ASPP1, a common activator of TP53, is inactivated by aberrant methylation of its promoter in acute lymphoblastic leukemia

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Oncogene

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  DOI 10.1038/onc.2012.593PMID 16314841
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• The normal epithelial cell-specific 1 (NES1) gene, a candidate tumor suppressor gene on chromosome 19q13.3–4, is downregulated by hypermethylation in acute lymphoblastic leukemia

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• Methylation of CpG dinucleotides and/or CCWGG motifs at the promoter of TP53 correlates with decreased gene expression in a subset of acute lymphoblastic leukemia patients

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• iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human

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• A B-cell acute lymphoblastic leukemia regulatory network defines novel therapeutic targets in IGH-CRLF 2 patients

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• Aspp1 Preserves Hematopoietic Stem Cell Pool Integrity and Prevents Malignant Transformation.

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