Evaluation of Combination Therapy in Animal Models of Cerebral Ischemia

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Journal of Cerebral Blood Flow and Metabolism

• Publication date

  2012-02-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1038/jcbfm.2011.203PMID 22293990PMCID PMC3318154
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Neuroprotection for ischemic stroke: Two decades of success and failure

  2011cited by this paper
• Combination Therapy of 17β-Estradiol and Recombinant Tissue Plasminogen Activator for Experimental Ischemic Stroke

  2010cited by this paper
• Publication Bias in Reports of Animal Stroke Studies Leads to Major Overstatement of Efficacy

  2010cited by this paper
• Cochrane Handbook for Systematic Reviews of Interventions

  2010cited by this paper
• Combination Treatment With VELCADE and Low-Dose Tissue Plasminogen Activator Provides Potent Neuroprotection in Aged Rats After Embolic Focal Ischemia

  2010cited by this paper
• Combination of NEP 1-40 Treatment and Motor Training Enhances Behavioral Recovery After a Focal Cortical Infarct in Rats

  2010cited by this paper
• Tacrolimus (FK506) suppresses rt-PA-induced hemorrhagic transformation in a rat thrombotic ischemia stroke model.

  2009cited by this paper
• Scope of preclinical testing versus quality control within experiments.

  2009cited by this paper
• Combination therapy with normobaric oxygen (NBO) plus thrombolysis in experimental ischemic stroke

  2009cited by this paper
• Evidence for the Efficacy of NXY-059 in Experimental Focal Cerebral Ischaemia Is Confounded by Study Quality

  2008cited by this paper
• Extension of the Thrombolytic Time Window With Minocycline in Experimental Stroke

  2008cited by this paper
• A critical appraisal of the NXY-059 neuroprotection studies for acute stroke: a need for more rigorous testing of neuroprotective agents in animal models of stroke.

  2007cited by this paper
• Evidence-Based Medical Therapy of Patients with Acute Coronary Syndromes

  2007cited by this paper
• Guidelines for the Early Management of Adults With Ischemic Stroke

  2007cited by this paper
• Recommendations from the STAIR V meeting on acute stroke trials, technology and outcomes.

  2007cited by this paper
• A review of agents patented for their neuroprotective properties.

  2006cited by this paper
• Management of acute stroke.

  2006cited by this paper
• 1,026 Experimental treatments in acute stroke

  2006cited by this paper
• Meta-analysis of mortality and cancer incidence among workers in the synthetic rubber-producing industry.

  2006cited by this paper
• Toward a Multimodal Neuroprotective Treatment of Stroke

  2006cited by this paper
• Systematic Review and Metaanalysis of the Efficacy of FK506 in Experimental Stroke

  2005cited by this paper
• Enhancing the Development and Approval of Acute Stroke Therapies: Stroke Therapy Academic Industry Roundtable

  2005cited by this paper
• Behavioral and histological effects of chronic antipsychotic and antidepressant drug treatment in aged rats with focal ischemic brain injury.

  2005cited by this paper
• Systematic review and meta‐analysis of the efficacy of melatonin in experimental stroke

  2005cited by this paper
• Advances in the combination of radiation therapy and chemotherapy against cancer.

  2004cited by this paper
• Pooling of Animal Experimental Data Reveals Influence of Study Design and Publication Bias

  2004influential reference
• The search for neuroprotective strategies in stroke.

  2004cited by this paper
• Advances in the combination of radiation therapy and chemotherapy against cancer.

  2004cited by this paper
• Effects of Combined Estrogen and Progesterone on Brain Infarction in Reproductively Senescent Female Rats

  2004cited by this paper
• Drug interactions: a review and update.

  2003cited by this paper
• Recommendations for Advancing Development of Acute Stroke Therapies: Stroke Therapy Academic Industry Roundtable 3

  2003cited by this paper
• Measuring inconsistency in meta-analyses

  2003cited by this paper
• Combination of dexanabinol and tempol in focal cerebral ischemia: is there a ceiling effect?

  2003cited by this paper
• Guidelines for the Early Management of Patients With Ischemic Stroke: A Scientific Statement From the Stroke Council of the American Stroke Association

  2003cited by this paper
• Neuroprotective effects of YM872 coadministered with t-PA in a rat embolic stroke model.

  2003cited by this paper
• Better blood pressure control: how to combine drugs

  2003cited by this paper
• How should meta‐regression analyses be undertaken and interpreted?

  2002cited by this paper
• Management of acute stroke.

