Characterization of chemically induced hepatotoxicity in collagen sandwiches of rat hepatocytes.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Toxicological Sciences

• Publication date

  2005-06-01

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1093/TOXSCI/KFI145PMID 15772367
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Decreased expression levels of rat liver glutathione S-transferase A2 and albumin during the acute phase response are mediated by HNF1 (hepatic nuclear factor 1) and IL6DEX-NP.

  2004cited by this paper
• Hepatotoxicity and Mechanism of Action of Haloalkanes: Carbon Tetrachloride as a Toxicological Model

  2003cited by this paper
• Long-Term Stable Cultures of Rat Hepatocytes: An in Vitro Model to Study Acute and Chronic Hepatic Inflammation

  2002cited by this paper
• Functional Behavior of Primary Rat Liver Cells in a Three-Dimensional Perfused Microarray Bioreactor

  2002cited by this paper
• Vinyl acetate-induced intracellular acidification: implications for risk assessment.

  2002cited by this paper
• Acetaminophen Hepatotoxicity: The First 35 Years

  2002cited by this paper
• Regulation of cell morphology and cytochrome P450 expression in human hepatocytes by extracellular matrix and cell-cell interactions

  2001cited by this paper
• Paracetamol (Acetaminophen)-Induced Toxicity: Molecular and Biochemical Mechanisms, Analogues and Protective Approaches

  2001cited by this paper
• Effects of epidermal growth factor on CYP inducibility by xenobiotics, DNA replication, and caspase activations in collagen I gel sandwich cultures of rat hepatocytes.

  2001cited by this paper
• Mechanisms of cadmium‐mediated acute hepatotoxicity

  2000cited by this paper
• Expression and regulation of cytochrome P450 enzymes in primary cultures of human hepatocytes

  2000influential reference
• Biotransformation of trichloroethylene in collagen gel sandwich cultures of rat hepatocytes

  2000cited by this paper
• Metabolism of para-aminophenol by rat hepatocytes.

  2000cited by this paper
• Biliary excretion in primary rat hepatocytes cultured in a collagen-sandwich configuration.

  1999cited by this paper
• Effect of epidermal growth factor in collagen gel cultures of rat hepatocytes.

  1999cited by this paper
• Development of a small-scale bioreactor for drug metabolism studies maintaining hepatospecific functions.

  1998cited by this paper
• Long‐term expression of differentiated functions in hepatocytes cultured in three‐dimensional collagen matrix

  1998cited by this paper
• Activation and detoxication of aflatoxin B1.

  1998cited by this paper
• Role of β1 Integrin Distribution in Morphology and Function of Collagen-Sandwiched Hepatocytes

  1997cited by this paper
• Drug metabolism in hepatocyte sandwich cultures of rats and humans.

  1997influential reference
• Effect of cell density and epidermal growth factor on the inducible expression of CYP3A and CYP1A genes in human hepatocytes in primary culture

  1997cited by this paper
• Mechanism of action of dietary chemoprotective agents in rat liver: induction of phase I and II drug metabolizing enzymes and aflatoxin B1 metabolism.

  1997cited by this paper
• Cell-cell interactions are essential for maintenance of hepatocyte function in collagen gel but not on matrigel.

  1997cited by this paper
• Strategies for restoration and maintenance of normal hepatic structure and function in long-term cultures of rat hepatocytes

  1996cited by this paper
• Suppression of constitutive cytochrome P450 gene expression by epidermal growth factor receptor ligands in cultured rat hepatocytes.

  1996cited by this paper
• Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF and TGF alpha in a chemically defined (HGM) medium

  1996influential reference
• Culture matrix configuration and composition in the maintenance of hepatocyte polarity and function.

  1996cited by this paper
• Rat hepatocytes with elevated metallothionein expression are resistant to N-methyl-N'-nitro-N-nitrosoguanidine cytotoxicity.

  1996cited by this paper
• The activity of cytochrome P450IA1 in stable cultured rat hepatocytes.

  1995influential reference
• Use of organotypical cultures of primary hepatocytes to analyse drug biotransformation in man and animals.

  1994cited by this paper
• Effect of collagen gel configuration on the cytoskeleton in cultured rat hepatocytes.

  1993cited by this paper
• Hepatocytes in collagen sandwich: evidence for transcriptional and translational regulation

  1992cited by this paper
• Isolation of heparan sulfate proteoglycan from beneath the monolayers of rat hepatocytes and its binding to type IV collagen

  1991cited by this paper
• Long‐Term in Vitro Function of Adult Hepatocytes in a Collagen Sandwich Configuration

  1991cited by this paper
• Importance of protein thiols during N-methyl-N'-nitro-N-nitrosoguanidine toxicity in primary rat hepatocytes.

  1990cited by this paper
• Cell-cell and cell-matrix interactions differentially regulate the expression of hepatic and cytoskeletal genes in primary cultures of rat hepatocytes.

  1988cited by this paper

• Drug-induced liver injury

  2019cites this paper
• Primary hepatocytes and their cultures for the testing of drug-induced liver injury.

