Pyruvate dehydrogenase and the regulation of glucose oxidation in hypertrophied rat hearts.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Cardiovascular Research

• Publication date

  2002-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0008-6363(01)00560-0PMID 11922894PMCID PMC2131743
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Semiquantitative analysis of collagen types in the hypertrophied left ventricle

  2001cited by this paper
• Dichloroacetate improves postischemic function of hypertrophied rat hearts.

  2000cited by this paper
• Expression and regulation of pyruvate dehydrogenase kinase isoforms in the developing rat heart and in adulthood: role of thyroid hormone status and lipid supply.

  2000cited by this paper
• Coordinate Regulation of Metabolic Enzyme Encoding Genes During Cardiac Development and Following Carvedilol Therapy in Spontaneously Hypertensive Rats

  2000cited by this paper
• Hypertrophied rat hearts are less responsive to the metabolic and functional effects of insulin.

  2000cited by this paper
• Myocardial oxygenation at high workstates in hearts with left ventricular hypertrophy.

  1999cited by this paper
• Glucose utilization and glycogen turnover are accelerated in hypertrophied rat hearts during severe low-flow ischemia.

  1999cited by this paper
• Glucose for the heart.

  1999cited by this paper
• Starvation and diabetes increase the amount of pyruvate dehydrogenase kinase isoenzyme 4 in rat heart.

  1998cited by this paper
• Isoenzymes of Pyruvate Dehydrogenase Phosphatase

  1998cited by this paper
• Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex.

  1998cited by this paper
• Rat models of hypertension, cardiac hypertrophy and failure.

  1998cited by this paper
• Pressure Overload Induced in Newborn Rats: Effects on Left Ventricular Growth, Morphology, and Function

  1998cited by this paper
• Energy metabolism in normal and hypertrophied right ventricle of the ferret heart.

  1997cited by this paper
• Inhibition of pyruvate dehydrogenase kinase by pyruvate in cultured cardiac myocytes.

  1997cited by this paper
• Regulation of myocardial carbohydrate metabolism under normal and ischaemic conditions. Potential for pharmacological interventions.

  1997cited by this paper
• Control of oxidative metabolism in volume-overloaded rat hearts: effect of propionyl-L-carnitine.

  1997cited by this paper
• Different mechanisms underlie the long‐term regulation of pyruvate dehydrogenase kinase (PDHK) by tri‐iodothyronine in heart and liver

  1997cited by this paper
• Dihydrolipoamide Dehydrogenase-binding Protein of the Human Pyruvate Dehydrogenase Complex

  1997cited by this paper
• The effects of hypertrophy and diabetes on cardiac pyruvate dehydrogenase activity.

  1997cited by this paper
• Measurements of fatty acid and carbohydrate metabolism in te isolated working rat heart

  1997cited by this paper
• Recovery of glycolysis and oxidative metabolism during postischemic reperfusion of hypertrophied rat hearts.

  1996cited by this paper
• Pyruvate inhibition of pyruvate dehydrogenase kinase

  1996cited by this paper
• Serum from patients with chronic renal insufficiency alters growth characteristics and ANP mRNA expression of adult rat cardiac myocytes.

  1996cited by this paper
• Ischemia and reperfusion injury in the hypertrophied heart.

  1996cited by this paper
• Fatty acid oxidation in the heart.

  1996cited by this paper
• Contribution of glycogen to aerobic myocardial glucose utilization.

  1996cited by this paper
• Myocardial high-energy phosphate and substrate metabolism in swine with moderate left ventricular hypertrophy.

  1995cited by this paper
• Differential expression of alpha- and beta-enolase genes during rat heart development and hypertrophy.

  1995cited by this paper
• Pretranslational regulation of pyruvate dehydrogenase complex subunits in white adipose tissue during the suckling-weaning transition in the rat.

  1995cited by this paper
• Molecular cloning of the p45 subunit of pyruvate dehydrogenase kinase.

  1994cited by this paper
• Interactive regulation of the pyruvate dehydrogenase complex and the carnitine palmitoyltransferase system

  1994cited by this paper
• Mechanisms modifying glucose oxidation in diabetes mellitus

  1994cited by this paper
• Contribution of oxidative metabolism and glycolysis to ATP production in hypertrophied hearts.

