Protective Effect of Phyllanthus Amarus by Modulation of Endogenous Biomarkers and DNA Damage in Acetic Acid Induced Ulcerative Colitis: Role of Phyllanthin and Hypophyllanthin

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Apollo Medicine

• Publication date

  2013-03-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1016/j.apme.2013.01.006
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Determination of risk factors and transmission pathways of Helicobacter pylori in asymptomatic subjects in Western India using polymerase chain reaction

  2012cited by this paper
• Effect of aqueous extract of Cucumis sativus Linn. fruit in ulcerative colitis in laboratory animals

  2012cited by this paper
• Cigarette smoking and H. pylori infection: A meta-analysis of literature

  2012cited by this paper
• Anticonvulsant activity of Argentum metallicum, a homeopathicpreparation

  2012cited by this paper
• PGI3 Determination of Efficacy, Adverse Drug Reactions and Cost Effectiveness of Three Triple Drug Regimens for the Treatment of H. Pylori Infected Acid Peptic Disease Patients

  2012cited by this paper
• Determination of efficacy, adverse drug reactions and cost effectiveness of three triple drug regimens for the treatment of Helicobacter pylori infected acid peptic disease patients

  2012cited by this paper
• Neuroprotective effect of naringin by modulation of endogenous biomarkers in streptozotocin induced painful diabetic neuropathy.

  2012cited by this paper
• ANTI-INFLAMMATORY EFFECT OF DAUCUS CAROTA ROOT ON EXPERIMENTAL COLITIS IN RATS Research Article

  2012cited by this paper
• Anti-arthritic and anti-inflammatory activity of Xanthium srtumarium L. ethanolic extract in Freund's complete adjuvant induced arthritis

  2012cited by this paper
• Therapeutic role of curcumin in prevention of biochemical and behavioral aberration induced by alcoholic neuropathy in laboratory animals.

  2012cited by this paper
• Determination of role of GABA and nitric oxide in anticonvulsant activity of Fragaria vesca L. ethanolic extract in chemically induced epilepsy in laboratory animals

  2012cited by this paper
• Effect of hydroalcoholic extract of Hibiscus rosa sinensis Linn. leaves in experimental colitis in rats.

  2012influential reference
• Anticonvulsant effect of fisetin by modulation of endogenous biomarkers

  2012cited by this paper
• Implications for Therapy

  2012cited by this paper
• Evaluation of ameliorative effect of quercetin in experimental model of alcoholic neuropathy in rats

  2012cited by this paper
• Patentability of Animal Models: India and the Globe

  2011cited by this paper
• Adherence to Anti-Retroviral Therapy among People Living with HIV and AIDS in Far West, Nepal

  2011cited by this paper
• Anti-inflammatory effects of methanol extract of Patrinia scabiosaefolia in mice with ulcerative colitis.

  2011cited by this paper
• The ameliorative effect of fisetin, a bioflavonoid, on ethanol-induced and pylorus ligation-induced gastric ulcer in rats

  2011cited by this paper
• Phytochemical analysis, antioxidant and anti-inflammatory activities of Phyllanthus simplex.

  2011cited by this paper
• Some Biochemical Effect of Intraperitoneal Administration of Phyllanthus amarus Aquoeus Extacts on Normaglycemic Albino Rats

  2010cited by this paper
• Protective activity of phyllanthin in ethanol-treated primary culture of rat hepatocytes.

  2010cited by this paper
• Evaluation of the antiamnesic effects of Phyllanthus amarus in mice.

  2007cited by this paper
• Antimicrobial potentiality of Phyllanthus amarus against drug resistant pathogens

  2006cited by this paper
• Phytochemicals from Phyllanthus niruri Linn. and their pharmacological properties: a review

  2006cited by this paper
• Rapid diagnosis of Helicobacter pylori infection in dyspeptic patients using salivary secretion: a non-invasive approach.

  2005cited by this paper
• Free radical scavenging reactions of sulfasalazine, 5-aminosalicylic acid and sulfapyridine: Mechanistic aspects and antioxidant activity

  2005cited by this paper
• Effects of Momordica charantia L. (Cucurbitaceae) on indomethacin-induced ulcer model in rats.

  2005cited by this paper
• Effect of polyherbal formulation on experimental models of inflammatory bowel diseases.

  2004cited by this paper
• Imbalanced secondary mucosal antioxidant response in inflammatory bowel disease

  2003cited by this paper
• The pathogenesis of inflammatory bowel disease: Translational implications for clinicians

  2002cited by this paper
• Oxidative stress as a pathogenic factor in inflammatory bowel disease — radicals or ridiculous?

  2002cited by this paper
• Nitric Oxide and Chronic Gut Inflammation: Controversies in Inflammatory Bowel Disease

  2002cited by this paper
• Effects of tumour necrosis factor-alpha synthesis inhibitors on rat trinitrobenzene sulphonic acid-induced chronic colitis.

