Mixed lineage leukemia: roles in human malignancies and potential therapy

No abstract is available for this paper.

• Publication year

  2010

• Venue

  The FEBS Journal

• Publication date

  2010-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1742-4658.2010.07608.xPMID 20236311
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Gene expression profiling-based dissection of MLL translocated and MLL germline acute lymphoblastic leukemia in infants.

  2010cited by this paper
• The AF4.MLL fusion protein is capable of inducing ALL in mice without requirement of MLL.AF4.

  2010cited by this paper
• New insights to the MLL recombinome of acute leukemias

  2009cited by this paper
• Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells

  2009cited by this paper
• KLF4 and PBX1 Directly Regulate NANOG Expression in Human Embryonic Stem Cells

  2009cited by this paper
• Two independent gene signatures in pediatric t(4;11) acute lymphoblastic leukemia patients

  2009cited by this paper
• Misguided Transcriptional Elongation Causes Mixed Lineage Leukemia

  2009cited by this paper
• HOXA9 is required for survival in human MLL-rearranged acute leukemias.

  2009cited by this paper
• Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling.

  2008cited by this paper
• Identification of an antiapoptotic protein complex at death receptors

  2008cited by this paper
• Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy

  2008cited by this paper
• Menin critically links MLL proteins with LEDGF on cancer-associated target genes.

  2008cited by this paper
• Glycogen synthase kinase-3 inhibition induces glioma cell death through c-MYC, nuclear factor-kappaB, and glucose regulation.

  2008cited by this paper
• In childhood acute lymphoblastic leukemia, blasts at different stages of immunophenotypic maturation have stem cell properties.

  2008cited by this paper
• Modeling chromosomal translocations using conditional alleles to recapitulate initiating events in human leukemias.

  2008cited by this paper
• H3K79 methylation profiles define murine and human MLL-AF4 leukemias.

  2008cited by this paper
• Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark.

  2007cited by this paper
• The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling.

  2007cited by this paper
• FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress.

  2007cited by this paper
• Combined effects of the two reciprocal t(4;11) fusion proteins MLL·AF4 and AF4·MLL confer resistance to apoptosis, cell cycling capacity and growth transformation

  2007cited by this paper
• Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential.

  2007cited by this paper
• Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation

  2007cited by this paper
• Spliced MLL fusions: a novel mechanism to generate functional chimeric MLL-MLLT1 transcripts in t(11;19)(q23;p13.3) leukemia

  2007cited by this paper
• The role of HOX genes in malignant myeloid disease

  2007cited by this paper
• A crosstalk between the Wnt and the adhesion-dependent signaling pathways governs the chemosensitivity of acute myeloid leukemia

  2006cited by this paper
• Controlling the elongation phase of transcription with P-TEFb.

  2006cited by this paper
• Persistent Transactivation by Meis1 Replaces Hox Function in Myeloid Leukemogenesis Models: Evidence for Co-Occupancy of Meis1-Pbx and Hox-Pbx Complexes on Promoters of Leukemia-Associated Genes

  2006cited by this paper
• KLF4, p21 and context-dependent opposing forces in cancer

  2006cited by this paper
• MLL associates specifically with a subset of transcriptionally active target genes.

  2005cited by this paper
• Octamer and Sox Elements Are Required for Transcriptional cis Regulation of Nanog Gene Expression

  2005cited by this paper
• Global and Hox-specific roles for the MLL1 methyltransferase.

  2005cited by this paper
• Interaction of MLL amino terminal sequences with menin is required for transformation.

  2005cited by this paper
• Continuous MLL-ENL expression is necessary to establish a "Hox Code" and maintain immortalization of hematopoietic progenitor cells.

  2005cited by this paper
• The eleven-nineteen-leukemia protein ENL connects nuclear MLL fusion partners with chromatin

  2005cited by this paper
• Modulation of cell cycle by graded expression of MLL-AF4 fusion oncoprotein

  2004cited by this paper
• Mechanisms of transformation by MLL.

  2004cited by this paper
• Leukemia Proto-Oncoprotein MLL Forms a SET1-Like Histone Methyltransferase Complex with Menin To Regulate Hox Gene Expression

  2004cited by this paper
• Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment.

  2004cited by this paper
• Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation.

  2004cited by this paper
• The human LASP1 gene is fused to MLL in an acute myeloid leukemia with t(11;17)(q23;q21)

  2003cited by this paper
• Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression.

  2003cited by this paper
• p21Cip1 Gene Expression Is Modulated by Egr1

  2003cited by this paper
• Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9.

