Osh4p is needed to reduce the level of phosphatidylinositol-4-phosphate on secretory vesicles as they mature

In yeast, the oxysterol-binding proteins Osh1–Osh7 are collectively needed to maintain the normal distribution of PI4P. Osh4p is recruited to secretory vesicles in a PI4P-dependent manner and plays an important role in vesicle maturation.

• Publication year

  2014

• Venue

  Molecular Biology of the Cell

• Publication date

  2014-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1091/mbc.E14-06-1087PMID 25165144PMCID 4214785
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Phosphoinositides: tiny lipids with giant impact on cell regulation.

  2013cited by this paper
• The synaptobrevin homologue Snc2p recruits the exocyst to secretory vesicles by binding to Sec6p

  2013cited by this paper
• Phosphorylation of the Rab exchange factor Sec2p directs a switch in regulatory binding partners

  2013cited by this paper
• Myosin-V is activated by binding secretory cargo and released in coordination with Rab/exocyst function.

  2012cited by this paper
• ER-to-plasma membrane tethering proteins regulate cell signaling and ER morphology.

  2012cited by this paper
• The dual PH domain protein Opy1 functions as a sensor and modulator of PtdIns(4,5)P2 synthesis

  2012cited by this paper
• GTPase networks in membrane traffic.

  2012cited by this paper
• Role of Rab GTPases in membrane traffic and cell physiology.

  2011cited by this paper
• PI4P and Rab inputs collaborate in myosin-V-dependent transport of secretory compartments in yeast.

  2011cited by this paper
• Osh4p exchanges sterols for phosphatidylinositol 4-phosphate between lipid bilayers

  2011influential reference
• Myosin V transports secretory vesicles via a Rab GTPase cascade and interaction with the exocyst complex.

  2011cited by this paper
• The Sterol‐Binding Protein Kes1/Osh4p Is a Regulator of Polarized Exocytosis

  2011influential reference
• Osh proteins regulate phosphoinositide metabolism at ER-plasma membrane contact sites.

  2011influential reference
• Establishing a Role for the GTPase Ypt1p at the Late Golgi

  2010cited by this paper
• Phosphatidylinositol 4-phosphate controls both membrane recruitment and a regulatory switch of the Rab GEF Sec2p.

  2010cited by this paper
• Lipid Binding Requirements for Oxysterol-binding Protein Kes1 Inhibition of Autophagy and Endosome-trans-Golgi Trafficking Pathways*

  2010cited by this paper
• Lipid-regulated sterol transfer between closely apposed membranes by oxysterol-binding protein homologues

  2009cited by this paper
• A general amphipathic alpha-helical motif for sensing membrane curvature.

  2007cited by this paper
• Growth Control of Golgi Phosphoinositides by Reciprocal Localization of Sac1 Lipid Phosphatase and Pik1 4‐Kinase

  2007cited by this paper
• A general amphipathic α-helical motif for sensing membrane curvature

  2007cited by this paper
• Homologues of Oxysterol‐Binding Proteins Affect Cdc42p‐ and Rho1p‐Mediated Cell Polarization in Saccharomyces cerevisiae

  2006cited by this paper
• The yeast lgl family member Sro7p is an effector of the secretory Rab GTPase Sec4p

  2006cited by this paper
• The rab exchange factor Sec2p reversibly associates with the exocyst.

  2006cited by this paper
• Coincidence detection in phosphoinositide signaling.

  2005cited by this paper
• Structural mechanism for sterol sensing and transport by OSBP-related proteins

  2005cited by this paper
• Organelle identity and the signposts for membrane traffic

  2005cited by this paper
• Multiple Pools of Phosphatidylinositol 4-Phosphate Detected Using the Pleckstrin Homology Domain of Osh2p*

  2004influential reference
• A role for yeast oxysterol-binding protein homologs in endocytosis and in the maintenance of intracellular sterol-lipid distribution

  2004influential reference
• Stt4 PI 4-kinase localizes to the plasma membrane and functions in the Pkc1-mediated MAP kinase cascade.

  2002cited by this paper
• Secretory vesicle transport velocity in living cells depends on the myosin-V lever arm length

  2002cited by this paper
• Mlc1p promotes septum closure during cytokinesis via the IQ motifs of the vesicle motor Myo2p

  2002cited by this paper
• Ypt32 recruits the Sec4p guanine nucleotide exchange factor, Sec2p, to secretory vesicles; evidence for a Rab cascade in yeast

  2002cited by this paper
• Overlapping functions of the yeast oxysterol-binding protein homologues.

