Lysophosphatidylcholine: A Novel Modulator of Trypanosoma cruzi Transmission

Lysophosphatidylcholine is a bioactive lipid that regulates a large number of cellular processes and is especially present during the deposition and infiltration of inflammatory cells and deposition of atheromatous plaque. Such molecule is also present in saliva and feces of the hematophagous organism Rhodnius prolixus, a triatominae bug vector of Chagas disease. We have recently demonstrated that LPC is a modulator of Trypanosoma cruzi transmission. It acts as a powerful chemoattractant for inflammatory cells at the site of the insect bite, which will provide a concentrated population of cells available for parasite infection. Also, LPC increases macrophage intracellular calcium concentrations that ultimately enhance parasite invasion. Finally, LPC inhibits NO production by macrophages stimulated by live T. cruzi, and thus interferes with the immune system of the vertebrate host. In the present paper, we discuss the main signaling mechanisms that are likely used by such molecule and their eventual use as targets to block parasite transmission and the pathogenesis of Chagas disease.

• Publication year

  2011

• Venue

  Journal of Parasitology Research

• Publication date

  2011-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1155/2012/625838PMID 22132309PMCID 3206328
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Chagas' Disease.

  2015cited by this paper
• Pattern recognition receptors and inflammation.

  2010cited by this paper
• Chagas disease.

  2010cited by this paper
• Emerging roles of secreted phospholipase A2 enzymes: Lessons from transgenic and knockout mice.

  2010cited by this paper
• The endless race between Trypanosoma cruzi and host immunity: lessons for and beyond Chagas disease

  2010influential reference
• Paralytic activity of lysophosphatidylcholine from saliva of the waterbug Belostoma anurum

  2010cited by this paper
• Phospholipase A2s: developing drug targets for atherosclerosis.

  2010cited by this paper
• An insight into the sialome of Glossina morsitans morsitans

  2010cited by this paper
• The effects of nitric oxide on the immune system during Trypanosoma cruzi infection.

  2009cited by this paper
• Analysis of salivary transcripts and antigens of the sand fly Phlebotomus arabicus

  2009cited by this paper
• Trypanosoma cruzi Triggers an Early Type I IFN Response In Vivo at the Site of Intradermal Infection1

  2009cited by this paper
• A borreliacidal factor in Amblyomma americanum saliva is associated with phospholipase A2 activity.

  2009cited by this paper
• G2A and LPC: regulatory functions in immunity.

  2009influential reference
• Biology of Secretory Phospholipase A2

  2008cited by this paper
• Lysophospholipid metabolism facilitates Toll‐like receptor 4 membrane translocation to regulate the inflammatory response

  2008influential reference
• Trypanosoma cruzi Infection Is Enhanced by Vector Saliva through Immunosuppressant Mechanisms Mediated by Lysophosphatidylcholine

  2008cited by this paper
• A Novel IFN Regulatory Factor 3-Dependent Pathway Activated by Trypanosomes Triggers IFN-β in Macrophages and Fibroblasts1

  2008cited by this paper
• Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development

  2008cited by this paper
• An insight into the salivary transcriptome and proteome of the soft tick and vector of epizootic bovine abortion, Ornithodoros coriaceus.

  2008cited by this paper
• The effect of phospholipase A2 from Crotalus durissus collilineatus on Leishmania (Leishmania) amazonensis infection

  2008cited by this paper
• An insight into the sialome of the soft tick, Ornithodorus parkeri.

  2008cited by this paper
• Migration to Apoptotic “Find-me” Signals Is Mediated via the Phagocyte Receptor G2A*

  2008cited by this paper
• Comparative sialomics between hard and soft ticks: implications for the evolution of blood-feeding behavior.

  2008cited by this paper
• Current concepts in immunoregulation and pathology of human Chagas disease

  2008cited by this paper
• Chronic American trypanosomiasis: parasite persistence in endomyocardial biopsies is associated with high-grade myocarditis

  2008cited by this paper
• Thromboxane A2 is a key regulator of pathogenesis during Trypanosoma cruzi infection

  2007cited by this paper
• An insight into the sialome of Anopheles funestus reveals an emerging pattern in anopheline salivary protein families.

  2007cited by this paper
• Toll‐like receptor 4 (TLR4)‐dependent proinflammatory and immunomodulatory properties of the glycoinositolphospholipid (GIPL) from Trypanosoma cruzi

  2007cited by this paper
• Lipid metabolism in Rhodnius prolixus (Hemiptera: Reduviidae): role of a midgut triacylglycerol-lipase.

  2007cited by this paper
• Cutting Edge: TLR9 and TLR2 Signaling Together Account for MyD88-Dependent Control of Parasitemia in Trypanosoma cruzi Infection1

  2006cited by this paper
• The non-venom insect phospholipases A2.

