Role of inflammation and infection in the pathogenesis of human acute liver failure: Clinical implications for monitoring and therapy.

Acute liver failure is a rare and devastating clinical condition. At present, emergency liver transplantation is the only life-saving therapy in advanced cases, yet the feasibility of transplantation is affected by the presence of systemic inflammation, infection and resultant multi-organ failure. The importance of immune dysregulation and acquisition of infection in the pathogenesis of acute liver failure and its associated complications is now recognised. In this review we discuss current thinking regarding the role of infection and inflammation in the pathogenesis of and outcome in human acute liver failure, the implications for the management of such patients and suggest directions for future research.

• Publication year

  2016

• Venue

  World Journal of Gastroenterology

• Publication date

  2016-07-14

• Fields of study

  Medicine

• Identifiers
  DOI 10.3748/wjg.v22.i26.5958PMID 27468190PMCID PMC4948263
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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