Arguing the case for the autotaxin-lysophosphatidic acid-lipid phosphate phosphatase 3-signaling nexus in the development and complications of atherosclerosis.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Arteriosclerosis, Thrombosis and Vascular Biology

• Publication date

  2014-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1161/ATVBAHA.113.302737PMID 24482375PMCID PMC3944085
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Transgenic 6F tomatoes act on the small intestine to prevent systemic inflammation and dyslipidemia caused by Western diet and intestinally derived lysophosphatidic acid[S]

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• Lipid Phosphate Phosphatase 3 Negatively Regulates Smooth Muscle Cell Phenotypic Modulation to Limit Intimal Hyperplasia

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• Mechanism of rapid elimination of lysophosphatidic acid and related lipids from the circulation of mice

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• Lysophosphatidic acid triggers mast cell-driven atherosclerotic plaque destabilization by increasing vascular inflammation[S]

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• Identification of CAD candidate genes in GWAS loci and their expression in vascular cells[S]

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• Increased lysophosphatidic acid levels in culprit coronary arteries of patients with acute coronary syndrome.

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• High-Density Lipoprotein and 4 F Peptide Reduce Systemic Inflammation by Modulating Intestinal Oxidized Lipid Metabolism Novel Hypotheses and Review of Literature

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• High-density lipoprotein and 4F peptide reduce systemic inflammation by modulating intestinal oxidized lipid metabolism: novel hypotheses and review of literature.

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• SnapShot: Bioactive lysophospholipids.

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• Procontractile G protein–mediated signaling pathways antagonistically regulate smooth muscle differentiation in vascular remodeling

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• Insights into the pharmacological relevance of lysophospholipid receptors

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• Lysophosphatidic acid targets vascular and oncogenic pathways via RAGE signaling

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• Insights into autotaxin: how to produce and present a lipid mediator

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• Lysophosphatidic Acid Activates Peroxisome Proliferator Activated Receptor-γ in CHO Cells That Over-Express Glycerol 3-Phosphate Acyltransferase-1

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• Lipid phosphate phosphatase-3 regulates tumor growth via β-catenin and Cyclin-D1 signaling

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• Lipoprotein-derived lysophosphatidic acid promotes atherosclerosis by releasing CXCL1 from the endothelium.

  2011cited by this paper
• L-5F, an apolipoprotein A-I mimetic, inhibits tumor angiogenesis by suppressing VEGF/basic FGF signaling pathways.

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• Binding of Autotaxin to Integrins Localizes Lysophosphatidic Acid Production to Platelets and Mammalian Cells*

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• Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

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• A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease

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• Intestine may be a major site of action for the apoA-I mimetic peptide 4F whether administered subcutaneously or orally[S]

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• The phospholipase A1 activity of lysophospholipase A-I links platelet activation to LPA production during blood coagulation[S]

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• Adipose-specific disruption of autotaxin enhances nutritional fattening and reduces plasma lysophosphatidic acid

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• Regulation of mammalian physiology, development, and disease by the sphingosine 1-phosphate and lysophosphatidic acid receptors.

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• Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M

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• Autotaxin Regulates Vascular Development via Multiple Lysophosphatidic Acid (LPA) Receptors in Zebrafish*

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• LPA receptors: subtypes and biological actions.

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• Phospholipase Cγ Activation Drives Increased Production of Autotaxin in Endothelial Cells and Lysophosphatidic Acid-Dependent Regression

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• Lipid Phosphate Phosphatase 3 Stabilization of β-Catenin Induces Endothelial Cell Migration and Formation of Branching Point Structures

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• Lysophosphatidic Acid Receptors LPA1 and LPA3 Promote CXCL12-Mediated Smooth Muscle Progenitor Cell Recruitment in Neointima Formation

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• Ca2+ signaling induced by sphingosine 1-phosphate and lysophosphatidic acid in mouse B cells

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• LPA4 regulates blood and lymphatic vessel formation during mouse embryogenesis.

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• Structural basis for substrate discrimination and integrin binding by autotaxin

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• Atherosclerotic lesion progression changes lysophosphatidic acid homeostasis to favor its accumulation.

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• Autotaxin Signaling via Lysophosphatidic Acid Receptors Contributes to Vascular Endothelial Growth Factor–Induced Endothelial Cell Migration

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• Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation

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• Regulation of blood and vascular cell function by bioactive lysophospholipids

  2009cited by this paper
• Lipid phosphate phosphohydrolase type 1 (LPP1) degrades extracellular lysophosphatidic acid in vivo.

