Retinopathy in a novel model of metabolic syndrome and type 2 diabetes: new insight on the inflammatory paradigm

No abstract is available for this paper.

• Publication year

  2014

• Venue

  The FASEB Journal

• Publication date

  2014-02-26

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1096/fj.12-215715PMID 24571922PMCID PMC3986844
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Dietary carbohydrate dictates development of Type 2 diabetes in the Nile rat.

  2013influential reference
• Diabetic Retinopathy: Targeting Vasoregression

  2011cited by this paper
• Retinal vascular tortuosity in persons with diabetes and diabetic retinopathy

  2011cited by this paper
• Australian rural football club leaders as mental health advocates: an investigation of the impact of the Coach the Coach project

  2010cited by this paper
• Nutritional correlates and dynamics of diabetes in the Nile rat (Arvicanthis niloticus): a novel model for diet-induced type 2 diabetes and the metabolic syndrome

  2010cited by this paper
• An animal model of spontaneous metabolic syndrome: Nile grass rat

  2010cited by this paper
• Retinal vascular changes and diabetic retinopathy

  2009cited by this paper
• Characterization of azurocidin as a permeability factor in the retina: involvement in VEGF-induced and early diabetic blood-retinal barrier breakdown.

  2008cited by this paper
• Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators

  2008cited by this paper
• VLA‐4 blockade suppresses endotoxin‐induced uveitis: in vivo evidence for functional integrin up‐regulation

  2007cited by this paper
• Developmental origin of fat: tracking obesity to its source.

  2007cited by this paper
• From mice to men: insights into the insulin resistance syndromes.

  2006cited by this paper
• Diabetic Retinopathy

  2006cited by this paper
• Preventive effects of glycaemic control on ocular complications of Spontaneously Diabetic Torii rat

  2006cited by this paper
• Integrin α4β1–VCAM-1–mediated adhesion between endothelial and mural cells is required for blood vessel maturation

  2005cited by this paper
• Pericytes and the Pathogenesis of Diabetic Retinopathy

  2005cited by this paper
• Integrin alpha4beta1-VCAM-1-mediated adhesion between endothelial and mural cells is required for blood vessel maturation.

  2005cited by this paper
• Simvastatin inhibits leukocyte accumulation and vascular permeability in the retinas of rats with streptozotocin-induced diabetes.

  2004influential reference
• The metabolic syndrome or the insulin resistance syndrome? Different names, different concepts, and different goals.

  2004cited by this paper
• Vascular leucocyte adhesion molecules unaltered in the human retina in diabetes

  2004cited by this paper
• Dyslipidemia, but not hyperglycemia, induces inflammatory adhesion molecules in human retinal vascular endothelial cells.

  2003cited by this paper
• Cerebral endothelial dysfunction in diabetes: intravital microscopic analysis using streptozotocin‐induced diabetic rats

  2003cited by this paper
• VEGF164 is proinflammatory in the diabetic retina.

  2003cited by this paper
• Is diabetic retinopathy an inflammatory disease?

  2002cited by this paper
• Leptin regulation of the immune response and the immunodeficiency of malnutrition 1

  2001cited by this paper
• Integrin-mediated neutrophil adhesion and retinal leukostasis in diabetes.

  2000cited by this paper
• Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition.

  1999influential reference
• In vivo demonstration of increased leukocyte entrapment in retinal microcirculation of diabetic rats.

  1998cited by this paper
• The Rising Global Burden of Diabetes and its Complications: Estimates and Projections to the Year 2010

  1997cited by this paper
• Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice.

  1996cited by this paper
• Accelerated death of retinal microvascular cells in human and experimental diabetic retinopathy.

  1996cited by this paper
• Enhanced expression of intracellular adhesion molecule-1 and P-selectin in the diabetic human retina and choroid.

  1995cited by this paper
• Endothelial function in the isolated perfused mesentery and aortae of rats with streptozotocin‐induced diabetes: effect of treatment with the aldose reductase inhibitor, ponalrestat

  1994influential reference
• Spontaneous Long-Term Hyperglycemic Rat With Diabetic Complications: Otsuka Long-Evans Tokushima Fatty (OLETF) Strain

  1992cited by this paper
• β-Cell Insensitivity to Glucose in the GK Rat, a Spontaneous Nonobese Model for Type II Diabetes

  1991cited by this paper
• Beta-cell insensitivity to glucose in the GK rat, a spontaneous nonobese model for type II diabetes.