  1994cited by this paper
• Glycolysis and glucose oxidation during reperfusion of ischemic hearts from diabetic rats.

  1994cited by this paper
• Epinephrine increases ATP production in hearts by preferentially increasing glucose metabolism.

  1994cited by this paper
• Primary structure of pyruvate dehydrogenase kinase establishes a new family of eukaryotic protein kinases.

  1993cited by this paper
• An imbalance between glycolysis and glucose oxidation is a possible explanation for the detrimental effects of high levels of fatty acids during aerobic reperfusion of ischemic hearts.

  1993cited by this paper
• Acetyl-CoA carboxylase regulation of fatty acid oxidation in the heart.

  1993cited by this paper
• Fatty acid oxidation and mechanical performance of volume-overloaded rat hearts.

  1992cited by this paper
• Myocardial Oxygen Consumption and the Left Ventricular Pressure‐Volume Area in Normal and Hypertrophic Canine Hearts

  1991cited by this paper
• A sensitive radioisotopic assay of pyruvate dehydrogenase complex in human muscle tissue.

  1991cited by this paper
• Molecular biology and biochemistry of pyruvate dehydrogenase complexes 1

  1990cited by this paper
• Radioisotopic assays of CoASH and carnitine and their acetylated forms in human skeletal muscle.

  1990cited by this paper
• Effects of moderate hypertension on cardiac function and metabolism in the rabbit.

  1988cited by this paper
• Fuel selection in animals.

  1986cited by this paper
• Glutamic dehydrogenase from rat heart mitochondria. I. Purification and physical properties including molecular weight determination.

  1984cited by this paper
• Effects of Mechanical Activity and Hormones on Myocardial Glucose and Fatty Acid Utilization

  1976cited by this paper
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper
• Dichloroacetate-lnduced Changes in Liver of Normal and Diabetic Rats

  1975cited by this paper
• Dichloroacetate-induced changes in liver of normal and diabetic rats.

  1975cited by this paper
• Relationship between carbohydrate and lipid metabolism and the energy balance of heart muscle.

  1974cited by this paper
• Regulation of heart muscle pyruvate dehydrogenase kinase.

  1974cited by this paper
• Effects of dichloroacetate on the metabolism of glucose, pyruvate, acetate, 3-hydroxybutyrate and palmitate in rat diaphragm and heart muscle in vitro and on extraction of glucose, lactate, pyruvate and free fatty acids by dog heart in vivo.

  1973cited by this paper
• Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

  1970cited by this paper
• Increased glycolytic metabolism in cardiac hypertrophy and congestive failure.

  1970cited by this paper

• Histone Modifications as Molecular Drivers of Cardiac Aging: Metabolic Alterations, Epigenetic Mechanisms, and Emerging Therapeutic Strategies.

  2025cites this paper
• Semaglutide ameliorates cardiac remodeling in male mice by optimizing energy substrate utilization through the Creb5/NR4a1 axis

  2024cites this paper
• The potential roles of exosomes in pathological cardiomyocyte hypertrophy mechanisms and therapy: A review

  2024cites this paper
• Pyruvate dehydrogenase kinase 2 knockdown restores the ability of amyotrophic lateral sclerosis‐linked SOD1G93A rat astrocytes to support motor neuron survival by increasing mitochondrial respiration

  2024cites this paper
• CRISPRi/a screens in human iPSC-cardiomyocytes identify glycolytic activation as a druggable target for doxorubicin-induced cardiotoxicity.

  2024cites this paper
• Role of STIM1 in the Regulation of Cardiac Energy Substrate Preference

  2023cites this paper
• Metabolic mechanisms in physiological and pathological cardiac hypertrophy: new paradigms and challenges

  2023cites this paper
• Metabolic adaptations in pressure overload hypertrophic heart

  2023cites this paper
• The dynamic interplay between cardiac mitochondrial health and myocardial structural remodeling in metabolic heart disease, aging, and heart failure

  2023cites this paper
• Metabolic landscape in cardiac aging: insights into molecular biology and therapeutic implications

  2023cites this paper
• Hyperpolarized [1-13C]Acetyl-l-Carnitine Probes Tricarboxylic Acid Cycle Activity In Vivo.

