Mutation of the Murine Bloom's Syndrome Gene Produces Global Genome Destabilization

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Molecular and Cellular Biology

• Publication date

  2006-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.00296-06PMID 16914751PMCID PMC1592839
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Epidermolysis Bullosa Nevi: Report of a Case and Review of the Literature

  2011cited by this paper
• Plk4 haploinsufficiency causes mitotic infidelity and carcinogenesis

  2005cited by this paper
• Partial downregulation of MAD1 causes spindle checkpoint inactivation and aneuploidy, but does not confer resistance towards taxol

  2005cited by this paper
• Adenomyoepithelial tumours and myoepithelial carcinomas of the breast – a spectrum of monophasic and biphasic tumours dominated by immature myoepithelial cells

  2005cited by this paper
• Increased chromosome instability but not cancer predisposition in haploinsufficient Bub3 mice

  2005cited by this paper
• Aneuploidy and cancer

  2004cited by this paper
• Phosphorylation of the Bloom's Syndrome Helicase and Its Role in Recovery from S-Phase Arrest

  2004cited by this paper
• Evidence for chromosome instability in vivo in bloom syndrome: Increased numbers of micronuclei in exfoliated cells

  2004cited by this paper
• Slippage of Mitotic Arrest and Enhanced Tumor Development in Mice with BubR1 Haploinsufficiency

  2004cited by this paper
• Constitutional hyperrecombinability and its consequences.

  2004cited by this paper
• Inactivation of hCDC4 can cause chromosomal instability

  2004cited by this paper
• Spontaneous and induced chromosomal damage and mutations in Bloom Syndrome mice.

  2004cited by this paper
• Chromosome instability and tumor predisposition inversely correlate with BLM protein levels.

  2003influential reference
• Multistep Carcinogenesis: A Chain Reaction of Aneuploidizations

  2003cited by this paper
• RecQ helicases: suppressors of tumorigenesis and premature aging.

  2003influential reference
• Instability of chromosome structure in cancer cells increases exponentially with degrees of aneuploidy.

  2003cited by this paper
• Hyper-recombination and genetic instability in BLM-deficient epithelial cells.

  2003cited by this paper
• Genomic instability — the engine of tumorigenesis?

  2003cited by this paper
• The Bloom's syndrome helicase suppresses crossing over during homologous recombination

  2003cited by this paper
• Adenomyoepithelioma of the breast: A cytologic dilemma. Report of a case and review of the literature

  2002cited by this paper
• Ability of the hydrophobic FGF and basic TAT peptides to promote cellular uptake of recombinant Cre recombinase: A tool for efficient genetic engineering of mammalian genomes

  2002cited by this paper
• Chromosomal instability in B-lymphoblasotoid cell lines from Werner and Bloom syndrome patients.

  2002cited by this paper
• Chromosomal aberrations in Bloom syndrome patients with myeloid malignancies.

  2001cited by this paper
• Numerous colonic adenomas in an individual with Bloom's syndrome.

  2001cited by this paper
• Sterility of Drosophila with mutations in the Bloom syndrome gene--complementation by Ku70.

  2001cited by this paper
• Chromosomal instability in BRCA1- or BRCA2-defective human cancer cells detected by spontaneous micronucleus assay.

  2001cited by this paper
• The Bloom's Syndrome Gene Product Interacts with Topoisomerase III*

  2000cited by this paper
• Aneuploidy and cancer

  2000cited by this paper
• Conditional mutagenesis in mice with heat shock promoter-driven cre transgenes

  2000cited by this paper
• Aneuploidy, the somatic mutation that makes cancer a species of its own.

  2000cited by this paper
• Comparative Genomic Hybridization Analysis of Myoepithelial Carcinoma of the Breast

  2000influential reference
• Cancer predisposition caused by elevated mitotic recombination in Bloom mice

  2000cited by this paper
• Nuclear structure in normal and Bloom syndrome cells.

  2000cited by this paper
• Myelodysplastic syndrome associated with monosomy 7 in a child with Bloom syndrome.

  2000cited by this paper
• Stage-specific apoptosis, developmental delay, and embryonic lethality in mice homozygous for a targeted disruption in the murine Bloom's syndrome gene.

  1998influential reference
• Efficient BLG-Cre Mediated Gene Deletion in the Mammary Gland

  1998cited by this paper
• Genetic instabilities in human cancers

  1998cited by this paper
• On the growth rates of human malignant tumors: Implications for medical decision making

  1997cited by this paper
• Bloom's syndrome. XX. The first 100 cancers.

