Homologous recombination induced by replication inhibition, is stimulated by expression of mutant p53

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Oncogene

• Publication date

  2002-01-17

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.onc.1205040PMID 11821962
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• p53 accumulates but is functionally impaired when DNA synthesis is blocked.

  2001cited by this paper
• Mechanisms and consequences of replication fork arrest.

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  2000influential reference
• Role of heteroduplex joints in the functional interactions between human Rad51 and wild-type p53

  2000cited by this paper
• Dissociation of p53-mediated suppression of homologous recombination from G1/S cell cycle checkpoint control

  2000cited by this paper
• Mutant p53 proteins stimulate spontaneous and radiation-induced intrachromosomal homologous recombination independently of the alteration of the transactivation activity and of the G1 checkpoint

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• Dissociation of the recombination control and the sequence-specific transactivation function of P53

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• The BRCA2 gene product functionally interacts with p53 and RAD51.

  1998cited by this paper
• Role of the human RAD51 protein in homologous recombination and double-stranded-break repair.

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• Increase of spontaneous intrachromosomal homologous recombination in mammalian cells expressing a mutant p53 protein

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• Interaction of p53 with the human Rad51 protein.

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• Association of BRCA1 with Rad51 in mitotic and meiotic cells.

  1997cited by this paper
• Inactivation of p53 results in high rates of homologous recombination

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  1996influential reference
• p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction.

  1996cited by this paper
• In vivo assay of p53 function in homologous recombination between simian virus 40 chromosomes

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• A general protocol for evaluating the specific effects of DNA replication inhibitors.

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• Rearrangement of the human tre oncogene by homologous recombination between Alu repeats of nucleotide sequences from two different chromosomes.

  1992cited by this paper
• Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells.

  1992cited by this paper
• Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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• Expression of recessive alleles by chromosomal mechanisms in retinoblastoma

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• When PIP2 Meets p53: Nuclear Phosphoinositide Signaling in the DNA Damage Response

  2022cites this paper
• Human RAD52 protein regulates homologous recombination and checkpoint function in BRCA2 deficient cells.

  2019cites this paper
• An LTR retrotransposon‐derived lncRNA interacts with RNF169 to promote homologous recombination

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• Functional relationship between p53 and RUNX proteins

  2018cites this paper
• p53 orchestrates DNA replication restart homeostasis by suppressing mutagenic RAD52 and POLθ pathways

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• p53 suppresses mutagenic RAD52 and POLθ pathways by orchestrating DNA replication restart homeostasis

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• Involvement of p53 in the repair of DNA double strand breaks: multifaceted Roles of p53 in homologous recombination repair (HRR) and non-homologous end joining (NHEJ).

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• p 53 modulates homologous recombination by transcriptional regulation of the RAD 51 gene

  2013cites this paper
• p53 suppresses BRCA2-stimulated ATPase and strand exchange functions of human RAD51.

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• p53 modulates homologous recombination at I-SceI-induced double-strand breaks through cell-cycle regulation

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• Chromosome instability and deregulated proliferation: an unavoidable duo

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• Uncoupling of RAD51 focus formation and cell survival after replication fork stalling in RAD51D null CHO cells

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• Oligo/Polynucleotide-Based Gene Modification: Strategies and Therapeutic Potential

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• ATR-p53 Restricts Homologous Recombination in Response to Replicative Stress but Does Not Limit DNA Interstrand Crosslink Repair in Lung Cancer Cells

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• Implication des mécanismes de la réparation de l'ADN dans la maintenance des télomères et l'instabilité chromosomique dans les cellules humaines

  2008cites this paper
• Modulation of p53 activities by the prolyl-isomerase PIN1 and the bromodomain protein BRD7

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• Rad51 overexpression contributes to chemoresistance in human soft tissue sarcoma cells: a role for p53/activator protein 2 transcriptional regulation

  2007cites this paper
• Absence of p53 Enhances Growth Defects and Etoposide Sensitivity of Human Cells Lacking the Bloom Syndrome Helicase BLM

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• DDB2-Independent Role for p53 in the Recovery from Ultraviolet Light-Induced Replication Arrest

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• p53 and DNA damage checkpoint responses in the human prostate

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• P53: Gatekeeper, Caretaker or Both?

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• Linking DNA damage to medulloblastoma tumorigenesis in patched heterozygous knockout mice

  2006cites this paper
• p53 modulates homologous recombination by transcriptional regulation of the RAD51 gene

  2006cites this paper
• Poly ( ADP-RIBOSE ) polymerase-1 ( Parp-1 ) antagonizes topoisomerase I-dependent recombination stimulation by P 53

  2006cites this paper
• Poly(ADP-RIBOSE) polymerase-1 (Parp-1) antagonizes topoisomerase I-dependent recombination stimulation by P53

  2006cites this paper
• p53 in recombination and repair

  2006cites this paper
• Generation of loss of heterozygosity and its dependency on p53 status in human lymphoblastoid cells

  2005cites this paper
• Transcription-independent suppression of DNA synthesis by p53 in sperm-irradiated mouse zygotes

  2005cites this paper
• Differences in the association of p53 phosphorylated on serine 15 and key enzymes of homologous recombination

  2005cites this paper
• Genetic interactions between RAD51 and its paralogues for centrosome fragmentation and ploidy control, independently of the sensitivity to genotoxic stresses

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• p53 Monitors Replication Fork Regression by Binding to “Chickenfoot” Intermediates*

  2005cites this paper
• Wild-type p53 stimulates homologous recombination upon sequence-specific binding to the ribosomal gene cluster repeat

  2005influential citation
• Alternative recombination pathways in UV-irradiated XP variant cells

  2005cites this paper
• Gene repair in mammalian cells is stimulated by the elongation of S phase and transient stalling of replication forks.

  2005cites this paper
• [Direct role of p53 on homologous recombination].

  2005cites this paper
• Role of p53 in Double-Strand Break Repair

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• Analysis of DNA Recombination Proteins in DNA Damage Response

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• Using methyl methanesulfonate (MMS) to stimulate targeted gene repair activity in mammalian cells

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• Rôle direct de p53 dans la recombinaison homologue

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• p53: traffic cop at the crossroads of DNA repair and recombination

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• Resistance to the antibiotic Zeocin by stable expression of the Sh ble gene does not fully suppress Zeocin-induced DNA cleavage in human cells.

  2005cites this paper
• Camptothecin enhances the frequency of oligonucleotide-directed gene repair in mammalian cells by inducing DNA damage and activating homologous recombination.

  2004cites this paper
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• The interaction of p53 with replication protein A mediates suppression of homologous recombination

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• Pathways for mitotic homologous recombination in mammalian cells.

  2003cites this paper
• Interacts with hRAD 51 and hRAD 54 , and Directly Modulates Homologous Recombination 1 , 2

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• BLM helicase‐dependent transport of p53 to sites of stalled DNA replication forks modulates homologous recombination

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• p53 interacts with hRAD51 and hRAD54, and directly modulates homologous recombination.

  2003cites this paper
• Activities of wildtype and mutant p53 in suppression of homologous recombination as measured by a retroviral vector system.

  2003cites this paper
• Wild-type p53 inhibits replication-associated homologous recombination

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• Association of p53 and MSH2 with recombinative repair complexes during S phase

  2002cites this paper