  2023cites this paper
• Metal dependent protein phosphatase PPM family in cardiac health and diseases

  2021cites this paper
• Cardiac Energy Metabolism in Heart Failure

  2021cites this paper
• Adaptive Cardiac Metabolism Under Chronic Hypoxia: Mechanism and Clinical Implications

  2021cites this paper
• Myocardial Tissue Characterization in Heart Failure with Preserved Ejection Fraction: From Histopathology and Cardiac Magnetic Resonance Findings to Therapeutic Targets

  2021cites this paper
• Hypoxia-inducible factor 1 signalling, metabolism and its therapeutic potential in cardiovascular disease.

  2019cites this paper
• Novel Concepts in Cardiac Energy Metabolism: From Biology to Disease

  2019cites this paper
• A porcine model of heart failure with preserved ejection fraction: magnetic resonance imaging and metabolic energetics

  2019cites this paper
• Cardioprotection conferred by rooibos (Aspalathus linearis): A mini review to highlight a potential mechanism of action

  2019cites this paper
• Immunometabolic cross-talk in the inflamed heart

  2019cites this paper
• Glucose Metabolism in Cardiac Hypertrophy and Heart Failure

  2019cites this paper
• Assessing the effect of hypoxia on cardiac metabolism using hyperpolarized 13C magnetic resonance spectroscopy

  2018cites this paper
• Enhanced Redox State and Efficiency of Glucose Oxidation With miR Based Suppression of Maladaptive NADPH-Dependent Malic Enzyme 1 Expression in Hypertrophied Hearts

  2018cites this paper
• Loss of Metabolic Flexibility in the Failing Heart

  2018cites this paper
• Metabolic remodelling in heart failure

  2018cites this paper
• AMPK regulates energy metabolism through the SIRT1 signaling pathway to improve myocardial hypertrophy.

  2018cites this paper
• Mitochondria and Cardiac Hypertrophy.

  2017cites this paper
• Activation of Pyruvate Dehydrogenase Activity by Dichloroacetate Improves Survival and Neurologic Outcomes After Cardiac Arrest in Rats

  2017cites this paper
• Metabolic remodeling in hypertrophied and failing myocardium: a review.

  2017cites this paper
• Mitochondrial Function, Biology, and Role in Disease: A Scientific Statement From the American Heart Association.

  2016cites this paper
• Metabolic reprogramming by the pyruvate dehydrogenase kinase-lactic acid axis: Linking metabolism and diverse neuropathophysiologies.

  2016cites this paper
• Triacylglycerol turnover in the failing heart.

  2016cites this paper
• The role of Pyruvate Dehydrogenase Complex in cardiovascular diseases.

  2015cites this paper
• Metabolic Efficiency Promotes Protection From Pressure Overload in Hearts Expressing Slow Skeletal Troponin I

  2015cites this paper
• Glucose Transporters in Cardiac Metabolism and Hypertrophy.

  2015cites this paper
• Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets

  2015cites this paper
• Causes of upregulation of glycolysis in lymphocytes upon stimulation. A comparison with other cell types.

  2015cites this paper
• Activation of pyruvate dehydrogenase by dichloroacetate has the potential to induce epigenetic remodeling in the heart.

  2015cites this paper
• Hyperpolarized 13C-magnetic resonance spectroscopy: are we ready for metabolic imaging?

  2014cites this paper
• The role of "glycolysis-uncoupling of glucose oxidation" in the progression of chronic cardiac hypertroph

  2013cites this paper
• Alteration of cardiac glucose metabolism in association to low birth weight: experimental evidence in lambs with left ventricular hypertrophy.

  2013cites this paper
• Alterations in mitochondrial function in cardiac hypertrophy and heart failure

  2013cites this paper
• The role of lysosomal acid lipase in regulation of the ATP-binding cassette transporter A1, high density lipoprotein and reverse cholesterol transport

  2013cites this paper
• Biophysical Mechanisms for the Metabolic Component of Impaired Heart Function

  2013cites this paper
• Mechanical function, glycolysis, and ultrastructure of perfused working mouse hearts following thoracic aortic constriction.

  2011cites this paper
• β-receptor antagonist treatment prevents activation of cell death signaling in the diabetic heart independent of its metabolic actions.