  1997cited by this paper
• The Bloom's syndrome gene product is homologous to RecQ helicases.

  1995cited by this paper
• Current protocols in human genetics

  1994cited by this paper
• DNA content histogram and cell-cycle analysis.

  1994cited by this paper
• Chapter 18 DNA Content Histogram and Cell-Cycle Analysis

  1994cited by this paper
• Analysis of Sister‐Chromatid Exchanges

  1994cited by this paper
• Bloom Syndrome: A Mendelian Prototype of Somatic Mutational Disease

  1993influential reference
• In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice.

  1993cited by this paper
• Bloom's syndrome

  1992cited by this paper
• An abnormal profile of DNA replication intermediates in Bloom's syndrome.

  1990cited by this paper
• Frequency of variant erythrocytes at the glycophorin-A locus in two Bloom's syndrome patients.

  1989cited by this paper
• Evidence for increased in vivo mutation and somatic recombination in Bloom's syndrome.

  1989cited by this paper
• Non-random chromosomal aberrations in a complex leukaemic clone of a Bloom's syndrome patient

  1988cited by this paper
• 5-Bromodeoxyuridine-dependent increase in sister chromatid exchange formation in Bloom's syndrome is associated with reduction in topoisomerase II activity.

  1987cited by this paper
• Bloom's syndrome: evidence for an increased mutation frequency in vivo.

  1983cited by this paper
• The origin of human cancers

  1981cited by this paper
• Elevated spontaneous mutation rate in Bloom syndrome fibroblasts.

  1981cited by this paper
• Bloom's syndrome, missing Y, hypogonadism and cancer.

  1980cited by this paper
• Bloom's syndrome, missing Y, hypogonadism and cancer

  1980cited by this paper
• The relationship between sister chromatid exchanges and chromosome aberrations in Bloom's syndrome.

  1977cited by this paper
• A retarded rate of DNA chain growth in Bloom's syndrome.

  1975cited by this paper
• Bloom's syndrome and Fanconi's anemia: Demonstration of two distinctive patterns of chromosome disruption and rearrangement

  1974cited by this paper
• A manyfold increase in sister chromatid exchanges in Bloom's syndrome lymphocytes.

  1974cited by this paper
• Chromosomal Breakage in a Rare and Probably Genetically Determined Syndrome of Man

  1965cited by this paper

• Mechanistic insight into anaphase bridge signaling to the abscission checkpoint

  2025cites this paper
• Induced somatic mutation accumulation during skeletal muscle regeneration reduces muscle strength

  2025cites this paper
• 5TH EDITION OF THE WORLD HEALTH ORGANIZATION CLASSIFICATION OF TUMORS OF THE HEMATOPOIETIC AND LYMPHOID TISSUES.

  2024cites this paper
• Copy number normalization distinguishes differential signals driven by copy number differences in ATAC-seq and ChIP-seq

  2024cites this paper
• Genomic instability and aging: Causes and consequences

  2021cites this paper
• Functions of BLM Helicase in Cells: Is It Acting Like a Double-Edged Sword?

  2021cites this paper
• DNA repair fidelity in stem cell maintenance, health, and disease.

  2020cites this paper
• Clinical Genetics and Genomics of Aging

  2020cites this paper
• Wilms tumor

  2020cites this paper
• Molecular Basis of Progeroid Diseases

  2020cites this paper
• Heterozygous germline BLM mutations increase susceptibility to asbestos and mesothelioma

  2020cites this paper
• Break-induced replication promotes fragile telomere formation

  2020cites this paper
• Multiple mutations acquired into canine RecQ-like helicases encoded by the aneuploid genome of transmissible sarcoma

  2018cites this paper
• Nanocarrier Composed of Magnetite Core Coated with Three Polymeric Shells Mediates LCS-1 Delivery for Synthetic Lethal Therapy of BLM-Defective Colorectal Cancer Cells.

  2018cites this paper
• DNA repair and cell cycle checkpoint defects in a mouse model of ‘BRCAness’ are partially rescued by 53BP1 deletion

  2018cites this paper
• BLM helicase regulates DNA repair by counteracting RAD51 loading at DNA double-strand break sites

  2017cites this paper
• 53BP1 regulates dna double-strand break repair in a mouse “BRCA-like” model by a non-resection mechanism

  2017cites this paper
• The bloom syndrome protein, BLM, inhibits homologous recombination by disrupting RAD51 nucleoprotein filaments

  2017cites this paper
• Mitotic Dysfunction Associated with Aging Hallmarks.

