HCV infection induces mitochondrial bioenergetic unbalance: causes and effects.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Biochimica et Biophysica Acta

• Publication date

  2009-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.bbabio.2008.11.008PMID 19094961
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• PPARalpha activation is essential for HCV core protein-induced hepatic steatosis and hepatocellular carcinoma in mice.

  2008cited by this paper
• Inhibition of hepatitis C virus (HCV) core protein- induced cell growth by non-structural protein 4A (NS4A) is mediated by mitochondrial dysregulation.

  2008cited by this paper
• The versatility of mitochondrial calcium signals: from stimulation of cell metabolism to induction of cell death.

  2008cited by this paper
• The mitochondrial death pathway.

  2008cited by this paper
• Expansion and evolution of cell death programmes

  2008cited by this paper
• Reactive oxygen species and HIF-1 signalling in cancer.

  2008cited by this paper
• Endoplasmic reticulum stress in disease pathogenesis.

  2008cited by this paper
• Regulation of gene expression by hypoxia.

  2008cited by this paper
• Carnitine palmitoyltransferase 1: Central to cell function

  2008cited by this paper
• Hepatitis C virus core protein increases mitochondrial ROS production by stimulation of Ca2+ uniporter activity

  2007cited by this paper
• Role of cardiolipin in cytochrome c release from mitochondria

  2007cited by this paper
• Analysis of Hepatitis C Virus Superinfection Exclusion by Using Novel Fluorochrome Gene-Tagged Viral Genomes

  2007cited by this paper
• Hepatitis C virus stabilizes hypoxia-inducible factor 1alpha and stimulates the synthesis of vascular endothelial growth factor.

  2007cited by this paper
• Replication of hepatitis C virus

  2007cited by this paper
• Chaperones as parts of organelle networks.

  2007cited by this paper
• Interaction of HCV core protein with 14-3-3epsilon protein releases Bax to activate apoptosis.

  2007cited by this paper
• Hepatitis C Virus Stabilizes Hypoxia-Inducible Factor 1α and Stimulates the Synthesis of Vascular Endothelial Growth Factor

  2007cited by this paper
• Mitochondrial membrane permeabilization in cell death.

  2007cited by this paper
• Interaction of HCV core protein with 14-3-3ε protein releases Bax to activate apoptosis

  2007cited by this paper
• Hepatitis C virus protein expression causes calcium‐mediated mitochondrial bioenergetic dysfunction and nitro‐oxidative stress

  2007cited by this paper
• Mechanisms and significance of liver steatosis in hepatitis C virus infection.

  2006cited by this paper
• Construction and characterization of infectious intragenotypic and intergenotypic hepatitis C virus chimeras.

  2006cited by this paper
• Hepatitis C virus non‐structural protein NS5A interacts with FKBP38 and inhibits apoptosis in Huh7 hepatoma cells

  2006cited by this paper
• Mitochondrial dysfunction in hepatitis C virus infection.

  2006cited by this paper
• Non-structural protein 4A of Hepatitis C virus accumulates on mitochondria and renders the cells prone to undergoing mitochondria-mediated apoptosis.

  2006cited by this paper
• Hepatitis C virus core protein inhibits deoxycholic acid-mediated apoptosis despite generating mitochondrial reactive oxygen species

  2006cited by this paper
• Subcellular Localization of Hepatitis C Virus Structural Proteins in a Cell Culture System That Efficiently Replicates the Virus

  2006cited by this paper
• Hepatitis C Virus Triggers Mitochondrial Permeability Transition with Production of Reactive Oxygen Species, Leading to DNA Damage and STAT3 Activation

  2006cited by this paper
• S-nitrosothiol inhibition of mitochondrial complex I causes a reversible increase in mitochondrial hydrogen peroxide production.

  2006cited by this paper
• Mitochondrial NADPH, transhydrogenase and disease.

  2006cited by this paper
• Causes and consequences of mitochondrial reactive oxygen species generation in hepatitis C

  2006cited by this paper
• HCV E2 may induce apoptosis of Huh-7 cells via a mitochondrial-related caspase pathway.

  2006cited by this paper
• Microdomains of intracellular Ca2+: molecular determinants and functional consequences.

  2006cited by this paper
• Proline hydroxylation and gene expression.

  2005cited by this paper
• Hepatitis C Virus Core Protein Inhibits Mitochondrial Electron Transport and Increases Reactive Oxygen Species (ROS) Production*

  2005cited by this paper
• Mitochondrial nitric oxide synthase.

