Virus-induced autoimmunity: epitope spreading to myelin autoepitopes in Theiler's virus infection of the central nervous system.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Advances in Virus Research

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0065-3527(01)56008-XPMID 11450300
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Pathologic Role and Temporal Appearance of Newly Emerging Autoepitopes in Relapsing Experimental Autoimmune Encephalomyelitis1

  2000cited by this paper
• Temporal Development of Autoreactive Th1 Responses and Endogenous Presentation of Self Myelin Epitopes by Central Nervous System-Resident APCs in Theiler’s Virus-Infected Mice1

  2000cited by this paper
• Central nervous system chemokine expression during Theiler's virus-induced demyelinating disease.

  1999cited by this paper
• Endogenous presentation of self myelin epitopes by CNS-resident APCs in Theiler's virus-infected mice.

  1999cited by this paper
• The functional significance of epitope spreading and its regulation by co‐stimulatory molecules

  1998cited by this paper
• Differential expression of inflammatory cytokines parallels progression of central nervous system pathology in two clinically distinct models of multiple sclerosis.

  1998cited by this paper
• Cytokines as intrinsic and exogenous regulators of pathogenesis in experimental autoimmune encephalomyelitis.

  1998cited by this paper
• Characterization of and Functional Antigen Presentation by Central Nervous System Mononuclear Cells from Mice Infected with Theiler’s Murine Encephalomyelitis Virus

  1998cited by this paper
• Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading

  1997cited by this paper
• Diversity and plasticity of self recognition during the development of multiple sclerosis.

  1997cited by this paper
• A T cell receptor antagonist peptide induces T cells that mediate bystander suppression and prevent autoimmune encephalomyelitis induced with multiple myelin antigens.

  1997cited by this paper
• Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein

  1996cited by this paper
• Flow cytometric and functional analyses of central nervous system-infiltrating cells in SJL/J mice with Theiler's virus-induced demyelinating disease. Evidence for a CD4+ T cell-mediated pathology.

  1996cited by this paper
• Adoptively transferred CD8+ T lymphocytes provide protection against TMEV-induced demyelinating disease in BALB/c mice.

  1996cited by this paper
• The pathogenesis of postinfectious myocarditis.

  1996cited by this paper
• Evolution of the T‐Cell Repertoire during the Course of Experimental Immune‐Mediated Demyelinating Diseases

  1995cited by this paper
• Inhibition of Theiler's virus-mediated demyelination by peripheral immune tolerance induction.

  1995cited by this paper
• Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis

  1995cited by this paper
• A genetic basis for familial aggregation in multiple sclerosis

  1995cited by this paper
• More genes versus environment

  1995cited by this paper
• Identification of a major T-cell epitope within VP3 amino acid residues 24 to 37 of Theiler's virus in demyelination-susceptible SJL/J mice

  1995cited by this paper
• Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein

  1995cited by this paper
• Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE.

  1995cited by this paper
• Plaque-associated expression of human herpesvirus 6 in multiple sclerosis.

  1995cited by this paper
• BALB/c substrain differences in susceptibility to Theiler's murine encephalomyelitis virus-induced demyelinating disease.

  1994cited by this paper
• A predominant viral epitope recognized by T cells from the periphery and demyelinating lesions of SJL/J mice infected with Theiler's virus is located within VP1(233-244).

  1994cited by this paper
• The immunopathogenesis and regulation of T-cell-mediated demyelinating diseases.

  1994cited by this paper
• Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus-induced demyelinating disease. V. Mapping of a dominant immunopathologic VP2 T cell epitope in susceptible SJL/J mice.

  1994cited by this paper
• Anergy in vivo: down-regulation of antigen-specific CD4+ Th1 but not Th2 cytokine responses.

  1994cited by this paper
• Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus-induced demyelinating disease. VI. Potentiation of demyelination with and characterization of an immunopathologic CD4+ T cell line specific for an immunodominant VP2 epitope.

  1994cited by this paper
• Superantigens: bacterial and viral proteins that manipulate the immune system.

  1993cited by this paper
• Effects of irradiation on development of Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease in genetically resistant mice.

  1993cited by this paper
• Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

  1993cited by this paper
• Induction of Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease in genetically resistant mice.

  1993cited by this paper
• Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice

  1993cited by this paper
• Split tolerance of Thl and Th2 cells in tolerance to Theiler's murine encephalomyelitis virus

  1993cited by this paper
• Epidemiologic evidence for multiple sclerosis as an infection

  1993cited by this paper
• The role of CD8+T cells in the acute and chronic phases of Theiler's murine encephalomyelitis virus-induced disease in mice.

