Metabolic activation and DNA binding of food mutagens and other environmental carcinogens in human mammary epithelial cells.

No abstract is available for this paper.

• Publication year

  1996

• Venue

  Carcinogenesis

• Publication date

  1996-08-01

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1093/CARCIN/17.8.1769PMID 8761441
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cytotoxicity, DNA adduct formation and DNA repair induced by 2-hydroxyamino-3-methylimidazo[4,5-f]quinoline and 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine in cultured human mammary epithelial cells.

  1995cited by this paper
• Inhibitory effect of dietary 4-ipomeanol on DNA adduct formation by the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in male CDF1 mice.

  1995cited by this paper
• Possible mechanisms for PhIP-DNA adduct formation in the mammary gland of female Sprague-Dawley rats.

  1995cited by this paper
• Carcinogen-DNA adducts in human breast tissue.

  1995cited by this paper
• DNA adduct levels of 2-amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine (PhIP) in tissues of cynomolgus monkeys after single or multiple dosing.

  1994cited by this paper
• Formation of DNA adducts by the food mutagen 2-amino-3,4,8-trimethyl-3H-imidazo[4,5-f]quinoxaline (4,8-DiMeIQx) in vitro and in vivo. Identification of a N2-(2'-deoxyguanosin-8-yl)-4,8-DiMeIQx adduct.

  1994cited by this paper
• DNA adduct formation of the food carcinogen 2-amino-3-methylimidazo[4,5- f]quinoline at the C-8 and N2 atoms of guanine.

  1994cited by this paper
• 32P-post-labelling analysis of DNA adducts formed by food-derived heterocyclic amines: evidence for incomplete hydrolysis and a procedure for adduct pattern simplification.

  1994cited by this paper
• Dietary carcinogens and mammary carcinogenesis. Induction of rat mammary carcinomas by administration of heterocyclin amines in cooked foods

  1994cited by this paper
• DNA adducts : identification and biological significance

  1994cited by this paper
• Mutagenic activation of IQ, PhIP and MeIQx by hepatic microsomes from rat, monkey and man: low mutagenic activation of MeIQx in cynomolgus monkeys in vitro reflects low DNA adduct levels in vivo.

  1993cited by this paper
• Does a genotoxic carcinogen contribute to human breast cancer? The value of mutational spectra in unravelling the aetiology of cancer.

  1993cited by this paper
• Biomonitoring of human exposure to carcinogenic nitroaromatic compounds: a pilot study on DNA adduct formation by 1,6-dinitropyrene in rats.

  1993cited by this paper
• Excretion of food-derived heterocyclic amine carcinogens into breast milk of lactating rats and formation of DNA adducts in the newborn.

  1993cited by this paper
• Environmental carcinogens that may be involved in human breast cancer etiology.

  1992cited by this paper
• Metabolic activation of the food mutagens 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ) to DNA binding species in human mammary epithelial cells.

  1992cited by this paper
• Human cancer: epidemiology and environmental causes: Epidemiological methods

  1992cited by this paper
• Characterization in vitro of luminal and myoepithelial cells isolated from the human mammary gland by cell sorting.

  1991cited by this paper
• A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).

  1991cited by this paper
• Comparative dose-response tumorigenicity studies of dibenzo[a,l]pyrene versus 7, 12-dimethylbenz[a]anthracene, benzo[a and two dibenzo[a,l]pyrene dihydrodiols in mouse skin and rat mammary gland

  1991cited by this paper
• Presence of carcinogenic heterocyclic amines in urine of healthy volunteers eating normal diet, but not of inpatients receiving parenteral alimentation.

  1991cited by this paper
• Comparative dose-response tumorigenicity studies of dibenzo[alpha,l]pyrene versus 7,12-dimethylbenz[alpha]anthracene, benzo[alpha]pyrene and two dibenzo[alpha,l]pyrene dihydrodiols in mouse skin and rat mammary gland.

