A new antioxidant compound H-290/51 attenuates nitric oxide synthase and heme oxygenase expression following hyperthermic brain injury

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Amino Acids

• Publication date

  Unknown publication date

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1007/s007260070069PMID 11026509
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Pathophysiology of hyperthermic brain injury. Current concepts, molecular mechanisms and pharmacological strategies.

  2000cited by this paper
• Pathophysiology of blood-brain barrier, brain edema and cell injury following hyperthermia : New role of heat shock protein, nitric oxide and carbon monoxide : an experimental study in rat using light and electron microscopy

  1999cited by this paper
• Nitric oxide in the pathophysiology of hyperthermic brain injury. Influence of a new anti-oxidant compound H-290/51

  1998cited by this paper
• Blood-brain barrier in stress: a gateway to various brain diseases.

  1998cited by this paper
• Nitric oxide and carbon monoxide in the brain pathology of heat stress.

  1998cited by this paper
• Neurobiology of the nitric oxide in the nervous system

  1998cited by this paper
• Pathophysiology of brain edema and cell changes following hyperthermic brain injury.

  1998cited by this paper
• Involvement of Nitric Oxide in the Pathophysiology of Acute Heat Stress in the Rat

  1997influential reference
• Involvement of nitric oxide in the pathophysiology of acute heat stress in the rat. Influence of a new antioxidant compound H-290/51.

  1997cited by this paper
• Role of neurochemicals in brain edema and cell changes following hyperthermic brain injury in the rat.

  1997cited by this paper
• Opioid Receptor Antagonists Attenuate Heat Stress‐Induced Reduction in Cerebral Blood Flow, Increased Blood‐Brain Barrier Permeability, Vasogenic Edema and Cell Changes in the Rat a

  1997cited by this paper
• Upregulation of hemeoxygenase-II in the rat spinal cord following heat stress

  1997cited by this paper
• Induction of heme oxygenase-1 (HO-1) in glia after traumatic brain injury.

  1996cited by this paper
• Nitric oxide neurotoxicity.

  1996influential reference
• The Biological Significance and Physiological Role of Heme Oxygenase

  1996influential reference
• Biochemical opening of the blood-brain barrier.

  1995cited by this paper
• The Neurobiology of NO・ and ・OH

  1994cited by this paper
• Gases as biological messengers: nitric oxide and carbon monoxide in the brain

  1994cited by this paper
• Effect of hyperthermia on the central nervous system: a review.

  1994cited by this paper
• Carbon monoxide: a putative neural messenger.

  1993influential reference
• Nitric oxide synthase in the rat anterior pituitary gland and the role of nitric oxide in regulation of luteinizing hormone secretion.

  1993cited by this paper
• Physiology and Pharmacology of the Blood-Brain Barrier

  1992cited by this paper
• Nitric oxide modulates microvascular permeability.

  1992cited by this paper
• Nitric oxide, a novel neuronal messenger.

  1992influential reference
• Rapid induction of heme oxygenase 1 mRNA and protein by hyperthermia in rat brain: heme oxygenase 2 is not a heat shock protein.

  1991influential reference
• Brain oedema and cellular changes induced by acute heat stress in young rats.

  1990cited by this paper
• Mediators of Blood-Brain Barrier Dysfunction and Formation of Vasogenic Brain Edema

  1988cited by this paper
• Effect of captopril (a converting enzyme inhibitor) on blood-brain barrier permeability and cerebral blood flow in normotensive rats.

  1987cited by this paper
• Influence of long-term acute heat exposure on regional blood-brain barrier permeability, cerebral blood flow and 5-HT level in conscious normotensive young rats.

  1987cited by this paper
• Probable involvement of 5-hydroxytryptamine in increased permeability of blood-brain barrier under heat stress in young rats.

  1986cited by this paper
• Role of 5-HT on increased permeability of blood-brain barrier under heat stress.

  1984cited by this paper
• Brain edema: pathology, diagnosis, and therapy. Introduction.

  1980cited by this paper

• Nanodelivery of traditional Chinese Gingko Biloba extract EGb-761 and bilobalide BN-52021 induces superior neuroprotective effects on pathophysiology of heat stroke.

  2021cites this paper
• Topical application of CNTF, GDNF and BDNF in combination attenuates blood-spinal cord barrier permeability, edema formation, hemeoxygenase-2 upregulation, and cord pathology.

  2021cites this paper
• Memantine protects blood-brain barrier integrity and attenuates neurological deficits through inhibiting nitric oxide synthase ser1412 phosphorylation in intracerebral hemorrhage rats: involvement of peroxynitrite-related matrix metalloproteinase-9/NLRP3 inflammasome activation.

  2021cites this paper
• Upregulation of hemeoxygenase enzymes HO-1 and HO-2 following ischemia-reperfusion injury in connection with experimental cardiac arrest and cardiopulmonary resuscitation: Neuroprotective effects of methylene blue.

  2021cites this paper
• Methamphetamine exacerbates pathophysiology of traumatic brain injury at high altitude. Neuroprotective effects of nanodelivery of a potent antioxidant compound H-290/51.

  2021cites this paper
• Transcriptomic and biochemical effects of pycnogenol in ameliorating heat stress-related oxidative alterations in rats.

  2020cites this paper
• Mild traumatic brain injury exacerbates Parkinson's disease induced hemeoxygenase-2 expression and brain pathology: Neuroprotective effects of co-administration of TiO2 nanowired mesenchymal stem cells and cerebrolysin.

