The Zds proteins control entry into mitosis and target protein phosphatase 2A to the Cdc25 phosphatase

Protein phosphatase 2A (PP2A) is a key regulator of mitosis, but the roles that it plays are poorly understood. New evidence in budding yeast shows that the Zds proteins form a tight stoichiometric complex with PP2A and target its activity to the Cdc25 phosphatase, which is a key regulator of entry into mitosis.

• Publication year

  2011

• Venue

  Molecular Biology of the Cell

• Publication date

  2011-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1091/mbc.E10-06-0487PMID 21119008PMCID 3016974
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Quantitative reconstitution of mitotic CDK1 activation in somatic cell extracts.

  2010cited by this paper
• Zds2p Regulates Swe1p-dependent Polarized Cell Growth in Saccharomyces cerevisiae via a Novel Cdc55p Interaction Domain

  2010cited by this paper
• Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2.

  2009cited by this paper
• Regulated activity of PP2A–B55δ is crucial for controlling entry into and exit from mitosis in Xenopus egg extracts

  2009cited by this paper
• The M phase kinase Greatwall (Gwl) promotes inactivation of PP2A/B55delta, a phosphatase directed against CDK phosphosites.

  2009cited by this paper
• Regulation of Mih1/Cdc25 by protein phosphatase 2A and casein kinase 1

  2008cited by this paper
• Cdc25A protein phosphatase: a therapeutic target for liver cancer therapies.

  2008cited by this paper
• Separase cooperates with Zds1 and Zds2 to activate Cdc14 phosphatase in early anaphase

  2008influential reference
• Mitotic CDKs control the metaphase-anaphase transition and trigger spindle elongation.

  2008cited by this paper
• The Septins Function in G1 Pathways that Influence the Pattern of Cell Growth in Budding Yeast

  2008cited by this paper
• Cdk1 coordinates cell-surface growth with the cell cycle

  2007cited by this paper
• Cdc25 and Wee1: analogous opposites?

  2007cited by this paper
• Cell Cycle: Principles of Control

  2007cited by this paper
• Toward a Comprehensive Atlas of the Physical Interactome of Saccharomyces cerevisiae*S

  2007cited by this paper
• Downregulation of PP2A(Cdc55) phosphatase by separase initiates mitotic exit in budding yeast.

  2006cited by this paper
• Mitotic phosphatases: no longer silent partners.

  2006cited by this paper
• Concerted mechanism of Swe1/Wee1 regulation by multiple kinases in budding yeast

  2005cited by this paper
• Cdk1-dependent regulation of the mitotic inhibitor Wee1.

  2005influential reference
• Conservation of mechanisms controlling entry into mitosis: budding yeast wee1 delays entry into mitosis and is required for cell size control.

  2003cited by this paper
• Wee1-dependent mechanisms required for coordination of cell growth and cell division

  2003cited by this paper
• The morphogenesis checkpoint: how yeast cells watch their figures.

  2003cited by this paper
• The septins

  2003cited by this paper
• Localization of Saccharomyces cerevisiae protein phosphatase 2A subunits throughout mitotic cell cycle.

  2002cited by this paper
• Functional organization of the yeast proteome by systematic analysis of protein complexes

  2002cited by this paper
• Checking cell size in yeast.

  2002cited by this paper
• Systematic Identification of Pathways That Couple Cell Growth and Division in Yeast

  2002cited by this paper
• G2/M arrest caused by actin disruption is a manifestation of the cell size checkpoint in fission yeast.

  2001cited by this paper
• A MAP kinase-dependent actin checkpoint ensures proper spindle orientation in fission yeast

  2001cited by this paper
• Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling.