  2006cited by this paper
• Protozoan encounters with Toll-like receptor signalling pathways: implications for host parasitism

  2006cited by this paper
• Phospholipase A1 from Trypanosoma cruzi infective stages generates lipid messengers that activate host cell protein kinase c

  2006cited by this paper
• Sabotage and exploitation in macrophages parasitized by intracellular protozoans.

  2005cited by this paper
• The Trypanosoma cruzi–host-cell interplay: location, invasion, retention

  2005cited by this paper
• Equivalent Effects of Snake PLA2 Neurotoxins and Lysophospholipid-Fatty Acid Mixtures

  2005cited by this paper
• Gi-independent macrophage chemotaxis to lysophosphatidylcholine via the immunoregulatory GPCR G2A.

  2005cited by this paper
• The transcriptome of the salivary glands of the female western black-legged tick Ixodes pacificus (Acari: Ixodidae).

  2005cited by this paper
• Structure-function relationships and mechanism of anticoagulant phospholipase A2 enzymes from snake venoms.

  2005cited by this paper
• Lysophosphatidylcholine-induced surface redistribution regulates signaling of the murine G protein-coupled receptor G2A.

  2005cited by this paper
• Impaired Production of Proinflammatory Cytokines and Host Resistance to Acute Infection with Trypanosoma cruzi in Mice Lacking Functional Myeloid Differentiation Factor 881

  2004influential reference
• Potential mechanisms for the enhancement of HERG K+ channel function by phospholipid metabolites

  2004cited by this paper
• Phospholipase A2 in salivary glands isolated from tobacco hornworms, Manduca sexta.

  2004cited by this paper
• Expression of Functional TLR4 Confers Proinflammatory Responsiveness to Trypanosoma cruzi Glycoinositolphospholipids and Higher Resistance to Infection with T. cruzi1

  2004cited by this paper
• Generation, specificity, and function of CD8+ T cells in Trypanosoma cruzi infection

  2004cited by this paper
• Clearance of apoptotic cells: getting rid of the corpses.

  2004cited by this paper
• Regulatory role of Toll-like receptor 2 during infection with Trypanosoma cruzi

  2004cited by this paper
• Innate and Acquired Immunity in the Pathogenesis of Chagas Disease

  2004cited by this paper
• Lysophosphatidylcholine Acts as an Anti-hemostatic Molecule in the Saliva of the Blood-sucking Bug Rhodnius prolixus*

  2003cited by this paper
• Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal.

  2003cited by this paper
• T cell chemotaxis to lysophosphatidylcholine through the G2A receptor

  2003cited by this paper
• Chagas disease: a role for autoimmunity?

  2003cited by this paper
• Plasma ceramide and lysophosphatidylcholine inversely correlate with mortality in sepsis patients Published, JLR Papers in Press, January 16, 2003. DOI 10.1194/jlr.M200401-JLR200

  2003cited by this paper
• Lysophosphatidylcholine regulates human microvascular endothelial cell expression of chemokines.

  2003cited by this paper
• I-PLA2 Activation during Apoptosis Promotes the Exposure of Membrane Lysophosphatidylcholine Leading to Binding by Natural Immunoglobulin M Antibodies and Complement Activation

  2002cited by this paper
• Glycosylphosphatidylinositol‐anchored mucin‐like glycoproteins isolated from Trypanosoma cruzi trypomastigotes induce in vivo leukocyte recruitment dependent on MCP‐1 production by IFN‐γ‐primed‐macrophages

  2002cited by this paper
• Proinflammatory activity of glycosylphosphatidylinositol anchors derived from Trypanosoma cruzi: structural and functional analyses

  2001cited by this paper
• Preliminary characterisation of esterase and platelet-activating factor (PAF)-acetylhydrolase activities from cat flea (Ctenocephalides felis) salivary glands.

  2001cited by this paper
• Sphingosylphosphorylcholine and Lysophosphatidylcholine Are Ligands for the G Protein-coupled Receptor GPR4*

  2001cited by this paper
• Activation of Toll-Like Receptor-2 by Glycosylphosphatidylinositol Anchors from a Protozoan Parasite1

  2001cited by this paper
• Lysophosphatidylcholine as a Ligand for the Immunoregulatory Receptor G2A

  2001cited by this paper
• DNA from Protozoan Parasites Babesia bovis, Trypanosoma cruzi, and T. brucei Is Mitogenic for B Lymphocytes and Stimulates Macrophage Expression of Interleukin-12, Tumor Necrosis Factor Alpha, and Nitric Oxide

  2001cited by this paper
• The development of Trypanosoma cruzi in triatominae.

  2000cited by this paper
• Uptake of apoptotic cells drives the growth of a pathogenic trypanosome in macrophages

  2000cited by this paper
• Highly purified glycosylphosphatidylinositols from Trypanosoma cruzi are potent proinflammatory agents

  2000cited by this paper
• A Toll-like receptor recognizes bacterial DNA

  2000cited by this paper
• Evidence for phospholipases from Trypanosoma cruzi active on phosphatidylinositol and inositolphosphoceramide.

