The potential role of MLC phosphatase and MAPK signalling in the pathogenesis of vascular dysfunction in heart failure

•  Clinical syndrome of heart failure •  Regulation of smooth muscle contractility •  Ca2+ sensitization •  Ca2+ desensitization •  MYPT1 isoforms and the sensitivity to cGMP •  cGMP and MYPT1 phosphorylation •  Vascular function and cGMP signalling •  Captopril therapy and MYPT1 Expression in HF •  Captopril therapy and gene expression •  Conclusions

• Publication year

  2008

• Venue

  Journal of Cellular and Molecular Medicine

• Publication date

  2008-10-13

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1582-4934.2008.00536.xPMID 19120700PMCID 2811849
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Uterine artery myosin phosphatase isoform switching and increased sensitivity to SNP in a rat L-NAME model of hypertension of pregnancy.

  2008cited by this paper
• High blood pressure arising from a defect in vascular function

  2008cited by this paper
• Gene Expression Profiles of Vascular Smooth Muscle Show Differential Expression of Mitogen-Activated Protein Kinase Pathways during Captopril Therapy of Heart Failure

  2008cited by this paper
• Cyclic GMP regulation of myosin phosphatase: a new piece for the puzzle?

  2007influential reference
• Controlling Gene Expression through RNA Regulons: The Role of the Eukaryotic Translation Initiation Factor eIF4E

  2007cited by this paper
• Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system.

  2007cited by this paper
• cGMP-Dependent Relaxation of Smooth Muscle Is Coupled With the Change in the Phosphorylation of Myosin Phosphatase

  2007influential reference
• Conditioning Effect of Blood Flow on Resistance Artery Smooth Muscle Myosin Phosphatase

  2007cited by this paper
• PHI‐1 interacts with the catalytic subunit of myosin light chain phosphatase to produce a Ca2+ independent increase in MLC20 phosphorylation and force in avian smooth muscle

  2006influential reference
• Reactive oxygen species signaling in vascular smooth muscle cells.

  2006cited by this paper
• Myosin phosphatase isoform switching in vascular smooth muscle development.

  2006cited by this paper
• Smooth muscle of telokin-deficient mice exhibits increased sensitivity to Ca2+ and decreased cGMP-induced relaxation

  2006cited by this paper
• The p38 mitogen-activated protein kinase signaling cascade in CD4 T cells

  2006cited by this paper
• Captopril prevents myosin light chain phosphatase isoform switching to preserve normal cGMP-mediated vasodilatation.

  2006influential reference
• Modulation of vascular smooth muscle signaling by reactive oxygen species.

  2006influential reference
• Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system.

  2005cited by this paper
• Actions Downstream of Cyclic GMP/Protein Kinase G Can Reverse Protein Kinase C-mediated Phosphorylation of CPI-17 and Ca2+Sensitization in Smooth Muscle*

  2004influential reference
• Unzipping the Role of Myosin Light Chain Phosphatase in Smooth Muscle Cell Relaxation*

  2004cited by this paper
• Molecular mechanisms regulating the myofilament response to Ca2+: Implications of mutations causal for familial hypertrophic cardiomyopathy

  2004cited by this paper
• Dynamic changes in expression of myosin phosphatase in a model of portal hypertension.

  2004cited by this paper
• Inhibitors of Protein Kinase Signaling Pathways: Emerging Therapies for Cardiovascular Disease

  2004cited by this paper
• Vascular Reactivity in Heart Failure: Role of Myosin Light Chain Phosphatase

  2004cited by this paper
• Cross-regulation between the renin-angiotensin system and inflammatory mediators in cardiac hypertrophy and failure.

  2004cited by this paper
• Smooth Muscle Phosphatase Is Regulated in Vivo by Exclusion of Phosphorylation of Threonine 696 of MYPT1 by Phosphorylation of Serine 695 in Response to Cyclic Nucleotides*

  2004influential reference
• Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase.

  2003influential reference
• TAO (Thousand-and-one Amino Acid) Protein Kinases Mediate Signaling from Carbachol to p38 Mitogen-activated Protein Kinase and Ternary Complex Factors*

  2003influential reference
• GDE1/MIR16 is a glycerophosphoinositol phosphodiesterase regulated by stimulation of G protein-coupled receptors

  2003cited by this paper
• Improving clinical outcomes with drug treatment in heart failure: what have trials taught?

  2003influential reference
• Heart failure.

  2003cited by this paper
• The AT(1)-type angiotensin receptor in oxidative stress and atherogenesis: part I: oxidative stress and atherogenesis.