  2009cited by this paper
• Blood relatives: dynamic regulation of bioactive lysophosphatidic acid and sphingosine-1-phosphate metabolism in the circulation.

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• Lysophosphatidic acid-induced arterial wall remodeling: requirement of PPARgamma but not LPA1 or LPA2 GPCR.

  2009cited by this paper
• Autotaxin/Lysopholipase D and Lysophosphatidic Acid Regulate Murine Hemostasis and Thrombosis*

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• Roles of lysophosphatidic acid in cardiovascular physiology and disease.

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• Lysophosphatidic Acid Receptors 1 and 2 Play Roles in Regulation of Vascular Injury Responses but Not Blood Pressure

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• Biological roles of lysophospholipid receptors revealed by genetic null mice: an update.

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• Positive Feedback between Vascular Endothelial Growth Factor-A and Autotaxin in Ovarian Cancer Cells

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• The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak

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• SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap

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• Sphingosine-1-Phosphate Receptor Subtypes Differentially Regulate Smooth Muscle Cell Phenotype

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• Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs

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• Autotaxin, a Secreted Lysophospholipase D, Is Essential for Blood Vessel Formation during Development

  2006cited by this paper
• Enzymatic analysis of lipid phosphate phosphatases.

  2006cited by this paper
• Autotaxin Stabilizes Blood Vessels and Is Required for Embryonic Vasculature by Producing Lysophosphatidic Acid*

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• Hydrolysis of Phosphatidylserine-exposing Red Blood Cells by Secretory Phospholipase A2 Generates Lysophosphatidic Acid and Results in Vascular Dysfunction*

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• Lysophosphatidic Acid Inhibits Adipocyte Differentiation via Lysophosphatidic Acid 1 Receptor-dependent Down-regulation of Peroxisome Proliferator-activated Receptor γ2*

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• Integral membrane lipid phosphatases/phosphotransferases: common structure and diverse functions.

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• Potential involvement of adipocyte insulin resistance in obesity-associated up-regulation of adipocyte lysophospholipase D/autotaxin expression

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• Lipid phosphate phosphatases and lipid phosphate signalling.

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• Lipid phosphate phosphatases and related proteins: Signaling functions in development, cell division, and cancer

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• Lysophosphatidic Acid Induces Neointima Formation Through PPARγ Activation

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• The plaque lipid lysophosphatidic acid stimulates platelet activation and platelet-monocyte aggregate formation in whole blood: involvement of P2Y1 and P2Y12 receptors.

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• Soma-Germ Line Competition for Lipid Phosphate Uptake Regulates Germ Cell Migration and Survival

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• Emigration of monocyte-derived cells from atherosclerotic lesions characterizes regressive, but not progressive, plaques.

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• The lipid phosphatase LPP3 regulates extra-embryonic vasculogenesis and axis patterning

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• Vascular Remodeling Induced by Naturally Occurring Unsaturated Lysophosphatidic Acid In Vivo

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• Subtype-Selective Antagonists of Lysophosphatidic Acid Receptors Inhibit Platelet Activation Triggered by the Lipid Core of Atherosclerotic Plaques

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• Autotaxin Is Released from Adipocytes, Catalyzes Lysophosphatidic Acid Synthesis, and Activates Preadipocyte Proliferation

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• Serum Lysophosphatidic Acid Is Produced through Diverse Phospholipase Pathways*

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• Roles for lipid phosphate phosphatases in regulation of cellular signaling.

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• Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARγ agonist

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• Increased formation of lysophosphatidic acids by lysophospholipase D in serum of hypercholesterolemic rabbits.

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• Phenotypic Modulation of Vascular Smooth Muscle Cells Induced by Unsaturated Lysophosphatidic Acids

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• Rho-Rho kinase is involved in smooth muscle cell migration through myosin light chain phosphorylation-dependent and independent pathways.

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• Platelet lipid(s) bound to albumin increases endothelial electrical resistance: mimicked by LPA.

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• Assembly of a fibronectin matrix by adherent platelets stimulated by lysophosphatidic acid and other agonists.

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• G-protein-coupled-receptor activation of the smooth muscle calponin gene.

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• Mice mutant for Ppap2c, a homolog of the germ cell migration regulator wunen, are viable and fertile

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• Quantitative Analysis of Lysophosphatidic Acid in Human Blood Fractions

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• Lysophosphatidic acid mediates the rapid activation of platelets and endothelial cells by mildly oxidized low density lipoprotein and accumulates in human atherosclerotic lesions.

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• Lysophosphatidic Acid Increases Tight Junction Permeability in Cultured Brain Endothelial Cells

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