  2020cites this paper
• Exacerbation of blood-brain barrier breakdown, edema formation, nitric oxide synthase upregulation and brain pathology after heat stroke in diabetic and hypertensive rats. Potential neuroprotection with cerebrolysin treatment.

  2019cites this paper
• Assessment of the protective effect of KN‐93 drug in systemic epilepsy disorders induced by pilocarpine in male rat

  2019cites this paper
• Histaminergic Receptors Modulate Spinal Cord Injury-Induced Neuronal Nitric Oxide Synthase Upregulation and Cord Pathology: New Roles of Nanowired Drug Delivery for Neuroprotection.

  2017cites this paper
• Cold Environment Exacerbates Brain Pathology and Oxidative Stress Following Traumatic Brain Injuries: Potential Therapeutic Effects of Nanowired Antioxidant Compound H-290/51

  2017influential citation
• EFFECTS OF A NOVEL INHIBITOR OF LIPID PEROXIDATION ON INJURY CAUSED BY OXIDATIVE STRESS AND ISCHEMIA-REPERFUSION

  2016cites this paper
• Cardiac Arrest Alters Regional Ubiquitin Levels in Association with the Blood–Brain Barrier Breakdown and Neuronal Damages in the Porcine Brain

  2015cites this paper
• TiO2-Nanowired Delivery of Mesenchymal Stem Cells Thwarts Diabetes- Induced Exacerbation of Brain Pathology in Heat Stroke: An Experimental Study in the Rat Using Morphological and Biochemical Approaches.

  2015cites this paper
• Administration of S-methyl-L-thiocitrulline protects against brain injuries after intracerebral hemorrhage.

  2014cites this paper
• cerebellar Purkinje cells of rats Heme oxygenase-1 aggravates heat stress-induced neuronal injury and decreases autophagy in

  2013cites this paper
• Heme oxygenase-1 aggravates heat stress-induced neuronal injury and decreases autophagy in cerebellar Purkinje cells of rats

  2013cites this paper
• Superior neuroprotective effects of cerebrolysin in nanoparticle-induced exacerbation of hyperthermia-induced brain pathology.

  2012cites this paper
• Nanowired drug delivery for neuroprotection in central nervous system injuries: modulation by environmental temperature, intoxication of nanoparticles, and comorbidity factors.

  2012cites this paper
• Prolonged latency to CNS-O2 toxicity induced by heat acclimation in rats is associated with increased antioxidative defenses and metabolic energy preservation.

  2012cites this paper
• Superior neuroprotective effects of cerebrolysin in heat stroke following chronic intoxication of Cu or Ag engineered nanoparticles. A comparative study with other neuroprotective agents using biochemical and morphological approaches in the rat.

  2011cites this paper
• Spatiotemporal nuclear factor interleukin‐6 expression in the rat brain during lipopolysaccharide‐induced fever is linked to sustained hypothalamic inflammatory target gene induction

  2011cites this paper
• Heat stress and ischemia/reperfusion cause oxidative stress via NADPH oxidase in hypothalamic neurons

  2009cites this paper
• Temperature disturbances in traumatic brain injury: relationship to secondary insults, barbiturate treatment and outcome

  2008cites this paper
• Interaction between amino acid neurotransmitters and opioid receptors in hyperthermia-induced brain pathology.

  2007cites this paper
• Neurotrophic factors in combination: a possible new therapeutic strategy to influence pathophysiology of spinal cord injury and repair mechanisms.

  2007cites this paper
• Drugs of abuse-induced hyperthermia, blood-brain barrier dysfunction and neurotoxicity: neuroprotective effects of a new antioxidant compound H-290/51.

  2007cites this paper
• Post-injury treatment with a new antioxidant compound H-290/51 attenuates spinal cord trauma-induced c-fos expression, motor dysfunction, edema formation, and cell injury in the rat.

  2006cites this paper
• Heat Stress Induces Downregulation of Hippocampal Superoxide Dismutase-1; a Possible Mechanism for Heat-Related Neuronal Cell Death

  2006cites this paper
• Zinc protoporphyrin IX attenuates closed head injury-induced edema formation, blood-brain barrier disruption, and serotonin levels in the rat.

  2006cites this paper
• Secondary Insults in Neurointensive Care of Patients with Traumatic Brain Injury

  2005cites this paper
• Role of Nitric Oxide on the Blood–Brain and Spinal Cord Barriers

  2004cites this paper
• The Heat Shock Proteins and Hemeoxygenase Response in Central Nervous System Injuries

  2004cites this paper
• Pathophysiology of the Blood–Spinal Cord Barrier in Traumatic Injury

  2004cites this paper
• Hyperthermia following traumatic brain injury: a critical evaluation.

  2003influential citation
• Heat acclimation prolongs the time to central nervous system oxygen toxicity in the rat. Possible involvement of HSP72.

  2003cites this paper
• Analysis of heme oxygenase isomers in rat.

  2002cites this paper
• A new antioxidant compound H-290/51 modulates glutamate and GABA immunoreactivity in the rat spinal cord following trauma

  2002cites this paper
• Nitric oxide synthase inhibitors in?uence dynorphin A (1–17) immunoreactivity in the rat brain following hyperthermia

  2002influential citation
• The effect of a low molecular weight inhibitor of lipid peroxidation on ultrastructural alterations to ischemia-reperfusion in the isolated rat heart.

  2001cites this paper