Year : 2003 Insulin activation of Rheb , a mediator of mTOR / S 6 K / 4 EBP signaling , is inhibited by TSC 1 and 2

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Unknown venue

• Publication date

  Unknown publication date

• Fields of study

  Not labeled

• Identifiers

  No identifiers available.

• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• CHAPTER 315 – Translational Control and Insulin Signaling

  2003cited by this paper
• The yeast model for Batten disease: a role for Btn2p in the trafficking of the Golgi-associated vesicular targeting protein, Yif1p.

  2003cited by this paper
• Progress towards understanding the neurobiology of Batten disease or neuronal ceroid lipofuscinosis

  2003cited by this paper
• The Mammalian Target of Rapamycin (mTOR) Partner, Raptor, Binds the mTOR Substrates p70 S6 Kinase and 4E-BP1 through Their TOR Signaling (TOS) Motif*

  2003cited by this paper
• Tsc tumour suppressor proteins antagonize amino-acid–TOR signalling

  2002cited by this paper
• Identification of TOR signaling complexes: more TORC for the cell growth engine.

  2002cited by this paper
• Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action.

  2002cited by this paper
• Rap-specific GTPase Activating Protein follows an Alternative Mechanism*

  2002influential reference
• TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

  2002influential reference
• Tuberous sclerosis complex tumor suppressor–mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent

  2002cited by this paper
• Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway.

  2002cited by this paper
• Rheb is in a high activation state and inhibits B-Raf kinase in mammalian cells

  2002cited by this paper
• TSC1–TSC2: a complex tale of PKB-mediated S6K regulation

  2002influential reference
• Tuberin Regulates p70 S6 Kinase Activation and Ribosomal Protein S6 Phosphorylation

  2002cited by this paper
• Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling.

  2002cited by this paper
• Mammalian TOR: A Homeostatic ATP Sensor

  2001cited by this paper
• Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size.

  2001cited by this paper
• Regulation of translation initiation by FRAP/mTOR.

  2001cited by this paper
• TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth.

  2001cited by this paper
• The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation.

  2001cited by this paper
• The Ras branch of small GTPases: Ras family members don't fall far from the tree.

  2000cited by this paper
• Action of BTN1, the yeast orthologue of the gene mutated in Batten disease

  1999cited by this paper
• Target of rapamycin (TOR): balancing the opposing forces of protein synthesis and degradation.

  1999cited by this paper
• Extracellular signal‐regulated activation of Rap1 fails to interfere in Ras effector signalling

  1998cited by this paper
• Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism*

  1998cited by this paper
• The genetic basis of tuberous sclerosis.

  1998cited by this paper
• 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway.

  1998cited by this paper
• Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase A-dependent signals

  1997influential reference
• Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin.

  1997cited by this paper
• Stimulation of gene induction and cell growth by the Ras effector Rlf

  1997cited by this paper
• Ras-like GTPases.

  1997cited by this paper
• The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases

  1996cited by this paper
• Structural and functional analysis of pp70S6k.

  1995cited by this paper
• Tuberous sclerosis.

  1994cited by this paper
• rheb, a growth factor- and synaptic activity-regulated gene, encodes a novel Ras-related protein.

  1994influential reference
• The GTPase superfamily: a conserved switch for diverse cell functions

  1990cited by this paper

• Oncogenes and Tumor Suppressors p 53 Deletion or Hotspot Mutations Enhance mTORC 1 Activity byAltering LysosomalDynamics of TSC 2 and Rheb

  2016cites this paper
• Mammalian target of rapamycin is required for phrenic long-term facilitation following severe but not moderate acute intermittent hypoxia.

  2015cites this paper
• Nitrogen-containing bisphosphonates induce apoptosis of hematopoietic tumor cells via inhibition of Ras signaling pathways and Bim-mediated activation of the intrinsic apoptotic pathway.

  2013cites this paper
• Host mTORC1 Signaling Regulates Andes Virus Replication

  2012cites this paper
• Inhibition of Protein Synthesis by TOR Inactivation Revealed a Conserved Regulatory Mechanism of the BiP Chaperone in Chlamydomonas 1 [ W ]

  2011cites this paper
• Determining the pathogenicity of patient-derived TSC2 mutations by functional characterization and clinical evidence

  2011cites this paper
• GADD34 inhibits mammalian target of rapamycin signaling via tuberous sclerosis complex and controls cell survival under bioenergetic stress.

  2007cites this paper
• - 1-Lipid Posttranslational Modifications : Farnesyl Transferase Inhibitors

  2005cites this paper
• Molecular mechanism and regulation of autophagy

  2005cites this paper