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Increased Sensitivity of Sars-Coronavirus to a Combination of Human Type I and Type II Interferons

C. Scagnolari,E. Vicenzi,F. Bellomi,M. G. Stillitano,D. Pinna,G. Poli,M. Clementi,F. Dianzani,G. Antonelli

Published 2004 in Antiviral Therapy

ABSTRACT

There is currently an urgent need to identify effective antiviral agents that will prevent and treat severe acute respiratory syndrome coronavirus (SARS-CoV) infection. In this study, we have investigated and compared the antiviral effect of different interferons (IFNs) on SARS-CoV replication in the epithelial kidney monkey Vero cell line. The results showed that SARS-CoV grown in Vero cells is moderately sensitive to IFN-β and only weakly sensitive to IFN-α and IFN-γ, in comparison to other IFN-sensitive viruses, such as those for encephalomyocarditis, vesicular stomatitis and Newcastle disease. Simultaneous incubation of Vero cells with IFN-β and IFN-γ indicated that they may act synergistically against SARS-CoV replication. The IFN-induced MxA protein was detected in the IFN-treated Vero cells. The data, however, suggest that the antiviral activity of IFN against SARS-CoV virus is independent of MxA expression.

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