  1992cited by this paper
• Cardiac Persistence of Cardioviral RNA Detected by Polymerase Chain Reaction in a Murine Model of Dilated Cardiomyopathy

  1992cited by this paper
• IgG subclass responses to Theiler's murine encephalomyelitis virus infection and immunization suggest a dominant role for Th1 cells in susceptible mouse strains.

  1992cited by this paper
• T cell sensitization to proteolipid protein in myelin basic protein-induced relapsing experimental allergic encephalomyelitis

  1991cited by this paper
• Successful treatment of paralytic relapses in adoptive experimental autoimmune encephalomyelitis via neuroantigen-specific tolerance.

  1991cited by this paper
• Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus-induced demyelinating disease. IV. Identification of an immunodominant T cell determinant on the N-terminal end of the VP2 capsid protein in susceptible SJL/J mice.

  1991cited by this paper
• Immunopathogenesis of multiple sclerosis.

  1991cited by this paper
• Immunopathological recognition of autoantigens in multiple sclerosis.

  1991cited by this paper
• Autoreactive T and B cells responding to myelin proteolipid protein in multiple sclerosis and controls

  1991cited by this paper
• Immunologic aspects of Theiler's murine encephalomyelitis virus infection

  1990cited by this paper
• Alterations in T cell antigen specificity and class II restriction during the course of chronic relapsing experimental allergic encephalomyelitis.

  1990cited by this paper
• Persistent anti-myelin basic protein IgG antibody response in multiple sclerosis cerebrospinal fluid.

  1990cited by this paper
• Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease☆

  1990cited by this paper
• T cells responsive to myelin basic protein in patients with multiple sclerosis.

  1990cited by this paper
• Monocytes/macrophages isolated from the mouse central nervous system contain infectious Theiler's murine encephalomyelitis virus (TMEV).

  1990cited by this paper
• Identification of a locus on mouse chromosome 3 involved in differential susceptibility to Theiler's murine encephalomyelitis virus-induced demyelinating disease

  1990cited by this paper
• T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis

  1990cited by this paper
• Inhibition of murine relapsing experimental autoimmune encephalomyelitis by immune tolerance to proteolipid protein and its encephalitogenic peptides.

  1990cited by this paper
• Specific immune regulation of chronic-relapsing experimental allergic encephalomyelitis in mice.

  1988cited by this paper
• The Theiler's murine encephalomyelitis virus (TMEV) model for multiple sclerosis shows a strong influence of the murine equivalents of HLA-A, B, and C.

  1987cited by this paper
• Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease. I. Cross-specificity among TMEV substrains and related picornaviruses, but not myelin proteins.

  1987cited by this paper
• The effect of L3T4 T cell depletion on the pathogenesis of Theiler's murine encephalomyelitis virus infection in CBA mice.

  1987cited by this paper
• Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease. II. Survey of host immune responses and central nervous system virus titers in inbred mouse strains.

  1987cited by this paper
• Variations in genetic control of susceptibility to Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease. I. Differences between susceptible SJL/J and resistant BALB/c strains map near the T cell beta-chain constant gene on chromosome 6.

  1987cited by this paper
• Kinetics and specificity of T and B cell responses in relapsing experimental allergic encephalomyelitis.

  1987cited by this paper
• Characterization of Theiler's murine encephalomyelitis virus (TMEV)-specific delayed-type hypersensitivity responses in TMEV-induced demyelinating disease: correlation with clinical signs.

  1986cited by this paper
• Demyelination induced by Theiler's virus: influence of the H-2 haplotype.

  1985cited by this paper
• Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease in mice is influenced by the H-2D region: correlation with TEMV-specific delayed-type hypersensitivity.

  1985cited by this paper
• Amino acid homology between the encephalitogenic site of myelin basic protein and virus: mechanism for autoimmunity.

  1985cited by this paper
• Serum and cells from Theiler's virus-infected mice fail to injure myelinating cultures or to produce in vivo transfer of disease. The pathogenesis of Theiler's virus-induced demyelination appears to differ from that of EAE.

  1984cited by this paper
• Genetic analysis of susceptibility to Theiler's virus-induced demyelinating disease in mice.

  1984cited by this paper
• Persistent infection of oligodendrocytes in Theiler's virus‐induced encephalomyelitis

  1983cited by this paper
• Ultrastructural immunohistochemical localization of virus in acute and chronic demyelinating Theiler's virus infection.

