Urinary Biomarkers for Chronic Kidney Disease with a Focus on Gene Transcript

Objective: In the upcoming era of precision medicine, searching for the early, noninvasive biomarkers has been the cornerstone and major challenge in the management of chronic kidney disease (CKD). Urine contains rich biological information which could be the ideal source for noninvasive biomarkers of CKD. This review will discuss the recent advance in urinary biomarker. Data Sources: This review was based on data in articles published in the PubMed databases up to June 20, 2017, with the following keywords: “Chronic kidney disease”, “Biomarker”, and “Urine”. Study Selection: Original articles and important reviews on urinary biomarker were selected for this review. Results: Urinary biomarker studies of CKD mainly focused on urine sediment, supernatant, and urinary extracellular vesicles. The gene transcript (microRNA [miRNA], messenger RNA [mRNA]) biomarkers have been recently shown with diagnostic potential for CKD reflecting kidney function and histological change. However, challenges regarding technique and data analysis need to be resolved before translation to clinic. Conclusions: Different fractions of urine contain rich information for biomarker discovery, among which urine (extracellular vesicles) mRNA, miRNA, might represent promising biomarker for CKD.

• Publication year

  2017

• Venue

  Chinese Medical Journal

• Publication date

  2017-09-20

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4103/0366-6999.213965PMID 28875962PMCID 5598339
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Feature selection and classification of urinary mRNA microarray data by iterative random forest to diagnose renal fibrosis: a two-stage study

  2017cited by this paper
• Incidence, Development, and Prognosis of Diabetic Kidney Disease in China: Design and Methods

  2017cited by this paper
• Unique Transcriptional Programs Identify Subtypes of AKI.

  2017cited by this paper
• Extracellular vesicles in diagnosis and therapy of kidney diseases.

  2016cited by this paper
• Identification of novel targets of diabetic nephropathy and PEDF peptide treatment using RNA-seq

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• Urinary mRNA for the Diagnosis of Renal Allograft Rejection: The Issue of Normalization

  2016cited by this paper
• Urinary Exosomal microRNA-451-5p Is a Potential Early Biomarker of Diabetic Nephropathy in Rats

  2016influential reference
• Diagnosis and Prediction of CKD Progression by Assessment of Urinary Peptides.

  2015cited by this paper
• Urinary vimentin mRNA as a potential novel biomarker of renal fibrosis.

  2015cited by this paper
• miR-29c in urinary exosomes as predictor of early renal fibrosis in lupus nephritis.

  2015cited by this paper
• Exosomes: Novel Biomarkers for Clinical Diagnosis

  2015cited by this paper
• The landscape of long noncoding RNAs in the human transcriptome

  2015cited by this paper
• Long Noncoding RNA Arid2-IR Is a Novel Therapeutic Target for Renal Inflammation.

  2015cited by this paper
• Extracellular RNAs: development as biomarkers of human disease

  2015cited by this paper
• Urine Monocyte Chemoattractant Protein-1 and Lupus Nephritis Disease Activity: Preliminary Report of a Prospective Longitudinal Study

  2015cited by this paper
• Urinary Extracellular Vesicles as Source of Biomarkers in Kidney Diseases

  2015cited by this paper
• The cellular signature of urinary immune cells in Lupus nephritis: new insights into potential biomarkers

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• Identification and Characterization of Circular RNAs As a New Class of Putative Biomarkers in Human Blood

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• miRNAs in urine: a mirror image of kidney disease?

  2015cited by this paper
• MicroRNAs and their applications in kidney diseases

  2015cited by this paper
• Circulating and urinary microRNA profile in focal segmental glomerulosclerosis: a pilot study

  2015cited by this paper
• Long Noncoding RNAs in Urine Are Detectable and May Enable Early Detection of Acute T Cell-Mediated Rejection of Renal Allografts.

  2015cited by this paper
• Noninvasive micromarkers.

  2014cited by this paper
• Identification of tubular injury microRNA biomarkers in urine: comparison of next-generation sequencing and qPCR-based profiling platforms

  2014cited by this paper
• Urine MicroRNA as Potential Biomarkers of Autosomal Dominant Polycystic Kidney Disease Progression: Description of miRNA Profiles at Baseline

  2014cited by this paper
• Inflammatory processes in renal fibrosis

  2014cited by this paper
• Multicentre prospective validation of a urinary peptidome-based classifier for the diagnosis of type 2 diabetic nephropathy.