  2001cited by this paper
• Dual targeting of Osh1p, a yeast homologue of oxysterol-binding protein, to both the Golgi and the nucleus-vacuole junction.

  2001cited by this paper
• Sac1 lipid phosphatase and Stt4 phosphatidylinositol 4-kinase regulate a pool of phosphatidylinositol 4-phosphate that functions in the control of the actin cytoskeleton and vacuole morphology.

  2001influential reference
• Compartmental specificity of cellular membrane fusion encoded in SNARE proteins

  2000cited by this paper
• SAC1 Encodes a Regulated Lipid Phosphoinositide Phosphatase, Defects in Which Can Be Suppressed by the Homologous Inp52p and Inp53p Phosphatases*

  2000cited by this paper
• Distinct roles for the yeast phosphatidylinositol 4-kinases, Stt4p and Pik1p, in secretion, cell growth, and organelle membrane dynamics.

  2000influential reference
• SAC1-like Domains of Yeast SAC1,INP52, and INP53 and of Human Synaptojanin Encode Polyphosphoinositide Phosphatases*

  1999influential reference
• The exocyst is an effector for Sec4p, targeting secretory vesicles to sites of exocytosis

  1999cited by this paper
• The yeast phosphatidylinositol-4-OH kinase Pik1 regulates secretion at the Golgi

  1999cited by this paper
• The Cooh-Terminal Domain of Myo2p, a Yeast Myosin V, Has a Direct Role in Secretory Vesicle Targeting

  1999cited by this paper
• Additional modules for versatile and economical PCR‐based gene deletion and modification in Saccharomyces cerevisiae

  1998cited by this paper
• Two New Ypt GTPases Are Required for Exit From the Yeast trans-Golgi Compartment

  1997cited by this paper
• Sec2p Mediates Nucleotide Exchange on Sec4p and Is Involved in Polarized Delivery of Post-Golgi Vesicles

  1997cited by this paper
• The Exocyst is a multiprotein complex required for exocytosis in Saccharomyces cerevisiae.

  1996cited by this paper
• Two GTPase isoforms, Ypt31p and Ypt32p, are essential for Golgi function in yeast.

  1996cited by this paper
• The Ypt1 GTPase is essential for the first two steps of the yeast secretory pathway

  1995cited by this paper
• The role of Myo2, a yeast class V myosin, in vesicular transport

  1995cited by this paper
• A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.

  1989cited by this paper
• The GTP-binding protein Ypt1 is required for transport in vitro: the Golgi apparatus is defective in ypt1 mutants

  1989cited by this paper
• Lyticase: Endoglucanase and Protease Activities That Act Together in Yeast Cell Lysis

  1980cited by this paper

• Maintenance of proper phosphatidylinositol-4-phosphate level by Stt4 and Sac1 contributes to vesicular transport to and from the plasma membrane

  2025cites this paper
• Regulation of yeast polarized exocytosis by phosphoinositide lipids

  2024cites this paper
• Reconstitution of ORP-mediated lipid exchange coupled to PI4P metabolism

  2024cites this paper
• Sac1 links phosphoinositide turnover to cryptococcal virulence

  2024cites this paper
• Specificity of lipid transfer proteins: an in vitro story.

  2024cites this paper
• Sac1 links phosphoinositide turnover to cryptococcal virulence

  2024cites this paper
• Insights into the role of sterol metabolism in antifungal drug resistance: a mini-review

  2024cites this paper
• Reconstitution of ORP-mediated lipid exchange process coupled to PI(4)P metabolism

  2023influential citation
• Osh-dependent and -independent Regulation of PI4P Levels During Polarized Growth of Saccharomyces cerevisiae

  2023cites this paper
• Exploring the consequences of redirecting an exocytic Rab onto endocytic vesicles

  2023cites this paper
• OSBP-mediated PI(4)P-cholesterol exchange at endoplasmic reticulum-secretory granule contact sites controls insulin secretion

  2023cites this paper
• Exploring the consequences of redirecting an exocytic Rab onto endocytic vesicles

  2023cites this paper
• Phosphatidylinositol-4-phosphate signaling regulates dense granule biogenesis and exocytosis in Toxoplasma gondii

  2023cites this paper
• Up-regulation of Osh6 boosts an anti-aging membrane trafficking pathway toward vacuoles

  2022cites this paper
• Coordination of inter-organelle communication and lipid fluxes by OSBP-related proteins.

