Calcium- and phosphatidylinositol 3-kinase/Akt-dependent activation of endothelial nitric oxide synthase by apigenin.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Life Science

• Publication date

  2010-12-18

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.lfs.2010.10.014PMID 21034748
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Apigenin: A Promising Molecule for Cancer Prevention

  2010cited by this paper
• Modulation of endothelial nitric oxide by plant-derived products.

  2009cited by this paper
• Apigenin protects endothelium-dependent relaxation of rat aorta against oxidative stress.

  2009cited by this paper
• Tannin 1-alpha-O-galloylpunicalagin induces the calcium-dependent activation of endothelial nitric-oxide synthase via the phosphatidylinositol 3-kinase/Akt pathway in endothelial cells.

  2008cited by this paper
• Estrogen and the Ca2+-mobilizing agonist ATP evoke acute NO synthesis via distinct pathways in an individual human vascular endothelium-derived cell.

  2008cited by this paper
• Regulation of endothelial and myocardial NO synthesis by multi-site eNOS phosphorylation.

  2007cited by this paper
• A Review of the bioactivity and potential health benefits of chamomile tea (Matricaria recutita L.)

  2006cited by this paper
• The Isoflavone Equol Mediates Rapid Vascular Relaxation

  2006cited by this paper
• p38 Mitogen-Activated Protein Kinase Activates eNOS in Endothelial Cells by an Estrogen Receptor α-Dependent Pathway in Response to Black Tea Polyphenols

  2005cited by this paper
• Red wine polyphenols‐induced, endothelium‐dependent NO‐mediated relaxation is due to the redox‐sensitive PI3‐kinase/Akt‐dependent phosphorylation of endothelial NO‐synthase in the isolated porcine coronary artery

  2005cited by this paper
• Quercetin-induced induction of the NO/cGMP pathway depends on Ca2+-activated K+ channel-induced hyperpolarization-mediated Ca2+-entry into cultured human endothelial cells.

  2005cited by this paper
• Endothelium-dependent and direct relaxation induced by ethyl acetate extract from Flos Chrysanthemi in rat thoracic aorta.

  2005cited by this paper
• Resveratrol suppresses IL-6-induced ICAM-1 gene expression in endothelial cells: effects on the inhibition of STAT3 phosphorylation.

  2005cited by this paper
• Flavonols, Flavones, Flavanones, and Human Health: Epidemiological Evidence

  2005cited by this paper
• A Constituent of Green Tea, Epigallocatechin-3-gallate, Activates Endothelial Nitric Oxide Synthase by a Phosphatidylinositol-3-OH-kinase-, cAMP-dependent Protein Kinase-, and Akt-dependent Pathway and Leads to Endothelial-dependent Vasorelaxation*

  2004cited by this paper
• Upregulation of Endothelial Nitric Oxide Synthase by Cyanidin-3-Glucoside, a Typical Anthocyanin Pigment

  2004cited by this paper
• Activation of Endothelial Nitric-oxide Synthase by the p38 MAPK in Response to Black Tea Polyphenols*

  2004cited by this paper
• Flavonoids from Artichoke (Cynara scolymus L.) Up-Regulate Endothelial-Type Nitric-Oxide Synthase Gene Expression in Human Endothelial Cells

  2004cited by this paper
• Akt-dependent phosphorylation of serine 1179 and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase 1/2 cooperatively mediate activation of the endothelial nitric-oxide synthase by hydrogen peroxide.

  2003cited by this paper
• Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase.

  2003cited by this paper
• Delphinidin, an active compound of red wine, inhibits endothelial cell apoptosis via nitric oxide pathway and regulation of calcium homeostasis

  2003cited by this paper
• Red wine polyphenols increase calcium in bovine aortic endothelial cells: a basis to elucidate signalling pathways leading to nitric oxide production

  2002cited by this paper
• Red Wine Polyphenols Enhance Endothelial Nitric Oxide Synthase Expression and Subsequent Nitric Oxide Release From Endothelial Cells

  2002cited by this paper
• Physiological mechanisms regulating the expression of endothelial-type NO synthase.

  2002cited by this paper
• Post-translational control of endothelial nitric oxide synthase: why isn't calcium/calmodulin enough?

  2001cited by this paper
• Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

  1999cited by this paper
• Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages.

  1999cited by this paper
• Modulation of Ras/Raf/extracellular signal-regulated kinase pathway by reactive oxygen species is involved in cyclic strain-induced early growth response-1 gene expression in endothelial cells.

  1999cited by this paper
• Structure-activity relationship and classification of flavonoids as inhibitors of xanthine oxidase and superoxide scavengers.

  1998cited by this paper
• Direct evidence of nitric oxide production from bovine aortic endothelial cells using new fluorescence indicators: diaminofluoresceins

  1998cited by this paper
• Activation of Protein Kinase Cα and/or ε Enhances Transcription of the Human Endothelial Nitric Oxide Synthase Gene

  1998cited by this paper
• Activation of protein kinase C alpha and/or epsilon enhances transcription of the human endothelial nitric oxide synthase gene.

  1998cited by this paper
• Cyclic strain-induced monocyte chemotactic protein-1 gene expression in endothelial cells involves reactive oxygen species activation of activator protein 1.

  1997cited by this paper
• Nitric oxide: an endogenous modulator of leukocyte adhesion.