  2001cited by this paper
• Septin-Dependent Assembly of a Cell Cycle-Regulatory Module in Saccharomyces cerevisiae

  2000cited by this paper
• A chemical switch for inhibitor-sensitive alleles of any protein kinase

  2000cited by this paper
• Loss of a Protein Phosphatase 2A Regulatory Subunit (Cdc55p) Elicits Improper Regulation of Swe1p Degradation

  2000influential reference
• Hsl7 Localizes to a Septin Ring and Serves as an Adapter in a Regulatory Pathway That Relieves Tyrosine Phosphorylation of Cdc28 Protein Kinase inSaccharomyces cerevisiae

  1999cited by this paper
• The Role of Actin in Spindle Orientation Changes during the Saccharomyces cerevisiae Cell Cycle

  1999cited by this paper
• The Elm1 Kinase Functions in a Mitotic Signaling Network in Budding Yeast

  1999influential reference
• Phosphorylation-Independent Inhibition of Cdc28p by the Tyrosine Kinase Swe1p in the Morphogenesis Checkpoint

  1999influential reference
• The Septins Are Required for the Mitosis-specific Activation of the Gin4 Kinase

  1998cited by this paper
• Protein identification at the low femtomole level from silver-stained gels using a new fritless electrospray interface for liquid chromatography-microspray and nanospray mass spectrometry.

  1998cited by this paper
• Additional modules for versatile and economical PCR‐based gene deletion and modification in Saccharomyces cerevisiae

  1998influential reference
• A Morphogenesis Checkpoint Monitors the Actin Cytoskeleton in Yeast

  1998cited by this paper
• Mutations in the Saccharomyces cerevisiae type 2A protein phosphatase catalytic subunit reveal roles in cell wall integrity, actin cytoskeleton organization and mitosis.

  1997cited by this paper
• Control of Mitotic Events by Nap1 and the Gin4 Kinase

  1997cited by this paper
• Saccharomyces cerevisiae Homologs of Mammalian B and B′ Subunits of Protein Phosphatase 2A Direct the Enzyme to Distinct Cellular Functions*

  1997cited by this paper
• Tripping the switch fantastic: how a protein kinase cascade can convert graded inputs into switch-like outputs.

  1996cited by this paper
• A search for proteins that interact genetically with histone H3 and H4 amino termini uncovers novel regulators of the Swe1 kinase in Saccharomyces cerevisiae.

  1996cited by this paper
• Femtomole sequencing of proteins from polyacrylamide gels by nano-electrospray mass spectrometry

  1996cited by this paper
• Yeast Protein Serine/Threonine Phosphatases: Multiple Roles and Diverse Regulation

  1996cited by this paper
• Protein phosphatase 2A regulates MPF activity and sister chromatid cohesion in budding yeast.

  1996cited by this paper
• ZDS1 and ZDS2, genes whose products may regulate Cdc42p in Saccharomyces cerevisiae

  1996influential reference
• Mutations in the homologous ZDS1 and ZDS2 genes affect cell cycle progression

  1996influential reference
• Phosphorylation and activation of the Xenopus Cdc25 phosphatase in the absence of Cdc2 and Cdk2 kinase activity.

  1995cited by this paper
• The role of Saccharomyces cerevisiae type 2A phosphatase in the actin cytoskeleton and in entry into mitosis.

  1995cited by this paper
• Cell cycle regulation of a Xenopus Wee1-like kinase.

  1995cited by this paper
• A cell cycle checkpoint monitors cell morphogenesis in budding yeast

  1995cited by this paper
• An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database

  1994cited by this paper
• Morphogenesis in the yeast cell cycle: regulation by Cdc28 and cyclins

  1993cited by this paper
• Phosphorylation and activation of human cdc25‐C by cdc2‐‐cyclin B and its involvement in the self‐amplification of MPF at mitosis.

  1993cited by this paper
• Properties of Saccharomyces cerevisiae wee1 and its differential regulation of p34CDC28 in response to G1 and G2 cyclins.

  1993cited by this paper
• Elimination of cdc2 phosphorylation sites in the cdc25 phosphatase blocks initiation of M-phase.

  1993cited by this paper
• Two distinct mechanisms for negative regulation of the Wee1 protein kinase.

