Lymphocyte apoptosis: induction by gene transfer techniques

No abstract is available for this paper.

• Publication year

  1997

• Venue

  Gene Therapy

• Publication date

  1997-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.gt.3300394PMID 9176514
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Target-induced death by apoptosis in human lymphokine-activated natural killer cells.

  1996cited by this paper
• Retroviral vector-mediated transfer of the tumor necrosis factor alpha gene into human cancer cells restores an apoptotic cell death program and induces a bystander-killing effect.

  1996cited by this paper
• Two pathways of exocytosis of cytoplasmic granule contents and target cell killing by cytokine-induced CD3+ CD56+ killer cells.

  1995cited by this paper
• Receptor-induced death in human natural killer cells: involvement of CD16

  1995cited by this paper
• Ligand binding to Fc gamma R induces c-myc-dependent apoptosis in IL-2-stimulated NK cells.

  1995cited by this paper
• IL-2 and IL-7 but not IL-12 protect natural killer cells from death by apoptosis and up-regulate bcl-2 expression.

  1995cited by this paper
• Cytokines and clinical gene therapy

  1995cited by this paper
• Cytokines and gene therapy.

  1995cited by this paper
• Receptor-Mediated Gene Transfer into Human T Lymphocytes via Binding of DNA/CD3 Antibody Particles to the CD3 T Cell Receptor Complex

  1995cited by this paper
• Calcineurin mediates human tumor necrosis factor alpha gene induction in stimulated T and B cells

  1994cited by this paper
• Propagation of large numbers of T cells with natural killer cell markers

  1994cited by this paper
• Lipopolysaccharide is a frequent contaminant of plasmid DNA preparations and can be toxic to primary human cells in the presence of adenovirus.

  1994cited by this paper
• A novel population of expanded human CD3+CD56+ cells derived from T cells with potent in vivo antitumor activity in mice with severe combined immunodeficiency.

  1994cited by this paper
• Treatment of 283 consecutive patients with metastatic melanoma or renal cell cancer using high-dose bolus interleukin 2.

  1994cited by this paper
• Upregulation of tumor necrosis factor-alpha production by retrovirally transduced human tumor-infiltrating lymphocytes using trans-retinoic acid.

  1994cited by this paper
• Tumor necrosis factor alpha (TNF alpha) downregulates c-kit proto-oncogene product expression in normal and acute myeloid leukemia CD34+ cells via p55 TNF alpha receptors.

  1994cited by this paper
• Tumour necrosis factor-induced cytotoxicity is accompanied by intracellular mitogenic signals in ME-180 human cervical carcinoma cells.

  1993cited by this paper
• Functional and molecular characterization of tumor-infiltrating lymphocytes transduced with tumor necrosis factor-alpha cDNA for the gene therapy of cancer in humans.

  1993cited by this paper
• Randomized phase III trial of treatment with high-dose interleukin-2 either alone or in combination with interferon alfa-2a in patients with advanced melanoma.

  1993cited by this paper
• Non-viral approaches to gene therapy.

  1993cited by this paper
• Transduction of human melanoma cell lines with the human interleukin-7 gene using retroviral-mediated gene transfer: comparison of immunologic properties with interleukin-2.

  1993cited by this paper
• Rapid transgene expression in lymphocyte and macrophage primary cultures after particle bombardment-mediated gene transfer.

  1993cited by this paper
• Propriocidal apoptosis of mature T lymphocytes occurs at S phase of the cell cycle

  1993cited by this paper
• Ligand-induced apoptosis of mature T lymphocytes (propriocidal regulation) occurs at distinct stages of the cell cycle.

  1993cited by this paper
• Apoptosis and disease.

  1993cited by this paper
• The expression of C-jun and junB mRNA in renal cell cancer and in vitro regulation by transforming growth factor beta 1 and tumor necrosis factor alpha 1.

  1992cited by this paper
• A comparative study of IL-12 (cytotoxic lymphocyte maturation factor)-, IL-2-, and IL-7-induced effects on immunomagnetically purified CD56+ NK cells.

  1992cited by this paper
• Cellular signaling in thymocyte apoptosis.

  1992cited by this paper
• Transcription of the tumor necrosis factor alpha gene is rapidly induced by anti-immunoglobulin and blocked by cyclosporin A and FK506 in human B cells.

  1992cited by this paper
• In vivo evaluation of the effects of interleukins 2, 4 and 7 on enhancing the immunotherapeutic efficacy of anti‐tumor cytotoxic T lymphocytes

  1991cited by this paper
• Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis.

  1991cited by this paper
• Use of a SCID mouse/human lymphoma model to evaluate cytokine-induced killer cells with potent antitumor cell activity

  1991cited by this paper
• Interleukin 7 induces CD4+ T cell-dependent tumor rejection

  1991cited by this paper
• Interleukin 7 enhances cytolytic T lymphocyte generation and induces lymphokine-activated killer cells from human peripheral blood

  1990cited by this paper
• Gene transfer into humans--immunotherapy of patients with advanced melanoma, using tumor-infiltrating lymphocytes modified by retroviral gene transduction.