  2001cited by this paper
• Reduced plasma antioxidant concentrations and increased oxidative DNA damage in inflammatory bowel disease.

  2001cited by this paper
• Contraceptive effects of Phyllanthus amarus in female mice

  2001cited by this paper
• Phyllanthus amarus extract administration increases the life span of rats with hepatocellular carcinoma.

  2000cited by this paper
• Anti-diarrhoeal and gastro-intestinal potentials of the aqueous extract of Phyllanthus amarus (Euphorbiaceae).

  2000cited by this paper
• Review article: the potential role of nitric oxide in chronic inflammatory bowel disorders

  1999cited by this paper
• Epidemiology and the natural course of inflammatory bowel disease.

  1999cited by this paper
• Lamina propria T cells in Crohn's disease and other gastrointestinal inflammation show defective CD2 pathway-induced apoptosis.

  1999cited by this paper
• Glutathione and its role in cellular functions.

  1999cited by this paper
• A review of the plants of the genus Phyllanthus: Their chemistry, pharmacology, and therapeutic potential

  1998cited by this paper
• Expression of nitric oxide synthases and formation of nitrotyrosine and reactive oxygen species in inflammatory bowel disease

  1998cited by this paper
• Role of cytokines and platelet-activating factor in inflammatory bowel disease

  1996cited by this paper
• Phyllanthus amarus down‐regulates hepatitis B virus mRNA transcription and replication

  1996cited by this paper
• Evaluating the antioxidant potential of new treatments for inflammatory bowel disease using a rat model of colitis.

  1996cited by this paper
• Effect of quercitrin on acute and chronic experimental colitis in the rat.

  1996cited by this paper
• Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis

  1995cited by this paper
• Experimental models of inflammatory bowel disease.

  1995cited by this paper
• Comparative hepatoprotective activity of three Phyllanthus species, P. urinaria, P. niruri and P. simplex, on carbon tetrachloride induced liver injury in the rat

  1995cited by this paper
• Analysis of the mechanisms underlying the antinociceptive effect of the extracts of plants from the genus Phyllanthus.

  1995cited by this paper
• Singapore Med J

  1993cited by this paper
• Nitric oxide synthase activity in ulcerative colitis and Crohn's disease.

  1993cited by this paper
• Tumour necrosis factor alpha in stool as a marker of intestinal inflammation.

  1992cited by this paper
• Oxygen radicals in ulcerative colitis.

  1992cited by this paper
• A comparative analysis of two models of colitis in rats.

  1992cited by this paper
• Role of reactive oxygen metabolites in experimental colitis.

  1990cited by this paper
• Clinical evidence supporting the radical scavenger mechanism of 5-aminosalicylic acid.

  1990cited by this paper
• Evidence for GABA-BZ receptor modulation in short-term memory passive avoidance task paradigm in mice.

  1990cited by this paper
• Cytotoxic mechanism of tumor necrosis factor‐α

  1990cited by this paper
• Inflammatory mediators of experimental colitis in rats.

  1989cited by this paper
• Hapten-induced model of chronic inflammation and ulceration in the rat colon.

  1989cited by this paper
• Spleen size in patients with inflammatory bowel disease

  1987cited by this paper
• Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity: Assessment of inflammation in rat and hamster models

  1984cited by this paper
• Carbon tetrachloride-induced liver injury in the rabbit.

  1983cited by this paper

• Phyllanthus amarus as a multifunctional medicinal herb: Bioactive compounds, mechanisms, and clinical perspectives

  2026cites this paper
• Phytopharmaceuticals: An Emerging Field for India's Herbal Tradition

  2025cites this paper
• Phyllanthin from Phyllanthus amarus exerts neuroprotective effects against spinal cord injury in experimental rats

  2025cites this paper
• Phyllanthin from Phyllanthus amarus protects the myocardium during pressure overload-induced cardiac hypertrophy by inhibiting the angiotensin-converting enzyme.

  2025influential citation
• Alginate-based microencapsulation enhances antinociceptive and anti-inflammatory activities of Phyllanthus amarus and Phyllanthus muellerianus

  2024cites this paper
• An update on the bioactivities and health benefits of two plant-derived lignans, phyllanthin and hypophyllanthin

  2024cites this paper
• Co-delivery of a curcumin and asafoetida as a bioavailable complex using fenugreek galactomannan hydrogel scaffold alleviates inflammatory bowel disease on experimental animals

  2024cites this paper
• Celebrating Excellence in Research of the Last 20 Years: A Look at Apollo Medicine’s Top 20 Most Cited Papers

  2024cites this paper
• Pharmacological activities and mechanisms of action of hypophyllanthin: A review

  2023cites this paper
• Eicosapentaenoic acid mitigates ulcerative colitis-induced by acetic acid through modulation of NF-κB and TGF-β/ EGFR signaling pathways.

