Zinc and Diabetic Retinopathy

Zinc (Zn) is an important nutrient that is involved in various physiological metabolisms. Zn dyshomeostasis is often associated with various pathogeneses of chronic diseases, such as metabolic syndrome, diabetes, and related complications. Zn is present in ocular tissue in high concentrations, particularly in the retina and choroid. Zn deficiencies have been shown to affect ocular development, cataracts, age-related macular degeneration, and even diabetic retinopathy. However, the mechanism by which Zn deficiency increases the prevalence of diabetic retinopathy remains unclear. In addition, due to the negative effect of Zn deficiency on the eye, Zn supplementation should prevent diabetic retinopathy; however, limited available data do not always support this notion. Therefore, the goal of this paper was to summarize these pieces of available information regarding Zn prevention of diabetic retinopathy. Current theories and possible mechanisms underlying the role of Zn in the eye-related diseases are discussed. The possible factors that affect the preventive effect of Zn supplementation on diabetic retinopathy were also discussed.

• Publication year

  2013

• Venue

  Journal of Diabetes Research

• Publication date

  2013-03-17

• Fields of study

  Medicine

• Identifiers
  DOI 10.1155/2013/425854PMID 23671870PMCID 3647550
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• REPUBLIQUE ALGERIENNE DEMOCRATIQUE ET POPULAIRE Ministère de l'Enseignement Supérieur et de la Recherche Scientifique Université des Sciences et de la Technologie d'Oran U. S. T. O.

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