  2002cited by this paper
• Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases

  2002cited by this paper
• The AT(1)-type angiotensin receptor in oxidative stress and atherogenesis: Part II: AT(1) receptor regulation.

  2002cited by this paper
• Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions.

  2001influential reference
• Activation of Myosin Light Chain Phosphatase in Intact Arterial Smooth Muscle During Nitric Oxide-induced Relaxation*

  2001influential reference
• Cytokines and Cytokine Receptors in Advanced Heart Failure: An Analysis of the Cytokine Database from the Vesnarinone Trial (VEST)

  2001cited by this paper
• Theodore Cooper Lecture: Tissue angiotensin and pathobiology of vascular disease: a unifying hypothesis.

  2001cited by this paper
• Site-specific Phosphorylation and Point Mutations of Telokin Modulate Its Ca2+-desensitizing Effect in Smooth Muscle*

  2001cited by this paper
• Role of Myosin Phosphatase Isoforms in cGMP-mediated Smooth Muscle Relaxation*

  2001cited by this paper
• Oxidative Stress in Arterial Hypertension: Role of NAD(P)H Oxidase

  2001cited by this paper
• Ca2+-independent Smooth Muscle Contraction

  2001cited by this paper
• Zipper-interacting Protein Kinase Induces Ca2+-free Smooth Muscle Contraction via Myosin Light Chain Phosphorylation*

  2001influential reference
• Impaired endothelium-mediated vasodilation is not the principal cause of vasoconstriction in heart failure.

  2000cited by this paper
• Determinants of the contractile properties in the embryonic chicken gizzard and aorta.

  2000cited by this paper
• Agonists Trigger G Protein-mediated Activation of the CPI-17 Inhibitor Phosphoprotein of Myosin Light Chain Phosphatase to Enhance Vascular Smooth Muscle Contractility*

  2000cited by this paper
• Signal transduction by G‐proteins, Rho‐kinase and protein phosphatase to smooth muscle and non‐muscle myosin II

  2000cited by this paper
• cGMP‐mediated phosphorylation of heat shock protein 20 may cause smooth muscle relaxation without myosin light chain dephosphorylation in swine carotid artery

  2000cited by this paper
• Increased NADH-oxidase-mediated superoxide production in the early stages of atherosclerosis: evidence for involvement of the renin-angiotensin system.

  1999cited by this paper
• Interactions between angiotensin II and nitric oxide during exercise in normal and heart failure rats.

  1999influential reference
• Inhibitory Phosphorylation Site for Rho-associated Kinase on Smooth Muscle Myosin Phosphatase*

  1999cited by this paper
• Cyclic GMP-dependent Protein Kinase Activates Cloned BKCa Channels Expressed in Mammalian Cells by Direct Phosphorylation at Serine 1072*

  1999cited by this paper
• Regulation of myosin phosphatase by a specific interaction with cGMP- dependent protein kinase Ialpha.

  1999influential reference
• The Large Conductance, Voltage-dependent, and Calcium-sensitive K+ Channel, Hslo, Is a Target of cGMP-dependent Protein Kinase Phosphorylation in Vivo *

  1998cited by this paper
• Acceleration of Myosin Light Chain Dephosphorylation and Relaxation of Smooth Muscle by Telokin

  1998cited by this paper
• Distinct molecular phenotypes in murine cardiac muscle development, growth, and hypertrophy.

  1998cited by this paper
• Myosin light chain phosphatase: subunit composition, interactions and regulation

  1998influential reference
• Role of NADH/NADPH oxidase-derived H2O2 in angiotensin II-induced vascular hypertrophy.

  1998influential reference
• Changes in skeletal muscle biochemistry and histology relative to fiber type in rats with heart failure.

  1997influential reference
• Differential effect of hydrogen peroxide and superoxide anion on apoptosis and proliferation of vascular smooth muscle cells.

  1997influential reference
• Reactive oxygen species induce apoptosis of vascular smooth muscle cell

  1997influential reference
• Impaired nitric oxide-mediated renal vasodilation in rats with experimental heart failure: role of angiotensin II.

  1997cited by this paper
• Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

  1996cited by this paper
• Selective activation of the mitogen-activated protein kinase subgroups c-Jun NH2 terminal kinase and p38 by IL-1 and TNF in human articular chondrocytes.

  1996influential reference
• A novel protein phosphatase-1 inhibitory protein potentiated by protein kinase C. Isolation from porcine aorta media and characterization.

  1995cited by this paper
• Characterization of the myosin-binding subunit of smooth muscle myosin phosphatase.

  1994cited by this paper
• Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.

  1994cited by this paper
• The nitric oxide and cGMP signal transduction system: regulation and mechanism of action.