  1991cited by this paper
• Covalent binding of dibenzpyrenes and benzo[a]pyrene to DNA: evidence for synergistic and inhibitory interactions when applied in combination to mouse skin.

  1990cited by this paper
• Tissue distribution of DNA adducts in CDF1 mice fed 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ).

  1990cited by this paper
• DNA adduct formation in target tissues of Sprague-Dawley rats, CD-1 mice and A/J mice following tumorigenic doses of 1-nitropyrene.

  1990cited by this paper
• 32P-postlabeling analysis of DNA adducts in human and rat mammary epithelial cells.

  1988cited by this paper
• Enhanced sensitivity of 32P-postlabeling analysis of aromatic carcinogen:DNA adducts.

  1985cited by this paper
• Dietary fat and mammary carcinogenesis.

  1984cited by this paper
• 32P-postlabeling analysis of non-radioactive aromatic carcinogen--DNA adducts.

  1982cited by this paper
• The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today.

  1981cited by this paper
• Preparation and identification of human breast epithelial cells in culture

  1980cited by this paper

• Spatial and temporal variations of nitro-polycyclic aromatic hydrocarbons in PM2.5 aerosols in Yangtze River Delta Region, China

  2013cites this paper
• Electrochemical studies of the interactional mechanism and scavenging activity of antioxidants towards dinitroaromatics

  2012cites this paper
• Effect of cereal grains on the formation of heterocyclic aromatic amines in fried beef patties

  2012cites this paper
• Dietary intake of meat and meat-derived heterocyclic aromatic amines and their correlation with DNA adducts in female breast tissue.

  2008cites this paper
• Diesel exhaust influences carcinogenic PAH-induced genotoxicity and gene expression in human breast epithelial cells in culture.

  2007influential citation
• Human breast biomonitoring and environmental chemicals: use of breast tissues and fluids in breast cancer etiologic research

  2007influential citation
• Effects of nitrated-polycyclic aromatic hydrocarbons and diesel exhaust particle extracts on cell signalling related to apoptosis: possible implications for their mutagenic and carcinogenic effects.

  2007cites this paper
• Genotoxicity of Human Mammary Lipid1

  2006cites this paper
• Heterocyclic amines: chemistry and health.

  2006cites this paper
• Human cytochromes P450 1A1 and 1B1 catalyze ring oxidation but not nitroreduction of environmental pollutant mononitropyrene isomers in primary cultures of human breast cells and cultured MCF-10A and MCF-7 cell lines.

  2004cites this paper
• Urinary N2-(2'-deoxyguanosin-8-yl)PhIP as a biomarker for PhIP exposure.

  2004cites this paper
• Metabolism and DNA binding of the environmental pollutant 6‐nitrochrysene in primary culture of human breast cells and in cultured MCF‐10A, MCF‐7 and MDA‐MB‐435s cell lines

  2002cites this paper
• Lavage and nipple aspiration of breast ductal fluids: A source of biomarkers for environmental mutagenesis

  2002cites this paper
• Dinitropyrenes induce gene mutations in multiple organs of the lambda/lacZ transgenic mouse (Muta Mouse).

  2002cites this paper
• 2‐Amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (PhIP)–induced mutagenesis in cultured Big Blue™ rat mammary epithelial and fibroblast cells

  2002influential citation
• Characterization of a major aromatic DNA adduct detected in human breast tissues

  2002cites this paper
• Analysis and quantification of DNA adducts of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in liver of rats by liquid chromatography/electrospray tandem mass spectrometry.

  2002cites this paper
• 2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridin e(PhIP)- Induced Mutagenesi si nCulture dBi gBlue ™Rat Mammar yEpithelia lan dFibroblas tCells

  2002cites this paper
• Quantifying the Effects of Preventive Foods on the Metabolism of a Prostate Carcinogen in Humans and in Prostate Cells Grown in Culture

  2001cites this paper
• 1,2‐dithiole‐3‐thione and its structural analogue oltipraz are potent inhibitors of dibenzo[a,l]pyrene‐DNA adduction in female Sprague‐Dawley rats

  2001cites this paper
• Biomarker Assays in Nipple Aspirate Fluid

  2001cites this paper
• Detection of PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) in the milk of healthy women.