  2023cites this paper
• Naringin-loaded Arabic gum/pectin hydrogel as a potential wound healing material.

  2022cites this paper
• Pre-clinical investigation of protective effect of nutraceutical D-glucosamine on TNBS-induced colitis

  2022cites this paper
• Histo-Pathology Of Some Internal Organs Of Broiler Chickens Infected With Salmonella enteritidis And Treated With Methanol Extract Of Phyllanthus amarus’ Leaves

  2022cites this paper
• The effect of woody endocarpium of walnut alcoholic extract on acetic acid-induced ulcerative colitis in rats

  2022cites this paper
• Evaluation of Phyllanthus amarus leaf meal for hepato nephro-protective potentials in broiler chickens

  2021cites this paper
• D-Pinitol-attenuated trinitrobenzene sulfonic acid-induced ulcerative colitis in experimental rats: possible through inhibition of nuclear factor-κb/nuclear factor of kappa light polypeptide gene enhancer in b-cell inhibitor-alpha pathway and activation of colonic tight junction proteins

  2021cites this paper
• Pharmacological Aspects of Phyllanthus fraternus Standardized Extract (Rich in Lignans and Tannins) as a Pain Modulator

  2020cites this paper
• Protective effects of flavonoid composition rich P. subpeltata Ortega. on indomethacin induced experimental ulcerative colitis in rat models of inflammatory bowel diseases.

  2020cites this paper
• Phyllathin From Phyllanthus Amarus Ameliorates Epileptic Convulsion and Kindling Associated Post-Ictal Depression in Mice via Inhibition of NF-κB/TLR-4 Pathway

  2020influential citation
• Elucidation of colon-protective efficacy of diosgenin in experimental TNBS-induced colitis: inhibition of NF-κB/IkB-α and Bax/Caspase-1 signaling pathways

  2020cites this paper
• Ulcerative colitis induced with acetic acid is ameliorated by Antrocaryon micraster through reduced serum levels of tumor necrosis factor alpha and interleukin-6 in sprague dawley rats

  2020cites this paper
• Piperine, a functional food alkaloid, exhibits inhibitory potential against TNBS-induced colitis via the inhibition of IκB-α/NF-κB and induces tight junction protein (claudin-1, occludin, and ZO-1) signaling pathway in experimental mice

  2019influential citation
• Diarylheptanoid, a constituent isolated from methanol extract of Alpinia officinarum attenuates TNF-α level in Freund's complete adjuvant-induced arthritis in rats.

  2019cites this paper
• A Qualitative Analysis of Tannin Type and Tannin Content in Meniran Tea (Phyllanthus Niruri Linn.) with Permanganometry Method

  2019cites this paper
• Protective effect of methylene blue on TNBS-induced colitis in rats mediated through the modulation of inflammatory and apoptotic signalling pathways

  2019cites this paper
• Phyllanthin and hypophyllanthin from Phyllanthus amarus ameliorates immune-inflammatory response in ovalbumin-induced asthma: role of IgE, Nrf2, iNOs, TNF-α, and IL’s

  2018cites this paper
• Neuroprotective effect of naringin, a flavone glycoside in quinolinic acid-induced neurotoxicity: Possible role of PPAR-γ, Bax/Bcl-2, and caspase-3.

  2018cites this paper
• Phyllanthin from Phyllanthus amarus inhibits LPS‐induced proinflammatory responses in U937 macrophages via downregulation of NF‐κB/MAPK/PI3K‐Akt signaling pathways

  2018cites this paper
• Neuroprotective effect of Azadirachta indica standardized extract in partial sciatic nerve injury in rats: Evidence from anti-inflammatory, antioxidant and anti-apoptotic studies

  2017cites this paper
• Rhapontin ameliorates colonic epithelial dysfunction in experimental colitis through SIRT1 signaling

  2017cites this paper
• Elucidation of protective efficacy of Pentahydroxy flavone isolated from Madhuca indica against arsenite-induced cardiomyopathy: Role of Nrf-2, PPAR-γ, c-fos and c-jun.

