HapMap tag-SNP analysis confirms a role for COMT in schizophrenia risk and reveals a novel association

No abstract is available for this paper.

• Publication year

  2012

• Venue

  European psychiatry

• Publication date

  2012-07-01

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1016/j.eurpsy.2010.08.004PMID 20934310
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Gender‐specific COMT Val158Met polymorphism association in Spanish schizophrenic patients

  2009cited by this paper
• Meta-analysis of association between genetic variants in COMT and schizophrenia: an update.

  2009cited by this paper
• Evidence of epistasis between the catechol-O-methyltransferase and aldehyde dehydrogenase 3B1 genes in paranoid schizophrenia.

  2009cited by this paper
• Genetic susceptibility to schizophrenia: role of dopaminergic pathway gene polymorphisms.

  2009cited by this paper
• A network of dopaminergic gene variations implicated as risk factors for schizophrenia.

  2008cited by this paper
• No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics.

  2008cited by this paper
• Differential association of the COMT Val158Met polymorphism with clinical phenotypes in schizophrenia and bipolar disorder.

  2008cited by this paper
• A second generation human haplotype map of over 3.1 million SNPs

  2007cited by this paper
• New functional single nucleotide polymorphism (Ala72Ser) in the COMT gene is associated with aggressive behavior in male schizophrenia

  2007cited by this paper
• Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder.

  2006cited by this paper
• Impact of complex genetic variation in COMT on human brain function

  2006cited by this paper
• JLIN: A java based linkage disequilibrium plotter

  2006cited by this paper
• Lack of association of the COMT (Val158/108 Met) gene and schizophrenia: a meta-analysis of case–control studies

  2005cited by this paper
• Behavioral and Brain Functions

  2005cited by this paper
• Association of Ala72Ser polymorphism with COMT enzyme activity and the risk of schizophrenia in Koreans

  2005influential reference
• Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain.

  2004cited by this paper
• WINPEPI (PEPI-for-Windows): computer programs for epidemiologists

  2004cited by this paper
• Catechol-O-methyltransferase gene Val108/158Met polymorphism, and susceptibility to schizophrenia: association is more significant in women.

  2004cited by this paper
• Family‐based and case–control study of catechol‐O‐methyltransferase in schizophrenia among Palestinian Arabs

  2003cited by this paper
• Association between a functional catechol O-methyltransferase gene polymorphism and schizophrenia: meta-analysis of case-control and family-based studies.

  2003cited by this paper
• A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain.

  2003cited by this paper
• Association between Val108/158 met polymorphism of the COMT gene and schizophrenia

  2003cited by this paper
• A highly significant association between a COMT haplotype and schizophrenia.

  2002cited by this paper
• Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia

  2001cited by this paper
• Catecholamines in patients with 22q11.2 deletion syndrome and the low-activity COMT polymorphism

  2001cited by this paper
• Methylation pharmacogenetics: catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase.

  1999cited by this paper
• 22q11 deletion syndrome: a genetic subtype of schizophrenia.

  1999cited by this paper
• Linkage disequilibrium on the COMT gene in French schizophrenics and controls.

  1999cited by this paper
• Association study of a functional catechol-O-methyltransferase gene polymorphism in Japanese schizophrenics.

  1998cited by this paper
• 22q11 deletion syndrome in adults with schizophrenia.

  1998cited by this paper
• Velocardiofacial manifestations and microdeletions in schizophrenic inpatients.

  1997cited by this paper
• Association of codon 108/158 catechol-O-methyltransferase gene polymorphism with the psychiatric manifestations of velo-cardio-facial syndrome.

  1996cited by this paper
• Preferential transmission of the high activity allele of COMT in schizophrenia

  1996cited by this paper
• Controlling the false discovery rate: a practical and powerful approach to multiple testing

  1995cited by this paper
• Psychometric properties of the positive and negative syndrome scale (PANSS) in schizophrenia.

  1994influential reference
• Chromosomal mapping of the human catechol-O-methyltransferase gene to 22q11.1----q11.2.

  1992cited by this paper
• Enzymatic O-methylation of epinephrine and other catechols.

  1958cited by this paper

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  2025cites this paper
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  2022cites this paper
• Schizophrenia spectrum and other psychotic disorders.

  2020cites this paper
• Depressive symptoms in schizophrenia and dopamine and serotonin gene polymorphisms

  2017influential citation
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  2016cites this paper
• A Tetra-Primer Amplification Refractory System Technique for the Cost-Effective and Novel Genotyping of Eight Single-Nucleotide Polymorphisms of the Catechol-O-Methyltransferase Gene

  2016cites this paper
• Stress, COMT Polymorphisms, and Depressive Symptoms in Older Australian Women: An Exploratory Study

  2016cites this paper
• Interaction of multiple gene variants and their effects on schizophrenia phenotypes.

  2016cites this paper
• Effect of Polymorphisms of Three Genes Mediating Monoamine Signalling on Brain Morphometry in Schizophrenia and Healthy Subjects

  2015cites this paper
• Proinflammatory genotype is associated with the frailty phenotype in the English Longitudinal Study of Ageing

  2015cites this paper
• Association of Histamine N-Methyltransferase Thr105Ile Polymorphism with Parkinson’s Disease and Schizophrenia in Han Chinese: A Case-Control Study

  2015cites this paper
• No association of catechol-O-methyltransferase (COMT) gene haplotypes in patients with schizophrenia in a Turkish sample

  2015cites this paper
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  2015cites this paper
• Association of the COMT and DRD2 Genes with the Ability of Schizophrenia Patients to Understand the Mental State of Other People

  2014cites this paper
• Genetic association of catechol-O-methyltransferase val(158)met polymorphism in Saudi schizophrenia patients.

  2014influential citation
• Polymorphisms in genes implicated in dopamine, serotonin and noradrenalin metabolism suggest association with cerebrospinal fluid monoamine metabolite concentrations in psychosis

  2014cites this paper
• Genome-wide DNA methylation analysis of human brain tissue from schizophrenia patients

  2014cites this paper
• Exploring Gene-Treatment Interactions: Dissociated Effect of COMT Val108/158Met Genotype on Negative Symptoms Response to Haloperidol and Risperidone Vs Clozapine

  2014cites this paper
• Subclinical Psychotic Experiences in Healthy Young Adults: Associations with Stress and Genetic Predisposition

  2014influential citation
• Gene-sex interactions in schizophrenia: focus on dopamine neurotransmission

  2014cites this paper
• [The association of COMT and DRD2 gene polymorphisms with a cognitive ability to understand others in schizophrenic patients].

  2013cites this paper
• Pharmacogenetics of Psychoactive Drugs

  2012cites this paper
• No association between catechol-o-methyltransferase Val108/158Met polymorphism and schizophrenia or its clinical symptomatology in a Mexican population

  2012cites this paper
• Genetic and functional analyses of early growth response (EGR) family genes in schizophrenia.

  2012cites this paper
• A novel SNP in COMT is associated with alcohol dependence but not opiate or nicotine dependence: a case control study

  2011influential citation