  2011cites this paper
• Elevation of cardiac glycolysis reduces pyruvate dehydrogenase but increases glucose oxidation

  2011cites this paper
• Determining the in vivo regulation of cardiac pyruvate dehydrogenase based on label flux from hyperpolarised [1‐13C]pyruvate

  2011cites this paper
• The Interplay between NF-kappaB and E2F1 Coordinately Regulates Inflammation and Metabolism in Human Cardiac Cells

  2011cites this paper
• Chapter 20 – Alterations in Cardiac Metabolism

  2011cites this paper
• Phosphorylation status of pyruvate dehydrogenase distinguishes metabolic phenotypes of cultured rat brain astrocytes and neurons

  2010cites this paper
• Valvular Heart Disease Glucose-Insulin-Potassium Reduces the Incidence of Low Cardiac Output Episodes After Aortic Valve Replacement for Aortic Stenosis in Patients With Left Ventricular Hypertrophy

  2010cites this paper
• Long-term effects of epoprostenol on the pulmonary vasculature in idiopathic pulmonary arterial hypertension.

  2010cites this paper
• Targeting malonyl CoA inhibition of mitochondrial fatty acid uptake as an approach to treat cardiac ischemia/reperfusion

  2009cites this paper
• Innate short-circuiting of mitochondrial metabolism in cardiac hypertrophy: identification of novel consequences of enhanced anaplerosis.

  2009cites this paper
• Stimulation of cardiac fatty acid oxidation by leptin is mediated by a nitric oxide-p38 MAPK-dependent mechanism.

  2009cites this paper
• Transcriptome of hypertension-induced left ventricular hypertrophy and its regression by antihypertensive therapies

  2009cites this paper
• Metoprolol represses PGC1alpha-mediated carnitine palmitoyltransferase-1B expression in the diabetic heart.

  2009cites this paper
• Metabolic remodelling of the failing heart: beneficial or detrimental?

  2009cites this paper
• Real‐time assessment of Krebs cycle metabolism using hyperpolarized C magnetic resonance spectroscopy

  2009cites this paper
• The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: resuscitating the hibernating right ventricle

  2009influential citation
• Substrate–Enzyme Competition Attenuates Upregulated Anaplerotic Flux Through Malic Enzyme in Hypertrophied Rat Heart and Restores Triacylglyceride Content: Attenuating Upregulated Anaplerosis in Hypertrophy

  2009cites this paper
• Metoprolol increases the expression of beta(3)-adrenoceptors in the diabetic heart: effects on nitric oxide signaling and forkhead transcription factor-3.

  2008cites this paper
• Cyclic GMP signaling in cardiomyocytes modulates fatty acid trafficking and prevents triglyceride accumulation.

  2008cites this paper
• Ischemic Preconditioning: From Molecular Mechanisms to Therapeutic Opportunities

  2008cites this paper
• Metoprolol improves cardiac function and modulates cardiac metabolism in the streptozotocin-diabetic rat.

  2008cites this paper
• Metabolic remodelling of the failing heart: beneficial or detrimental?

  2008cites this paper
• AMPK and metabolic adaptation by the heart to pressure overload.

  2007cites this paper
• Attenuated cardioprotective response to bradykinin, but not classical ischaemic preconditioning, in DOCA-salt hypertensive left ventricular hypertrophy.

  2007cites this paper
• Recruitment of Compensatory Pathways to Sustain Oxidative Flux With Reduced Carnitine Palmitoyltransferase I Activity Characterizes Inefficiency in Energy Metabolism in Hypertrophied Hearts

  2007cites this paper
• Gender and post-ischemic recovery of hypertrophied rat hearts

  2006cites this paper
• Expression profiling reveals differences in metabolic gene expression between exercise‐induced cardiac effects and maladaptive cardiac hypertrophy

  2005cites this paper
• Gene expression of energy and protein metabolism in hearts of hypertensive nitric oxide- or GSH-depleted mice.

  2005cites this paper
• Regular exercise is associated with a protective metabolic phenotype in the rat heart.

  2004cites this paper
• Gene-environment interactions in wet beriberi: effects of thiamine depletion in CD36-defect rats.

  2003cites this paper
• Gene-environment interactions in wet beriberi : effects of thiamine depletion in CD 36-defect rats

  2003cites this paper
• Glycolysis and pyruvate oxidation in cardiac hypertrophy--why so unbalanced?

  2003cites this paper
• Accelerated rates of glycolysis in cardiac hypertrophy : are they a methodological artifact?

  2002influential citation