p53 gene mutation and loss of heterozygosity are associated with increased risk of disease progression in adult T cell leukemia.

No abstract is available for this paper.

• Publication year

  1995

• Venue

  Leukemia

• Publication date

  1995-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 7723391
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• How loops, beta sheets, and alpha helices help us to understand p53.

  1994cited by this paper
• Loss of heterozygosity and p53 gene mutations in breast cancer.

  1994cited by this paper
• p53 is required for radiation-induced apoptosis in mouse thymocytes

  1993cited by this paper
• p53 gene mutations in multiple myeloma are associated with advanced forms of malignancy.

  1993cited by this paper
• WAF1, a potential mediator of p53 tumor suppression.

  1993cited by this paper
• Thymocyte apoptosis induced by p53-dependent and independent pathways

  1993cited by this paper
• Structural and functional analysis of oncogenes and tumor suppressor genes in adult T-cell leukemia/lymphoma shows frequent p53 mutations.

  1992cited by this paper
• p53 function and dysfunction.

  1992cited by this paper
• Clonal expansion of p53 mutant cells is associated with brain tumour progression

  1992cited by this paper
• Mutations of the p53 gene in adult T-cell leukemia.

  1992cited by this paper
• Frequent p53 gene mutations in blast crisis of chronic myelogenous leukemia, especially in myeloid crisis harboring loss of a chromosome 17p.

  1992cited by this paper
• p53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features.

  1992cited by this paper
• Diagnostic criteria and classification of clinical subtypes of adult T‐cell leukaemia‐lymphoma

  1991cited by this paper
• The spectrum of molecular alterations in the evolution of chronic myelocytic leukemia.

  1991cited by this paper
• p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia.

  1991cited by this paper
• Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation.

  1991cited by this paper
• p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis.

  1990cited by this paper
• Cell cycle control by p53 in normal (3T3) and chemically transformed (Meth A) mouse cells. I. Regulation of p53 expression.

  1990cited by this paper
• Cell cycle control of p53 in normal (3T3) and chemically transformed (Meth A) mouse cells. II. Requirement for cell cycle progression.

  1990cited by this paper
• Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction.

  1989cited by this paper
• Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms.

  1989cited by this paper
• G1 events and regulation of cell proliferation.

  1989cited by this paper
• Multi‐step Carcinogenesis Model for Adult T‐cell Leukemia

  1989cited by this paper
• Risk of adult T-cell leukaemia/lymphoma in HTLV-I carriers.

  1987cited by this paper
• Primary structure polymorphism at amino acid residue 72 of human p53

  1987cited by this paper
• Variation in the clinical courses of adult T‐cell leukemia

  1985cited by this paper
• Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease.

  1982cited by this paper
• The sequence of a human immunoglobulin epsilon heavy chain constant region gene, and evidence for three non‐allelic genes.

  1982cited by this paper
• Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma

  1980cited by this paper
• Adult T-cell leukemia: clinical and hematologic features of 16 cases.

  1977cited by this paper
• Detection of specific sequences among DNA fragments separated by gel electrophoresis.

  1975cited by this paper

• From regulation to deregulation of p53 in hematologic malignancies: implications for diagnosis, prognosis and therapy

  2024cites this paper
• Diagnostic Utility of SOX4 Expression in Adult T-Cell Leukemia/Lymphoma

  2021cites this paper
• HTLV-1 as a Model for Virus and Host Coordinated Immunoediting

  2019cites this paper
• Title ATF 3 , an HTLV-1 bZip factor binding protein , promotesproliferation of adult T-cell leukemia cells

  2019cites this paper
• Human T-cell leukaemia virus type 1: parasitism and pathogenesis

  2017cites this paper
• T Cell Receptor Vβ Staining Identifies the Malignant Clone in Adult T cell Leukemia and Reveals Killing of Leukemia Cells by Autologous CD8+ T cells

  2016cites this paper
• HTLV-I Tax-Mediated Inactivation of Cell Cycle Checkpoints and DNA Repair Pathways Contribute to Cellular Transformation: "A Random Mutagenesis Model".

  2015cites this paper
• Mutation Analysis for TP53 in Chronic-Type Adult T-Cell Leukemia/Lymphoma.

  2015cites this paper
• Incidence of Adult T-Cell Leukemia/Lymphoma in Nonendemic Areas

  2015cites this paper
• Point mutations in TP53 but not in p15Ink4b and p16Ink4a genes represent poor prognosis factors in acute adult T cell leukemia/lymphoma

  2015cites this paper
• Human T-Cell Leukemia Virus Type 1: Pathogenesis and Host Immune Response

  2014cites this paper
• Heat shock protein 90 inhibitor NVP-AUY922 exerts potent activity against adult T-cell leukemia–lymphoma cells

  2014cites this paper
• Molecular characterization of chronic-type adult T-cell leukemia/lymphoma.

  2014cites this paper
• LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription

  2013cites this paper
• transformed cells - HTLV-I B pathway in κ Transcriptional activation of hTERT through the NF-

  2013cites this paper
• ANÁLISE DOS NÍVEIS DE CARGA PROVIRAL E DA EXPRESSÃO DOS GENES VIRAIS tax E HBZ NA LEUCEMIA/LINFOMA DE CÉLULAS T DO ADULTO (ATL)

  2013cites this paper
• Title LKB 1 tumor suppressor and salt-inducible kinases negativelyregulate human T-cell leukemia virus type 1 transcription

  2013cites this paper
• Molecular Hallmarks of Adult T Cell Leukemia

  2012cites this paper
• Estudo de alterações genéticas associadas à leucemia/linfoma de células T do adulto no estado da Bahia

  2012cites this paper
• Human T-Cell Lymphotropic Virus (HTLV-1) and Adult T-Cell Leukemia

  2011cites this paper
• ATF3, an HTLV-1 bZip factor binding protein, promotes proliferation of adult T-cell leukemia cells

  2011cites this paper
• Frequent expression of gp46 in adult T‐cell leukemia/lymphoma: An immunohistochemical study of 40 cases

  2010cites this paper
• Promoter methylation of the bone morphogenetic protein‐6 gene in association with adult T‐cell leukemia

  2008cites this paper
• The State of the Art in the Pathogenesis of ATL and New Potential Targets Associated with HTLV-1 and ATL

  2007cites this paper
• Human T-cell leukemia virus type I induces adult T-cell leukemia: from clinical aspects to molecular mechanisms.