  1991cited by this paper
• Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

  1990cited by this paper

• Gut microbiota-derived isoxanthohumol metabolite, 8-prenylnaringenin, mitigates endothelial dysfunction in Angiotensin II-induced hypertension through G protein-coupled estrogen receptor-mediated eNOS activation.

  2026cites this paper
• The Role of the NO/cGMP Pathway and SKCa and IKCa Channels in the Vasodilatory Effect of Apigenin 7-Glucoside

  2025cites this paper
• Potential of functional flavonoids in targeting vasospasm through modulation of oxidative stress and SPC-induced signaling pathways

  2025cites this paper
• Therapeutic potential of natural flavonoids in atherosclerosis through endothelium-protective mechanisms: An update.

  2025cites this paper
• Analysis of Molecular Mechanism of Erxian Decoction in Treating Osteoporosis Based on Formula Optimization Model

  2021cites this paper
• Protective effect of apigenin on ethylene glycol-induced urolithiasis via attenuating oxidative stress and inflammatory parameters in adult male Wistar rats.

  2021cites this paper
• Protective Effects of Ethanol Extract of Brazilian Green Propolis and Apigenin against Weak Ultraviolet Ray-B-Induced Barrier Dysfunction via Suppressing Nitric Oxide Production and Mislocalization of Claudin-1 in HaCaT Cells

  2021cites this paper
• Phenolic Compounds Exerting Lipid-Regulatory, Anti-Inflammatory and Epigenetic Effects as Complementary Treatments in Cardiovascular Diseases

  2020cites this paper
• Myricetin from Rhodomyrtus tomentosa (Aiton) Hassk fruits attenuates inflammatory responses in histamine-exposed endothelial cells

  2020cites this paper
• Inhibition of Endothelial Dysfunction by Dietary Flavonoids and Preventive Effects Against Cardiovascular Disease.

  2019cites this paper
• TRPM2 ion channel promotes gastric cancer migration, invasion and tumor growth through the AKT signaling pathway

  2019cites this paper
• Antihypertensive Effects of Two Novel Angiotensin I-Converting Enzyme (ACE) Inhibitory Peptides from Gracilariopsis lemaneiformis (Rhodophyta) in Spontaneously Hypertensive Rats (SHRs)

  2018cites this paper
• Intravenous administration of retinoic acid-loaded polymeric nanoparticles prevents ischemic injury in the immature brain.

  2018cites this paper
• Effect of angiotensin I-converting enzyme (ACE) inhibition and nitric oxide (NO) production of 6,6′-bieckol, a marine algal polyphenol and its anti-hypertensive effect in spontaneously hypertensive rats

  2017cites this paper
• Hydro-alcoholic extract of Matricaria recutita exhibited dual anti-spasmodic effect via modulation of Ca2+ channels, NO and PKA2-kinase pathway in rabbit jejunum

  2017cites this paper
• Mechanism of endothelial nitric oxide synthase phosphorylation and activation by tentacle extract from the jellyfish Cyanea capillata

  2017cites this paper
• Effective screening for the anti-hypertensive of selected herbs used in the traditional Korean medicines

  2016cites this paper
• Carbon monoxide releasing molecule induces endothelial nitric oxide synthase activation through a calcium and phosphatidylinositol 3-kinase/Akt mechanism.

  2016cites this paper
• Activity of red wine polyphenols on endothelial no-synthase (eNOS)

  2016cites this paper
• Vascular Endothelial Dysfunction and Atherosclerosis: Role of Nitric Oxide System

  2015cites this paper
• Gallic acid isolated from Spirogyra sp. improves cardiovascular disease through a vasorelaxant and antihypertensive effect.

  2015cites this paper
• Angiotensin I-converting enzyme (ACE) inhibition and nitric oxide (NO)-mediated antihypertensive effect of octaphlorethol A isolated from Ishige sinicola: In vitro molecular mechanism and in vivo SHR model

  2015cites this paper
• Regulation of Endothelial Nitric Oxide Synthase and High-Density Lipoprotein Quality by Estradiol in Cardiovascular Pathology

  2014cites this paper
• Cardiovascular Pathology Regulation of Endothelial Nitric Oxide Synthase and High-Density Lipoprotein Quality by Estradiol in

  2014cites this paper
• Bioactive-rich extracts of persimmon, but not nettle, Sideritis, dill or kale, increase eNOS activation and NO bioavailability and decrease endothelin-1 secretion by human vascular endothelial cells.

  2013cites this paper
• Pre-treatment with calcium prevents endothelial cell activation induced by multiple activators, necrotic trophoblastic debris or IL-6 or preeclamptic sera: possible relevance to the pathogenesis of preeclampsia.

  2013cites this paper
• eNOS Promoter Activation by Red Wine Polyphenols: an Interaction Study

  2013cites this paper
• Distinct mechanisms of relaxation to bioactive components from chamomile species in porcine isolated blood vessels.

  2013cites this paper
• The Effect of Moist Air on Skin Blood Flow and Temperature in Subjects With and Without Diabetes

  2012cites this paper
• Ischemic Neurodegeneration in Stroke-Prone Spontaneously Hypertensive Rats and Its Prevention with Antioxidants Such as Polyphenols

  2012cites this paper
• Nitric oxide involvement in the acrosome reaction triggered by leptin in pig sperm

  2011cites this paper