  2014cited by this paper
• CD2AP mRNA in urinary exosome as biomarker of kidney disease.

  2014cited by this paper
• MicroRNA-29c in urinary exosome/microvesicle as a biomarker of renal fibrosis.

  2013cited by this paper
• Circulating nucleic acids as biomarkers in breast cancer

  2013cited by this paper
• Isolation and Quantification of MicroRNAs from Urinary Exosomes/Microvesicles for Biomarker Discovery

  2013cited by this paper
• Exosomes and the kidney: Blaming the messenger

  2013cited by this paper
• ISEV position paper: extracellular vesicle RNA analysis and bioinformatics

  2013cited by this paper
• Secreted microRNAs: a new form of intercellular communication.

  2012cited by this paper
• Urinary mRNA markers of epithelial–mesenchymal transition correlate with progression of diabetic nephropathy

  2012cited by this paper
• Prevalence of chronic kidney disease in China: a cross-sectional survey.

  2012cited by this paper
• A Pilot Trial Assessing Urinary Gene Expression Profiling with an mRNA Array for Diabetic Nephropathy

  2012cited by this paper
• Expression of miR-146a and miR-155 in the urinary sediment of systemic lupus erythematosus

  2012cited by this paper
• Application of systems biology to the study of chronic kidney disease.

  2012cited by this paper
• Urinary Podocyte-Associated mRNA profile in Various Stages of Diabetic Nephropathy

  2011cited by this paper
• Exosomes and the kidney: prospects for diagnosis and therapy of renal diseases

  2011cited by this paper
• Evaluation of external RNA controls for the standardisation of gene expression biomarker measurements

  2010cited by this paper
• Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells*♦

  2010cited by this paper
• Application of Antibody Array Technology in the Analysis of Urinary Cytokine Profiles in Patients with Chronic Kidney Disease

  2006cited by this paper
• mRNA expression of target genes in the urinary sediment as a noninvasive prognostic indicator of CKD.

  2006cited by this paper
• The clinical course of peritoneal dialysis-related peritonitis caused by Corynebacterium species.

  2005cited by this paper
• Noninvasive diagnosis of renal-allograft rejection by measurement of messenger RNA for perforin and granzyme B in urine.

  2001cited by this paper
• PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS Macrophage microvesicles induce macrophage differentiation and miR-223 transfer

  year unknowncited by this paper

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  2025cites this paper
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  2023cites this paper
• Urinary miR-16-5p can be used as a potential marker of endocapillary hypercellularity in IgA nephropathy

  2023cites this paper
• Tissue Culture Models of AKI: From Tubule Cells to Human Kidney Organoids

  2022cites this paper
• Tissue Culture Models of Acute Kidney Injury: From Tubule Cells to Human Kidney Organoids.

  2022cites this paper
• Exosomal miRNAs in urine associated with children's cardiorenal parameters: a cross-sectional study

  2021cites this paper
• Urine S-Adenosylmethionine are Related to Degree of Renal Insufficiency in Patients with Chronic Kidney Disease.

  2020cites this paper
• Urinary MicroRNAs in Environmental Health: Biomarkers of Emergent Kidney Injury and Disease

  2020cites this paper
• Effects of Chronic Kidney Disease and Uremic Toxins on Extracellular Vesicle Biology

  2020cites this paper
• Genomic biomarkers for chronic kidney disease: the first step towards personalized medicine?

  2019cites this paper
• Chronic kidney disease: a review of proteomic and metabolomic approaches to membranous glomerulonephritis, focal segmental glomerulosclerosis, and IgA nephropathy biomarkers

  2019cites this paper
• Epithelial-fibroblast cross talk aggravates the impact of the nephrotoxin ochratoxin A.

  2019cites this paper
• Urinary Biomarkers of Renal Fibrosis.

  2019cites this paper
• Tiny Non-coding RNAs in Body Fluids, Possible Biomarkers for Autosomal Dominant Polycystic Kidney Disease.

  2019cites this paper
• microRNA‐206 overexpression inhibits epithelial‐mesenchymal transition and glomerulosclerosis in rats with chronic kidney disease by inhibiting JAK/STAT signaling pathway

  2019cites this paper
• Urinary cytokines and mRNA expression as biomarkers of disease activity in lupus nephritis

  2018cites this paper