  1991cited by this paper
• Activated monocytes and granulocytes, capillary nonperfusion, and neovascularization in diabetic retinopathy.

  1991cited by this paper
• Decreased Fluidity of Polymorphonuclear Leukocyte Membrane in Streptozocin-Induced Diabetic Rats

  1990cited by this paper
• A New Genetically Obese-Hyperglycemic Rat (Wistar Fatty)

  1981cited by this paper
• Hyperinsulinemia in pre-weaning diabetes (db) mice

  1974cited by this paper
• Accelerated triglyceride secretion. A metabolic consequence of obesity.

  1973cited by this paper
• The influence of genetic background on the expression of the obese (ob) gene in the mouse

  1973cited by this paper
• Diabetes in the KK mouse

  1970cited by this paper

• The Protective Effect of Topical PACAP38 in Retinal Morphology and Function of Type 2 Diabetic Retinopathy

  2025cites this paper
• Association of the apoptotic markers Apo1/Fas and cCK-18 and the adhesion molecule ICAM-1 with Type 1 diabetes mellitus in children and adolescents

  2024cites this paper
• A translational model of chronic diabetic nephropathy in the Nile grass rat

  2024cites this paper
• Current understanding of subclinical diabetic retinopathy informed by histology and high‐resolution in vivo imaging

  2024cites this paper
• Aquaporins contribute to vacuoles formation in Nile grass type II diabetic rats

  2023cites this paper
• Insulin and circadian rhythm genes of the Nile rat (Arvicanthis niloticus) are conserved and orthologous to those in the rat, mouse and human

  2023cites this paper
• Immunological consequences of compromised ocular immune privilege accelerate retinal degeneration in retinitis pigmentosa

  2022cites this paper
• Type 2 Diabetes Mellitus: Pathogenic Features and Experimental Models in Rodents

  2022cites this paper
• Studies of the retinal microcirculation using human donor eyes and high-resolution clinical imaging: Insights gained to guide future research in diabetic retinopathy.

  2022cites this paper
• Longer Interscan Times in OCT Angiography Detect Slower Capillary Flow in Diabetic Retinopathy

  2022cites this paper
• Artesunate alleviates diabetic retinopathy by activating autophagy via the regulation of AMPK/SIRT1 pathway

  2021cites this paper
• Diabetic cataract in the Nile grass rat: A longitudinal phenotypic study of pathology formation

  2021cites this paper
• MicroRNAs may provide new strategies in the treatment and diagnosis of diabetic retinopathy: Importance of VEGF

  2021cites this paper
• The innate immune system in diabetic retinopathy.

  2021cites this paper
• Innate immune response in retinal homeostasis and inflammatory disorders.

  2020cites this paper
• Electrophysiology of the Inner Retina in Health and Disease: EAAT5 in the Rod Bipolar Cell and Oscillatory Potentials in Diabetes

  2020cites this paper
• Blood-retinal barrier as a converging pivot in understanding the initiation and development of retinal diseases

  2020cites this paper
• Metabolic Syndrome is Associated with Ocular Hypertension and Glaucoma.

  2020cites this paper
• New Insights Into Immunological Therapy for Retinal Disorders

  2020cites this paper
• Intercellular adhesive molecule-1 (ICAM-1) in proliferative diabetic retinopathy

  2020cites this paper
• Diurnal rodents as pertinent animal models of human retinal physiology and pathology.

  2020cites this paper
• Relationships among resistin, adiponectin, and leptin and microvascular complications in patients with type 2 diabetes mellitus

  2019cites this paper
• Vascular changes in diabetic retinopathy – A longitudinal study in the Nile rat

  2019cites this paper
• THE ROLE OF ADIPONECTIN AND TOLL-LIKE RECEPTOR 4 GENE POLYMORPHISMS ON NON-PROLIFERATIVE RETINOPATHY IN TYPE 2 DIABETES MELLITUS PATIENTS. A CASE-CONTROL STUDY IN ROMANIAN CAUCASIANS PATIENTS.