  2005cited by this paper
• Hepatitis C Virus Core Protein Modulates TRAIL-Mediated Apoptosis by Enhancing Bid Cleavage and Activation of Mitochondria Apoptosis Signaling Pathway1

  2005cited by this paper
• Hepatitis C virus, ER stress, and oxidative stress.

  2005cited by this paper
• Hypoxia-inducible factor 1: regulation by hypoxic and non-hypoxic activators.

  2005cited by this paper
• Signal Peptide Cleavage and Internal Targeting Signals Direct the Hepatitis C Virus p7 Protein to Distinct Intracellular Membranes

  2005cited by this paper
• Production of infectious hepatitis C virus in tissue culture from a cloned viral genome

  2005cited by this paper
• Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

  2005cited by this paper
• Hypoxia‐inducible factor as a physiological regulator

  2005cited by this paper
• Hepatitis C virus core triggers apoptosis in liver cells by inducing ER stress and ER calcium depletion

  2005cited by this paper
• Mitochondrial dysfunction in hepatitis C.

  2005cited by this paper
• Reactive oxygen species in tumor progression.

  2005cited by this paper
• Molecular Determinants for Subcellular Localization of Hepatitis C Virus Core Protein

  2005cited by this paper
• E2 of Hepatitis C Virus Inhibits Apoptosis1

  2005cited by this paper
• A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

  2005cited by this paper
• Mitochondria and calcium signaling.

  2005cited by this paper
• Inhibition of hepatitis C virus core protein expression in immortalized human hepatocytes induces cytochrome c-independent increase in Apaf-1 and caspase-9 activation for cell death.

  2005cited by this paper
• Intracellular localization of NS3 and C proteins in chronic hepatitis C

  2005cited by this paper
• Global epidemiology of hepatitis C virus infection.

  2005cited by this paper
• Dantrolene – A review of its pharmacology, therapeutic use and new developments

  2004cited by this paper
• Glutaredoxin 2 Catalyzes the Reversible Oxidation and Glutathionylation of Mitochondrial Membrane Thiol Proteins

  2004cited by this paper
• Hepatitis C Virus Suppresses the IRE1-XBP1 Pathway of the Unfolded Protein Response*

  2004cited by this paper
• Mitochondrial Calcium Transport Systems: Properties, Regulation, and Taxonomic Features

  2004cited by this paper
• Calcium, ATP, and ROS: a mitochondrial love-hate triangle.

  2004cited by this paper
• Molecular events associated with reactive oxygen species and cell cycle progression in mammalian cells.

  2004cited by this paper
• Targeting of Hepatitis C Virus Core Protein to Mitochondria through a Novel C-Terminal Localization Motif

  2004cited by this paper
• Nitric oxide and calcium together inactivate mitochondrial complex I and induce cytochrome c release.

  2003cited by this paper
• Mitochondrial formation of reactive oxygen species

  2003cited by this paper
• Hepatitis C virus nonstructural proteins are localized in a modified endoplasmic reticulum of cells expressing viral subgenomic replicons.

  2002cited by this paper
• Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein.

  2002cited by this paper
• Endoplasmic reticulum (ER) stress: hepatitis C virus induces an ER-nucleus signal transduction pathway and activates NF-kappaB and STAT-3.

  2002cited by this paper
• Cellular response to oxidative stress: Signaling for suicide and survival *

  2002cited by this paper
• Model for Hepatitis C Virus-associated Hepatocarcinogenesis Oxidative Stress in the Absence of Inflammation in a Mouse Updated

  2001cited by this paper
• Oxidative phosphorylation at the fin de siècle.

  1999cited by this paper
• Hepatocellular mitochondrial alterations in patients with chronic hepatitis C: ultrastructural and biochemical findings

  1999cited by this paper
• Continuous human cell lines inducibly expressing hepatitis C virus structural and nonstructural proteins

  1998cited by this paper
• Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha.

  1998cited by this paper
• Role of the Mitochondrial Permeability Transition Pore in Apoptosis

  1997cited by this paper
• Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane

  1994cited by this paper

• Does oncolytic viruses‐mediated metabolic reprogramming benefit or harm the immune microenvironment?

  2024cites this paper
• Positive-strand RNA virus replication organelles at a glance

  2024cites this paper
• Involvement of mitochondrial fatty acid β-oxidation in the antiviral innate immune response in head kidney macrophages of large yellow croaker (Larimichthys crocea).

