2014cites this paper
• Tcf7l2 Is Required for Left-Right Asymmetric Differentiation of Habenular Neurons

  2014cites this paper
• TCF7L2 in mouse pancreatic beta cells plays a crucial role in glucose homeostasis by regulating beta cell mass

  2014cites this paper
• Disrupting hedgehog and WNT signaling interactions promotes cleft lip pathogenesis.

  2014cites this paper
• Wnt signalling in mouse gastrulation and anterior development: new players in the pathway and signal output.

  2013cites this paper
• Is there a role for reactive oxygen species in zebrafish embryonic development

  2013cites this paper
• IS THERE A ROLE FOR REACTIVE OXYGEN SPECIES IN ZEBRAFISH EMBRYOGENESIS?

  2013cites this paper
• Postnatal isoform switch and protein localization of LEF1 and TCF7L2 transcription factors in cortical, thalamic, and mesencephalic regions of the adult mouse brain

  2012influential citation
• A Critical Role for the Wnt Effector Tcf4 in Adult Intestinal Homeostatic Self-Renewal

  2012cites this paper
• Intrinsic properties of Tcf1 and Tcf4 splice variants determine cell-type-specific Wnt/β-catenin target gene expression

  2012cites this paper
• VAX1 mutation associated with microphthalmia, corpus callosum agenesis, and orofacial clefting: The first description of a VAX1 phenotype in humans

  2012cites this paper
• β-catenin is selectively required for the expansion and regeneration of mature pancreatic acinar cells in mice

  2012cites this paper
• The role of the Wnt signaling pathway in incretin hormone production and function

  2012cites this paper
• The involvement of the wnt signaling pathway and TCF7L2 in diabetes mellitus: The current understanding, dispute, and perspective

  2012cites this paper
• Dominant-negative isoforms of Tcf/Lef proteins in development and disease

  2011cites this paper
• Wnt signaling meets internal dissent.

  2011influential citation
• Serveur Académique Lausannois SERVAL serval.unil.ch

  year unknowninfluential citation