Post-GWAS: where next? More samples, more SNPs or more biology?

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Heredity

• Publication date

  2013-06-12

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/hdy.2013.52PMID 23759726PMCID PMC3860164
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Incorporating Prior Biologic Information for High-Dimensional Rare Variant Association Studies

  2013cited by this paper
• Genome-Wide Association Analysis of Oxidative Stress Resistance in Drosophila melanogaster

  2012cited by this paper
• Heritability in the genome-wide association era

  2012cited by this paper
• The Drosophila melanogaster Genetic Reference Panel

  2012cited by this paper
• Evolution and Functional Impact of Rare Coding Variation from Deep Sequencing of Human Exomes

  2012cited by this paper
• The mystery of missing heritability: Genetic interactions create phantom heritability

  2012influential reference
• Using Whole-Genome Sequence Data to Predict Quantitative Trait Phenotypes in Drosophila melanogaster

  2012cited by this paper
• Parameters in Dynamic Models of Complex Traits are Containers of Missing Heritability

  2012cited by this paper
• Introduction to Quantitative Genetics

  2012cited by this paper
• Genome-Wide Association for Sensitivity to Chronic Oxidative Stress in Drosophila melanogaster

  2012cited by this paper
• Genetic variation in the Yolk protein expression network of Drosophila melanogaster: sex-biased negative correlations with longevity

  2012cited by this paper
• A mixed-model approach for genome-wide association studies of correlated traits in structured populations

  2012cited by this paper
• Statistical Applications in Genetics and Molecular Biology Approximately Sufficient Statistics and Bayesian Computation

  2011cited by this paper
• Statistical Applications in Genetics and Molecular Biology On Optimal Selection of Summary Statistics for Approximate Bayesian Computation

  2011cited by this paper
• Lack of confidence in approximate Bayesian computation model choice

  2011cited by this paper
• Choice of Summary Statistic Weights in Approximate Bayesian Computation

  2011cited by this paper
• Order‐preserving principles underlying genotype–phenotype maps ensure high additive proportions of genetic variance

  2011cited by this paper
• Prediction of flowering time in Brassica oleracea using a quantitative trait loci-based phenology model.

  2011cited by this paper
• The Drosophila Gap Gene Network Is Composed of Two Parallel Toggle Switches

  2011cited by this paper
• Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

  2010cited by this paper
• Deciphering a transcriptional regulatory code: modeling short-range repression in the Drosophila embryo

  2010cited by this paper
• Variance component model to account for sample structure in genome-wide association studies

  2010cited by this paper
• ABC-SysBio—approximate Bayesian computation in Python with GPU support

  2010cited by this paper
• Allele Interaction – Single Locus Genetics Meets Regulatory Biology

  2010cited by this paper
• Thermodynamic modeling of transcription: sensitivity analysis differentiates biological mechanism from mathematical model-induced effects

  2010cited by this paper
• Missing heritability and strategies for finding the underlying causes of complex disease

  2010cited by this paper
• The genotype-phenotype relationship in multicellular pattern-generating models - the neglected role of pattern descriptors

  2009cited by this paper
• Finding the missing heritability of complex diseases

  2009cited by this paper
• The ABC of reverse engineering biological signalling systems.

  2009cited by this paper
• Approximate Bayesian computation scheme for parameter inference and model selection in dynamical systems

  2009cited by this paper
• Natural genetic variation in transcriptome reflects network structure inferred with major effect mutations: insulin/TOR and associated phenotypes in Drosophila melanogaster

  2009cited by this paper
• Simulation-based model selection for dynamical systems in systems and population biology

  2009cited by this paper
• Curses--winner's and otherwise--in genetic epidemiology.

