A novel enteric neuron–glia coculture system reveals the role of glia in neuronal development

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Journal of Physiology

• Publication date

  2017-01-15

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1113/JP271989PMID 27436013PMCID PMC5233665
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Postnatal development of the myenteric glial network and its modulation by butyrate.

  2016influential reference
• Microbiota Controls the Homeostasis of Glial Cells in the Gut Lamina Propria

  2015cited by this paper
• Heterogeneity and phenotypic plasticity of glial cells in the mammalian enteric nervous system

  2015cited by this paper
• Nerve fiber outgrowth is increased in the intestinal mucosa of patients with irritable bowel syndrome.

  2015cited by this paper
• Targeting the CD80/CD86 costimulatory pathway with CTLA4‐Ig directs microglia toward a repair phenotype and promotes axonal outgrowth

  2015cited by this paper
• Glial cell line-derived neurotrophic factor promotes barrier maturation and wound healing in intestinal epithelial cells in vitro.

  2015cited by this paper
• Enteric glia express proteolipid protein 1 and are a transcriptionally unique population of glia in the mammalian nervous system

  2015cited by this paper
• Changes in Nicotinic Neurotransmission during Enteric Nervous System Development

  2015cited by this paper
• Astrocyte-encoded positional cues maintain sensorimotor circuit integrity

  2014cited by this paper
• GDNF is Involved in the Barrier-Inducing Effect of Enteric Glial Cells on Intestinal Epithelial Cells Under Acute Ischemia Reperfusion Stimulation

  2014cited by this paper
• Ca2+ responses in enteric glia are mediated by connexin-43 hemichannels and modulate colonic transit in mice.

  2014cited by this paper
• A Novel Bidirectional Interaction between endothelin-3 and Retinoic Acid in Rat Enteric Nervous System Precursors

  2013cited by this paper
• Planar cell polarity genes control the connectivity of enteric neurons.

  2013influential reference
• Impaired Spatial Memory in Mice Lacking CD3ζ Is Associated with Altered NMDA and AMPA Receptors Signaling Independent of T-Cell Deficiency

  2013cited by this paper
• GDNF Signaling Levels Control Migration and Neuronal Differentiation of Enteric Ganglion Precursors

  2013cited by this paper
• Emerging roles of astrocytes in neural circuit development

  2013cited by this paper
• The enteric nervous system.

  2012cited by this paper
• Myenteric neurons of the mouse small intestine undergo significant electrophysiological and morphological changes during postnatal development

  2012cited by this paper
• Novel functional roles for enteric glia in the gastrointestinal tract

  2012cited by this paper
• Adenylate cyclase 5 coordinates the action of ADP, P2Y1, P2Y13 and ATP-gated P2X7 receptors on axonal elongation

  2012cited by this paper
• The omega‐6 fatty acid derivative 15‐deoxy‐Δ12,14‐prostaglandin J2 is involved in neuroprotection by enteric glial cells against oxidative stress

  2012cited by this paper
• Enteric glia promote intestinal mucosal healing via activation of focal adhesion kinase and release of proEGF.

  2011cited by this paper
• Glial cell line‐derived neurotrophic factor is a key neurotrophin in the postnatal enteric nervous system

  2011cited by this paper
• Homeodomain Interacting Protein Kinase 2 Regulates Postnatal Development of Enteric Dopaminergic Neurons and Glia via BMP Signaling

  2011cited by this paper
• Assisted morphogenesis: glial control of dendrite shapes.

  2010cited by this paper
• Postnatal development of myenteric neurochemical phenotype and impact on neuromuscular transmission in the rat colon.

  2010influential reference
• The Timing and Location of Glial Cell Line-Derived Neurotrophic Factor Expression Determine Enteric Nervous System Structure and Function

  2010cited by this paper
• Developmental determinants of the independence and complexity of the enteric nervous system.

  2010cited by this paper
• Enteric glial cells protect neurons from oxidative stress in part via reduced glutathione

  2010cited by this paper
• The role of neural activity in the migration and differentiation of enteric neuron precursors

  2010cited by this paper
• KIF26A is an unconventional kinesin and regulates GDNF-Ret signaling in enteric neuronal development.

  2009cited by this paper
• Development of the enteric nervous system: bringing together cells, signals and genes

  2009cited by this paper
• Retinoic acid regulates murine enteric nervous system precursor proliferation, enhances neuronal precursor differentiation, and reduces neurite growth in vitro.

  2008cited by this paper
• TGFβ signals regulate axonal development through distinct Smad-independent mechanisms

  2008cited by this paper
• Activity‐dependent regulation of tyrosine hydroxylase expression in the enteric nervous system

  2008cited by this paper
• Colonic neuropathological aspects in patients with intractable constipation due to obstructed defecation

  2007cited by this paper
• Conditional ablation of GFRα1 in postmigratory enteric neurons triggers unconventional neuronal death in the colon and causes a Hirschsprung's disease phenotype

  2007cited by this paper
• Enteric nervous system

  2007cited by this paper
• Development of colonic motility in the neonatal mouse-studies using spatiotemporal maps.

