Inhibition of Bcr serine kinase by tyrosine phosphorylation

No abstract is available for this paper.

• Publication year

  1996

• Venue

  Molecular and Cellular Biology

• Publication date

  1996-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.16.3.998PMID 8622703PMCID PMC231082
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS

  1995cited by this paper
• Differential complementation of Bcr-Abl point mutants with c-Myc.

  1994influential reference
• Bcr‐Abl oncoproteins bind directly to activators of the Ras signalling pathway.

  1994cited by this paper
• Tyrosine phosphorylation of P160 BCR by P210 BCR-ABL.

  1993cited by this paper
• Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

  1993cited by this paper
• SH1 domain autophosphorylation of P210 BCR/ABL is required for transformation but not growth factor independence

  1993cited by this paper
• BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein.

  1993cited by this paper
• BCR-ABL tyrosine kinase is autophosphorylated or transphosphorylates P160 BCR on tyrosine predominantly within the first BCR exon.

  1993cited by this paper
• Site-directed mutagenesis of virtually any plasmid by eliminating a unique site.

  1992influential reference
• The BCR gene encodes a novel serine/threonine kinase activity within a single exon.

  1991cited by this paper
• Activation of tyrosinase kinase and microfilament-binding functions of c-abl by bcr sequences in bcr/abl fusion proteins

  1991cited by this paper
• A manual sequencing method for identification of phosphorylated amino acids in phosphopeptides.

  1991cited by this paper
• Current status of the BCR gene and its involvement with human leukemia.

  1991cited by this paper
• Regulatory phosphorylation of the p34cdc2 protein kinase in vertebrates.

  1991cited by this paper
• Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates.

  1991cited by this paper
• Acute leukaemia in bcr/abl transgenic mice

  1990cited by this paper
• P210 BCR-ABL is complexed to P160 BCR and ph-P53 proteins in K562 cells.

  1990cited by this paper
• Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome.

  1990cited by this paper
• Characterization of bcr gene products in hematopoietic cells.

  1989cited by this paper
• Altered phosphorylation and activation of pp60c-src during fibroblast mitosis.

  1988influential reference
• Evidence that the phl gene encodes a 160,000-dalton phosphoprotein with associated kinase activity.

  1987cited by this paper
• 6 Viral Oncogenes and Tyrosine Phosphorylation

  1986cited by this paper
• The human cellular abl gene product in the chronic myelogenous leukemia cell line K562 has an associated tyrosine protein kinase activity.

  1985cited by this paper
• Evidence of a new chimeric bcr/c-abl mRNA in patients with chronic myelocytic leukemia and the Philadelphia chromosome.

  1985cited by this paper
• Fused transcript of abl and bcr genes in chronic myelogenous leukaemia

  1985cited by this paper
• An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity.

  1984cited by this paper
• Reaction of the adenine nucleotide analogue 5'-p-fluorosulfonylbenzoyl adenosine at distinct tyrosine and cysteine residues of rabbit muscle pyruvate kinase.

  1981influential reference
• Transforming gene product of Rous sarcoma virus phosphorylates tyrosine

  1980influential reference

• MEK1/2 regulate normal BCR and ABL1 tumor-suppressor functions to dictate ATO response in TKI-resistant Ph+ leukemia

  2023cites this paper
• Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-mediated Targeted Protein Degradation.

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• Molecular processes involved in B cell acute lymphoblastic leukaemia

  2017cites this paper
• Opening the door to the development of novel Abl kinase inhibitors.

  2016cites this paper
• BCR: a new target in resistance mediated by BCR/ABL-315I?

  2016cites this paper
• The Functional Interplay Between the t(9;22)-Associated Fusion Proteins BCR/ABL and ABL/BCR in Philadelphia Chromosome-Positive Acute Lymphatic Leukemia

  2015cites this paper
• Induced by Bcr-Abl Cytokine-independent Outgrowth of Myeloid Leukemia Cells The c-Fes Protein-Tyrosine Kinase Suppresses

  2013cites this paper
• p210 bcr-abl In Vivo Signalling by Oncoprotein Tyrosine Kinase Protein Tyrosine Phosphatase 1B Antagonizes

  2013cites this paper
• Regulation of dendritic arborization by BCR Rac1 GTPase-activating protein, a substrate of PTPRT

  2012cites this paper
• BIOLOGICAL MECHANISMS AND CLINICAL IMPLICATIONS OF BCR-ABL-INDUCED MITOCHONDRIAL OXIDATIVE STRESS AND CELL SURVIVAL IN CHRONIC MYELOID LEUKEMIA

  2012cites this paper
• The isolation and characterisation of MHC-presented peptides from CML-derived cell-lines, with a focus on post-translational modification

  2011cites this paper
• Localisation, activity and targeting of Bcr-Abl in chronic myeloid leukaemia

  2011cites this paper
• ORIGINAL ARTICLE Janus kinase 2 regulates Bcr-Abl signaling in chronic myeloid leukemia

  2011cites this paper
• Janus kinase 2 regulates Bcr–Abl signaling in chronic myeloid leukemia

  2010cites this paper
• Functional proteomics of Bcr-Abl signaling

  2009cites this paper
• Mobilité cellulaire induite par les chimères Bcr-Abl : un nouveau modèle pour l'exploration des voies effectrices des petites protéines G de la famille Rho

  2008cites this paper
• Kinase domain mutants of Bcr enhance Bcr-Abl oncogenic effects

  2008cites this paper
• Protein kinases that phosphorylate 14-3-3 isoforms

  2006cites this paper
• Bcr is a negative regulator of the Wnt signalling pathway

  2005cites this paper
• The BCR-ABL story: bench to bedside and back.