  1990cited by this paper
• Tumor necrosis factor alpha down-regulates c-myc mRNA expression and induces in vitro monocytic differentiation in fresh blast cells from patients with acute myeloblastic leukemia.

  1990cited by this paper
• Induction of murine lymphokine-activated killer cells by recombinant IL-7.

  1990cited by this paper
• A new approach to the adoptive immunotherapy of cancer with tumor-infiltrating lymphocytes.

  1986cited by this paper
• Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis

  1984cited by this paper
• Lymphokine-activated killer cell phenomenon. Lysis of natural killer- resistant fresh solid tumor cells by interleukin 2-activated autologous human peripheral blood lymphocytes

  1982cited by this paper
• Apoptosis: A Basic Biological Phenomenon with Wide-ranging Implications in Tissue Kinetics

  1972cited by this paper

• Barcoded screening identifies nanocarriers for protein delivery to kidney

  2025cites this paper
• SLC15A3 plays a crucial role in pulmonary fibrosis by regulating macrophage oxidative stress

  2024cites this paper
• Caspase inhibition improves viability and efficiency of liposomal transfection

  2023cites this paper
• Apolipoprotein C3 facilitates internalization of cationic lipid nanoparticles into bone marrow-derived mouse mast cells

  2023cites this paper
• In vivo imaging of nanoparticle-labeled CAR T cells

  2022cites this paper
• Delivery strategies of RNA therapeutics for ex vivo and in vivo B-cell malignancies

  2022cites this paper
• Non-viral siRNA delivery to T cells: Challenges and opportunities in cancer immunotherapy.

  2022cites this paper
• Mechanical Stimulation after Centrifuge-Free Nano-Electroporative Transfection Is Efficient and Maintains Long-Term T Cell Functionalities.

  2021cites this paper
• Hydrogel‐Induced Cell Membrane Disruptions Enable Direct Cytosolic Delivery of Membrane‐Impermeable Cargo

  2021cites this paper
• DNA/RNA heteroduplex oligonucleotide technology for regulating lymphocytes in vivo

  2021cites this paper
• Non-invasive cell-tracking methods for adoptive T cell therapies.

  2021cites this paper
• Emerging Roles of 1D Vertical Nanostructures in Orchestrating Immune Cell Functions

  2020cites this paper
• Charge-Altering Releasable Transporters Enable Specific Phenotypic Manipulation of Resting Primary Natural Killer Cells

  2020cites this paper
• Functionalization Of T Lymphocytes With Citrate-Coated Superparamagnetic Iron Oxide Nanoparticles For Magnetically Controlled Immune Therapy

  2019cites this paper
• T cells loaded with magnetic nanoparticles are retained in peripheral lymph nodes by the application of a magnetic field

  2019cites this paper
• NAD-linked mechanisms of gene de-repression and a novel role for CtBP in persistent adenovirus infection of lymphocytes

  2019cites this paper
• Identification and characterization of new factors regulating the phenotype of Th17 and Th22 cells

  2018cites this paper
• Enhanced mRNA delivery into lymphocytes enabled by lipid-varied libraries of charge-altering releasable transporters

  2018cites this paper
• Electroporation characteristics of human primary T cells

  2018cites this paper
• Viable and efficient electroporation-based genetic manipulation of unstimulated human T cells

  2018cites this paper
• Development of Chimeric Cas9 Nucleases for Accurate and Flexible Genome Editing

  2017cites this paper
• A novel rapid and reproducible flow cytometric method for optimization of transfection efficiency in cells

  2017cites this paper
• Current Progress in Non-viral RNAi-Based Delivery Strategies to Lymphocytes.

  2017cites this paper
• iBAC Technologies for Neurological Disease

  2016cites this paper
• Restoring anti-tumor functions of T cells via nanoparticle-mediated immune checkpoint modulation.

  2016cites this paper
• Developing peptide technologies to combat cancer and monogenetic disorders

  2016cites this paper
• The role of the GRB2 family of adaptor proteins in T cell receptor-mediated signaling

  2015cites this paper
• Rigorous optimization and validation of potent RNA CAR T cell therapy for the treatment of common epithelial cancers expressing folate receptor

  2015cites this paper
• Optimization of Methods for the Genetic Modification of Human T Cells

  2015cites this paper
• T cells and reactive oxygen species

  2015cites this paper
• Large volume flow electroporation of mRNA: clinical scale process.

  2013cites this paper
• An Efficient Low Cost Method for Gene Transfer to T Lymphocytes

  2013cites this paper
• Approaches for Studying the Role(s) of Gap Junctions in the Immune System

  2013cites this paper
• Low Voltage Pulse Application to Biological Cells

  2013cites this paper
• Reduction of CD147 surface expression on primary T cells leads to enhanced cell proliferation.

  2012cites this paper
• High transfection efficiency of porcine peripheral blood T cells via nucleofection.

  2011cites this paper
• Dependence on electric field intensities of cell biological effects induced by microsecond pulsed electric fields

  2011cites this paper
• Induction of apoptosis in sonoporation and ultrasonic gene transfer.

