CK1 activates minus-end–directed transport of membrane organelles along microtubules

This study shows that the signal transduction pathway responsible for the initiation of minus-end–directed movement of membrane-bounded pigment granules in melanophores involves sequential activation of protein phosphatase 2A and casein kinase 1 and that this activation correlates with increased phosphorylation of the dynein intermediate chain.

• Publication year

  2011

• Venue

  Molecular Biology of the Cell

• Publication date

  2011-04-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1091/mbc.E10-09-0741PMID 21307338PMCID 3078062
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2009cited by this paper
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  2009cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2007cited by this paper
• Multiscale trend analysis of microtubule transport in melanophores.

  2005influential reference
• Intracellular organelle transport: few motors, many signals.

  2005influential reference
• The casein kinase 1 family: participation in multiple cellular processes in eukaryotes.

  2005cited by this paper
• D4476, a cell‐permeant inhibitor of CK1, suppresses the site‐specific phosphorylation and nuclear exclusion of FOXO1a

  2004influential reference
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  2004cited by this paper
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  2004influential reference
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  2004influential reference
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  2004influential reference
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  2004cited by this paper
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  2004cited by this paper
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  2003cited by this paper
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  2003cited by this paper
• The molecular motor toolbox for intracellular transport.

  2003cited by this paper
• Interactions and regulation of molecular motors in Xenopus melanophores

  2002influential reference
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  2002cited by this paper
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  2002cited by this paper
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• Catalytic Activity of Protein Kinase CK1δ (Casein Kinase 1δ) Is Essential for Its Normal Subcellular Localization

  2001cited by this paper
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  2001cited by this paper
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  1999influential reference
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  1999influential reference
• Myosin cooperates with microtubule motors during organelle transport in melanophores.

  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
• Regulation of Organelle Movement in Melanophores by Protein Kinase A (PKA), Protein Kinase C (PKC), and Protein Phosphatase 2A (PP2A)

  1998influential reference
• Heterotrimeric Kinesin II Is the Microtubule Motor Protein Responsible for Pigment Dispersion in Xenopus Melanophores

  1998cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1996cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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