  1982cited by this paper
• The effect of short-term and chronic immunosuppression on Theiler's virus demyelination.

  1982cited by this paper
• Theiler's virus persists in glial cells during demyelinating disease.

  1981cited by this paper
• Current perspectives of neuroimmunologic disease: multiple sclerosis and experimental allergic encephalomyelitis (1,2).

  1981cited by this paper
• Current perspectives of neuroimmunologic disease: multiple sclerosis and experimental allergic encephalomyelitis (1,2).

  1981cited by this paper
• Purification of Theiler's Murine Encephalomyelitis Virus and Analysis of the Structural Virion Polypeptides: Correlation of the Polypeptide Profile with Virulence

  1980cited by this paper
• Persistent Theiler's murine encephalomyelitis virus infection in mice depends on plaque size.

  1980cited by this paper
• Schwann cell remyelination and recurrent demyelination in the central nervous system of mice infected with attenuated Theiler's virus.

  1980cited by this paper
• Recurrent demyelination in chronic central nervous system infection produced by Theiler's murine encephalomyelitis virus.

  1979cited by this paper
• Contrasting effects of immunosuppression on Theiler's virus infection in mice

  1977cited by this paper
• Theiler's virus-induced demyelination: prevention by immunosuppression.

  1976cited by this paper
• Demyelinative myelopathy in mice induced by the DA virus.

  1976cited by this paper
• Theiler's virus infection in mice: an unusual biphasic disease process leading to demyelination

  1975cited by this paper
• Primary demyelination in Theiler's virus infection. An ultrastructural study.

  1975cited by this paper
• SPONTANEOUS ENCEPHALOMYELITIS OF MICE, A NEW VIRUS DISEASE

  1934cited by this paper

• Therapeutic effects of estrogens on inflammatory demyelination in a mouse model of multiple sclerosis.

  2025cites this paper
• Autoantibodies in COVID-19: implications for disease severity and clinical outcomes

  2025cites this paper
• Immunological and virological triggers of type 1 diabetes: insights and implications

  2024cites this paper
• The Role of Viral Infections in the Onset of Autoimmune Diseases

  2023cites this paper
• Autoimmune complications of COVID‐19

  2021cites this paper
• Identifying the culprits in neurological autoimmune diseases

  2019cites this paper
• The Pathophysiology of Arthritis Due to Viruses and Vaccines

  2019cites this paper
• Viruses and Autoimmunity: A Review on the Potential Interaction and Molecular Mechanisms

  2019cites this paper
• Neurological syndromes driven by postinfectious processes or unrecognized persistent infections

  2018cites this paper
• Disease prevalence in a rural Andean population of central Peru: a focus on autoimmune and allergic diseases

  2016cites this paper
• Theiler’s Murine Encephalomyelitis Virus-Induced Demyelinating Disease (TMEV-IDD) and Autoimmunity

  2015cites this paper
• Chapter 60 – Acute Disseminated Encephalomyelitis

  2015cites this paper
• Unresolved issues in theories of autoimmune disease using myocarditis as a framework.

  2015cites this paper
• Microbial view of central nervous system autoimmunity

  2014cites this paper
• Defining a new biomarker for the autoimmune component of Multiple Sclerosis: Th40 cells.

  2014cites this paper
• Revista3Vol89ingles-Bruno_Layout 1

  2014cites this paper
• Regulatory T-cell vaccination independent of auto-antigen

  2014cites this paper
• The protective and pathologic roles of toll-like receptors in arthritogenic alphavirus infection

  2013cites this paper
• Genomic analysis of ERVWE2 locus in patients with multiple sclerosis: absence of genetic association but potential role of human endogenous retrovirus type W elements in molecular mimicry with myelin antigen

  2013cites this paper
• Involvement of IL-1R/TLR signalling in experimental autoimmune encephalomyelitis and multiple sclerosis.

  2012cites this paper
• Current theories for multiple sclerosis pathogenesis and treatment

  2012influential citation
• Estrogen Therapy in a Viral Murine Model of Multiple Sclerosis

  2012influential citation
• Autoimmunity in the Mediation of Granulomatous Amoebic Encephalitis: Implications for Therapy

  2011cites this paper
• Experimental encephalomyocarditis virus infection in small laboratory rodents.

  2011cites this paper
• Paired analysis of TCRα and TCRβ chains at the single-cell level in mice.

  2011cites this paper
• Contribution of CD8 T lymphocytes to the immuno-pathogenesis of multiple sclerosis and its animal models.