  2019cites this paper
• TGFβ1-mediated suppression of cytochrome P450(CYP) induction responses in rat hepatocyte-fibroblast co-cultures.

  2018cites this paper
• OriginaIArtiele An in vivo comet assay of multiple organs < liver , kidney and bone marrow ) in mice treated with methyl methanesulfonate and acetaminophen accompanied by hematology andlor blood chemistry

  2018cites this paper
• Multi-Cellular Organotypic Liver Models for the Investigation of Chemical Toxicity and Liver Fibrosis

  2018cites this paper
• In Vitro Intestinal and Liver Models for Toxicity Testing.

  2017cites this paper
• Scaffold‐Free Liver‐On‐A‐Chip with Multiscale Organotypic Cultures

  2017cites this paper
• Studies on the biological functions of CPS1 in AFB1 induced hepatocarcinogenesis.

  2016cites this paper
• Determination of liver specific toxicities in rat hepatocytes by high content imaging during 2-week multiple treatment.

  2015cites this paper
• Valproic acid biotransformation and toxicity in sandwich-cultured rat hepatocytes

  2014cites this paper
• Hepatocytes maintain greater fluorescent bile acid accumulation and greater sensitivity to drug‐induced cell death in three‐dimensional matrix culture

  2014cites this paper
• Water residing in small ultrastructural spaces plays a critical role in the mechanical behavior of bone.

  2014cites this paper
• Sandwich-cultured hepatocytes: utility for in vitro exploration of hepatobiliary drug disposition and drug-induced hepatotoxicity

  2013cites this paper
• In vitro testicular toxicity models: opportunities for advancement via biomedical engineering techniques.

  2013cites this paper
• Primary hepatocyte cultures for pharmaco-toxicological studies: at the busy crossroad of various anti-dedifferentiation strategies

  2013cites this paper
• Application of quantitative time-lapse imaging (QTLI) for evaluation of Mrp2-based drug-drug interaction induced by liver metabolites.

  2012cites this paper
• Proteomics in the search for mechanisms and biomarkers of drug-induced hepatotoxicity.

  2012cites this paper
• Toxicology of dimethyl and monomethyl derivatives of acetamide and formamide: a second update

  2012cites this paper
• Chapter 9 - Potential of ‘Omics’ Technologies for Implementation in Research on Phytotherapeutical Toxicology

  2012cites this paper
• A robust high-throughput sandwich cell-based drug screening platform.

  2011cites this paper
• Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes.

  2011cites this paper
• Paracetamol treatment increases telomerase activity in rat embryonic liver cells

  2011cites this paper
• Toxicogenomics and Animal Alternatives

  2011cites this paper
• Enhancement of the predicted drug hepatotoxicity in gel entrapped hepatocytes within polysulfone-g-poly (ethylene glycol) modified hollow fiber.

  2010cites this paper
• Adipocyte‐derived basement membrane extract with biological activity: applications in hepatocyte functional augmentation in vitro

  2010cites this paper
• Three-dimensional culture of hepatocytes for prediction of drug-induced hepatotoxicity

  2010influential citation
• Hepatocyte differentiation.

  2010cites this paper
• Liver tissue engineering in the evaluation of drug safety

  2009cites this paper
• An in vivo comet assay of multiple organs (liver, kidney and bone marrow) in mice treated with methyl methanesulfonate and acetaminophen accompanied by hematology and/or blood chemistry.

  2008cites this paper
• Primary hepatocytes as a model to analyze species-specific toxicity and drug metabolism.

  2008cites this paper
• Primary hepatocytes as a model to analyze species-specific toxicity and drug metabolism

  2008cites this paper
• Identification and characterization of a novel prespheroid 3-dimensional hepatocyte monolayer on galactosylated substratum.

  2007cites this paper
• Primary culture of rat hepatocytes in 96-well plates: effects of extracellular matrix configuration on cytochrome P450 enzyme activity and inducibility, and its application in in vitro cytotoxicity screening.

  2007cites this paper
• A sandwich-cultured rat hepatocyte system with increased metabolic competence evaluated by gene expression profiling.

  2007cites this paper
• An in vitro model for long-term hepatotoxicity testing utilizing rat hepatocytes entrapped in micro-hollow fiber reactor

  2007cites this paper
• Isoniazid-induced hepatotoxicity in rat hepatocytes of gel entrapment culture.

  2006cites this paper
• Characterization of the secreted proteome of rat hepatocytes cultured in collagen sandwiches.

  2005cites this paper
• Identification and Characterization of a Novel Prespheroid 3-Dimensional Hepatocyte Monolayer on Galactosylated Substratum

  year unknowncites this paper
• Non-commercial Research and Educational Use including without Limitation Use in Instruction at Your Institution, Sending It to Specific Colleagues That You Know, and Providing a Copy to Your Institution's Administrator. All Other Uses, Reproduction and Distribution, including without Limitation Comm

  year unknowncites this paper