  2001cites this paper
• Preneoplastic Prostate Lesions

  2001cites this paper
• Identification and tissue distribution of the novel human cytochrome P450 2S1 (CYP2S1).

  2001cites this paper
• Genotoxins and the initiation of sporadic breast cancer.

  2001cites this paper
• Analysis of DNA adducts by accelerator mass spectrometry in human breast tissue after administration of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and benzo[a]pyrene.

  2000cites this paper
• Current status of the cytosolic sulfotransferases in the metabolic activation of promutagens and procarcinogens.

  2000cites this paper
• Mammary expression of xenobiotic metabolizing enzymes and their potential role in breast cancer.

  2000cites this paper
• Identification of urine metabolites of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine following consumption of a single cooked chicken meal in humans.

  2000cites this paper
• Inhibition of benzo[a]pyrene- and 1,6-dinitropyrene-DNA adduct formation in human mammary epithelial cells bydibenzoylmethane and sulforaphane.

  2000cites this paper
• Activation of genotoxins to DNA-damaging species in exfoliated breast milk cells.

  2000cites this paper
• Creatine and creatinine metabolism.

  2000cites this paper
• Assessing the human intake of heterocyclic amines: limited loss of information using reduced sets of questions.

  1999cites this paper
• DNA adducts of heterocyclic amine food mutagens: implications for mutagenesis and carcinogenesis.

  1999cites this paper
• Diet-gene interactions in sporadic and hereditary colorectal carcinogenesis : epidemiological perspectives

  1999cites this paper
• DNA adduct formation and persistence in rat tissues following exposure to the mammary carcinogen dibenzo[a,l]pyrene.

  1999cites this paper
• Metabolism of benzo[a]pyrene to trans-7,8-dihydroxy-7, 8-dihydrobenzo[a]pyrene by recombinant human cytochrome P450 1B1 and purified liver epoxide hydrolase.

  1999cites this paper
• DNA adducts in normal tissue adjacent to breast cancer: a review.

  1999cites this paper
• Bioactivation of the cooked food mutagen N-hydroxy-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by estrogen sulfotransferase in cultured human mammary epithelial cells.

  1998cites this paper
• DNA adducts in human breast tissue: association with N-acetyltransferase-2 (NAT2) and NAT1 genotypes.

  1998cites this paper
• Food-derived carcinogens and breast cancer risk.

  1998cites this paper
• Identification of CYP2A3 as a major cytochrome P450 enzyme in the female peripubertal rat breast.

  1998cites this paper
• Activation of heterocyclic amines by combinations of prostaglandin H synthase-1 and -2 with N-acetyltransferase 1 and 2.

  1998cites this paper
• Interindividual variation in the metabolic activation of heterocyclic amines and their N-hydroxy derivatives in primary cultures of human mammary epithelial cells.

  1998cites this paper
• Determination of the enzymes responsible for activation of the heterocyclic amine 2-amino-3-methylimidazo[4,5-f]quinoline in the human breast.

  1998cites this paper
• The 1996 Veylien Henderson Award of the Society of Toxicology of Canada. Current concepts: neutrophils and the activation of carcinogens in the breast and other organs.

  1998cites this paper
• Microsome-mediated bioactivation of dibenzo[a,l]pyrene and identification of DNA adducts by 32P-postlabeling.

  1997cites this paper
• DNA damage in breast epithelial cells: detection by the single-cell gel (comet) assay and induction by human mammary lipid extracts.

  1997cites this paper
• Genotoxicity of human mammary lipid.

  1996cites this paper