  2011cites this paper
• Pentapeptide commonality between Corynebacterium diphtheriae toxin and the Homo sapiens proteome.

  2011cites this paper
• Interferon Induced with Helicase C Domain 1 (IFIH1) and Virus-Induced Autoimmunity: A Review

  2010cites this paper
• Development of autoimmune process in rats immunized with influenza vaccine

  2009cites this paper
• Is multiple sclerosis a mitochondrial disease?

  2009cites this paper
• Mapping the human proteome for non-redundant peptide islands

  2008cites this paper
• Hepatitis B Virus (HBV) and Autoimmune Disease

  2008cites this paper
• Molecular mimicry in neurological disease: what is the evidence?

  2008cites this paper
• Host immune responses to coxsackievirus B3.

  2008cites this paper
• Hepatitis B: infection, vaccination and autoimmunity.

  2008cites this paper
• Protective and Regenerative Autoimmunity in CNS Injury

  2008cites this paper
• 45and Regenerative Autoimmunity in CNS Injury

  2008cites this paper
• Myelin oligodendrocyte glycoprotein peptide-induced experimental allergic encephalomyelitis and T cell responses are unaffected by immunoproteasome deficiency.

  2007cites this paper
• Tolerance in the absence of autoantigen.

  2007cites this paper
• Autoimmunity in coxsackievirus B3 induced myocarditis

  2006cites this paper
• Virus-mediated autoimmunity in Multiple Sclerosis

  2006cites this paper
• Preliminary data on Pemphigus vulgaris treatment by a proteomics-defined peptide: a case report

  2006cites this paper
• Innate and adaptive immune responses of the central nervous system.

  2006cites this paper
• Cure of Chronic Viral Infection and Virus-Induced Type 1 Diabetes by Neutralizing Antibodies

  2006cites this paper
• Cure of Chronic Viral Infection and Virus-Induced Type 1 Diabetes by Neutralizing Antibodies

  2006cites this paper
• Infections and Autoimmunity—Good or Bad?1

  2005cites this paper
• Infections and autoimmunity

  2005cites this paper
• Elevated immunoglobulin G antibodies to the proline‐rich amino‐terminal region of Epstein–Barr virus nuclear antigen‐2 in sera from patients with systemic connective tissue diseases and from a subgroup of Sjögren's syndrome patients with pulmonary involvements

  2005cites this paper
• Auto-immunité physiologique et pathologique dans les maladies neurologiques

  2005cites this paper
• [Physiological and pathological autoimmunity in neurological disease].

  2005cites this paper
• Immunology of multiple sclerosis.

  2005cites this paper
• Multiple Sclerosis: Therapy

  2004cites this paper
• Structural availability influences the capacity of autoantigenic epitopes to induce a widespread lupus-like autoimmune response.

  2004cites this paper
• Computational peptide dissection of Melan-a/MART-1 oncoprotein antigenicity.

  2004cites this paper
• Serum antibody reactivity to human intracisternal A-type particle retrovirus proteins in systemic sclerosis patients.

  2004cites this paper
• A viral epitope that mimics a self antigen can accelerate but not initiate autoimmune diabetes.

  2004cites this paper
• Evidence that factors other than particular thyrotropin receptor T cell epitopes contribute to the development of hyperthyroidism in murine Graves’ disease

  2004cites this paper
• Theiler's Virus Infection: a Model for Multiple Sclerosis

  2004cites this paper
• Investigating the regulatory cells that mediate recovery from CNS-targeted autoimmune disease

  2004cites this paper
• Self and non-self discrimination is needed for the existence rather than deletion of autoimmunity: the role of regulatory T cells in protective autoimmunity

  2004cites this paper
• Coxsackievirus B1-induced chronic inflammatory myopathy: differences in induction of autoantibodies to muscle and nuclear antigens by cloned myopathic and amyopathic viruses.

  2003cites this paper
• Cutting Edge: CD40-Induced Expression of Recombination Activating Gene (RAG) 1 and RAG2: A Mechanism for the Generation of Autoaggressive T Cells in the Periphery1

  2003cites this paper
• The role of IFN-γ in immune responses to viral infections of the central nervous system

  2002cites this paper
• The role of IFN-gamma in immune responses to viral infections of the central nervous system.

  2002cites this paper
• Perspectives on the role of endogenous human retroviruses in autoimmune diseases.

  2002cites this paper
• The Natural Killer Cell – Friend or Foe in Autoimmune Disease?

  2002cites this paper
• Gulsen Tukenmez Demirci

  year unknowncites this paper