Mutational analysis of the Menkes copper P-type ATPase (ATP7A).

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Biochemical and Biophysical Research Communications - BBRC

• Publication date

  2003-02-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0006-291X(03)00010-XPMID 12565888
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Introducing Wilson disease mutations into the zinc-transporting P-type ATPase of Escherichia coli. The mutation P634L in the 'hinge' motif (GDGXNDXP) perturbs the formation of the E2P state.

  2002cited by this paper
• Copper-regulated Trafficking of the Menkes Disease Copper ATPase Is Associated with Formation of a Phosphorylated Catalytic Intermediate*

  2002cited by this paper
• The Regulation of Catalytic Activity of the Menkes Copper-translocating P-type ATPase

  2001cited by this paper
• 18O-exchange evidence that mutations of arginine in a signature sequence for P-type pumps affect inorganic phosphate binding.

  2001cited by this paper
• Effect of the toxic milk mutation (tx) on the function and intracellular localization of Wnd, the murine homologue of the Wilson copper ATPase.

  2001cited by this paper
• Structure-function analysis of purified Enterococcus hirae CopB copper ATPase: effect of Menkes/Wilson disease mutation homologues.

  2001cited by this paper
• 18O-Exchange Evidence That Mutations of Arginine in a Signature Sequence for P-Type Pumps Affect Inorganic Phosphate Binding†

  2001cited by this paper
• Genetic characterization of the (534)DPPR motif of the yeast plasma membrane H(+)-ATPase.

  2000cited by this paper
• Similar splice-site mutations of the ATP7A gene lead to different phenotypes: classical Menkes disease or occipital horn syndrome.

  2000cited by this paper
• Genetic characterization of the 534DPPR motif of the yeast plasma membrane H+-ATPase

  2000cited by this paper
• Copper-dependent trafficking of Wilson disease mutant ATP7B proteins.

  2000cited by this paper
• A Novel Method for Measurement of Submembrane ATP Concentration*

  2000cited by this paper
• The Role of GMXCXXC Metal Binding Sites in the Copper-induced Redistribution of the Menkes Protein*

  1999cited by this paper
• Functional Analysis of the N-terminal CXXC Metal-binding Motifs in the Human Menkes Copper-transporting P-type ATPase Expressed in Cultured Mammalian Cells*

  1999cited by this paper
• Defective copper-induced trafficking and localization of the Menkes protein in patients with mild and copper-treated classical Menkes disease.

  1999cited by this paper
• ATP‐dependent copper transport by the Menkes protein in membrane vesicles isolated from cultured Chinese hamster ovary cells

  1998cited by this paper
• Functional Expression of the Menkes Disease Protein Reveals Common Biochemical Mechanisms Among the Copper-transporting P-type ATPases*

  1998cited by this paper
• Functional analysis and intracellular localization of the human menkes protein (MNK) stably expressed from a cDNA construct in Chinese hamster ovary cells (CHO-K1).

  1998cited by this paper
• Evolution of Substrate Specificities in the P-Type ATPase Superfamily

  1998cited by this paper
• A Golgi localization signal identified in the Menkes recombinant protein.

  1998cited by this paper
• A C-terminal di-leucine is required for localization of the Menkes protein in the trans-Golgi network.

  1998cited by this paper
• Functional expression of the Wilson disease protein reveals mislocalization and impaired copper-dependent trafficking of the common H1069Q mutation.

  1998cited by this paper
• A proposal for the Mg2+ binding site of P-type ion motive ATPases and the mechanism of phosphoryl group transfer.

  1997cited by this paper
• Site-directed mutagenesis of the sodium pump: analysis of mutations to amino acids in the proposed nucleotide binding site by stable oxygen isotope exchange.

  1997cited by this paper
• Intrahepatic transplantation of normal hepatocytes prevents Wilson's disease in Long-Evans cinnamon rats.

  1996cited by this paper
• Structural organization, ion transport, and energy transduction of P-type ATPases.

  1996cited by this paper
• Topology prediction for helical transmembrane proteins at 86% accuracy–Topology prediction at 86% accuracy

  1996cited by this paper
• Ligand‐regulated transport of the Menkes copper P‐type ATPase efflux pump from the Golgi apparatus to the plasma membrane: a novel mechanism of regulated trafficking.