  2008cited by this paper
• Data and Theory Point to Mainly Additive Genetic Variance for Complex Traits

  2008influential reference
• The road to genome-wide association studies

  2008cited by this paper
• Mapping the Genetic Architecture of Gene Expression in Human Liver

  2008cited by this paper
• A Multiobjective Evolutionary-Simplex Hybrid Approach for the Optimization of Differential Equation Models of Gene Networks

  2008cited by this paper
• Moving toward a system genetics view of disease

  2007cited by this paper
• QTL methodology for response curves on the basis of non-linear mixed models, with an illustration to senescence in potato

  2006cited by this paper
• Modern computational approaches for analysing molecular genetic variation data

  2006cited by this paper
• Stochastic Simulation

  2005cited by this paper
• Genetic variation for expression of the sex determination pathway genes in Drosophila melanogaster.

  2005cited by this paper
• Gene-to-phenotype models and complex trait genetics

  2005cited by this paper
• Flowering time control: gene network modelling and the link to quantitative genetics

  2005cited by this paper
• Modelling genetic networks with noisy and varied experimental data: the circadian clock in Arabidopsis thaliana.

  2005cited by this paper
• Analysing the genetic control of peach fruit quality through an ecophysiological model combined with a QTL approach.

  2005cited by this paper
• Extension of a genetic network model by iterative experimentation and mathematical analysis

  2005cited by this paper
• Merging genomic control networks and soil-plant-atmosphere-continuum models

  2005cited by this paper
• How should we explain variation in the genetic variance of traits?

  2004cited by this paper
• Comparing Genetic Programming and Evolution Strategies on Inferring Gene Regulatory Networks

  2004cited by this paper
• On Systems Thinking, Systems Biology, and the in Silico Plant

  2004cited by this paper
• Biochemistry of Signal Transduction and Regulation 3rd ed

  2003cited by this paper
• A Genetic Neural Network Model of Flowering Time Control in Arabidopsis thaliana

  2003cited by this paper
• Crop modeling, QTL mapping, and their complementary role in plant breeding

  2003cited by this paper
• Markov chain Monte Carlo without likelihoods

  2003cited by this paper
• Combining Quantitative Trait Loci Analysis and an Ecophysiological Model to Analyze the Genetic Variability of the Responses of Maize Leaf Growth to Temperature and Water Deficit1

  2003cited by this paper
• Estimation of gene regulatory network by genetic algorithm and pairwise correlation analysis

  2003cited by this paper
• Virtual plants: modelling as a tool for the genomics of tolerance to water deficit.

  2003cited by this paper
• A Genetic Neural Network Model of Flowering Time Control in

  2003cited by this paper
• On the Future of Data Analysis

  2002cited by this paper
• The GP Problem: Quantifying Gene-to-Phenotype Relationships

  2002cited by this paper
• Hierarchical Organization of Modularity in Metabolic Networks

  2002cited by this paper
• Sequential Monte Carlo samplers

  2002cited by this paper
• The genetic architecture of quantitative traits.

  2001cited by this paper
• Detecting the undetected: estimating the total number of loci underlying a quantitative trait.

  2000cited by this paper
• Genetics and analysis of quantitative traits

  1999cited by this paper
• The power of association studies to detect the contribution of candidate genetic loci to variation in complex traits.

  1999cited by this paper
• Biochemistry of signal transduction and regulation

  1999cited by this paper
• Buddha's Little Finger

  1998cited by this paper
• QU-GENE: a simulation platform for quantitative analysis of genetic models

  1998cited by this paper
• Inferring coalescence times from DNA sequence data.

  1997cited by this paper
• Crop Modeling: From Infancy to Maturity

  1996cited by this paper
• Age-specific inbreeding depression and components of genetic variance in relation to the evolution of senescence.