  2003cited by this paper
• Pharmacological inhibitors of cyclin-dependent kinases.

  2002cited by this paper
• ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation.

  2002cited by this paper
• The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia

  2001cited by this paper
• MLL-ENL causes a reversible and myc-dependent block of myelomonocytic cell differentiation.

  2001cited by this paper
• Flavopiridol Inhibits P-TEFb and Blocks HIV-1 Replication*

  2000cited by this paper
• HRX Leukemic Fusion Proteins Form a Heterocomplex with the Leukemia-associated Protein SET and Protein Phosphatase 2A*

  1997cited by this paper
• Gene Transfer into Hematopoietic Stem Cells of Nonhuman Primates

  1996cited by this paper
• Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275.

  1992cited by this paper
• A trithorax–like gene is interrupted by chromosome 11q23 translocations in acute leukaemias

  1992cited by this paper
• Molecular characterization of the trithorax gene, a positive regulator of homeotic gene expression in Drosophila.

  1991cited by this paper
• Cloning and molecular characterization of the trithorax locus of Drosophila melanogaster.

  1989cited by this paper

• The clinical observation of none-promyelocytic AML patients inducted with idarubicin or daunorubicin included standard regimens: a tertiary care center experience

  2025cites this paper
• The differential expression of AFF3 in cervical cancer and its correlation with clinicopathological features and prognosis

  2024cites this paper
• Megakaryocyte progenitor cell function is enhanced upon aging despite the functional decline of aged hematopoietic stem cells

  2021cites this paper
• The Clot Thickens: Recent Clues on Hematopoietic Stem Cell Contribution to Age-Related Platelet Biology Open New Questions

  2021cites this paper
• Bisphenol A affects endometrial stromal cells decidualization, involvement of epigenetic regulation.

  2020cites this paper
• Integrated transcriptomic and epigenetic data analysis identifiesaberrant expression of genes in acute myeloid leukemia with MLL-AF9 translocation

  2019cites this paper
• The hunt for RNA polymerase II elongation factors: a historical perspective

  2019cites this paper
• MLL1 promotes myogenesis by epigenetically regulating Myf5

  2019cites this paper
• Chromatin-Remodeled State in Lymphoma

  2019cites this paper
• Bioinformatics Analysis of Differentially Expressed Genes and Their Functional Enrichment in Acute Myeloid Leukemia Bearing MLL Translocation

  2019cites this paper
• Development of novel PROTAC Small-Molecule Degraders of MDM2 Protein and Peptidomimetic Inhibitors Targeting WDR5-MLL1 Protein-Protein Interaction

  2018cites this paper
• Isolation of MLL1 Inhibitory RNA Aptamers

  2018cites this paper
• Targeting protein-protein interaction between MLL1 and reciprocal proteins for leukemia therapy.

  2018cites this paper
• Molecular biomarkers in acute myeloid leukemia.

  2017cites this paper
• Epigenetic regulation of NOTCH1 and NOTCH3 by KMT2A inhibits glioma proliferation

  2017cites this paper
• TGFβ/SMAD signalling modulates MLL and MLL-AF4 mediated 5-lipoxygenase promoter activation.

  2017cites this paper
• MLL1 promotes cervical carcinoma cell tumorigenesis and metastasis through interaction with β-catenin

  2016cites this paper
• CCI-007, a novel small molecule with cytotoxic activity against infant leukemia with MLL rearrangements

  2016cites this paper
• Étude des gènes de fusion MLL dans les leucémies aigues humaines

  2016cites this paper
• AF4 and AF4-MLL mediate transcriptional elongation of 5-lipoxygenase mRNA by 1, 25-dihydroxyvitamin D3

  2015cites this paper
• Registered report: Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukemia

  2015cites this paper
• MLL Leukemia and Future Treatment Strategies

  2015cites this paper
• ARTD 1 Suppresses Interleukin 6 Expression by Repressing MLL 1-Dependent Histone H 3 Trimethylation

  2015cites this paper
• Epigenetic alterations in acute myeloid leukemias

  2015cites this paper
• ARTD1 Suppresses Interleukin 6 Expression by Repressing MLL1-Dependent Histone H3 Trimethylation

  2015cites this paper
• Evolutionary divergence of Threonine Aspartase1 leads to species-specific substrate recognition

  2015cites this paper
• The role of topoisomerase II beta on breakage and proximity of RUNX1 to partner alleles RUNX1T1 and EVI1

  2014influential citation
• Biology of Human Tumors Concurrent Alterations in TERT , KDM 6 A , and the BRCA Pathway in Bladder Cancer

  2014cites this paper
• MYELOID NEOPLASIA Downregulation of RUNX 1 / CBF b by MLL fusion proteins enhances hematopoietic stem cell self-renewal

  2014cites this paper
• Inhibition of class I HDACs abrogates the dominant effect of MLL-AF4 by activation of wild-type MLL

  2014cites this paper
• Concurrent Alterations in TERT, KDM6A, and the BRCA Pathway in Bladder Cancer

  2014cites this paper
• Downregulation of RUNX1/CBFβ by MLL fusion proteins enhances hematopoietic stem cell self-renewal.