  2004cites this paper
• Signal transduction pathways in Bcr-Abl transformed cells.

  2004cites this paper
• Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53

  2004cites this paper
• Preparation and Application of Polyclonal and Monoclonal Sequence‐Specific Anti‐Phosphoamino Acid Antibodies

  2003cites this paper
• Molecular pathogenesis of chronic myeloid leukaemia

  2003cites this paper
• Phosphotyrosine Mapping in Bcr/Abl Oncoprotein Using Phosphotyrosine-specific Immonium Ion Scanning*

  2003cites this paper
• Bcr and Abl interaction: oncogenic activation of c-Abl by sequestering Bcr.

  2003cites this paper
• Molecular cloning and characterization of the guinea pig cholinephosphotransferase gene.

  2003cites this paper
• Advances in Brief Bcr and Abl Interaction : Oncogenic Activation of c-Abl by Sequestering Bcr 1

  2003cites this paper
• The Bcr Kinase Downregulates Ras Signaling by Phosphorylating AF-6 and Binding to Its PDZ Domain

  2003influential citation
• The Role of IFN in Tumor Resistance

  2003cites this paper
• Recognition of multiple substrate motifs by the c-ABL protein tyrosine kinase.

  2002cites this paper
• Differential expression of cholinephosphotransferase in normal and cancerous human mammary epithelial cells.

  2002cites this paper
• Studying the pathogenesis of BCR–ABL+ leukemia in mice

  2002cites this paper
• Inhibition of the Bcr-Abl oncoprotein by Bcr requires phosphoserine 354.

  2002cites this paper
• Studying the pathogenesis of BCR–ABL+ leukemia in mice

  2002cites this paper
• Bcr: a negative regulator of the Bcr-Abl oncoprotein in leukemia

  2002cites this paper
• Phosphorylation on tyrosine-15 of p34(Cdc2) by ErbB2 inhibits p34(Cdc2) activation and is involved in resistance to taxol-induced apoptosis.

  2002cites this paper
• Molecular Biology of Chronic Myeloid Leukemia

  2001cites this paper
• Preparation and application of antibodies to phosphoamino acid sequences.

  2001cites this paper
• BCR gene expression blocks Bcr-Abl induced pathogenicity in a mouse model

  2001influential citation
• Expression of a truncated first exon BCR sequence in chronic myelogenous leukemia cells blocks cell growth and induces cell death.

  2001cites this paper
• Expression of bcr–abl mRNA in individual chronic myelogenous leukaemia cells as determined by in situ amplification

  2001cites this paper
• The NH2-Terminal Coiled-Coil Domain and Tyrosine 177 Play Important Roles in Induction of a Myeloproliferative Disease in Mice by Bcr-Abl

  2001cites this paper
• The BCR gene and philadelphia chromosome-positive leukemogenesis.

  2001cites this paper
• Expression on human eosinophils of CD148: a membrane tyrosine phosphatase. Implications in the effector function of eosinophils

  2000cites this paper
• The molecular biology of chronic myeloid leukemia.

  2000cites this paper
• Cytoplasmic and nuclear localization of the 130 and 160 kDa Bcr proteins

  2000cites this paper
• The c-Fes protein-tyrosine kinase suppresses cytokine-independent outgrowth of myeloid leukemia cells induced by Bcr-Abl.

  2000cites this paper
• Bcr-Abl with an SH3 Deletion Retains the Ability To Induce a Myeloproliferative Disease in Mice, yet c-Abl Activated by an SH3 Deletion Induces Only Lymphoid Malignancy

  1999cites this paper
• Polarized distribution of Bcr-Abl in migrating myeloid cells and co-localization of Bcr-Abl and its target proteins

  1999cites this paper
• Molecular pathogenesis of chronic myeloid leukemia: implications for new therapeutic strategies

  1999cites this paper
• Bcr: a negative regulator of the Bcr-Abl oncoprotein

  1999cites this paper
• CD148, a new membrane tyrosine phosphatase involved in leukocyte function.

  1999cites this paper
• Peptide containing the BCR oligomerization domain (AA 1-160) reverses the transformed phenotype of p210bcr–abl positive 32D myeloid leukemia cells

  1998cites this paper
• Requirement of two specific tyrosine residues for the catalytic activity of Bcr serine/threonine kinase

  1998cites this paper
• Bcr/Abl associated leukemogenesis in bcr null mutant mice

  1998cites this paper
• Antagonistic effects of ABL and BCRABL proteins on proliferation and the response to genotoxic stress in normal and leukemic myeloid cells.

  1998cites this paper
• Protein Tyrosine Phosphatase 1B Antagonizes Signalling by Oncoprotein Tyrosine Kinase p210 bcr-abl In Vivo

  1998cites this paper
• p 210 bcr-abl In Vivo Signalling by Oncoprotein Tyrosine Kinase Protein Tyrosine Phosphatase 1 B Antagonizes

  1998cites this paper
• The involvement of Bcr in leukemias with the Philadelphia chromosome.

  1998cites this paper
• Effect of Bcr sequences on the cellular function of the Bcr-Abl oncoprotein

  1997cites this paper
• Bcr phosphorylated on tyrosine 177 binds Grb2

  1997cites this paper
• The molecular biology of chronic myeloid leukaemia.

  1996cites this paper
• Sequences within the first exon of BCR inhibit the activated tyrosine kinases of c-Abl and the Bcr-Abl oncoprotein.

  1996influential citation
• Co-expression with BCR Induces Activation of the FES Tyrosine Kinase and Phosphorylation of Specific N-terminal BCR Tyrosine Residues*

  1996cites this paper