  2017cites this paper
• Effect of salbutamol against the experimental acute colitis in rat model

  2017cites this paper
• Phyllanthin: A Potential Lead Molecule for the Future Needs

  2017cites this paper
• Anti‐inflammatory and antioxidant potential of Guaianolide isolated from Cyathocline purpurea: Role of COX‐2 inhibition

  2017cites this paper
• Ameliorative effect of naringin in acetaminophen-induced hepatic and renal toxicity in laboratory rats: role of FXR and KIM-1

  2016cites this paper
• Flax Lignan Concentrate Ameliorates Nω-Nitro-L-Arginine Methyl Ester (L-NAME)-Induced Hypertension: Role of Antioxidant, Angiotensin-Converting Enzyme and Nitric Oxide

  2016cites this paper
• Evaluation of Anti-Hyperlipidemic Potential of Prosopis cineraria Extract Against High Fat Diet Induced Hyperlipidemia in Laboratory Rat

  2016cites this paper
• Flax lignan concentrate reverses alterations in blood pressure, left ventricular functions, lipid profile and antioxidant status in DOCA-salt induced renal hypertension in rats

  2016cites this paper
• Wound healing potential of naringin ointment formulation via regulating the expression of inflammatory, apoptotic and growth mediators in experimental rats

  2016cites this paper
• Hepatoprotective effect of withanolide-rich fraction in acetaminophen-intoxicated rat: decisive role of TNF-α, IL-1β, COX-II and iNOS

  2016influential citation
• Ameliorative Effect of Alkaloidal Fraction of Leaves of Alstonia scholaris Against Acetic Acid Induced Colitis via Modulation of Oxido-nitrosative and Pro-inflammatory Cytokines

  2016cites this paper
• lax lignan concentrate attenuate hypertension and abnormal left entricular contractility via modulation of endogenous biomarkers n two-kidney-one-clip ( 2 K 1 C ) hypertensive rats

  2016cites this paper
• Ameliorative Effect of Ginger Extract in Acetic Acid Induced Ulcerative Colitis in Rats

  2016cites this paper
• Anti-apoptotic effects of phyllanthin against alcoholinduced liver cell death

  2016cites this paper
• Flax lignan concentrate attenuate hypertension and abnormal left ventricular contractility via modulation of endogenous biomarkers in two-kidney-one-clip (2K1C) hypertensive rats

  2016cites this paper
• Ameliorative effect of berberine against gentamicin-induced nephrotoxicity in rats via attenuation of oxidative stress, inflammation, apoptosis and mitochondrial dysfunction

  2016cites this paper
• Anti-inflammatory Effect of Grape Seed Extract on Bronchial Asthma Induced in Mice

  2016cites this paper
• Renoprotective effect of berberine via intonation on apoptosis and mitochondrial-dependent pathway in renal ischemia reperfusion-induced mutilation

  2015cites this paper
• Antiulcer Potential of Morin in Acetic acid-Induced Gastric Ulcer via Modulation of Endogenous Biomarkers in Laboratory Animals

  2015cites this paper
• l-Arginine attenuates the ethylene glycol induced urolithiasis in ininephrectomized hypertensive rats: role of KIM-1, NGAL, and NOs

  2015cites this paper
• Naringin ameliorates sodium arsenite-induced renal and hepatic toxicity in rats: decisive role of KIM-1, Caspase-3, TGF-β, and TNF-α

  2015cites this paper
• Pain Modulation by Lignans (Phyllanthin and Hypophyllanthin) and Tannin (Corilagin) Rich Extracts of Phyllanthus amarus in Carrageenan‐induced Thermal and Mechanical Chronic Muscle Hyperalgesia

  2015cites this paper
• Chondroprotective potential of Phyllanthus amarus Schum. & Thonn. in experimentally induced cartilage degradation in the explants culture model

  2015cites this paper
• Protective action of the phyllanthin against carbon tetrachloride-induced hepatocyte damage in Cyprinus carpio

  2015cites this paper
• Omega-3-fatty acid adds to the protective effect of flax lignan concentrate in pressure overload-induced myocardial hypertrophy in rats via modulation of oxidative stress and apoptosis.

  2015cites this paper
• In-vitro Free Radicals Scavenging and Antioxidant Activity of Rice Bran Extract

  2015cites this paper
• Artemisia pallens alleviates acetaminophen induced toxicity via modulation of endogenous biomarkers

  2015cites this paper
• Hepatoprotective and antioxidant effects of phyllanthin against carbon tetrachloride-induced liver injury in Cyprinus carpio

  2014cites this paper
• An Overview of Important Ethnomedicinal Herbs of Phyllanthus Species: Present Status and Future Prospects

  2014cites this paper
• Naringin, a flavanone glycoside, promotes angiogenesis and inhibits endothelial apoptosis through modulation of inflammatory and growth factor expression in diabetic foot ulcer in rats.

  2014cites this paper
• Hesperidin, a flavanoglycone attenuates experimental diabetic neuropathy via modulation of cellular and biochemical marker to improve nerve functions

  2014cites this paper
• Naringin ameliorates acetic acid induced colitis through modulation of endogenous oxido-nitrosative balance and DNA damage in rats

  2013cites this paper
• Antiulcer activity of aqueous extract of leaves of Madhuca indica J. F. Gmel against naproxen induced gastric mucosal injury in rats

  2013cites this paper
• Endothelin receptor blocker bosentan inhibits hypertensive cardiac fibrosis in pressure overload-induced cardiac hypertrophy in rats

  2013cites this paper