  2019cites this paper
• In contrast to Western diet, a plant‐based, high‐fat, low‐sugar diet does not exacerbate retinal endothelial injury in streptozotocin‐induced diabetes

  2019cites this paper
• Genetic Permissiveness and Dietary Glycemic Load Interact to Predict Type-II Diabetes in the Nile rat (Arvicanthis niloticus)

  2019cites this paper
• Metabolik Sendrom ve Göz Hastalıkları ile İlişkisi: Kısa Derleme

  2019cites this paper
• Retinal vascular tortuosity in schizophrenia and bipolar disorder.

  2019cites this paper
• Palm Fruit Bioactives augment expression of Tyrosine Hydroxylase in the Nile Grass Rat basal ganglia and alter the colonic microbiome

  2019cites this paper
• Characterization of the Nile Grass Rat as a Unique Model for Type 2 Diabetic Polyneuropathy

  2018cites this paper
• Intravitreal injection of a Rho-kinase inhibitor (fasudil) combined with bevacizumab versus bevacizumab monotherapy for diabetic macular oedema: a pilot randomised clinical trial

  2018cites this paper
• The Nile Rat (Arvicanthis niloticus) as a Superior Carbohydrate-Sensitive Model for Type 2 Diabetes Mellitus (T2DM)

  2018cites this paper
• Prostaglandin E2/EP2 receptor signalling pathway promotes diabetic retinopathy in a rat model of diabetes

  2018cites this paper
• Vascular Cell Adhesion Molecule 1, Intercellular Adhesion Molecule 1, and Cluster of Differentiation 146 Levels in Patients with Type 2 Diabetes with Complications

  2017cites this paper
• Optical Coherence Tomography Angiography Reveals Spatial Bias of Macular Capillary Dropout in Diabetic Retinopathy.

  2017cites this paper
• Low glycemic load diets protect against metabolic syndrome and Type 2 diabetes mellitus in the male Nile rat.

  2017cites this paper
• Is leukostasis a crucial step or epiphenomenon in the pathogenesis of diabetic retinopathy?

  2017cites this paper
• Molecular Imaging of Retinal Endothelial Injury in Diabetic Animals

  2017cites this paper
• Modifications in Retinal Mitochondrial Respiration Precede Type 2 Diabetes and Protracted Microvascular Retinopathy.

  2017cites this paper
• Cichoric acid improved hyperglycaemia and restored muscle injury via activating antioxidant response in MLD-STZ-induced diabetic mice.

  2017cites this paper
• Rho-Kinase/ROCK as a Potential Drug Target for Vitreoretinal Diseases

  2017cites this paper
• Forskolin attenuates retinal inflammation in diabetic mice

  2017cites this paper
• Rodent Models of Diabetes

  2016cites this paper
• Vascular Normalization by ROCK Inhibitor: Therapeutic Potential of Ripasudil (K-115) Eye Drop in Retinal Angiogenesis and Hypoxia.

  2016cites this paper
• Toll-like receptor 2 and type 2 diabetes

  2016cites this paper
• Is There any Correlation Between Diabetic Retinopathy and Risk of Cardiovascular Disease?

  2016cites this paper
• Metabolic syndrome and eye diseases.

  2016cites this paper
• Functional Deficits Precede Structural Lesions in Mice With High-Fat Diet–Induced Diabetic Retinopathy

  2016cites this paper
• Thrombosis and Hemorrhage in Diabetic Retinopathy: A Perspective from an Inflammatory Standpoint

  2015cites this paper
• β-Glucans (Saccharomyces cereviseae) Reduce Glucose Levels and Attenuate Alveolar Bone Loss in Diabetic Rats with Periodontal Disease

  2015cites this paper
• Emerging Roles of Pericytes in the Regulation of the Neurovascular Unit in Health and Disease

  2014cites this paper
• Molecular imaging reveals elevated VEGFR‐2 expression in retinal capillaries in diabetes: a novel biomarker for early diagnosis

  2014cites this paper