  2024cites this paper
• Leveraging metformin to combat hepatocellular carcinoma: its therapeutic promise against hepatitis viral infections

  2024cites this paper
• HCV and HCC Tango—Deciphering the Intricate Dance of Disease: A Review Article

  2023cites this paper
• A case of post‐COVID‐19 myalgic encephalomyelitis/chronic fatigue syndrome characterized by post‐exertional malaise and low serum acylcarnitine level

  2023cites this paper
• Comparison of serum acylcarnitine levels in patients with myalgic encephalomyelitis/chronic fatigue syndrome and healthy controls: a systematic review and meta-analysis

  2023cites this paper
• Impact of nitric oxide in liver cancer microenvironment.

  2022cites this paper
• СОСТОЯНИЕ МИТОХОНДРИЙ CD4+ ТЛИМФОЦИТОВ У ВИЧ/ВГС КОИНФИЦИРОВАННЫХ ПАЦИЕНТОВ С РАЗЛИЧНОЙ ЭФФЕКТИВНОСТЬЮ

  2021cites this paper
• State of CD4+ T-lymphocytes mitochondria in HIV/HCV coinfected patients with different efficiency of immune system restoration during antiretroviral therapy

  2021cites this paper
• Endoplasmic Reticulum & Mitochondrial Calcium homeostasis: The Interplay with Viruses.

  2021cites this paper
• Redox Control of the Immune Response in the Hepatic Progenitor Cell Niche

  2020cites this paper
• Targeted Metabolic Reprogramming to Improve the Efficacy of Oncolytic Virus Therapy.

  2020cites this paper
• Competition for nutrients and its role in controlling immune responses

  2019cites this paper
• Cellular Gene Expression during Hepatitis C Virus Replication as Revealed by Ribosome Profiling

  2019cites this paper
• Oxidative stress response in the pathogenesis of dengue virus virulence, disease prognosis and therapeutics: an update

  2019cites this paper
• Hepatitis C Virus Downregulates Core Subunits of Oxidative Phosphorylation, Reminiscent of the Warburg Effect in Cancer Cells

  2019cites this paper
• Molecular Pathology of HTLV-1

  2019cites this paper
• Transforming Growth Factor β Acts as a Regulatory Molecule for Lipogenic Pathways among Hepatitis C Virus Genotype-Specific Infections

  2019cites this paper
• Mitochondrial Proteins Coded by Human Tumor Viruses

  2018cites this paper
• Metabolic effects of hypoxia and chronic hepatitis C

  2018cites this paper
• Redox cell signaling and hepatic progenitor cells.

  2018cites this paper
• Tissue-resident NK cells differ in their expression profile of the nutrient transporters Glut1, CD98 and CD71

  2018cites this paper
• Targeting Endoplasmic Reticulum and/or Mitochondrial Ca2+ Fluxes as Therapeutic Strategy for HCV Infection

  2018cites this paper
• Molecular basis of hepatocellular carcinoma induced by hepatitis C virus infection

  2017cites this paper
• Implications of oxidative stress on viral pathogenesis

  2017cites this paper
• Magnetomitotransfer: An efficient way for direct mitochondria transfer into cultured human cells

  2016cites this paper
• Structural Changes In Cells Imaged by Soft X-ray Cryo-Tomography During Hepatitis C Virus Infection.

  2016cites this paper
• Nutrient sensing, signal transduction and immune responses.

  2016cites this paper
• Oxidative stress and neuropsychiatric disorders in the life spectrum

  2016cites this paper
• Mitochondrial Biology in Hepatobiliary Tumors: Changes of the Cellular Energy Factory

  2016cites this paper
• Molecular mechanisms of hepatitis C virus-induced hepatocellular carcinoma.

  2016influential citation
• Cellular stress responses in hepatitis C virus infection: Mastering a two-edged sword.

  2015cites this paper
• Hepatitis C Virus Attenuates Mitochondrial Lipid β-Oxidation by Downregulating Mitochondrial Trifunctional-Protein Expression

  2015cites this paper
• Metabolic regulation of natural killer cells.

  2015cites this paper
• Quantitative Proteomics Identifies Serum Response Factor Binding Protein 1 as a Host Factor for Hepatitis C Virus Entry

  2015cites this paper
• Oxidative stress as a crucial factor in liver diseases.

