Oral Delivery of Mycobacterium bovis BCG in a Lipid Formulation Induces Resistance to Pulmonary Tuberculosis in Mice

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Infection and Immunity

• Publication date

  2003-01-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1128/IAI.71.1.101-108.2003PMID 12496154PMCID PMC143408
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Development of intestinal function in mammals.

  1973cited by this paper
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