  1996cited by this paper
• Bayesianly Justifiable and Relevant Frequency Calculations for the Applied Statistician

  1984cited by this paper
• Monte Carlo Sampling Methods Using Markov Chains and Their Applications

  1970cited by this paper
• Equation of State Calculations by Fast Computing Machines

  1953cited by this paper
• Edinburgh Research Explorer Genome-wide association scan meta-analysis identifies three loci influencing adiposity and fat distribution

  year unknowncited by this paper

• Breeding perspectives on tackling trait genome-to-phenome (G2P) dimensionality using ensemble-based genomic prediction

  2025influential citation
• 2-Categorical Foundations for Multiparameter Persistence

  2025cites this paper
• A major QTL region associated with powdery mildew resistance in leaves and fruits of the reconstructed garden strawberry

  2025cites this paper
• Genomic determinants, architecture, and constraints in drought-related traits in Corymbia calophylla

  2024cites this paper
• Genes and Sales

  2023cites this paper
• Two decades of harnessing standing genetic variation for physiological traits to improve drought tolerance in maize

  2023cites this paper
• Variants in the CETP gene affect levels of HDL cholesterol by reducing the amount, and not the specific lipid transfer activity, of secreted CETP

  2023cites this paper
• Genetic variants in DDO and PEX5L in peroxisome‐related pathways predict non‐small cell lung cancer survival

  2022cites this paper
• Breeding crops for drought-affected environments and improved climate resilience

  2022cites this paper
• Building causal knowledge in behavior genetics

  2022cites this paper
• Modeling of Flowering Time in Vigna radiata with Approximate Bayesian Computation

  2021cites this paper
• Predicting trait phenotypes from knowledge of the topology of gene networks

  2021cites this paper
• Perspectives on Applications of Hierarchical Gene-To-Phenotype (G2P) Maps to Capture Non-stationary Effects of Alleles in Genomic Prediction

  2021cites this paper
• Using Genetic Marginal Effects to Study Gene-Environment Interactions with GWAS Data

  2021cites this paper
• Identification, deployment, and transferability of quantitative trait loci from genome-wide association studies in plants

  2020cites this paper
• Modelling selection response in plant breeding programs using crop models as mechanistic gene-to-phenotype (CGM-G2P) multi-trait link functions

  2020cites this paper
• Novel genetic variants of PIP5K1C and MVB12B of the endosome-related pathway predict cutaneous melanoma-specific survival.

  2020cites this paper
• Genetic architecture of a body color cline in Drosophila americana

  2020cites this paper
• Modelling selection response in plant-breeding programs using crop models as mechanistic gene-to-phenotype (CGM-G2P) multi-trait link functions

  2020cites this paper
• Population Studies of the Heritable Influences on the Mind and Brain

  2019cites this paper
• Down-regulated RGS5 by genetic variants impairs endothelial cell function and contributes to coronary artery disease.

  2019cites this paper
• Computational discovery of Genetic Markers for Type 2 diabetes

  2019cites this paper
• Integrating genome-wide association mapping of additive and dominance genetic effects to improve genomic prediction accuracy in Eucalyptus

  2019cites this paper
• Quantitative Phenomics of Growth and Size in Animals

  2019cites this paper
• Enhancing Genetic Gain through Genomic Selection: From Livestock to Plants

  2019cites this paper
• Candidate genes and genome-wide association study of grain protein content and protein deviation in durum wheat

  2019cites this paper
• ADGRL3 (LPHN3) variants predict substance use disorder

  2019cites this paper
• Why does the magnitude of genotype‐by‐environment interaction vary?

  2018cites this paper
• Bayesian updating during development predicts genotypic differences in plasticity

  2018cites this paper
• Accelerating crop genetic gains with genomic selection

  2018cites this paper
• SNP‐skimming: A fast approach to map loci generating quantitative variation in natural populations

  2018cites this paper
• Established and emerging strategies to crack the genetic code of obesity

  2018cites this paper
• Large‐effect loci affect survival in Tasmanian devils (Sarcophilus harrisii) infected with a transmissible cancer

  2018cites this paper
• An Approximate Likelihood Perspective on ABC Methods

  2017cites this paper
• Leveraging biological insight and environmental variation to improve phenotypic prediction: Integrating crop growth models (CGM) with whole genome prediction (WGP)

  2017cites this paper
• Critical Issues in Genetic Association Studies

  2017cites this paper
• Systematic Identification and Analysis of Cell-state-associated cisregulatory Elements Using Statistical Approaches

  2017cites this paper
• The genetic epidemiology of substance use disorder: A review.