  1993cited by this paper
• Impaired endothelium-mediated vasodilation in the peripheral vasculature of patients with congestive heart failure.

  1992influential reference
• Myosin light chain phosphatase activities and the effects of phosphatase inhibitors in tonic and phasic smooth muscle.

  1992cited by this paper
• Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial. The SAVE Investigators.

  1992influential reference
• Ventricular function and contractile proteins in the infarcted overloaded rat heart.

  1991influential reference
• A comparison of enalapril with hydralazine-isosorbide dinitrate in the treatment of chronic congestive heart failure.

  1991cited by this paper
• Endothelium‐Dependent Vasodilation Is Attenuated in Patients With Heart Failure

  1991cited by this paper
• Heart failure: mechanisms of cardiac and vascular dysfunction and the rationale for pharmacologic intervention

  1990influential reference
• Regional variation in rat cardiac myosin isoenzymes and ATPase activity after infarction.

  1989influential reference
• Heart failure depresses endothelium-dependent responses in canine femoral artery.

  1989influential reference
• Calcium‐force relationships as detected with aequorin in two different vascular smooth muscles of the ferret.

  1985cited by this paper
• The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

  1980cited by this paper
• Myocardial Infarct Size and Ventricular Function in Rats

  1979influential reference
• Sustained reduction of cardiac impedance and preload in congestive heart failure with the antihypertensive vasodilator prazosin.

  1977cited by this paper
• Heart Failure

  1937cited by this paper

• Astrocytes from lamina cribrosa are involved in the autoregulatory function of optic nerve head vessels in vitro

  2025cites this paper
• Molecular and metabolic landscape of adenosine triphosphate-induced cell death in cardiovascular disease

  2024cites this paper
• Signaling pathways and targeted therapy for myocardial infarction

  2022cites this paper
• The antihypertensive effect of MK on spontaneously hypertensive rats through the AMPK/Akt/eNOS/NO and ERK1/2/Cx43 signaling pathways

  2021cites this paper
• A self‐organized actomyosin drives multiple intercellular junction disruption and directly promotes neutrophil recruitment in lipopolysaccharide‐induced acute lung injury

  2018influential citation
• Revisiting the Role of TRP, Orai, and ASIC Channels in the Pulmonary Arterial Response to Hypoxia

  2018cites this paper
• Efectos de 2-aminoetildifenilborinato en la expresión de quinasas y mitógenos involucrados en la regulación del estado contráctil de arterias pulmonares de corderos con hipertensión pulmonar

  2017cites this paper
• Myosin phosphatase isoforms and related transcripts in the pig coronary circulation and effects of exercise and chronic occlusion.

  2015cites this paper
• Isoproterenol Induces Vascular Oxidative Stress and Endothelial Dysfunction via a Giα-Coupled β2-Adrenoceptor Signaling Pathway

  2014cites this paper
• Brain natriuretic peptide protects against hyperresponsiveness of human asthmatic airway smooth muscle via an epithelial cell-dependent mechanism.

  2014cites this paper
• Pravastatin slows the progression of heart failure by inhibiting the c-Jun N-terminal kinase-mediated intrinsic apoptotic signaling pathway.

  2013cites this paper
• Proteomics screen to reveal molecular changes mediated by C722G missense mutation in CHRM2 gene.

  2013cites this paper
• Altered Reactivity of Tertiary Mesenteric Arteries following Acute Myocardial Ischemia

  2012cites this paper
• Dietary genistein enhances phosphorylation of regulatory myosin light chain in the myocardium of ovariectomized mice

  2012cites this paper
• The myosin phosphatase targeting protein (MYPT) family: a regulated mechanism for achieving substrate specificity of the catalytic subunit of protein phosphatase type 1δ.

  2011cites this paper
• Influence of elastin-derived peptides, glucose, LDL and oxLDL on nitric oxide synthase expression in human umbilical artery endothelial cells.

  2011cites this paper
• Hypoxia modulates the expression of leucine zipper-positive MYPT1 and its interaction with protein kinase G and Rho kinases in pulmonary arterial smooth muscle cells

  2011cites this paper
• Proteomic analysis of metabolic, cytoskeletal and stress response proteins in human heart failure

  2011cites this paper
• Role of rho kinase in the functional and dysfunctional tonic smooth muscles.

  2011cites this paper
• Heterogeneity in relaxation of different sized porcine coronary arteries to nitrovasodilators: role of PKG and MYPT1

  2011cites this paper
• Protein Kinases as Drug Development Targets for Heart Disease Therapy

  2010cites this paper
• World Journal of Cardiology

  year unknowncites this paper