  1996cited by this paper
• Isolation of a candidate gene for Menkes disease that encodes a potential heavy metal binding protein

  1993cited by this paper
• The Wilson disease gene is a putative copper transporting P–type ATPase similar to the Menkes gene

  1993cited by this paper
• Isolation of a partial candidate gene for Menkes disease by positional cloning

  1993cited by this paper
• Isolation and characterization of a human liver cDNA as a candidate gene for Wilson disease.

  1993cited by this paper
• Isolation of a candidate gene for Menkes disease and evidence that it encodes a copper–transporting ATPase

  1993cited by this paper
• The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene

  1993cited by this paper
• The Metabolic basis of inherited disease

  1989cited by this paper
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper

• Genetics and Pathogenesis of Hemophagocytic Lymphohistiocytosis

  2018cites this paper
• Copper Homeostasis in Gram-Negative Bacteria

  2018cites this paper
• Copper and Bacteria: Evolution, Homeostasis and Toxicity

  2018influential citation
• A proteomic‐based investigation of potential copper‐responsive biomarkers: Proteins, conceptual networks, and metabolic pathways featuring Penicillium janthinellum from a heavy metal‐polluted ecological niche

  2017cites this paper
• Modulation and Functional Role of the Orientations of the N- and P-Domains of Cu+ -Transporting ATPase along the Ion Transport Cycle.

  2015cites this paper
• Metabolizm miedzi oraz charakterystyka dziedzicznych zespołów chorobowych, na tle niedoboru miedzi, spowodowanych zaburzeniami aktywności białka ATP7A

  2014cites this paper
• Copper Transporting ATPases in Mammalian Cells

  2013cites this paper
• In silico modeling of the Menkes copper-translocating P-type ATPase 3rd metal binding domain predicts that phosphorylation regulates copper-binding

  2011cites this paper
• The Lipid Acyl-Chain Dynamics in Giant Liposomes and Characterization of Domain 4 of the Wilson Disease Protein

  2010cites this paper
• Inherited defects in lymphocyte cytotoxic activity

  2010cites this paper
• Characterisation and expression of copper homeostasis genes in sea bream (Sparus aurata)

  2009cites this paper
• Delivery of the Cu-transporting ATPase ATP7B to the plasma membrane in Xenopus oocytes.

  2008cites this paper
• Characterization of the role of copper transporting ATPase, ATP7B (Wilsons disease protein), in copper homeostasis.

  2008cites this paper
• Trafficking of the copper-ATPases, ATP7A and ATP7B: role in copper homeostasis.

  2007cites this paper
• Hepatic copper-transporting ATPase ATP7B: function and inactivation at the molecular and cellular level

  2007cites this paper
• Function and regulation of human copper-transporting ATPases.

  2007influential citation
• Biochemical basis of regulation of human copper-transporting ATPases.

  2007cites this paper
• Purification and membrane reconstitution of catalytically active Menkes copper-transporting P-type ATPase (MNK; ATP7A).

  2007cites this paper
• A Single PDZ Domain Protein Interacts with the Menkes Copper ATPase, ATP7A

  2005cites this paper
• Introducing Wilson disease mutations into ZntA : Studies on the nucleotide and metal-binding sites of a bacterial zinc-translocating P-type ATPase

  2004cites this paper
• Copper stimulates trafficking of a distinct pool of the Menkes copper ATPase (ATP7A) to the plasma membrane and diverts it into a rapid recycling pool.

  2004cites this paper
• The Distinct Functional Properties of the Nucleotide-binding Domain of ATP7B, the Human Copper-transporting ATPase*

  2004cites this paper
• Signals regulating trafficking of Menkes (MNK; ATP7A) copper-translocating P-type ATPase in polarized MDCK cells.

  2004cites this paper
• The nucleotide-binding domain of the Zn2+-transporting P-type ATPase from Escherichia coli carries a glycine motif that may be involved in binding of ATP.

  2004cites this paper
• Molecular modelling of the nucleotide-binding domain of Wilson's disease protein: location of the ATP-binding site, domain dynamics and potential effects of the major disease mutations.

  2004cites this paper