  2009cites this paper
• Non-viral Mediated Gene Delivery for Therapeutic Applications

  2006cites this paper
• Efficient nonviral gene delivery into primary lymphocytes from rats and mice

  2006cites this paper
• High-efficiency transfection of primary human and mouse T lymphocytes using RNA electroporation.

  2006cites this paper
• ΠΑΝΕΠΙΣΤΗΜΙΟ ΠΑΤΡΩΝ

  2006cites this paper
• Intracellular trafficking of nonviral vectors

  2005cites this paper
• The therapeutic potential of ex vivo expanded natural killer (NK) cells for immunotherapy of cancer

  2005cites this paper
• Genetic modification of hematopoietic stem cells with nonviral systems: past progress and future prospects

  2005cites this paper
• Cytokine-induced killer cells showing multidrug resistance and remaining cytotoxic activity to tumor cells after transfected with mdr1 cDNA.

  2004cites this paper
• Gene transfection into fetal sheep airways in utero using guanidinium‐cholesterol cationic lipids

  2004cites this paper
• Gene transfer into human T lymphocytes and natural killer cells by Ad5/F35 chimeric adenoviral vectors.

  2004cites this paper
• Nanosecond, high‐intensity pulsed electric fields induce apoptosis in human cells

  2003cites this paper
• Aberrant T‐Cell Receptor Signalling of Interferon‐γ‐ and Tumour Necrosis Factor‐α‐Producing Cytotoxic CD8+ Vδ1/Vβ16 T Cells in a Patient with Chronic Neutropenia

  2003cites this paper
• Aberrant T-cell receptor signalling of interferon-gamma- and tumour necrosis factor-alpha-producing cytotoxic CD8+ Vdelta1/Vbeta16 T cells in a patient with chronic neutropenia.

  2003cites this paper
• Diverse Effects of Nanosecond Pulsed Electric Fields on Cells and Tissues

  2003influential citation
• Gene Therapy of Lymphoma

  2002cites this paper
• Efficiency of lipofection of adherent cells is limited by apoptosis.

  2002cites this paper
• Receptor-mediated gene delivery to human peripheral blood mononuclear cells using anti-CD3 antibody coupled to polyethylenimine

  2001cites this paper
• Differential Apoptosis Effects of Primate Lentiviral Vpr and Vpx in Mammalian Cells

  2000cites this paper
• Tumorantigen-gepulste dendritische Zellen zur Steigerung der Zytotoxizität immunologischer Effektorzellen bei Tumoren des gastroenteropankreatischen Systems

  2000cites this paper
• High-level transgene expression in primary human T lymphocytes and adult bone marrow CD34+ cells via electroporation-mediated gene delivery

  2000cites this paper
• Neuronal Control of the Immune Response in the Central Nervous System: From Pathogenesis to Therapy

  2000cites this paper
• Human T lymphocyte genetic modification with naked DNA.

  2000cites this paper
• Induction of Apoptosis in B Lymphoma Cells by Activation with CD40L

  2000cites this paper
• Increase in proliferation rate and normalization of TNF-α secretion by blockage of gene transfer–induced apoptosis in lymphocytes using low-dose cyclosporine A

  2000cites this paper
• Apoptosis in cancer: therapeutic implications.

  2000cites this paper
• Comparison of non-viral transfection methods in melanoma cell primary cultures.

  2000cites this paper
• Deterin, a New Inhibitor of Apoptosis from Drosophila melanogaster *

  2000cites this paper
• Neuro-Immune Interactions in Neurologic and Psychiatric Disorders

  2000cites this paper
• Differential apoptosis effects of primate lentiviral Vpr and Vpx in mammalian cells.

  2000cites this paper
• Apoptosis induced by DNA uptake limits transfection efficiency.

  1999cites this paper
• Gene transfer into CD4+ T lymphocytes: Green fluorescent protein-engineered, encephalitogenic T cells illuminate brain autoimmune responses

  1999cites this paper
• Ligand—Polycation Conjugates for Receptor-Targeted Gene Transfer

  1999cites this paper
• Phase I clinical study applying autologous immunological effector cells transfected with the interleukin-2 gene in patients with metastatic renal cancer, colorectal cancer and lymphoma

  1999cites this paper
• Successful Transfection of Lymphocytes by Ternary Lipoplexes

  1999cites this paper
• Opportunities and challenges in targeting genes for therapy

  1999cites this paper
• Apoptosis: a novel therapeutic tool?

  1998cites this paper
• Cell death and cancer: replacement of apoptotic genes and inactivation of death suppressor genes in therapy

  1998cites this paper
• Ligand-targeted receptor-mediated vectors for gene delivery

  1998cites this paper
• Increase of proliferation rate and enhancement of antitumor cytotoxicity of expanded human CD3+CD56+ immunologic effector cells by receptor-mediated transfection with the interleukin-7 gene

  1998cites this paper
• Increase of cytotoxic sensitivity of primary human melanoma cells transfected with the interleukin-7 gene to autologous and allogeneic immunologic effector cells.

  1997cites this paper