Bilateral Idiopathic Adrenal Hyperplasia: Genetics and Beyond

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Hormone and Metabolic Research

• Publication date

  2015-11-26

• Fields of study

  Medicine

• Identifiers
  DOI 10.1055/s-0035-1565198PMID 26610199
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Inherited forms of mineralocorticoid hypertension.

  2015cited by this paper
• Aldosterone-stimulating somatic gene mutations are common in normal adrenal glands

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• Novel somatic mutations and distinct molecular signature in aldosterone-producing adenomas.

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• Primary Aldosteronism and ARMC5 Variants.

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• Genome-Wide Meta-Analyses of Plasma Renin Activity and Concentration Reveal Association With the Kininogen 1 and Prekallikrein Genes

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• Different Somatic Mutations in Multinodular Adrenals With Aldosterone-Producing Adenoma

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• Recurrent gain of function mutation in calcium channel CACNA1H causes early-onset hypertension with primary aldosteronism

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• An update on novel mechanisms of primary aldosteronism.

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• Novel somatic mutations in primary hyperaldosteronism are related to the clinical, radiological and pathological phenotype

  2015cited by this paper
• Genetic Spectrum and Clinical Correlates of Somatic Mutations in Aldosterone-Producing Adenoma

  2014cited by this paper
• Role for Germline Mutations and a Rare Coding Single Nucleotide Polymorphism Within the KCNJ5 Potassium Channel in a Large Cohort of Sporadic Cases of Primary Aldosteronism

  2014cited by this paper
• Diastrophic Dysplasia Sulfate Transporter (SLC26A2) Is Expressed in the Adrenal Cortex and Regulates Aldosterone Secretion

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• Adrenal nodularity and somatic mutations in primary aldosteronism: one node is the culprit?

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• Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension

  2013cited by this paper
• Genetic Variations in the KCNJ5 Gene in Primary Aldosteronism Patients from Xinjiang, China

  2013cited by this paper
• Somatic and germline CACNA1D calcium channel mutations in aldosterone-producing adenomas and primary aldosteronism

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• Cardiovascular Complications Associated With Primary Aldosteronism: A Controlled Cross-Sectional Study

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• Severe hyperaldosteronism in neonatal Task3 potassium channel knockout mice is associated with activation of the intraadrenal renin-angiotensin system.

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• Association of the variations in the HSD3&bgr; gene with primary aldosteronism

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• ARMC5 mutations in macronodular adrenal hyperplasia with Cushing's syndrome.

  2013cited by this paper
• Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension

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• Task3 potassium channel gene invalidation causes low renin and salt-sensitive arterial hypertension.

  2012cited by this paper
• KCNJ5 Mutations in European Families With Nonglucocorticoid Remediable Familial Hyperaldosteronism

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• Potassium channel mutant KCNJ5 T158A expression in HAC-15 cells increases aldosterone synthesis.

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• TASK-3 Channel Deletion in Mice Recapitulates Low-Renin Essential Hypertension

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• Hypertension with or without adrenal hyperplasia due to different inherited mutations in the potassium channel KCNJ5

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• The potassium channel, Kir3.4 participates in angiotensin II-stimulated aldosterone production by a human adrenocortical cell line.

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• APEX1 Regulation of Aldosterone Synthase Gene Transcription Is Disrupted by a Common Polymorphism in Humans

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• Prevalence, Clinical, and Molecular Correlates of KCNJ5 Mutations in Primary Aldosteronism

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• Variations in the potassium channel genes KCNK3 and KCNK9 in relation to blood pressure and aldosterone production: an exploratory study.

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• Prevalence and Characteristics of Familial Hyperaldosteronism: The PATOGEN Study (Primary Aldosteronism in TOrino-GENetic forms)

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• Prevalence of Primary Aldosteronism in Patient’s Cohorts and in Population-based Studies – A Review of the Current Literature

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• Adrenal Cortex Remodeling and Functional Zona Glomerulosa Hyperplasia in Primary Aldosteronism

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• The Functional c.-2G>C Variant of the Mineralocorticoid Receptor Modulates Blood Pressure, Renin, and Aldosterone Levels

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  2008cited by this paper
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  2008cited by this paper
• TASK channel deletion in mice causes primary hyperaldosteronism

  2008cited by this paper
• Invalidation of TASK1 potassium channels disrupts adrenal gland zonation and mineralocorticoid homeostasis

  2008cited by this paper
• Diagnosis and treatment of low‐renin hypertension

  2007cited by this paper
• Association of the C−344T aldosterone synthase gene variant with essential hypertension: a meta-analysis

  2007cited by this paper
• Clinical and Genetic Correlates of Aldosterone-to-Renin Ratio and Relations to Blood Pressure in a Community Sample

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• Association between aldosterone production and variation in the 11beta-hydroxylase (CYP11B1) gene.

  2006cited by this paper
• A prospective study of the prevalence of primary aldosteronism in 1,125 hypertensive patients.

  2006cited by this paper
• Trends in the prevalence of primary aldosteronism, aldosterone-producing adenomas, and surgically correctable aldosterone-dependent hypertension.

  2004cited by this paper
• Serum aldosterone and the incidence of hypertension in nonhypertensive persons.

  2004cited by this paper
• Treatment of familial hyperaldosteronism type I: only partial suppression of adrenocorticotropin required to correct hypertension.

  2000cited by this paper
• A novel genetic locus for low renin hypertension: familial hyperaldosteronism type II maps to chromosome 7 (7p22)

  2000cited by this paper
• Primary aldosteronism: learning from the study of familial varieties.

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• Associations between human aldosterone synthase (CYP11B2) gene polymorphisms and left ventricular size, mass, and function.

  1998cited by this paper
• A chimaeric llβ-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension

  1992cited by this paper
• CLINICAL AND PATHOLOGICAL DIVERSITY OF PRIMARY ALDOSTERONISM, INCLUDING A NEW FAMILIAL VARIETY

  1991cited by this paper
• Characterization of a group of essential hypertensives with impaired regulation of aldosterone.

  1982cited by this paper

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• Homeobox A5 activates p53 pathway to inhibit proliferation and promote apoptosis of adrenocortical carcinoma cells by inducing Aldo-Keto reductase family 1 member B10 expression

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• MicroRNAs and Adrenocortical Tumors: Where do we Stand on Primary Aldosteronism?

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• Recent insights into sodium and potassium handling by the aldosterone-sensitive distal nephron: implications on pathophysiology and drug discovery

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• Predicting factors related with uncured hypertension after retroperitoneal laparoscopic adrenalectomy for unilateral primary aldosteronism

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• Evaluation and Management of Primary Hyperaldosteronism.

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• Treatment of Primary Aldosteronism with mTORC1 Inhibitors.

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• Sekundäre Hypertonie durch primären Hyperaldosteronismus

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• Significant prevalence of NR3C1 mutations in incidentally discovered bilateral adrenal hyperplasia: results of the French MUTA-GR Study.

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• Development and validation of subtype prediction scores for the workup of primary aldosteronism

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• Upregulation of PCP4 in human aldosterone-producing adenomas fosters human adrenocortical tumor cell growth via AKT and AMPK pathway.

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