  2007cited by this paper
• Proinflammatory cytokines induce neurotrophic factor expression in enteric glia: a key to the regulation of epithelial apoptosis in Crohn's disease.

  2006cited by this paper
• Culturing hippocampal neurons

  2006cited by this paper
• MRS2500 [2-Iodo-N6-methyl-(N)-methanocarba-2′-deoxyadenosine-3′,5′-bisphosphate], a Potent, Selective, and Stable Antagonist of the Platelet P2Y1 Receptor with Strong Antithrombotic Activity in Mice

  2006cited by this paper
• Selective injury to dopaminergic neurons up-regulates GDNF in substantia nigra postnatal cell cultures: role of neuron-glia crosstalk.

  2006cited by this paper
• Changes in enteric neurone phenotype and intestinal functions in a transgenic mouse model of enteric glia disruption

  2005cited by this paper
• The human enteric nervous system

  2004cited by this paper
• Intercellular calcium waves in cultured enteric glia from neonatal guinea pig

  2003cited by this paper
• Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling

  2003cited by this paper
• Acquisition of neuronal and glial markers by neural crest–derived cells in the mouse intestine

  2003cited by this paper
• Neuronal and glial localization of GABA transporter immunoreactivity in the myenteric plexus

  2002cited by this paper
• L-Arginine Immunoreactive Enteric Glial Cells in the Enteric Nervous System of Rat Ileum

  2001cited by this paper
• Patch-clamp study of neurons and glial cells in isolated myenteric ganglia.

  2000cited by this paper
• ATP-Mediated Glia Signaling

  2000influential reference
• Multipotential progenitors of the mammalian enteric nervous system capable of colonising aganglionic bowel in organ culture.

  1999cited by this paper
• Inhibition of in vitro enteric neuronal development by endothelin-3: mediation by endothelin B receptors.

  1999cited by this paper
• Neurturin and GDNF promote proliferation and survival of enteric neuron and glial progenitors in vitro.

  1998cited by this paper
• Capacitative Ca2+ entry in enteric glia induced by thapsigargin and extracellular ATP.

  1998cited by this paper
• GFR alpha1-deficient mice have deficits in the enteric nervous system and kidneys.

  1998cited by this paper
• Renal agenesis and the absence of enteric neurons in mice lacking GDNF

  1996cited by this paper
• ATP mediates fast synaptic potentials in enteric neurons

  1994cited by this paper
• Anti-transforming growth factor (TGF)-beta antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-beta interactions in human breast cancer progression.

  1993cited by this paper
• Establishment and properties of separate cultures of enteric neurons and enteric glia.

  1988cited by this paper
• The enteric nervous system in tissue culture. I. Cell types and their interactions in explants of the myenteric and submucous plexuses from guinea pig, rabbit and rat.

  1983cited by this paper
• Astrocyte-like glia in the peripheral nervous system: an immunohistochemical study of enteric glia

  1983influential reference
• Evidence for the presence of S-100 protein in the glial component of the human enteric nervous system

  1982influential reference
• Glial cells in the enteric nervous system contain glial fibrillary acidic protein

  1980influential reference

• Short-Chain Fatty Acids Elicit Differential Expression of Growth Factors and Pro-Inflammatory Cytokines in Immortalized Rat Enteric Glial Cells

  2026cites this paper
• Exploring the diversity of biological processes regulated by glial cell line-derived neurotrophic factor, a pleiotropic molecule with therapeutic potential

  2025cites this paper
• Muscarinic Receptor-Mediated Electroacupuncture Modulation of Reactive Enteric Glial Cells Ameliorates Postoperative Ileus

  2025cites this paper
• The Double‐Edged Sword: The Complex Function of Enteric Glial Cells in Neurodegenerative Diseases

  2025cites this paper
• Contribution of neuroligin and neurexin alternative splicing to the establishment of enteric neuronal synaptic specificity.

  2025cites this paper
• Neutrophils in the Focus: Impact on Neuroimmune Dynamics and the Gut–Brain Axis

  2024cites this paper
• Indigenous gut microbiota constitutively drive release of ciliary neurotrophic factor from mucosal enteric glia to maintain the homeostasis of enteric neural circuits

  2024cites this paper
• Mesenchymal GDNF promotes intestinal enterochromaffin cell differentiation

  2024cites this paper
• Multi-platform analysis revealed the substance basis and mechanism of Wei-Tong-Xin in ameliorating ENS dysfunction for dyspepsia treatment.

  2024cites this paper
• Enteric Glia.