  2002cited by this paper
• Combination Therapies and the Theoretical Limits of Evidence-Based Medicine

  2001cited by this paper
• Trim and Fill: A Simple Funnel‐Plot–Based Method of Testing and Adjusting for Publication Bias in Meta‐Analysis

  2000cited by this paper
• Reduction of Tissue Plasminogen Activator-Induced Hemorrhage and Brain Injury by Free Radical Spin Trapping after Embolic Focal Cerebral Ischemia in Rats

  2000cited by this paper
• Calcineurin inhibitors FK506 and SDZ ASM 981 alleviate the outcome of focal cerebral ischemic/reperfusion injury.

  1999cited by this paper
• Neuroprotection as initial therapy in acute stroke. Third Report of an Ad Hoc Consensus Group Meeting. The European Ad Hoc Consensus Group.

  1998cited by this paper
• Neuroprotection as Initial Therapy in Acute Stroke

  1998cited by this paper
• Neuroprotection afforded by a combination of eliprodil and a thrombolytic agent, rt-PA, in a rat thromboembolic stroke model.

  1997cited by this paper
• Explaining heterogeneity in meta-analysis: a comparison of methods.

  1997cited by this paper
• Bias in meta-analysis detected by a simple, graphical test

  1997influential reference
• Effect of hypothermia and delayed thrombolysis in a rat embolic stroke model

  1994cited by this paper
• Neuroprotection by Excitatory Amino Acid Antagonist Augments the Benefit of Thrombolysis in Embolic Stroke in Rats

  1993cited by this paper
• Influence of Tissue Plasminogen Activator and Heparin on Cerebral Ischemia in a Rabbit Model

  1992cited by this paper
• Meta-analysis in clinical trials.

  1986cited by this paper

• How to Pick a Neuroprotective Drug in Stroke Without Losing Your Mind?

  2025cites this paper
• Failed Neuroprotection Trials: An Evaluation of Complexity and Clinical Trial Design.

  2025cites this paper
• Optimized dose of hydrogen-enriched water with minocycline combination therapy in experimental ischemic stroke.

  2025cites this paper
• Stroke: Current State of the Problem

  2025cites this paper
• Summer school for systematic reviews of animal studies: Fostering evidence-based and rigorous animal research.

  2024cites this paper
• The Influence of Oxidative Stress Markers in Patients with Ischemic Stroke

  2024cites this paper
• [Oxidative stress in the pathogenesis of stroke and its correction].

  2023cites this paper
• The Role of Oxidative Stress in Acute Ischemic Stroke-Related Thrombosis

  2022cites this paper
• Oxidative Stress in Ischemia/Reperfusion Injuries following Acute Ischemic Stroke

  2022cites this paper
• Identifying stroke therapeutics from preclinical models: A protocol for a novel application of network meta-analysis [version 1; peer review: 2 approved]

  2021cites this paper
• Oxidative Stress in the Brain: Basic Concepts and Treatment Strategies in Stroke

  2021cites this paper
• CNB‐001, a pleiotropic drug is efficacious in embolized agyrencephalic New Zealand white rabbits and ischemic gyrencephalic cynomolgus monkeys

  2019cites this paper
• NG2-glia cell proliferation and differentiation by glial growth factor 2 (GGF2), a strategy to promote functional recovery after ischemic stroke.

  2019cites this paper
• Natural Products for the Treatment of Neurodegenerative Diseases.

  2019cites this paper
• Identifying stroke therapeutics from preclinical models: A protocol for a novel application of network meta-analysis

  2019cites this paper
• Bis(propyl)-cognitin potentiates rehabilitation of treadmill exercise after a transient focal cerebral ischemia, possibly via inhibiting NMDA receptor and regulating VEGF expression.

  2019cites this paper
• Genome Analysis Reveals a Synergistic Mechanism of Ursodeoxycholic Acid and Jasminoidin in Mice Brain Repair After Ischemia/Reperfusion: Crosstalk Among Muti-Pathways

  2019cites this paper
• Intravenous xenogeneic human cardiosphere‐derived cell extracellular vesicles (exosomes) improves behavioral function in small‐clot embolized rabbits

  2018cites this paper
• The Synergistic Combination of Everolimus and Paroxetine Exerts Post-ischemic Neuroprotection In Vitro

  2018cites this paper
• Variability of functional outcome measures used in animal models of stroke and vascular cognitive impairment – a review of contemporary studies

  2018cites this paper
• Co-administration of liposomal fasudil and tissue plasminogen activator ameliorated ischemic brain damage in occlusion model rats prepared by photochemically induced thrombosis.