  1993cited by this paper
• Nim1 kinase promotes mitosis by inactivating Wee1 tyrosine kinase

  1993cited by this paper
• Mechanisms that help the yeast cell cycle clock tick: G2 cyclins transcriptionally activate G2 cyclins and repress G1 cyclins.

  1993cited by this paper
• CLB5 and CLB6, a new pair of B cyclins involved in DNA replication in Saccharomyces cerevisiae.

  1993cited by this paper
• Dephosphorylation of cdc25-C by a type-2A protein phosphatase: specific regulation during the cell cycle in Xenopus egg extracts.

  1993cited by this paper
• Casein kinase I-like protein kinases encoded by YCK1 and YCK2 are required for yeast morphogenesis

  1993cited by this paper
• Purification of a multiprotein complex containing centrosomal proteins from the Drosophila embryo by chromatography with low-affinity polyclonal antibodies.

  1992cited by this paper
• Periodic changes in phosphorylation of the Xenopus cdc25 phosphatase regulate its activity.

  1992cited by this paper
• Characterization of four B-type cyclin genes of the budding yeast Saccharomyces cerevisiae.

  1992cited by this paper
• Regulation of the cdc25 protein during the cell cycle in Xenopus extracts.

  1992influential reference
• Yeast casein kinase I homologues: an essential gene pair.

  1992cited by this paper
• CDC55, a Saccharomyces cerevisiae gene involved in cellular morphogenesis: identification, characterization, and homology to the B subunit of mammalian type 2A protein phosphatase

  1991cited by this paper
• Immunofluorescence methods for yeast.

  1991cited by this paper
• cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2.

  1991cited by this paper
• The role of CDC28 and cyclins during mitosis in the budding yeast S. cerevisiae.

  1991cited by this paper
• The cdc25 protein controls tyrosine dephosphorylation of the cdc2 protein in a cell-free system.

  1991cited by this paper
• Conservation of mitotic controls in fission and budding yeasts.

  1989cited by this paper
• Negative regulation of mitosis by wee1+, a gene encoding a protein kinase homolog.

  1987cited by this paper
• cdc25+ functions as an inducer in the mitotic control of fission yeast.

  1986cited by this paper
• Ultrasensitivity in biochemical systems controlled by covalent modification. Interplay between zero-order and multistep effects.

  1984cited by this paper
• An amplified sensitivity arising from covalent modification in biological systems.

  1981cited by this paper
• Control of cell size at division in fission yeast by a growth-modulated size control over nuclear division.

  1977cited by this paper
• Genetic control of the cell division cycle in the fission yeast Schizosaccharomyces pombe

  1976cited by this paper
• Genetic control of cell size at cell division in yeast

  1975cited by this paper
• Processing of Adenovirus 2-Induced Proteins

  1973cited by this paper

• The diverging role of CDC14B: from mitotic exit in yeast to cell fate control in humans

  2023cites this paper
• Targeting CDK1 in cancer: mechanisms and implications

  2023cites this paper
• The CWI Pathway: A Versatile Toolbox to Arrest Cell-Cycle Progression

  2021cites this paper
• Haspin Modulates the G2/M Transition Delay in Response to Polarization Failures in Budding Yeast

  2021cites this paper
• Signalling mechanisms involved in stress response to antifungal drugs.

  2020cites this paper
• Ser/Thr protein phosphatases in fungi: structure, regulation and function

  2019influential citation
• SILAC-based phosphoproteomics reveals new PP2A-Cdc55-regulated processes in budding yeast

  2018cites this paper
• Prolonged cyclin-dependent kinase inhibition results in septin perturbations during return to growth and mitosis

  2018cites this paper
• Characterisation of the phosphatase control system that prevents premature mitotic entry in mammalian cells

  2017cites this paper
• Protein Kinase C Controls Binding of Igo/ENSA Proteins to Protein Phosphatase 2A in Budding Yeast*

  2017influential citation
• Wee1 and Cdc25 are controlled by conserved PP2A-dependent mechanisms in fission yeast