  2007cites this paper
• Downregulation of drs mRNA expression is associated with the progression of adult T-cell leukemia/lymphoma.

  2007cites this paper
• Leukaemogenic mechanism of human T‐cell leukaemia virus type I

  2007cites this paper
• [HTLV-I and leukemogenesis].

  2006cites this paper
• Down‐regulation of ASY/Nogo transcription associated with progression of adult T‐cell leukemia/lymphoma

  2006cites this paper
• Methylation analysis of the adenomatous polyposis coli (APC) gene in adult T-cell leukemia/lymphoma.

  2006cites this paper
• Impact of p53 aberration on the progression of Adult T-cell Leukemia/Lymphoma.

  2006cites this paper
• Adult T-cell leukaemia/lymphoma

  2006cites this paper
• Chapter 3 – Molecular Biology of Lymphoma

  2006cites this paper
• Methylation of the MLH1 gene in hematological malignancies.

  2005cites this paper
• Inactivation of tumor suppressor genes and the progression of adult T-cell leukemia-lymphoma

  2005cites this paper
• Human T cell leukemia virus type 1: the role of Tax in leukemogenesis.

  2005cites this paper
• Human T-cell leukemia virus type I (HTLV-I) infection and the onset of adult T-cell leukemia (ATL)

  2005cites this paper
• Cytogenetics of lymphomas

  2005cites this paper
• Human leukocyte antigen‐class II‐negative long‐term cultured human T‐cell leukemia virus type‐I‐infected T‐cell lines with progressed cytological properties significantly induce superantigen‐dependent normal T‐cell proliferation

  2005cites this paper
• Setting the stage for transformation: HTLV-1 Tax inhibition of p53 function.

  2005cites this paper
• Role of Tax protein in human T-cell leukemia virus type-I leukemogenicity

  2004cites this paper
• Transcriptional activation of hTERT through the NF-kappaB pathway in HTLV-I-transformed cells.

  2004cites this paper
• The HTLV-1 tax oncoprotein attenuates DNA damage induced G1 arrest and enhances apoptosis in p53 null cells.

  2003influential citation
• Cutaneous Type of Adult T Cell Leukemia/Lymphoma: A New Entity among Cutaneous Lymphomas

  2003cites this paper
• Inactivation of hTERT transcription by Tax

  2003cites this paper
• Leukemogenesis of Adult T-Cell Leukemia

  2003cites this paper
• Activation of HTLV-I long terminal repeat by apoptosis inducing agents: mechanism and implications for HTLV-I pathogenicity (review).

  2003cites this paper
• Dual mutations in the AML1 and FLT3 genes are associated with leukemogenesis in acute myeloblastic leukemia of the M0 subtype

  2003cites this paper
• Tumor suppressor genes in normal and malignant hematopoiesis

  2002cites this paper
• Pathology of lymphoma progression

  2001cites this paper
• Possible Involvement of Interferon Regulatory Factor 4 (IRF4) in a Clinical Subtype of Adult T‐Cell Leukemia

  2001cites this paper
• p53, bcl-2 and bax abnormalities in non-Hodgkin's lymphomas of the head and neck.

  2000cites this paper
• Mutación del gen p53 en el cáncer de la vesícula biliar

  2000cites this paper
• [P53 gene mutation in gallbladder cancer].

  2000cites this paper
• Expression of cell cycle regulating proteins in an unusual transformation of mantle cell lymphoma.

  1999cites this paper
• Implication of HTLV-I infection, strongyloidiasis, and P53 overexpression in the development, response to treatment, and evolution of non-Hodgkin's lymphomas in an endemic area (Martinique, French West Indies).

  1999cites this paper
• Expression of Cell Cycle Regulating Proteins in an Unusual Transformation of Mantle Cell Lymphoma.

  1999cites this paper
• Human T-Cell Lymphotropic/Leukemia Virus Type 1 Tax Abrogates p53-Induced Cell Cycle Arrest and Apoptosis through Its CREB/ATF Functional Domain

  1998cites this paper
• Pooled analysis of p53 mutations in hematological malignancies

  1998cites this paper
• Correlation of telomerase activity with development and progression of adult T-cell leukemia.

  1998cites this paper
• The non-random distribution of point mutations in leukaemia and myelodysplasia--a possible pointer to their aetiology.

  1997cites this paper
• Discrepancy, coincidence or evidence in chronic idiopathic spastic paraparesis throughout the world. A meta-analysis on 2811 patients.

  1997cites this paper
• Extensive analysis of the retinoblastoma gene in adult T cell leukemia/lymphoma (ATL)

  1997cites this paper
• [p53 and hematologic malignancies].

  1997cites this paper
• Correlation between mutations in p53 gene and protein expression in human lymphomas

  1997cites this paper
• Exon 5 mutations in the p53 gene in relapsed childhood acute lymphoblastic leukemia.

  1997cites this paper
• p53 mutations in mantle cell lymphoma are associated with variant cytology and predict a poor prognosis.

  1996cites this paper