  2017cites this paper
• Translating natural genetic variation to gene expression in a computational model of the Drosophila gap gene regulatory network

  2017cites this paper
• Understanding the Roles of Genetic and Environmental Influences on the Neurobiology of Nicotine Use

  2017cites this paper
• The carotenoid biosynthetic and catabolic genes in wheat and their association with yellow pigments

  2017cites this paper
• Genomewide association mapping and pathway analysis of meat tenderness in Polled Nellore cattle.

  2017cites this paper
• Functional mapping and annotation of genetic associations with FUMA

  2017cites this paper
• Mapping the genomic architecture of adaptive traits with interspecific introgressive origin: a coalescent-based approach

  2016cites this paper
• A Hypothesis for Using Pathway Genetic Load Analysis for Understanding Complex Outcomes in Bilirubin Encephalopathy

  2016cites this paper
• Forest tree genomics: 10 achievements from the past 10 years and future prospects

  2016cites this paper
• Concepts and Relevance of Genome-Wide Association Studies

  2016cites this paper
• Gene networks and developmental context: the importance of understanding complex gene expression patterns in evolution

  2016cites this paper
• Use of Crop Growth Models with Whole-Genome Prediction: Application to a Maize Multienvironment Trial

  2016cites this paper
• The power of Oxford Nanopore MinION in human leukocyte antigen immunogenetics

  2016cites this paper
• Promises and Challenges of Big Data Computing in Health Sciences

  2015cites this paper
• Systems biology of plant molecular networks: from networks to models

  2015cites this paper
• Dissecting genetic variation in European Scots pine ( Pinus sylvestris L.) : special emphasis on polygenic adaptation

  2015cites this paper
• Distributed analysis of expression quantitative trait loci in Apache Spark

  2015cites this paper
• The locus of sexual selection: moving sexual selection studies into the post‐genomics era

  2015cites this paper
• Integrating Crop Growth Models with Whole Genome Prediction through Approximate Bayesian Computation

  2015cites this paper
• DETECTING CRYPTIC INDIRECT GENETIC EFFECTS

  2014cites this paper
• The Genetics of Common Epilepsy Disorders: Lessons Learned from the Channelopathy Era

  2014cites this paper
• Next-Generation Sequencing Studies: Optimal Design and Analysis, Missing Heritability and Rare Variants

  2014cites this paper
• Genetic Variants and Risk in Sudden Cardiac Death Syndromes

  2014cites this paper
• The role of extrinsic noise in biomolecular information processing systems : an in silico analysis

  2014cites this paper
• Predicting the future of plant breeding: complementing empirical evaluation with genetic prediction

  2014cites this paper
• Genome-wide association mapping of molecular and physiological component traits in maize

  2014cites this paper
• Remind me again what disease we are studying? A population genetics, genetic analysis, and real data perspective on why progress on identifying genetic influences on common epilepsies has been so slow.

  2014cites this paper
• Clinal Variation at Phenology-Related Genes in Spruce: Parallel Evolution in FTL2 and Gigantea?

  2014cites this paper
• Genetic evaluation models and strategies for potato variety selection.

  2014cites this paper
• Genetic interactions matter more in less-optimal environments: a Focused Review of “Phenotype uniformity in combined-stress environments has a different genetic architecture than in single-stress treatments” (Makumburage and Stapleton, 2011)

  2014cites this paper
• SNP characteristics predict replication success in association studies

  2014cites this paper
• Translational paradigms in pharmacology and drug discovery.

  2014cites this paper
• Special issues on advances in quantitative genetics: introduction

  2013cites this paper
• Approximation Bayesian Computation.

  2013cites this paper
• Ecological genomics of local adaptation

  2013cites this paper