  2017cites this paper
• The Saccharomyces cerevisiae Ptc1 protein phosphatase attenuates G2‐M cell cycle blockage caused by activation of the cell wall integrity pathway

  2016cites this paper
• Zds1/Zds2–PP2ACdc55 complex specifies signaling output from Rho1 GTPase

  2016influential citation
• Zds1/Zds2–PP2A Cdc55 complex specifies signaling output from Rho1 GTPase

  2015influential citation
• Zds1/Zds2–PP2A Cdc55 complex specifies signaling output from Rho1 GTPase

  2015influential citation
• CHARACTERIZATION OF MITOTIC REGULATORS ACM1 AND CDC14

  2015cites this paper
• Cdk1-Dependent Phosphorylation of the APC-Cdc20 Regulates its Activation at Anaphase Onset in S. cerevisiae

  2015cites this paper
• Budding yeast Rho1 guanosine triphosphatase (GTPase) plays an essential role in polarized cell growth by regulating cell wall glucan synthesis and actin

  2015influential citation
• Zds1/Zds2–PP2A Cdc55 complex specifies signaling output from Rho1 GTPase

  2015influential citation
• Comparative genetic analysis of PP2A-Cdc55 regulators in budding yeast

  2014cites this paper
• Compact Modeling of Allosteric Multisite Proteins: Application to a Cell Size Checkpoint

  2014influential citation
• The Greatwall-PP2A axis in cell cycle control.

  2014cites this paper
• Cell cycle checkpoint regulators reach a zillion

  2013cites this paper
• New substrates and functions of PP2A-Cdc55 phospatase in the mitotic exit

  2013influential citation
• Dual Regulation of the Mitotic Exit Network (MEN) by PP2A-Cdc55 Phosphatase

  2013cites this paper
• Budding Yeast Greatwall and Endosulfines Control Activity and Spatial Regulation of PP2ACdc55 for Timely Mitotic Progression

  2013influential citation
• A Wee1 checkpoint inhibits anaphase onset

  2013cites this paper
• Mih1/Cdc25 is negatively regulated by Pkc1 in Saccharomyces cerevisiae

  2013cites this paper
• Nuclear PP2A-Cdc55 prevents APC-Cdc20 activation during the spindle assembly checkpoint

  2013cites this paper
• Plasma membrane growth during the cell cycle: unsolved mysteries and recent progress.

  2012cites this paper
• Faculty of Graduate and Postdoctoral Studies

  2012cites this paper
• Separase biosensor reveals that cohesin cleavage timing depends on phosphatase PP2A(Cdc55) regulation.

  2012cites this paper
• Human Cdc14A regulates Wee1 stability by counteracting CDK-mediated phosphorylation

  2012cites this paper
• Mitotic Exit and Separation of Mother and Daughter Cells

  2012cites this paper
• A link between mitotic entry and membrane growth suggests a novel model for cell size control

  2012influential citation
• Yeast Protein Phosphatase 2A-Cdc55 Regulates the Transcriptional Response to Hyperosmolarity Stress by Regulating Msn2 and Msn4 Chromatin Recruitment

  2012cites this paper
• Zds1 regulates PP2ACdc55 activity and Cdc14 activation during mitotic exit through its Zds_C motif

  2012cites this paper
• Protein phosphatase 2A controls the order and dynamics of cell-cycle transitions.

  2011cites this paper
• Identification of a Zds-like gene ZDS3 as a new mediator of stress resistance, capsule formation and virulence of the human pathogenic yeast Cryptococcus neoformans.

  2011cites this paper
• Spatial regulation of Cdc55–PP2A by Zds1/Zds2 controls mitotic entry and mitotic exit in budding yeast

  2011influential citation
• A phosphatase threshold sets the level of Cdk1 activity in early mitosis in budding yeast

  2011cites this paper
• Zds2p Regulates Swe1p-dependent Polarized Cell Growth in Saccharomyces cerevisiae via a Novel Cdc55p Interaction Domain

  2010cites this paper
• Jcb: Article

  year unknowncites this paper