  2022cites this paper
• Creating and sensing asymmetric lipid distributions throughout the cell

  2022cites this paper
• Two distinct lipid transporters together regulate invasive filamentous growth in the human fungal pathogen Candida albicans

  2022cites this paper
• Who’s in control? Principles of Rab GTPase activation in endolysosomal membrane trafficking and beyond

  2021cites this paper
• Coupled sterol synthesis and transport machineries at ER–endocytic contact sites

  2021cites this paper
• Suppression of Vps13 adaptor protein mutants reveals a central role for PI4P in regulating prospore membrane extension

  2021cites this paper
• The Link between VAPB Loss of Function and Amyotrophic Lateral Sclerosis

  2021cites this paper
• ORP/Osh mediate cross-talk between ER-plasma membrane contact site components and plasma membrane SNAREs

  2020cites this paper
• Direct trafficking pathways from the Golgi apparatus to the plasma membrane

  2020cites this paper
• Lipid Exchangers: Cellular Functions and Mechanistic Links With Phosphoinositide Metabolism

  2020cites this paper
• Structural and Functional Specialization of OSBP-Related Proteins

  2020influential citation
• The PI(4)P phosphatase Sac2 controls insulin granule docking and release

  2019influential citation
• An electrostatic switching mechanism to control the lipid transfer activity of Osh6p

  2019cites this paper
• VAPB depletion alters neuritogenesis and phosphoinositide balance in motoneuron-like cells: relevance to VAPB-linked amyotrophic lateral sclerosis

  2019cites this paper
• Mechanisms and regulation of plasma membrane-endoplasmic reticulum Membrane Contact Sites in Saccharomyces cerevisiae

  2018cites this paper
• The Oxysterol-Binding Protein Cycle: Burning Off PI(4)P to Transport Cholesterol.

  2018cites this paper
• The phosphoinositide phosphatase Sac1 regulates cell shape and microtubule stability in the developing Drosophila eye

  2018cites this paper
• Lipid transfer proteins: the lipid commute via shuttles, bridges and tubes

  2018cites this paper
• Sac1, a lipid phosphatase at the interface of vesicular and nonvesicular transport

  2018influential citation
• Membrane dynamics and organelle biogenesis—lipid pipelines and vesicular carriers

  2017cites this paper
• Lipid-dependent regulation of exocytosis in S. cerevisiae by OSBP homolog (Osh) 4

  2017influential citation
• The regulation of cell polarity by lipid transfer proteins of the SEC14 family.

  2017cites this paper
• Oxysterol-binding protein ORP3 rescues the Amyotrophic Lateral Sclerosis-linked mutant VAPB phenotype.

  2016cites this paper
• Lipids and Their Trafficking: An Integral Part of Cellular Organization.

  2016cites this paper
• The counterflow transport of sterols and PI4P.

  2016cites this paper
• Running up that hill: How to create cellular lipid gradients by lipid counter-flows.

  2016cites this paper
• Phosphoinositides in Control of Membrane Dynamics.

  2016cites this paper
• New molecular mechanisms of inter-organelle lipid transport.

  2016cites this paper
• Peripheral membrane proteins: Tying the knot between experiment and computation.

  2016cites this paper
• OSBP-Related Protein Family: Mediators of Lipid Transport and Signaling at Membrane Contact Sites.

  2016cites this paper
• The casein kinases Yck1p and Yck2p act in the secretory pathway, in part, by regulating the Rab exchange factor Sec2p

  2016cites this paper
• Regulation of membrane traffic by Rab GEF and GAP cascades

  2016cites this paper
• Functional Analysis of Sterol Transporter Orthologues in the Filamentous Fungus Aspergillus nidulans

  2015cites this paper
• OSBP-Related Protein Family in Lipid Transport Over Membrane Contact Sites

  2015cites this paper
• Phospholipase C and D regulation of Src, calcium release and membrane fusion during Xenopus laevis development.

  2015cites this paper
• vCLAMPs-an intimate link between vacuoles and mitochondria.

  2015cites this paper