  2000cited by this paper
• beta-Chemokines enhance parasite uptake and promote nitric oxide-dependent microbiostatic activity in murine inflammatory macrophages infected with Trypanosoma cruzi.

  1999cited by this paper
• β-Chemokines Enhance Parasite Uptake and Promote Nitric Oxide-Dependent Microbiostatic Activity in Murine Inflammatory Macrophages Infected with Trypanosoma cruzi

  1999cited by this paper
• The structure, biosynthesis and functions of glycosylphosphatidylinositol anchors, and the contributions of trypanosome research.

  1999cited by this paper
• Phospholipase A2 activity in salivary glands and saliva of the lone star tick (Acari: Ixodidae) during tick feeding.

  1998cited by this paper
• Isolation of an Entamoeba histolytica intracellular alkaline phospholipase A2

  1998cited by this paper
• Cecílio Romaña, o sinal de Romaña e a doença de Chagas

  1997cited by this paper
• Pre-Oral Digestion: A Phospholipase A2 Associated with Oral Secretions in Adult Burying Beetles, Nicrophorus marginatus

  1997cited by this paper
• [Cecílio Romaña, Romaña's sign and Chagas' disease].

  1997cited by this paper
• Immunological control of Trypanosoma cruzi infection and pathogenesis of Chagas' disease.

  1997cited by this paper
• A novel phospholipase A2 activity in saliva of the lone star tick, Amblyomma americanum (L.).

  1997cited by this paper
• What can we learn from prostaglandins and related eicosanoids in insects?

  1996cited by this paper
• Kinetoplast DNA signatures of Trypanosoma cruzi strains obtained directly from infected tissues.

  1996cited by this paper
• Amplification of a Trypanosoma cruzi DNA sequence from inflammatory lesions in human chagasic cardiomyopathy.

  1993cited by this paper
• Insect immune response to bacterial infection is mediated by eicosanoids.

  1991cited by this paper
• Pathogenesis of Chagas' disease.

  1991cited by this paper
• Impairment of endothelium-dependent arterial relaxation by lysolecithin in modified low-density lipoproteins

  1990cited by this paper
• Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes

  1989cited by this paper
• Regulation of protein kinase C by lysophospholipids. Potential role in signal transduction.

  1988cited by this paper
• [Pathogenesis of Chagas' disease].

  1987cited by this paper
• Glycosyl-sn-1,2-dimyristylphosphatidylinositol is covalently linked to Trypanosoma brucei variant surface glycoprotein.

  1985cited by this paper
• Modulation of macrophage interaction with Trypanosoma cruzi by phospholipase A2-sensitive components of the parasite membrane.

  1984cited by this paper

• Candidate serum metabolite biomarkers of subclinical Haemonchus contortus infection in sheep

  2025cites this paper
• Free GPIs and Comparison of GPI Structures Among Species

  2025cites this paper
• Could mosquito bites facilitate IgE sensitization to food and inhalant allergens?

  2023cites this paper
• Lipid metabolism in Trypanosoma cruzi: a review.

  2020cites this paper
• The mechanisms of lysophosphatidylcholine in the development of diseases.

  2020cites this paper
• Lysophosphatidylcholine triggers cell differentiation in the protozoan parasite Herpetomonas samuelpessoai through the CK2 pathway

  2019cites this paper
• Bioactive lipids regulate Trypanosoma cruzi development

  2019cites this paper
• Vector transmission: How it works, what transmits, where it occurs

  2017cites this paper
• Host triacylglycerols shape the lipidome of intracellular trypanosomes and modulate their growth

  2017cites this paper
• Schistosomal-derived lysophosphatidylcholine triggers M2 polarization of macrophages through PPARγ dependent mechanisms.

  2017cites this paper
• Here, There, and Everywhere: The Ubiquitous Distribution of the Immunosignaling Molecule Lysophosphatidylcholine and Its Role on Chagas Disease

  2016cites this paper
• Effect of the saliva from different triatomine species on the biology and immunity of TLR-4 ligand and Trypanosoma cruzi-stimulated dendritic cells

  2016cites this paper
• Expression And Functional Analysis Of Lipids And Glycolipids From The Mammal-Dwelling Stages Of Trypanosoma Cruzi

  2015cites this paper
• Triatominae biochemistry goes to school: Evaluation of a novel tool for teaching basic biochemical concepts of chagas disease vectors

  2014cites this paper
• Structural and Functional Analysis of a Platelet-Activating Lysophosphatidylcholine of Trypanosoma cruzi

  2014cites this paper
• Metabolic Signatures of Triatomine Vectors of Trypanosoma cruzi Unveiled by Metabolomics

  2013cites this paper
• Lysophosphatidylcholine Triggers TLR2- and TLR4-Mediated Signaling Pathways but Counteracts LPS-Induced NO Synthesis in Peritoneal Macrophages by Inhibiting NF-κB Translocation and MAPK/ERK Phosphorylation

  2013cites this paper