  2017cites this paper
• BLM helicase regulates DNA repair by counteracting RAD51 loading at DNA double-strand break sites

  2017cites this paper
• Mcmdc2, a minichromosome maintenance (MCM) paralog, is required for repair of meiotic DNA breaks and homolog pairing in mouse meiosis

  2016cites this paper
• Manipulation of DNA Repair Proficiency in Mouse Models of Colorectal Cancer

  2016cites this paper
• BLM promotes the activation of Fanconi Anemia signaling pathway

  2016cites this paper
• Repair of Meiotic DNA Breaks and Homolog Pairing in Mouse Meiosis Requires a Minichromosome Maintenance (MCM) Paralog

  2016cites this paper
• NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity

  2015cites this paper
• Cooperation of Blm and Mus81 in development, fertility, genomic integrity and cancer suppression

  2014cites this paper
• TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling

  2014influential citation
• Human RecQ helicases in DNA repair, recombination, and replication.

  2014cites this paper
• Histone chaperones: assisting histone traffic and nucleosome dynamics.

  2014cites this paper
• BLM and RAD51 Genes Polymorphism and Susceptibility to Breast Cancer

  2013cites this paper
• Loss of Mismatch Repair in the Aging Human Hematopoietic Stem Cell

  2013cites this paper
• Nucleic Acids Research

  2013cites this paper
• Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching

  2012cites this paper
• Synergic and Opposing Activities of Thermophilic RecQ-like Helicase and Topoisomerase 3 Proteins in Holliday Junction Processing and Replication Fork Stabilization*

  2012cites this paper
• A Conditional Mouse Model for Measuring the Frequency of Homologous Recombination Events In Vivo in the Absence of Essential Genes

  2011cites this paper
• Tumor hypoxia and genetic alterations in sporadic cancers

  2011cites this paper
• Mammalian BLM helicase is critical for integrating multiple pathways of meiotic recombination

  2010influential citation
• Transgenic oncogenes induce oncogene-independent cancers with individual karyotypes and phenotypes.

  2010cites this paper
• Loss of Blm enhances basal cell carcinoma and rhabdomyosarcoma tumorigenesis in Ptch1+/- mice.

  2010cites this paper
• Loss of Blm enhances basal cell carcinoma and rhabdomyosarcoma tumorigenesis in Ptch11/2 mice

  2010cites this paper
• Formation of Complex and Unstable Chromosomal Translocations in Yeast

  2010cites this paper
• Topo IIIα and BLM Act within the Fanconi Anemia Pathway in Response to DNA-Crosslinking Agents

  2009cites this paper
• Linking Human RecQ Helicases to DNA Damage Response and Aging

  2009cites this paper
• An unusual case of Bloom syndrome presenting with basal cell carcinoma.

  2009cites this paper
• Genomic Instability Resulting from Blm Deficiency Compromises Development, Maintenance, and Function of the B Cell Lineage1

  2009cites this paper
• New approaches for modelling sporadic genetic disease in the mouse

  2009cites this paper
• FINAL APPROVAL OF DISSERTATION Doctor of Philosophy in Biomedical Sciences

  2008cites this paper
• Functional analysis of the Rad51d (E233G) breast cancer associated polymorphism and a pharmacogenetic evaluation of RAD51D status

  2008cites this paper
• The Relevance of Mouse Models to Understanding the Development and Progression of Human Breast Cancer

  2008cites this paper
• Drosophila bloom helicase maintains genome integrity by inhibiting recombination between divergent DNA sequences

  2008cites this paper
• A Genetic Analysis of Genomic Stability in Caenorhabditis Elegans : A Dissertation

  2007cites this paper
• The Bloom's Syndrome Helicase Is Critical for Development and Function of the αβ T-Cell Lineage

  2007influential citation
• The Bloom’s Syndrome Helicase Is Critical for Development and Function of the (cid:2)(cid:3) T-Cell Lineage (cid:1) †

  2007influential citation
• The role of DNA damage repair in aging of adult stem cells

  2007cites this paper
• Special Considerations in Mouse Models of Breast Cancer

  2007cites this paper
• The Bloom's syndrome helicase is critical for development and function of the alphabeta T-cell lineage.

  2007cites this paper
• Molecular genetics of RecQ helicase disorders

  2007cites this paper
• Genetic analysis and meiotic role of the Saccharomyces cerevisiae RecQ helicase SGS1

  2007cites this paper
• Jcb: Article

  year unknowncites this paper