  2014cites this paper
• RNA Viruses: ROS-Mediated Cell Death

  2014cites this paper
• Enterovirus 71 Induces Mitochondrial Reactive Oxygen Species Generation That is Required for Efficient Replication

  2014cites this paper
• mTORC 1-dependent metabolic reprogramming is a prerequisite for Natural Killer cell effector function

  2014cites this paper
• Protective role of amantadine in mitochondrial dysfunction and oxidative stress mediated by hepatitis C virus protein expression.

  2014cites this paper
• mTORC1-Dependent Metabolic Reprogramming Is a Prerequisite for NK Cell Effector Function

  2014cites this paper
• Reactive Oxygen Species (ROS) and Liver Disease Therapy

  2014cites this paper
• Hepatitis C Virus Infection Viral RNA Replication at the Onset of Sigma-1 Receptor Regulates Early Steps of

  2014cites this paper
• Interactions Between Hepatitis C Virus and Mitochondria: Impact on Pathogenesis and Innate Immunity

  2013cites this paper
• Oxidative stress and hepatitis C virus

  2013cites this paper
• A distinct subgroup of cardiomyopathy patients characterized by transcriptionally active cardiotropic erythrovirus and altered cardiac gene expression

  2013cites this paper
• Fluorescence Lifetime Imaging of Alterations to Cellular Metabolism by Domain 2 of the Hepatitis C Virus Core Protein

  2013cites this paper
• Targeting mitochondria in the infection strategy of the hepatitis C virus.

  2013cites this paper
• Virus-induced changes in mitochondrial bioenergetics as potential targets for therapy.

  2013cites this paper
• Sigma-1 Receptor Regulates Early Steps of Viral RNA Replication at the Onset of Hepatitis C Virus Infection

  2013cites this paper
• Alcohol's effect on other chronic liver diseases.

  2012cites this paper
• Molecular Features of Lymphoproliferation in Mixed Cryoglobulinemia

  2012cites this paper
• PPARs and HCV-Related Hepatocarcinoma: A Mitochondrial Point of View

  2012cites this paper
• Viral product trafficking to mitochondria, mechanisms and roles in pathogenesis.

  2012cites this paper
• The cyclophilin inhibitor alisporivir prevents hepatitis C virus–mediated mitochondrial dysfunction

  2012cites this paper
• Systems biology methods help develop a better understanding of hepatitis C virus–induced liver injury

  2012cites this paper
• Decreased mitochondrial deoxyribonucleic acid and increased oxidative damage in chronic hepatitis C.

  2012cites this paper
• Herpes simplex type 1 activates glycolysis through engagement of the enzyme 6-phosphofructo-1-kinase (PFK-1).

  2012cites this paper
• Topological analysis of protein co-abundance networks identifies novel host targets important for HCV infection and pathogenesis

  2012cites this paper
• This information is current as Neurodegeneration To Prevent Demyelination and Reticulum Stress Are Coregulated by Crocin Neuroinflammation and Endoplasmic Power

  2011cites this paper
• Occult hepatitis C virus elicits mitochondrial oxidative stress in lymphocytes and triggers PI3-kinase-mediated DNA damage response.

  2011cites this paper
• Long‐chain acylcarnitine deficiency in patients with chronic fatigue syndrome. Potential involvement of altered carnitine palmitoyltransferase‐I activity

  2011cites this paper
• Neuroinflammation and Endoplasmic Reticulum Stress Are Coregulated by Crocin To Prevent Demyelination and Neurodegeneration

  2011cites this paper
• Network based analysis of hepatitis C virus core and NS4B protein interactions.

  2010cites this paper
• Targeting mitochondria: a new promising approach for the treatment of liver diseases.

  2010cites this paper
• Alcohol and hepatitis C virus--interactions in immune dysfunctions and liver damage.

  2010cites this paper
• Mitochondrial dysfunction in autism spectrum disorders: cause or effect?

  2010cites this paper
• Hepatitis C virus‐induced oxidative stress and mitochondrial dysfunction: A focus on recent advances in proteomics

  2010cites this paper
• Genetic variability of HVRII mtDNA in cord blood and respiratory morbidity in children.

  2009cites this paper
• Hepatitis C Virus-Linked Mitochondrial Dysfunction Promotes Hypoxia-Inducible Factor 1α-Mediated Glycolytic Adaptation

  2009cites this paper