  2018cites this paper
• Reframing the Biological Basis of Neuroprotection Using Functional Genomics: Differentially Weighted, Time-Dependent Multifactor Pathogenesis of Human Ischemic Brain Damage

  2018cites this paper
• Combination therapy with liposomal neuroprotectants and tissue plasminogen activator for treatment of ischemic stroke

  2017cites this paper
• Anesthetic Neuroprotection in Experimental Stroke in Rodents: A Systematic Review and Meta-analysis

  2017cites this paper
• Combination Therapy with Thrombolysis

  2017cites this paper
• Usefulness of Liposomal Neuroprotectants for the Treatment of Ischemic Stroke

  2017cites this paper
• Hypothermia and the Evaluation of Combination Therapies for Neonatal Hypoxic-Ischemic Brain Damage

  2016cites this paper
• Oxygen or cooling, to make a decision after acute ischemia stroke

  2016cites this paper
• Normobaric Hyperoxia Extends Neuro- and Vaso-Protection of N-Acetylcysteine in Transient Focal Ischemia

  2016cites this paper
• Anesthesia for Endovascular Approaches to Acute Ischemic Stroke.

  2016cites this paper
• The effect of combined therapies on recovery after acquired brain injury: Systematic review of preclinical studies combining enriched environment, exercise, or task-specific training with other therapies

  2016cites this paper
• Vertical and Horizontal Convergences of Targeting Pathways in Combination Therapy with Baicalin and Jasminoidin for Cerebral Ischemia.

  2016cites this paper
• Assessment of dose–effect and therapeutic time window in preclinical studies of rhEGF and GHRP-6 coadministration for stroke therapy

  2016cites this paper
• Combination of thrombolytic therapy and neuroprotective therapy in acute ischemic stroke: is it important?

  2015cites this paper
• Neuroprotective effect of ginsenoside-Rg1 on cerebral ischemia/reperfusion injury in rats by downregulating protease-activated receptor-1 expression.

  2015cites this paper
• Stroke and Traumatic Brain Injury

  2014cites this paper
• AFTER TRANSIENT CEREBRAL ISCHEMIA

  2014cites this paper
• Blood-brain barrier leakage after transient cerebral ischemia

  2014cites this paper
• Edaravone Improves Functional and Structural Outcomes in Animal Models of Focal Cerebral Ischemia: A Systematic Review

  2014cites this paper
• Early ischemic blood brain barrier damage: a potential indicator for hemorrhagic transformation following tissue plasminogen activator (tPA) thrombolysis?

  2014cites this paper
• Bone Marrow Cell Transplantation Time-Dependently Abolishes Efficacy of Granulocyte Colony-Stimulating Factor After Stroke in Hypertensive Rats

  2014cites this paper
• Hypothermia protects human neurons

  2014cites this paper
• Systems Pharmacology Dissection of Multi-Scale Mechanisms of Action for Herbal Medicines in Stroke Treatment and Prevention

  2014cites this paper
• Oxidative Stress and the Use of Antioxidants in Stroke

  2014cites this paper
• Neurotoxicity and Stroke

  2014cites this paper
• Pharmacological Treatment of Acute Ischemic Stroke

  2013cites this paper
• Combined Antiapoptotic and Antioxidant Approach to Acute Neuroprotection for Stroke in Hypertensive Rats

  2013cites this paper
• Hypertension and Experimental Stroke Therapies

  2013cites this paper
• Efficacy of mild hypothermia (35°C) and moderate hypothermia (33°C) with and without magnesium when administered 30min post-reperfusion after 90min of middle cerebral artery occlusion in Spontaneously Hypertensive rats.

  2013cites this paper
• Issues related to development of antiepileptogenic therapies

  2013cites this paper
• Normobaric hyperoxia combined with minocycline provides greater neuroprotection than either alone in transient focal cerebral ischemia.

  2013cites this paper
• Traitement de l'ischémie cérébrale

  2012cites this paper
• Stroke outcome in the ketogenic state – a systematic review of the animal data

  2012cites this paper
• Comparing Hypothermia and Magnesium After Global Ischemia—Editorial Commentary on Li et al., 2011

  2012cites this paper
• Do stroke models model stroke?

  2012influential citation
• Therapeutic imaging window of cerebral infarction revealed by multisequence magnetic resonance imaging: An animal and clinical study

  2012cites this paper
• Combined Anti-apoptotic and Anti-oxidant Approach to Acute Neuroprotection for Stroke in Hypertensive Rats Shrsp Heart and Liver Rna. Pet3a_ngb Was a Gift from Professor

  year unknowncites this paper