  2014cites this paper
• A systematic description of MLL fusion gene formation.

  2014cites this paper
• The genome-wide molecular signature of transcription factors in leukemia.

  2014cites this paper
• RUNX1 Is a Key Target in t(4;11) Leukemias that Contributes to Gene Activation through an AF4-MLL Complex Interaction

  2013cites this paper
• Nucleosome occupancy and gene regulation during tumorigenesis.

  2013cites this paper
• Transcriptional regulation and its misregulation in disease.

  2013cites this paper
• Epigenetic Alterations in Oncogenesis

  2013cites this paper
• Transcriptional regulation of haematopoietic stem cells.

  2013cites this paper
• Trithorax Genes in Prostate Cancer

  2013cites this paper
• Thermodynamic and structural characterization of the interaction between WD-40 repeat protein 5 (WDR5) and human SET1 family methyltransferases

  2013cites this paper
• Model for MLL translocations in therapy-related leukemia involving topoisomerase IIβ-mediated DNA strand breaks and gene proximity

  2012influential citation
• Multiple clonal MLL fusions in a patient receiving CHOP‐based chemotherapy

  2012cites this paper
• Role of Histone Methylation in Cognition and Effects of Different Durations of Environmental Enrichment on Learning and Memory

  2012cites this paper
• Transcription and Epigenetic Regulation

  2012cites this paper
• Overexpression of the Catalytically Impaired Taspase1T234V or Taspase1D233A Variants Does Not Have a Dominant Negative Effect in T(4;11) Leukemia Cells

  2012cites this paper
• Molecular and Epigenetic Mechanisms of MLL in Human Leukemogenesis

  2012cites this paper
• Menin as a hub controlling mixed lineage leukemia

  2012cites this paper
• GAS41 amplification results in overexpression of a new spindle pole protein

  2012cites this paper
• TOP3A, a new partner gene fused to MLL in an adult patient with de novo acute myeloid leukaemia

  2012cites this paper
• Mixed lineage leukaemia-4 regulates cell-cycle progression and cell viability and its depletion suppresses growth of xenografted tumour in vivo

  2012cites this paper
• Цитогенетическая и молекулярно-генетическая характеристики острых лейкозов у детей первого года жизни

  2011cites this paper
• Bioassays to Monitor Taspase1 Function for the Identification of Pharmacogenetic Inhibitors

  2011cites this paper
• MLL-SEPTIN gene fusions in hematological malignancies

  2011cites this paper
• The heterogeneity of pediatric MLL-rearranged acute myeloid leukemia

  2011cites this paper
• Recognition of post-translational histone modifications by antibodies and epigenetic reading domains

  2011cites this paper
• Biochemistry of the Mixed Lineage Leukemia 1 (MLL1) Protein and Targeted Therapies for Associated Leukemia

  2011influential citation
• The identification of transcription factors expressed in the notochord of Ciona intestinalis adds new potential players to the brachyury gene regulatory network

  2011cites this paper
• The Importin‐Alpha/Nucleophosmin Switch Controls Taspase1 Protease Function

  2011cites this paper
• The role of MLL/AF4 in leukaemic cell biology

  2011cites this paper
• Histone H3 lysine 79 methyltransferase Dot1 is required for immortalization by MLL oncogenes.

  2010cites this paper
• Molecular and Cellular Pathobiology Histone H 3 Lysine 79 Methyltransferase Dot 1 Is Required for Immortalization by MLL Oncogenes

  2010cites this paper
• Mixed lineage leukemia: a structure–function perspective of the MLL1 protein

  2010cites this paper
• Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing

  2010cites this paper
• Cell-based Analysis of Structure-Function Activity of Threonine Aspartase 1*

  2010cites this paper
• Mixed lineage leukemia: histone H3 lysine 4 methyltransferases from yeast to human

  2010cites this paper
• Interpretation of developmental signaling at chromatin: the Polycomb perspective.

  2010cites this paper
• MIT Open Access Articles Transcriptional Regulation and Its Misregulation in Disease

  year unknowncites this paper