  2024cites this paper
• The Physiology of Enteric Glia

  2024influential citation
• The regulation of enteric neuron connectivity by semaphorin 5A is affected by the autism-associated S956G missense mutation

  2024cites this paper
• Plp1 in the enteric nervous system is preferentially expressed during early postnatal development in mouse as DM20, whose expression appears reliant on an intronic enhancer

  2023cites this paper
• Cytological, molecular, cytogenetic, and physiological characterization of a novel immortalized human enteric glial cell line

  2023cites this paper
• A functional network of highly pure enteric neurons in a dish

  2023cites this paper
• Effect of Reactive EGCs on Intestinal Motility and Enteric Neurons During Endotoxemia

  2022cites this paper
• Chronic microglial inflammation promotes neuronal lactate supply but impairs its utilization in primary rat astrocyte-neuron co-cultures.

  2022cites this paper
• 5/6 nephrectomy affects enteric glial cells and promotes impaired antioxidant defense in the colonic neuromuscular layer.

  2022cites this paper
• Adhesion of Gastric Cancer Cells to the Enteric Nervous System: Comparison between the Intestinal Type and Diffuse Type of Gastric Cancer

  2022cites this paper
• The microbiota–gut–brain axis: pathways to better brain health. Perspectives on what we know, what we need to investigate and how to put knowledge into practice

  2022cites this paper
• ROLE OF ENTERIC GLIA AND MICROBIOTA-GUT-BRAIN AXIS IN PARKINSON DISEASE PATHOGENESIS.

  2022cites this paper
• A Simple Method for Purified Primary Culture of Enteric Glial Cells from Mouse Small Intestine.

  2022cites this paper
• The ephrin receptor EphB2 regulates the connectivity and activity of enteric neurons

  2021cites this paper
• Enteric glial biology, intercellular signalling and roles in gastrointestinal disease

  2021cites this paper
• Differential gene expression analysis and weighted gene co-expression network analysis reveal mechanism behind the development of duodenal carcinoma in familial adenomatous polyposis

  2021cites this paper
• A Novel Role of A2AR in the Maintenance of Intestinal Barrier Function of Enteric Glia from Hypoxia-Induced Injury by Combining with mGluR5

  2021cites this paper
• Enteric glial cells exert neuroprotection from hyperglycemia-induced damage via Akt/GSK3β pathway

  2021cites this paper
• Enteric glia in homeostasis and disease: From fundamental biology to human pathology

  2021cites this paper
• Automated computational analysis reveals structural changes in the enteric nervous system of nNOS deficient mice

  2021cites this paper
• Fecal Supernatant from Adult with Autism Spectrum Disorder Alters Digestive Functions, Intestinal Epithelial Barrier, and Enteric Nervous System

  2021cites this paper
• Reactive Enteric Glial Cells Participate in Paralytic Ileus by Damaging Nitrergic Neurons During Endotoxemia

  2021cites this paper
• To learn, to remember, to forget—How smart is the gut?

  2020cites this paper
• Neuron–Glia Interaction in the Developing and Adult Enteric Nervous System

  2020influential citation
• Semaphorin 3A controls enteric neuron connectivity and is inversely associated with synapsin 1 expression in Hirschsprung disease

  2020cites this paper
• Generation and Optimization of Highly Pure Motor Neurons from Human Induced Pluripotent Stem Cells via Lentiviral Delivery of Transcription Factors.

  2020cites this paper
• The role of GDNF and its receptor GFRa1 in neuronal development and function

  2020cites this paper
• Progenitor populations within the vertebrate enteric nervous system

  2019cites this paper
• Novel Insights on the Toxicity of Phycotoxins on the Gut through the Targeting of Enteric Glial Cells

  2019cites this paper
• Advances in morphologic study of enteric glial cells

  2019cites this paper
• Diadenosine tetraphosphate activates P2Y1 receptors that cause smooth muscle relaxation in the mouse colon.

  2019cites this paper
• Enteric glial cell activation protects enteric neurons from damage due to diabetes in part via the promotion of neurotrophic factor release

  2018cites this paper
• Maternal protein restriction induces gastrointestinal dysfunction and enteric nervous system remodeling in rat offspring

  2018cites this paper
• Enteric nervous system development: what could possibly go wrong?

  2018cites this paper
• From Cultured Rodent Neurons to Human Brain Tissue: Model Systems for Pharmacological and Translational Neuroscience.

  2018cites this paper
• The Tenascin-C-Derived Peptide VSWRAPTA Promotes Neuronal Branching Via Transcellular Activation of the Focal Adhesion Kinase (FAK) and the ERK1/2 Signaling Pathway In Vitro

  2018cites this paper
• Colorectal Cancer Cells Adhere to and Migrate Along the Neurons of the Enteric Nervous System

  2017cites this paper
• Arundic Acid Prevents Developmental Upregulation of S100B Expression and Inhibits Enteric Glial Development

  2017cites this paper
• Potential roles of enteric glia in bridging neuroimmune communication in the gut.

  2017cites this paper
• Rodent Enteric Glia Culture.

  year unknowncites this paper